{"title":"Xanomeline-trospium significantly improves cognition in acute schizophrenia","authors":"","doi":"10.1002/pu.31284","DOIUrl":"https://doi.org/10.1002/pu.31284","url":null,"abstract":"<p>The drug combining xanomeline and trospium chloride (Cobenfy®) significantly improved cognition relative to placebo in cognitively impaired adults with acute schizophrenia, a study based on data from two Phase 3 trials has found. Changes in cognition were not significantly correlated with changes in symptoms of schizophrenia, study investigators reported. Study results were published online Dec. 11, 2024, in the <i>American Journal of Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study suggests value of including genetic testing in clozapine monitoring","authors":"","doi":"10.1002/pu.31290","DOIUrl":"https://doi.org/10.1002/pu.31290","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Depression study shows influence of patients' treatment expectancies","authors":"","doi":"10.1002/pu.31291","DOIUrl":"https://doi.org/10.1002/pu.31291","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Varenicline shows best results for smokers with current or past depression","authors":"","doi":"10.1002/pu.31287","DOIUrl":"https://doi.org/10.1002/pu.31287","url":null,"abstract":"<p>Among smokers with current or past major depressive disorder, varenicline offered the most favorable combination of efficacy and safety in an analysis of the approved treatment options for smoking cessation. None of the studied treatments resulted in an increased risk of neuropsychiatric adverse events in individuals with a depression history.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Olanzapine plus samidorphan shows long-term safety in patients with schizophrenia","authors":"","doi":"10.1002/pu.31293","DOIUrl":"https://doi.org/10.1002/pu.31293","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nicotinic receptor modulator shows promise in PTSD treatment","authors":"","doi":"10.1002/pu.31294","DOIUrl":"https://doi.org/10.1002/pu.31294","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brexpiprazole-sertraline combination improves symptoms of PTSD","authors":"","doi":"10.1002/pu.31285","DOIUrl":"https://doi.org/10.1002/pu.31285","url":null,"abstract":"<p>Combination treatment with brexpiprazole and sertraline was significantly more effective than sertraline plus placebo in reducing symptoms of post-traumatic stress disorder (PTSD) in adults, a Phase 3 study has found. The brexpiprazole-sertraline combination also showed good safety results in line with the safety profile of brexpiprazole. Study results were published online Dec. 18, 2024, in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychotropic-induced lipid disturbances","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31286","DOIUrl":"https://doi.org/10.1002/pu.31286","url":null,"abstract":"<p>Use of psychotropic drugs, especially but not only most second-generation antipsychotics, is associated with higher levels of lipids, posing an increased risk for developing cardiovascular disease (Pillinger et al., 2020). There is also evidence that plasma lipid levels and dyslipidemia are substantially impacted by clinical and genetic factors (Ramasamy, 2016).</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psilocybin therapy might help frontline pandemic workers","authors":"","doi":"10.1002/pu.31292","DOIUrl":"https://doi.org/10.1002/pu.31292","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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