THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019最新文献

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Effect of punch angle and punch radius on bend angle through air V-bending of sheet metal 冲头角度和冲头半径对金属板空气v形弯曲弯曲角的影响
M. A. Suyuti, M. Iswar, R. Nur
{"title":"Effect of punch angle and punch radius on bend angle through air V-bending of sheet metal","authors":"M. A. Suyuti, M. Iswar, R. Nur","doi":"10.1063/1.5138306","DOIUrl":"https://doi.org/10.1063/1.5138306","url":null,"abstract":"Nowadays, the process of metal forming in the industrial of welding and machinery is developing very rapidly, especially the bending process. In the manufacturing process, bending processes are often carried out to make and repair products such as electronic panel components, automobile vehicle panels, tool-boxes, burning fish, agricultural machinery and mechanization tools, etc. The complex-shaped bend parts with high precision are increasingly needed. To achieve high precision of parts, especially the bend angle, a suitable design of process parameters is strictly considered. An experimental study was conducted to determine the effect of punch parameters (i.e. punch radius and punch angle) on the bend angle in the V-bending process. Bending tests carried out several variable variations, including the punch angle (i.e. 85°, 87.5°, and 90°), and punch radius (i.e. 1 mm, 1.5 mm and 2 mm). The angle of 85° of die is constant. The analysis of variance (ANOVA) techniques was carried out to investigate the degree of significant process parameters in the air V-bending process. The results revealed that the degree of significant process parameters in air V-bending process depended on the punch angle. It can be concluded that the punch angle is significantly affected to the bend angle (less than 90° or more than 90°) while compared to the punch radius.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"325 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75931365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Analysis of superheater tubes degradation at a tangentially fired pulverized coal power plant 切向燃烧煤粉电厂过热器管退化分析
Muhammad Aujul Majdi, Suwarno
{"title":"Analysis of superheater tubes degradation at a tangentially fired pulverized coal power plant","authors":"Muhammad Aujul Majdi, Suwarno","doi":"10.1063/1.5138325","DOIUrl":"https://doi.org/10.1063/1.5138325","url":null,"abstract":"Thinning of boiler tubing is one of common failure mechanism of coal-based boiler unit. An ultrasonic thickness testing (UT) is typically used to determine the state of boiler tube thickness and is done during a yearly overhaul. The usefulness of thickness data can be problematic due to some fluctuation and irregularities in the data. In the present work, UT data from 4 years inspection will be analyzed with the aim to understand the fundamental mechanism for thinning of the superheater tube. Some part of the UT data is analyzed to obtain the thinning rate of the superheater tube. The thinning trend is the basis for predicting the value of thickness and compared with actual measurement values. The predicted and actual values were tested with statistical operation to observe the significant difference between both values and also the quality of prediction.Thinning of boiler tubing is one of common failure mechanism of coal-based boiler unit. An ultrasonic thickness testing (UT) is typically used to determine the state of boiler tube thickness and is done during a yearly overhaul. The usefulness of thickness data can be problematic due to some fluctuation and irregularities in the data. In the present work, UT data from 4 years inspection will be analyzed with the aim to understand the fundamental mechanism for thinning of the superheater tube. Some part of the UT data is analyzed to obtain the thinning rate of the superheater tube. The thinning trend is the basis for predicting the value of thickness and compared with actual measurement values. The predicted and actual values were tested with statistical operation to observe the significant difference between both values and also the quality of prediction.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78231159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsteady simulations of Savonius and Icewind turbine blade design using fluid-structure interaction method 基于流固耦合法的Savonius和Icewind风力机叶片设计非定常仿真
Z. Lillahulhaq, Vivien S. Djanali
{"title":"Unsteady simulations of Savonius and Icewind turbine blade design using fluid-structure interaction method","authors":"Z. Lillahulhaq, Vivien S. Djanali","doi":"10.1063/1.5138264","DOIUrl":"https://doi.org/10.1063/1.5138264","url":null,"abstract":"Wind turbine performance can be increased by using the optimum shape of the blade. Most of the previous numerical studies on Savonius wind turbine simulation used constant angular velocity as input data. Usually, the value of constant angular velocity was obtained from experimental data. In the actual case, the rotation of the rotor, i.e. the angular velocity of the blades, results from the interaction between fluids around the wind turbine with the turbine blades, in which there are changes of the moment of inertia. Rotation of the wind turbine can be simulated using the fluid-structure interaction method with one-degree of freedom. This study compares the performance of a rotor turbine using straight Savonius blades, to that using the Icewind turbine blades. In the steady and unsteady simulations, fluid was defined as incompressible, viscous, and uniform air which flow from inlet free stream. The simulation object rotates in one-degree of freedom in the overset mesh area. Icewind turbine generates higher coefficient power compares to the standard Savonius turbine, when it