THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019最新文献

{"title":"Effect of Sundanese music on daytime sleep quality based on EEG signal","authors":"D. E. Kusumandari, M. A. Suhendra, M. Rizqyawan, A. I. Simbolon, A. Turnip, P. Wardono, Adriani Rizka","doi":"10.1063/1.5139394","DOIUrl":"https://doi.org/10.1063/1.5139394","url":null,"abstract":"In theory, Daytime sleep is decreasing stress and increasing mood, focus, cognitive function. In this research, we would like to know the impact of Sundanese music on sleep quality based EEG signals in the daytime. The extraction features used wavelet Daubechies D8 level 7 and Fast Fourier Transform to divide it to alpha and theta band ranges. The experimental results from 10 subjects showed that using Sundanese music as treatment can make brain activity become calm and relax. Also, using T-Test to find relationships and influences between pre and post-treatment and The Result of T-Test showed that the value (p) is below 0.05 (p< 0.05), then these treatment has affected and it can to be alternative for day time sleep therapy.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72807921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total phenolic, UPLC-QTOF-MS analysis and antidepressant-like effect in the mice forced swim test of Jamu Neuropathic Pain Reducer","authors":"A. Hanifah, D. Tristantini","doi":"10.1063/1.5139347","DOIUrl":"https://doi.org/10.1063/1.5139347","url":null,"abstract":"Neuropathic (nerve) pain is caused by damage, dysfunction or injury of nerves it will affect patient’s quality of life because of chronicity and intensity. The pharmaceutical drug commonly used to treat neuropathic pain is antidepressants. However, Anti-depressant drug has dangerous side effects if consumed continuously. Herbs treatments use throughout the world for the treatment of neuropathic pain. Jamu Neuropathic Pain Reducer, which consists of aqueous multi herbs extract of nutmeg seed (Myristica fragrans), clove bud (Syzygium aromaticum) and red ginger rhizome (Zingiber officinale var rubrum) was extracted with variation temperature (60, 80, 100 ℃). This study aimed to figure out the total phenolic content (TPC) in the Jamu Neuropathic Pain Reducer used the Folin-Ciocalteu method. The highest TPC (33.58 ± 1.473mg GAE/g herb) happened at temperature 80 ℃. UPLC-QTOF-MS applied to identify the major bioactive compound in Jamu Neuropathic Pain Reducer extract used temperature extraction 80 ℃, analysis revealed the presence of compounds such as adenine, chlorogenic acid, miquelianin, quercitrin, 6-gingerol, myristicin, and eugenol. Jamu Neuropathic Pain Reducer reduced the immobility duration compared with the control negative (distilled water) (p < 0.001). The reductions of the immobility time were 8.3%, 36.4% and 30.1% for dosage 16.25 mL/kg, 32.5 mL/kg and 65 mL/kg, therefore, Jamu Neuropathic Pain Reducer had the potential to be an alternative as herbal medicine for neuropathic pain that less expensive and has minimum side effect.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78455059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topology optimization on geometry of 3D printed “Impulse RC Alien 4 Inch” racing quadcopter frame with polylactic acid material","authors":"Imang Eko Saputro, A. Wikarta, A. Muhtar","doi":"10.1063/1.5138342","DOIUrl":"https://doi.org/10.1063/1.5138342","url":null,"abstract":"The racing quadcopter is one of Unmanned Aerial Vehicle (UAV) type which is for high speed. A frame of the racing quadcopter used carbon fiber material because of its lightness and rigidity; however, it is costly. Because of that, it is essential to consider alternative material, such as polylactic acid (PLA). However, the PLA frame needs some optimization treatments to achieve similar mass and rigidity as the carbon fiber. One of the structural optimization methods that can be used is topology optimization. Although this method will generate some intricate details in geometry, which is difficult for conventional manufacturing, however, with the additive manufacturing technology, the complex geometry is no longer a barrier. The aim of this research is prototyping “the best design” frame using a 3D printer, based on simulation results of stress and total deformation of the racing quadcopter from topology optimization method. The methodology started from the quadcopter modeling, initial simulation with carbon fiber frame and PLA frame using the static structural simulation of finite element software. Continued by topology optimization simulation with some retain masses to obtain some redesign models. The next stage is the final simulation on the redesign models using a similar method as the initial simulation, and then the analysis is established to achieve “the best design”. The last stage is model manufacturing using a 3D printer, model testing, and result evaluation. As a result, “the best design” is achieved from doubling the thickness of PLA frame, establishing redesign of 60% retains mass topology optimization. Then both “the best design” manufacturing and testing are done well, although with some defects.