发布求助
文献互助 智能选刊 最新文献

Synlett最新文献

筛选
英文 中文
Activating Methanol for Chemoselective Transfer Hydrogenation of Chalcones Using an SNS-Ruthenium Complex 利用 SNS-Ruthenium 复合物活化甲醇以进行查耳酮的化学选择性转移加氢反应
IF 2 4区 化学
Synlett Pub Date : 2024-09-09 DOI: 10.1055/a-2384-6441
Kailash Mohar, Hirak Jyoti Phukan, Avijit Mondal, Kaushik Soni, Dipankar Srimani
{"title":"Activating Methanol for Chemoselective Transfer Hydrogenation of Chalcones Using an SNS-Ruthenium Complex","authors":"Kailash Mohar, Hirak Jyoti Phukan, Avijit Mondal, Kaushik Soni, Dipankar Srimani","doi":"10.1055/a-2384-6441","DOIUrl":"https://doi.org/10.1055/a-2384-6441","url":null,"abstract":"<p>Methanol is gaining popularity as a transfer-hydrogenating agent in catalytic reduction reactions because of its bulk-scale production and inexpensive nature. Current research interests include the utilization of methanol as a safe and sustainable hydrogen source for chemical synthesis and drug development. In particular, the chemoselective reduction of α,β-unsaturated ketones is of great interest because of their prevalence in many natural products. We investigated the potential application of acridine-derived SNS-Ru pincer complexes in methanol activation for chemoselective reduction of chalcones. Our developed catalytic system showed broad substrate tolerance, including substrates containing reducible functional groups. Control experiments and postsynthetic applications are also highlighted.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nickel-Catalyzed Radical Hydroalkylative Dearomatization of Indoles with Alkyl Bromides 镍催化的吲哚与烷基溴的自由基氢烷基化反应
IF 2 4区 化学
Synlett Pub Date : 2024-09-04 DOI: 10.1055/a-2382-0292
Hao-Tian Dai, Xu-Lun Huang, Yuan-Zheng Cheng, Shu-Li You
{"title":"Nickel-Catalyzed Radical Hydroalkylative Dearomatization of Indoles with Alkyl Bromides","authors":"Hao-Tian Dai, Xu-Lun Huang, Yuan-Zheng Cheng, Shu-Li You","doi":"10.1055/a-2382-0292","DOIUrl":"https://doi.org/10.1055/a-2382-0292","url":null,"abstract":"<p>Dearomatization of indole derivatives offers a straightforward approach to accessing the indoline framework. However, highly efficient dearomatization of indoles bearing electron-deficient groups remains underdeveloped. Herein, a nickel-catalyzed intermolecular hydroalkylative dearomatization reaction of indoles with simple alkyl bromides through a single-electron-transfer process is reported. A wide variety of indole derivatives bearing various functional groups were compatible with this protocol and reacted with primary, secondary, or tertiary alkyl bromides to afford a series of indolines in good yields (up to 82%) and with excellent diastereoselectivity (up to >20:1). Notably, a nickel-mediated hydrogen-atom-transfer process was observed when terminal alkyl bromides were employed as the radical precursors, which resulted in branched products.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron(III) Triflate and γ-Cyclodextrin-Catalyzed Hydroarylation of Alkenes with 1-Naphthols and 2-Naphthols 三氟化铁和 γ-环糊精催化烯烃与 1-萘酚和 2-萘酚的加氢反应
IF 2 4区 化学
Synlett Pub Date : 2024-09-04 DOI: 10.1055/a-2382-3010
Meng-Xue Hu, Peng Chen, Le-Wei Miao, Jianghuan Shi, Yi-Jun Jiang
{"title":"Iron(III) Triflate and γ-Cyclodextrin-Catalyzed Hydroarylation of Alkenes with 1-Naphthols and 2-Naphthols","authors":"Meng-Xue Hu, Peng Chen, Le-Wei Miao, Jianghuan Shi, Yi-Jun Jiang","doi":"10.1055/a-2382-3010","DOIUrl":"https://doi.org/10.1055/a-2382-3010","url":null,"abstract":"<p>A Fe(OTf)<sub>3</sub> and γ-cyclodextrin-catalyzed hydroarylation of alkenes with 1-naphthols or 2-naphthols is demonstrated. This efficient and general method delivers a wide range of benzylic naphthols from readily available starting materials with high chemo- and regioselectivity in up to 99% yield, with no need for a strong base or additive.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral π-Conjugated Double Helical Aminyl Diradical with the Triplet Ground State 具有三重基态的手性π-共轭双螺旋氨酰基二旋体
