Introduction of Fluorinated Groups via Photoredox-Catalyzed C–H Functionalization of (Hetero-)Arenes

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC
Synlett Pub Date : 2024-08-23 DOI:10.1055/a-2377-0629
Jonas F. Goebel, Sourav Manna, Pierpaolo Satta, Nikolaos V. Tzouras, Lukas J. Gooßen
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引用次数: 0

Abstract

In recent years, there have been increasing efforts in the development of methodologies for incorporating fluorine-containing functional groups into organic scaffolds. Modern techniques have made fluorinated molecules more accessible than ever before, but many fluorination reactions still have limitations in their generality, predictability, sustainability, and cost-effectiveness. The methodological progress has a significant impact on drug discovery and materials science research. Photoredox catalysis has enabled the discovery of effective methods, providing access to druglike molecules. Photochemical methods paired with C–H functionalization provide powerful tools for property-driven research. Herein, we examine recent developments at the interface of photoredox catalysis and C–H functionalization.

1 Introduction

2 Fluorinations

3 Fluoroalkylations

4 Fluoroalkoxylations

5 Conclusion

Abstract Image

通过光氧化催化(杂)烯的 C-H 功能化引入氟化基团
近年来,人们越来越努力地开发将含氟官能团纳入有机支架的方法。现代技术使含氟分子比以往任何时候都更容易获得,但许多氟化反应在通用性、可预测性、可持续性和成本效益方面仍有局限。方法上的进步对药物发现和材料科学研究产生了重大影响。光氧化催化技术使人们能够发现有效的方法,从而获得类似药物的分子。光化学方法与 C-H 功能化相配合,为性质驱动型研究提供了强大的工具。在此,我们将探讨光氧化催化和 C-H 功能化界面的最新进展。1 引言 2 氟化反应 3 氟烷基化反应 4 氟烷氧基化反应 5 结论
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Synlett
Synlett 化学-有机化学
CiteScore
3.40
自引率
5.00%
发文量
369
审稿时长
1 months
期刊介绍: SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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