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"32 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72583717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shelf life estimation of anti-atherosclerosis herbs using ASLT: Critical water content and sorption isotherms model","authors":"D. Tristantini, M. Ramadhan, A. Hanifah","doi":"10.1063/1.5139350","DOIUrl":"https://doi.org/10.1063/1.5139350","url":null,"abstract":"An unhealthy lifestyle could trigger increased levels of cholesterol, hypertension, and obesity, even atherosclerosis. Atherosclerosis is hardening and tightening of the arteries that cause the blocking of blood circulation. Anti-atherosclerosis herbs consist of tanjung leaf (Mimusops elengi L.), starfruit leaf (Averrhoa carambola L.), and temulawak (Curcuma xanthorrhiza R.) are empirically believed has antioxidant, anti-cholesterol, antiplatelets, and anti- hyperglycemic activity. Since anti-atherosclerosis herbs are going to be mass-produced, packaging and herbs stability must be considered carefully to preserve flavonoid content within. Therefore, the expired date information on food packaging is mandatory according to UU No.18/2012 about food and PP No. 69/1999 about food labeling and advertising. The shelf life of anti-atherosclerosis herbs was estimated by accelerated shelf-life test (ASLT) method based on the critical water content approach and sorption isotherms model (Labuza equation). In the study, the organoleptic test and mold test were carried out as well to determine critical condition. Packaging permeability was a parameter in the Labuza equation and was measured by the gravimetric method. The results of this study, the shelf life of anti-atherosclerosis herbs was predicted to be 233 days in filter bag and aluminum foil packaging when it stored at a temperature of 30°C and relative humidity (RH) of 75%.An unhealthy lifestyle could trigger increased levels of cholesterol, hypertension, and obesity, even atherosclerosis. Atherosclerosis is hardening and tightening of the arteries that cause the blocking of blood circulation. Anti-atherosclerosis herbs consist of tanjung leaf (Mimusops elengi L.), starfruit leaf (Averrhoa carambola L.), and temulawak (Curcuma xanthorrhiza R.) are empirically believed has antioxidant, anti-cholesterol, antiplatelets, and anti- hyperglycemic activity. Since anti-atherosclerosis herbs are going to be mass-produced, packaging and herbs stability must be considered carefully to preserve flavonoid content within. Therefore, the expired date information on food packaging is mandatory according to UU No.18/2012 about food and PP No. 69/1999 about food labeling and advertising. The shelf life of anti-atherosclerosis herbs was estimated by accelerated shelf-life test (ASLT) method based on the critical water content approach and sorption isotherms model (Labuza equation). In the stu...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"339 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75481809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral activity of Ceiba pentandra and Eugenia uniflora leaf extracts to dengue virus serotype-2 in Huh 7it-1 cell line","authors":"B. Dewi, M. Angelina, Sabda Ardiantara, Agung Riyanto Prakoso, H. Desti, T. M. Sudiro","doi":"10.1063/1.5139340","DOIUrl":"https://doi.org/10.1063/1.5139340","url":null,"abstract":"Dengue Fever (DF) is an infectious disease caused by dengue virus (DENV) infection which is transmitted by Aedes aegypti and Aedes albopictus mosquito bite. There are approximately 50 million DENV cases annually in the world with 500 thousand cases hospitalized. Incidence rate of DENV infection is increasing in Indonesia every year. Specific antiviral that can inhibit or mitigate the progression of the disease have been investigated for many decades. However, until now, management of DENV patients is only supportive. Specific antiviral drug to DENV is not available yet. The objective of this study is to determine antiviral activity of Ceiba pentandra and Eugenia uniflora leaf extract against DENV replication in Huh7it-1 cell line. Study design was an experimental study with a Focus assay and MTT assay to determine the effectivity and toxicity, respectively. Ceiba pentandra leaf extract showed IC50, CC50 and SI of 15.49 µg/ml, 81.1 µg/ml and 5.23. In other hand, E. uniflora revealed IC50, CC50, and SI of 19.83 µg/ml, 134.42 µg/ml and 6.78. We concluded that C. pentandra and E. uniflora leaf extract have potential as antiviral drug to DENV. Further studies are needed to explore the substance of C. pentandra and E. uniflora leaf extract that have antiviral activities to DENV.Dengue Fever (DF) is an infectious disease caused by dengue virus (DENV) infection which is transmitted by Aedes aegypti and Aedes albopictus mosquito bite. There are approximately 50 million DENV cases annually in the world with 500 thousand cases hospitalized. Incidence rate of DENV infection is increasing in Indonesia every year. Specific antiviral that can inhibit or mitigate the progression of the disease have been investigated for many decades. However, until now, management of DENV patients is only supportive. Specific antiviral drug to DENV is not available yet. The objective of this study is to determine antiviral activity of Ceiba pentandra and Eugenia uniflora leaf extract against DENV replication in Huh7it-1 cell line. Study design was an experimental study with a Focus assay and MTT assay to determine the effectivity and toxicity, respectively. Ceiba pentandra leaf extract showed IC50, CC50 and SI of 15.49 µg/ml, 81.1 µg/ml and 5.23. In other hand, E. uniflora revealed IC50, CC50, and SI of 1...