IF 2 4区 化学
Synlett Pub Date : 2024-09-02 DOI: 10.1055/a-2379-9406
Haoxin Guo, Andrzej Rajca
{"title":"Chiral π-Conjugated Double Helical Aminyl Diradical with the Triplet Ground State","authors":"Haoxin Guo, Andrzej Rajca","doi":"10.1055/a-2379-9406","DOIUrl":"https://doi.org/10.1055/a-2379-9406","url":null,"abstract":"<p>We describe effective development of the highly diastereoselective synthesis of double helical tetraamine <b>2</b>-H<sub>2</sub>-C<sub>2</sub> and propose a mechanism for its formation. The resolution of <b>2</b>-H<sub>2</sub>-C<sub>2</sub> is facilitated by a high racemization barrier of 43 kcal mol<sup>–1</sup> and it is implemented via either a chiral auxiliary or preparative supercritical fluid chromatography. This enables preparation of the first high-spin neutral diradical, with spin density delocalized within an enantiomeric double helical π-system. The presence of two effective 3-electron C–N bonds in the diradical leads to: (1) the triplet (S = 1) high-spin ground state with a singlet-triplet energy gap of 0.4 kcal mol<sup>–1</sup> and (2) the long half-life of up to 6 days in 2-MeTHF at room temperature. The diradical possesses a racemization barrier of at least 26 kcal mol<sup>–1</sup> in 2-MeTHF at 293 K and chiroptical properties, with an absorption anisotropy factor |g| ≈ 0.005 at 548 nm. These unique magnetic and optical properties of our diradical form the basis for the development of next-generation spintronic devices.</p> <p>1 Introduction</p> <p>2 Synthesis and Resolution of the <i>C</i>\u0000<sub>2</sub>-Symmetric Double Helical Tetraamine 2-H<sub>2</sub>-<i>C</i>\u0000<sub>2</sub>\u0000</p> <p>3 Synthesis and Characterization of Neutral High-Spin Aminyl Diradical <b>2<sup>2•</sup>\u0000</b>-<i>C</i>\u0000<sub>2</sub>\u0000</p> <p>4 Conclusion</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dehydrosilylation of Alcohols Using Gold Nanoparticles Deposited on Citric Acid Modified Fibrillated Cellulose 使用沉积在柠檬酸改性纤维素上的金纳米粒子对醇进行脱氢硅烷化处理
IF 2 4区 化学
Synlett Pub Date : 2024-09-02 DOI: 10.1055/a-2379-9191
Butsaratip Suwattananuruk, Yuta Uetake, Hidehiro Sakurai
{"title":"Dehydrosilylation of Alcohols Using Gold Nanoparticles Deposited on Citric Acid Modified Fibrillated Cellulose","authors":"Butsaratip Suwattananuruk, Yuta Uetake, Hidehiro Sakurai","doi":"10.1055/a-2379-9191","DOIUrl":"https://doi.org/10.1055/a-2379-9191","url":null,"abstract":"<p>The development of an effective catalytic system for the dehydrogenative coupling of hydrosilanes with alcohols remains an ongoing challenge, particularly for alcohol protection applications. In this study, we report the development and optimization of a highly efficient gold catalyst supported on fibrillated cellulose modified with citric acid. The catalyst exhibited remarkable catalytic activity under mild conditions with 0.01–0.05 mol% of Au loading, facilitating the formation of silyl ethers with excellent yield. Notably, our catalytic system overcomes the need for excess alcohol, typically required in such reactions, making it highly practical for alcohol protection applications. This work represents a significant advancement in the field of dehydrosilylation catalysis, offering a sustainable, efficient, and environmentally friendly approach for the synthesis of functional silanol-based materials and alcohol protection applications. The scope of substrates and the utility of the catalyst have been thoroughly studied.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature-Controlled Synthesis of Thiophenol-VBXs from EBXs and Thiophenols 由 EBX 和噻吩酚在温控下合成噻吩酚-VBXs
