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The Brown University Psychopharmacology Update最新文献

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The frustrating disconnect between genetics and psychopharmacology 遗传学和精神药理学之间令人沮丧的脱节
The Brown University Psychopharmacology Update Pub Date : 2025-03-27 DOI: 10.1002/pu.31302
Lawrence H. Price M.D.
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引用次数: 0
Xanomeline-trospium significantly improves cognition in acute schizophrenia Xanomeline-trospium可显著改善急性精神分裂症患者的认知能力
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31284
{"title":"Xanomeline-trospium significantly improves cognition in acute schizophrenia","authors":"","doi":"10.1002/pu.31284","DOIUrl":"https://doi.org/10.1002/pu.31284","url":null,"abstract":"<p>The drug combining xanomeline and trospium chloride (Cobenfy®) significantly improved cognition relative to placebo in cognitively impaired adults with acute schizophrenia, a study based on data from two Phase 3 trials has found. Changes in cognition were not significantly correlated with changes in symptoms of schizophrenia, study investigators reported. Study results were published online Dec. 11, 2024, in the <i>American Journal of Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study suggests value of including genetic testing in clozapine monitoring 研究提示基因检测在氯氮平监测中的价值
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31290
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引用次数: 0
Depression study shows influence of patients' treatment expectancies 抑郁症研究显示患者治疗预期的影响
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31291
{"title":"Depression study shows influence of patients' treatment expectancies","authors":"","doi":"10.1002/pu.31291","DOIUrl":"https://doi.org/10.1002/pu.31291","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Varenicline shows best results for smokers with current or past depression 伐尼克兰对目前或过去患有抑郁症的吸烟者效果最好
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31287
{"title":"Varenicline shows best results for smokers with current or past depression","authors":"","doi":"10.1002/pu.31287","DOIUrl":"https://doi.org/10.1002/pu.31287","url":null,"abstract":"<p>Among smokers with current or past major depressive disorder, varenicline offered the most favorable combination of efficacy and safety in an analysis of the approved treatment options for smoking cessation. None of the studied treatments resulted in an increased risk of neuropsychiatric adverse events in individuals with a depression history.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Olanzapine plus samidorphan shows long-term safety in patients with schizophrenia 奥氮平加萨米多芬在精神分裂症患者中显示长期安全性
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31293
{"title":"Olanzapine plus samidorphan shows long-term safety in patients with schizophrenia","authors":"","doi":"10.1002/pu.31293","DOIUrl":"https://doi.org/10.1002/pu.31293","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nicotinic receptor modulator shows promise in PTSD treatment 尼古丁受体调节剂有望用于PTSD治疗
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31294
{"title":"Nicotinic receptor modulator shows promise in PTSD treatment","authors":"","doi":"10.1002/pu.31294","DOIUrl":"https://doi.org/10.1002/pu.31294","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brexpiprazole-sertraline combination improves symptoms of PTSD 布雷哌唑-舍曲林联合治疗可改善PTSD症状
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31285
{"title":"Brexpiprazole-sertraline combination improves symptoms of PTSD","authors":"","doi":"10.1002/pu.31285","DOIUrl":"https://doi.org/10.1002/pu.31285","url":null,"abstract":"<p>Combination treatment with brexpiprazole and sertraline was significantly more effective than sertraline plus placebo in reducing symptoms of post-traumatic stress disorder (PTSD) in adults, a Phase 3 study has found. The brexpiprazole-sertraline combination also showed good safety results in line with the safety profile of brexpiprazole. Study results were published online Dec. 18, 2024, in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychotropic-induced lipid disturbances 精神药物引起的脂质紊乱
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31286
Y. W. Francis Lam Pharm.D., FCCP
{"title":"Psychotropic-induced lipid disturbances","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31286","DOIUrl":"https://doi.org/10.1002/pu.31286","url":null,"abstract":"<p>Use of psychotropic drugs, especially but not only most second-generation antipsychotics, is associated with higher levels of lipids, posing an increased risk for developing cardiovascular disease (Pillinger et al., 2020). There is also evidence that plasma lipid levels and dyslipidemia are substantially impacted by clinical and genetic factors (Ramasamy, 2016).</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psilocybin therapy might help frontline pandemic workers 裸盖菇素治疗可能有助于一线疫情工作者
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31292
{"title":"Psilocybin therapy might help frontline pandemic workers","authors":"","doi":"10.1002/pu.31292","DOIUrl":"https://doi.org/10.1002/pu.31292","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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