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83494838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the effect of different frequencies on the irradiance of dental LEDs using pulse width modulation","authors":"Rosalind Fawnia Margeritha, T. Abuzairi","doi":"10.1063/1.5139395","DOIUrl":"https://doi.org/10.1063/1.5139395","url":null,"abstract":"","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77519987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of porous stemmed hip prosthesis for children","authors":"D. P. Malau, M. S. Utomo, D. Annur, T. Asmaria, Yogi Prabowo, A. Rahyussalim, S. Supriadi, M. I. Amal","doi":"10.1063/1.5139393","DOIUrl":"https://doi.org/10.1063/1.5139393","url":null,"abstract":"Femur bone stress shielding is known to be a significant factor in aseptic loosening or failure of hip replacements. This paper considers the development of a porous stemmed hip implant for children patient in order to reduce the effects of stress shielding and also maintaining acceptably low levels of stress in other areas of prosthesis. By using finite element modeling, the stresses in the proximal femur using porous stem were calculated and analyzed. The developed model is considered safe in terms of mechanical strength. The porous region does not bring significant effect on stress distribution but produces a considerable amount of compressive strain.Femur bone stress shielding is known to be a significant factor in aseptic loosening or failure of hip replacements. This paper considers the development of a porous stemmed hip implant for children patient in order to reduce the effects of stress shielding and also maintaining acceptably low levels of stress in other areas of prosthesis. By using finite element modeling, the stresses in the proximal femur using porous stem were calculated and analyzed. The developed model is considered safe in terms of mechanical strength. The porous region does not bring significant effect on stress distribution but produces a considerable amount of compressive strain.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78229580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of an optimum method for power generation using flare gas from oil refinery plants","authors":"B. A. Dwiyantoro, Farai William Saungweme","doi":"10.1063/1.5138290","DOIUrl":"https://doi.org/10.1063/1.5138290","url":null,"abstract":"Today the world is facing global warming as one of its main issues, this is mainly caused by a rise in carbon dioxide and other greenhouse gases concentration in the atmosphere. Flaring is one of the major causes of the increase in greenhouse gases, 145 billion cubic meters of natural gas was flared in 2018. Indonesia being an archipelago nation and located near the equator suffers greatly from these global warming impacts. The impacts include environmental degradation, health implications and economic effects. This study is intended to develop a power plant configuration that can be adopted at an already existing plant to use flare gas as a complementary fuel. The energy of the flare gas will be converted into mechanical energy through thermal power plant instead of being vented as presently. Two possible plant configurations were developed and simulated using Thermo-flow and the results were compared. Both configurations employ the combined cycle concept, where a gas turbine is coupled with a steam turbine. The main difference between the two configurations is that configuration 1 uses a Heat Recovery Steam Generator whilst the second configuration uses common Heat Exchangers in-between the gas turbine and the Rankine cycle. The results show that configuration 1 would generate a net power of 40.948MW whilst configuration 2 would generate 32.924MW.Today the world is facing global warming as one of its main issues, this is mainly caused by a rise in carbon dioxide and other greenhouse gases concentration in the atmosphere. Flaring is one of the major causes of the increase in greenhouse gases, 145 billion cubic meters of natural gas was flared in 2018. Indonesia being an archipelago nation and located near the equator suffers greatly from these global warming impacts. The impacts include environmental degradation, health implications and economic effects. This study is intended to develop a power plant configuration that can be adopted at an already existing plant to use flare gas as a complementary fuel. The energy of the flare gas will be converted into mechanical energy through thermal power plant instead of being vented as presently. Two possible plant configurations were developed and simulated using Thermo-flow and the results were compared. Both configurations employ the combined cycle concept, where a gas turbine is coupled with a steam turb...