IF 2 4区 化学
Synlett Pub Date : 2024-08-30 DOI: 10.1055/a-2377-0118
Jun Li, Chuang Zhou, Lian-Mei Chen, Xing-Yu Chen, Xiao-Qiang Guo, Tai-Ran Kang
{"title":"Temperature-Controlled Synthesis of Thiophenol-VBXs from EBXs and Thiophenols","authors":"Jun Li, Chuang Zhou, Lian-Mei Chen, Xing-Yu Chen, Xiao-Qiang Guo, Tai-Ran Kang","doi":"10.1055/a-2377-0118","DOIUrl":"https://doi.org/10.1055/a-2377-0118","url":null,"abstract":"<p>Vinylbenziodoxolones (VBXs) are important electrophilic alkene synthons. However, the synthesis of <i>cis</i>-thiophenol-VBX reagents from ethynylbenziodoxolones (EBXs) and thiophenols remains challenging. Herein, we explore an efficient method for the synthesis of <i>cis</i>-thiophenol-VBXs in excellent yield with excellent regio- and stereoselectivities from EBXs and thiophenols under temperature-controlled conditions.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the Intermolecular Asymmetric Allylic Functionalization of Unreactive Acyclic Alkenes 非活性无环烯的分子间不对称烯丙基官能团化研究进展
IF 2 4区 化学
Synlett Pub Date : 2024-08-29 DOI: 10.1055/a-2375-7634
Mingyue Zhang, Mengmeng Zhang, Changsheng Li, Wenyang Wang, Guohui Shi, Shipeng Luo, Liang-An Chen, Qiang Dai
{"title":"Advances in the Intermolecular Asymmetric Allylic Functionalization of Unreactive Acyclic Alkenes","authors":"Mingyue Zhang, Mengmeng Zhang, Changsheng Li, Wenyang Wang, Guohui Shi, Shipeng Luo, Liang-An Chen, Qiang Dai","doi":"10.1055/a-2375-7634","DOIUrl":"https://doi.org/10.1055/a-2375-7634","url":null,"abstract":"<p>Allylic C(<i>sp</i>\u0000<sup>3</sup>)–H functionalized architectures are not only widely present in natural products, pharmaceuticals, and functional organic materials, but also serve as versatile building blocks to furnish important functionalized molecules in synthetic chemistry. Accordingly, various strategies to access allylic functionalized alkenes in a stereoselective manner have been developed. However, chemo-, regio- and stereoselective intermolecular asymmetric allylic functionalization (AAF) of unreactive acyclic alkene (UAA) from readily available materials, representing a highly atom- and step-economic approach toward the generation of structural complexity, remains elusive and challenging. Herein, we review all intermolecular asymmetric catalyzed methods, with emphasis on the construction of chiral allylic units by activation of allylic C–H bonds of UAAs. Our analysis serves to document the considerable and rapid progress within the field, while also highlighting the limitations of current methods.</p> <p>1 Introduction</p> <p>2 Asymmetric Allylic Oxygenation</p> <p>3 Asymmetric Allylic Amination</p> <p>4 Asymmetric Allylic Carbonization</p> <p>5 Asymmetric Allylic Sulfuration</p> <p>6 Conclusion and Outlook</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Synthesis of N-Substituted Phosphinecarboxamides from [TBA][P(SiCl3)2] and Isonitriles 由 [TBA][P(SiCl3)2]和异腈直接合成 N-取代的膦甲酰胺
IF 2 4区 化学
Synlett Pub Date : 2024-08-29 DOI: 10.1055/s-0043-1775388
Bo Yang, Xin Wang, Yao Chai, Wen-Bo Xu, Ya-Ling Tian, Yong-Jun Ma, Anwar I. Alduma, Xin-Rui Cao, Xi-Cun Wang, Dong-Ping Chen, Zheng-Jun Quan
