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The Brown University Psychopharmacology Update最新文献

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Psilocybin shows mixed results for patients with treatment-resistant depression 裸盖菇素对难治性抑郁症患者的疗效好坏参半
The Brown University Psychopharmacology Update Pub Date : 2026-05-29 DOI: 10.1002/pu.31461
{"title":"Psilocybin shows mixed results for patients with treatment-resistant depression","authors":"","doi":"10.1002/pu.31461","DOIUrl":"https://doi.org/10.1002/pu.31461","url":null,"abstract":"<p>Patients with treatment-resistant depression who received psilocybin-assisted psychotherapy showed clinically meaningful improvement in depressive symptoms relative to placebo, a Phase 2b trial has found. However, the study did not show a significant effect on the primary outcome of treatment response 6 weeks after the first of two doses of psilocybin. Study results were published online March 18, 2026 in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 7","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148099496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clozapine shows benefit in first-episode psychosis after one failed trial 氯氮平在一次失败的试验后显示对首发精神病有益
The Brown University Psychopharmacology Update Pub Date : 2026-05-29 DOI: 10.1002/pu.31462
{"title":"Clozapine shows benefit in first-episode psychosis after one failed trial","authors":"","doi":"10.1002/pu.31462","DOIUrl":"https://doi.org/10.1002/pu.31462","url":null,"abstract":"<p>Individuals with first-episode psychosis who were switched to clozapine after a failed antipsychotic trial saw greater improvement than those receiving olanzapine or amisulpride, a sequential trial has found. The results offer some evidence to counteract the common recommendation to initiate clozapine only after at least two failed antipsychotic trials. Study results were published online March 11, 2026 in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 7","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148099940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of maternal acetaminophen use on child neurodevelopment 母亲使用对乙酰氨基酚对儿童神经发育的影响
The Brown University Psychopharmacology Update Pub Date : 2026-05-29 DOI: 10.1002/pu.31463
Y. W. Francis Lam Pharm.D., FCCP
{"title":"Impact of maternal acetaminophen use on child neurodevelopment","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31463","DOIUrl":"https://doi.org/10.1002/pu.31463","url":null,"abstract":"<p>Acetaminophen is one of the most common over-the-counter (OTC) medications taken for relief of fever and pain, including minor discomforts during pregnancy. It is also associated with little risk of dose-related toxicity, outside of hepatotoxicity from a significant amount of ingestion over a limited time of one to two days.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 7","pages":"2-3"},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148099621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When both treatments unblinded, psychedelics not more effective than antidepressants 当两种治疗方法都没有盲法时，迷幻药并不比抗抑郁药更有效
The Brown University Psychopharmacology Update Pub Date : 2026-05-29 DOI: 10.1002/pu.31464
{"title":"When both treatments unblinded, psychedelics not more effective than antidepressants","authors":"","doi":"10.1002/pu.31464","DOIUrl":"https://doi.org/10.1002/pu.31464","url":null,"abstract":"<p>A systematic review and meta-analysis comprising 24 trials has concluded that when both psychedelic and antidepressant trials in the treatment of depression are unblinded, psychedelics are no more effective than open-label antidepressants. The findings call into question some optimistic projections about the efficacy of psychedelics in depression treatment.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148099941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis finds little benefit from cannabinoids for behavioral disorders 荟萃分析发现大麻素对行为障碍几乎没有好处
The Brown University Psychopharmacology Update Pub Date : 2026-05-29 DOI: 10.1002/pu.31466
{"title":"Meta-analysis finds little benefit from cannabinoids for behavioral disorders","authors":"","doi":"10.1002/pu.31466","DOIUrl":"https://doi.org/10.1002/pu.31466","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 7","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148099943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-dose psilocybin with CBT more effective than nicotine patch for smoking cessation 单剂量裸盖菇素配合CBT戒烟比尼古丁贴片更有效
The Brown University Psychopharmacology Update Pub Date : 2026-05-29 DOI: 10.1002/pu.31467
{"title":"Single-dose psilocybin with CBT more effective than nicotine patch for smoking cessation","authors":"","doi":"10.1002/pu.31467","DOIUrl":"https://doi.org/10.1002/pu.31467","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148099944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Brown University Psychopharmacology Update Pub Date : 2026-04-30
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引用次数: 0
The Brown University Psychopharmacology Update Pub Date : 2026-04-30
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引用次数: 0
The Brown University Psychopharmacology Update Pub Date : 2026-04-30
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引用次数: 0
The Brown University Psychopharmacology Update Pub Date : 2026-04-30
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引用次数: 0
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