Synthesis, Characterization and Biological Activity Study of Cobalt(II), Nickel(II) and Copper(II) Complexes Derived from Mixed Bi dentate Ligands of Oxime and Phenanthroline11

Abstract

The present work involves the synthesis and characterization of cobalt (II), nickel (II) and copper (II) complexes derived from (1:1:1) mole ratios of coumarine-oxime:1,10-phenanthroline:metal ions with respect to the continuous variation method of Job via spectroscopic studies. The isolated metal complexes were characterized with their ligands of 3-acetoxime-coumarine by elemental analyses, FT-IR, EI-MS and NMR spectra. The flame atomic absorption spectroscopy, molar conductivity in DMF and magnetic moment measurements were also employed to determine the supposed molecular weights and their geometry. Furthermore the gravimetric thermal analysis (TG-DTA) was estimated for copper(II) and nickel(II) complexes and the observed data form weight loss percents confirmed the suggested chemical formulas and structures of complexes. The results observed from UV-Visible spectra and elemental analyses together with mass spectra confirmed the octahedral geometry around the cobalt(II) and copper(II) ions whereas the diamagnetic complex of nickel(II) was square-planner in [Ni(Phen)(L)]Cl2 formula. As well as the biological activities of complexes solutions were tested against two types of bacteria and the inhibition zones data proved that all solutions were active compared with standard drugs of 10 ppm concentrations.