{"title":"Direct Synthesis of N-Substituted Phosphinecarboxamides from [TBA][P(SiCl3)2] and Isonitriles","authors":"Bo Yang, Xin Wang, Yao Chai, Wen-Bo Xu, Ya-Ling Tian, Yong-Jun Ma, Anwar I. Alduma, Xin-Rui Cao, Xi-Cun Wang, Dong-Ping Chen, Zheng-Jun Quan","doi":"10.1055/s-0043-1775388","DOIUrl":"https://doi.org/10.1055/s-0043-1775388","url":null,"abstract":"<p>In this investigation, <i>N</i>-substituted phosphinecarboxamides were produced through the reaction of [TBA][P(SiCl<sub>3</sub>)<sub>2</sub>] with isonitriles. This method capitalizes on the flexibility of isonitriles as a source of both nitrogen and carbonyl groups, offering a novel route to the generation of PH<sub>2</sub>-type compounds. This approach is characterized by rapid reaction times, simple procedural requirements, compatibility with a diverse array of substrates, and the conversion of [TBA][P(SiCl<sub>3</sub>)<sub>2</sub>] into organic phosphorus compounds. Additionally, we systematically studied the reaction mechanism of isonitrile with [TBA][P(SiCl<sub>3</sub>)<sub>2</sub>] through controlled experiments and density functional theory (DFT) calculations.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Chiral L2/Z-Type Ligands Featuring a Bisoxazoline Framework and Their Application to Palladium-Catalyzed Asymmetric Allylic Alkylation 具有双噁唑啉框架的手性 L2/Z 型配体的合成及其在钯催化不对称烯丙基烷基化中的应用
IF 2 4区 化学
Synlett Pub Date : 2024-08-26 DOI: 10.1055/a-2377-0844
Hikaru Takahashi, Takashi Shibata, Daisuke Naito, Ryo Murakami, Fuyuhiko Inagaki
{"title":"Synthesis of Chiral L2/Z-Type Ligands Featuring a Bisoxazoline Framework and Their Application to Palladium-Catalyzed Asymmetric Allylic Alkylation","authors":"Hikaru Takahashi, Takashi Shibata, Daisuke Naito, Ryo Murakami, Fuyuhiko Inagaki","doi":"10.1055/a-2377-0844","DOIUrl":"https://doi.org/10.1055/a-2377-0844","url":null,"abstract":"<p>Chiral L<sub>2</sub>/Z*-type ligands featuring a bisoxazoline framework have been successfully synthesized and applied in asymmetric allylic alkylation. These ligands, designed based on an oxazoline skeleton and derived from chiral amino acid derivatives, incorporate antimony and bismuth as Z-type ligands. Ligands with bulky, electron-withdrawing groups on antimony and bismuth showed enhanced catalytic performance. This research highlights the potential of these novel chiral L<sub>2</sub>/Z*-type ligands to improve asymmetric catalysis.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction of Fluorinated Groups via Photoredox-Catalyzed C–H Functionalization of (Hetero-)Arenes 通过光氧化催化（杂）烯的 C-H 功能化引入氟化基团
IF 2 4区 化学
Synlett Pub Date : 2024-08-23 DOI: 10.1055/a-2377-0629
Jonas F. Goebel, Sourav Manna, Pierpaolo Satta, Nikolaos V. Tzouras, Lukas J. Gooßen
{"title":"Introduction of Fluorinated Groups via Photoredox-Catalyzed C–H Functionalization of (Hetero-)Arenes","authors":"Jonas F. Goebel, Sourav Manna, Pierpaolo Satta, Nikolaos V. Tzouras, Lukas J. Gooßen","doi":"10.1055/a-2377-0629","DOIUrl":"https://doi.org/10.1055/a-2377-0629","url":null,"abstract":"<p>In recent years, there have been increasing efforts in the development of methodologies for incorporating fluorine-containing functional groups into organic scaffolds. Modern techniques have made fluorinated molecules more accessible than ever before, but many fluorination reactions still have limitations in their generality, predictability, sustainability, and cost-effectiveness. The methodological progress has a significant impact on drug discovery and materials science research. Photoredox catalysis has enabled the discovery of effective methods, providing access to druglike molecules. Photochemical methods paired with C–H functionalization provide powerful tools for property-driven research. Herein, we examine recent developments at the interface of photoredox catalysis and C–H functionalization.</p> <p>1 Introduction</p> <p>2 Fluorinations</p> <p>3 Fluoroalkylations</p> <p>4 Fluoroalkoxylations</p> <p>5 Conclusion</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信