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76870067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of use of solar panels on micro scale fixed-wing UAV type as a power recharging system","authors":"I. Ridwan, Alfindo","doi":"10.1063/1.5135553","DOIUrl":"https://doi.org/10.1063/1.5135553","url":null,"abstract":"Unmanned Aerial Vehicle (UAV), popularly known as drone, is a type of aerial explorer robot that can be controlled remotely to carry out certain missions. One type of UAV for carrying out a flying mission is a fixed-wing type. It is widely used for mapping and monitoring equipment. This type of drone has limited flight time because the battery used has limited capacity, especially in micro scale UAVs with±2 kg weight. Therefore, sometimes the drone must return to replace the battery before the mission is complete. In this condition, experimental research is needed with the addition of solar panels in the wings to increase flight time. The method used to solve this problem is by designing an electronic component UAV which is integrated with a solar panel charger system, an airframe with 2.125 kg flight weight, 18 m/s cruise speed, 1.63 m wingspan, and 0.37 m2 wing surface area. The solar cells used are Sunpower C60, are arranged in series of 10 pieces with 21% maximum efficiency and 0.132 m2 total surface area. The solar panel charger system is integrated with UAV electronic components that use the Tarot2814 brushless motor with 290 W maximum power, ESC 30 A, 4S Sony VTC6 3000 mAh battery, LM2587 5A step-up module, and Arduino solar charge controller. The results of the research prove that micro scale UAV-Solar can add flight time for 2 minutes with an intensity of solar radiation average of 929.46 W/m2. During flight testing, solar cells produce an average power of 15.14 W with a maximum efficiency of 14.8% and a total flight time of 15 minutes. This proves that the addition of solar panels to UAV micro scale fixed wing types can be realized.Unmanned Aerial Vehicle (UAV), popularly known as drone, is a type of aerial explorer robot that can be controlled remotely to carry out certain missions. One type of UAV for carrying out a flying mission is a fixed-wing type. It is widely used for mapping and monitoring equipment. This type of drone has limited flight time because the battery used has limited capacity, especially in micro scale UAVs with±2 kg weight. Therefore, sometimes the drone must return to replace the battery before the mission is complete. In this condition, experimental research is needed with the addition of solar panels in the wings to increase flight time. The method used to solve this problem is by designing an electronic component UAV which is integrated with a solar panel charger system, an airframe with 2.125 kg flight weight, 18 m/s cruise speed, 1.63 m wingspan, and 0.37 m2 wing surface area. The solar cells used are Sunpower C60, are arranged in series of 10 pieces with 21% maximum efficiency and 0.132 m2 total surface ...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88673903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of adding microalgae Spirulina platensis in making antibacterial soap","authors":"Martha Fransisca, Dianursanti","doi":"10.1063/1.5139330","DOIUrl":"https://doi.org/10.1063/1.5139330","url":null,"abstract":"The infection of methicillin-resistant Staphylococcus aureus (MRSA) has increased to 8% in 2017 in Indonesia. This infection commonly occurs in hospital thus, individuals must maintain personal hygiene such as using antibacterial soap. Several commercial antibacterial soap in Indonesia still use triclosan and triclocarban as antibacterial agent. This is a problem because they have been banned by Food and Drug Administration (FDA) in 2017. The use of them can disturb human reproduction system which lead to infertility and destroy algal growth. This study utilized Spirulina platensis and virgin coconut oil (VCO) as fatty acid source which reacted with sodium hydroxide to make soap. Furthermore, VCO also acted as antibacterial agent which can kill bacteria. Film-formed soap is expected to lessen soap and water waste. This soap was made by the hot process method at a temperature of 65°C. The examination done were free alkali, free fatty acid values, pH values, water content and antibacterial activity toward S. aureus. The result showed that all sample met the Indonesian National Standard (SNI) of hard soap. The use of VCO can substitute chemical-based antibacterial agent in soap because it has same ability in killing S. aureus in soap (at 25% dilution) which resulted in safer and environmentally friendly soap. The optimum composition in soap making were found in the use of 1 g S. platensis.The infection of methicillin-resistant Staphylococcus aureus (MRSA) has increased to 8% in 2017 in Indonesia. This infection commonly occurs in hospital thus, individuals must maintain personal hygiene such as using antibacterial soap. Several commercial antibacterial soap in Indonesia still use triclosan and triclocarban as antibacterial agent. This is a problem because they have been banned by Food and Drug Administration (FDA) in 2017. The use of them can disturb human reproduction system which lead to infertility and destroy algal growth. This study utilized Spirulina platensis and virgin coconut oil (VCO) as fatty acid source which reacted with sodium hydroxide to make soap. Furthermore, VCO also acted as antibacterial agent which can kill bacteria. Film-formed soap is expected to lessen soap and water waste. This soap was made by the hot process method at a temperature of 65°C. The examination done were free alkali, free fatty acid values, pH values, water content and antibacterial activity toward S...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84906380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}