operates at very low wind speed, with the inlet free stream velocity below 4 m/s. This phenomenon is affected by the unsymmetrical shape of Icewind which allowed the fluid flow behind the reversing blade and sweep away the wake area, particularly effective at very low wind speed. The Savonius wind turbine, which is configured with endplates and overlap blades, rotates in high angular velocity and generates the highest peak coefficient of power. Fluid from the advancing blade is flowing through the overlap. The overlap flow fills the wake area and reduces backflow behind the reversing blade.Wind turbine performance can be increased by using the optimum shape of the blade. Most of the previous numerical studies on Savonius wind turbine simulation used constant angular velocity as input data. Usually, the value of constant angular velocity was obtained from experimental data. In the actual case, the rotation of the rotor, i.e. the angular velocity of the blades, results from the interaction between fluids around the wind turbine with the turbine blades, in which there are changes of the moment of inertia. Rotation of the wind turbine can be simulated using the fluid-structure interaction method with one-degree of freedom. This study compares the performance of a rotor turbine using straight Savonius blades, to that using the Icewind turbine blades. In the steady and unsteady simulations, fluid was defined as incompressible, viscous, and uniform air which flow from inlet free stream. The simulation object rotates in one-degree of freedom in the overset mesh area. Icewind turbine generates highe...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81706678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The effect of processing parameter on composite’s impact strength of continuous unidirectional polypropylene-glass fiber composite 工艺参数对连续单向聚丙烯-玻璃纤维复合材料冲击强度的影响
S. Wicaksono, H. Rochardjo, Budiyantoro Cahyo
{"title":"The effect of processing parameter on composite’s impact strength of continuous unidirectional polypropylene-glass fiber composite","authors":"S. Wicaksono, H. Rochardjo, Budiyantoro Cahyo","doi":"10.1063/1.5138330","DOIUrl":"https://doi.org/10.1063/1.5138330","url":null,"abstract":"Polypropylene-Glass fiber composite is one of the cost-effective materials in engineering applications. Continuous Glass Fiber-Reinforced composite manufactured using injection molding temperature is an interesting topic to be researched. Further knowledge on how injection molding processing parameter variables could affect the mechanical properties of the composite can give an insight to understand one of the many factors determining the mechanical properties of composite material. This study aims to find the correlation between impact strength of polypropylene-glass fiber composite with processing parameters of injection molding process namely temperature and injection pressure.Polypropylene-Glass fiber composite is one of the cost-effective materials in engineering applications. Continuous Glass Fiber-Reinforced composite manufactured using injection molding temperature is an interesting topic to be researched. Further knowledge on how injection molding processing parameter variables could affect the mechanical properties of the composite can give an insight to understand one of the many factors determining the mechanical properties of composite material. This study aims to find the correlation between impact strength of polypropylene-glass fiber composite with processing parameters of injection molding process namely temperature and injection pressure.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82350204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of coolant flow on various hot gas plenum geometry of the non commercial power reactor (RDNK) 非商用动力堆(RDNK)不同热气室几何形状冷却剂流动分析
M. Yunus, Farisy Yogatama Sulistyo, Kiswanta, M. Subekti
{"title":"Analysis of coolant flow on various hot gas plenum geometry of the non commercial power reactor (RDNK)","authors":"M. Yunus, Farisy Yogatama Sulistyo, Kiswanta, M. Subekti","doi":"10.1063/1.5135521","DOIUrl":"https://doi.org/10.1063/1.5135521","url":null,"abstract":"On design criteria of cooling process in HTGR reactor, besides considering the structural strength of the reactor core and gas mixing performance, the pressure drop in the core reactor as well as the bottom reflector, is maintained as low as possible in order to avoid leakage or bypass flow. To investigate the effect of varying hot gas plenum geometry to the coolant flow behavior in the bottom reflector structure of the RDNK reactor, computational fluid dynamic simulation has been carried out. There are three variations of the hot gas plenum high that is 150 mm, 200 mm, and 250 mm. The models are simulated by using Fluent software. By simulating the cooling process in the bottom reflector it was obtained differences in temperature and pressure drop of each model. As a result of pressure drop, it was found that a model with a hot gas plenum height of 250 mm has the lowest pressure drop. Meanwhile, the average temperature of the outlet channel of all simulation model is not significantly different.On design criteria of cooling process in HTGR reactor, besides considering the structural strength of the reactor core and gas mixing performance, the pressure drop in the core reactor as well as the bottom reflector, is maintained as low as possible in order to avoid leakage or bypass flow. To investigate the effect of varying hot gas plenum geometry to the coolant flow behavior in the bottom reflector structure of the RDNK reactor, computational fluid dynamic simulation has been carried out. There are three variations of the hot gas plenum high that is 150 mm, 200 mm, and 250 mm. The models are simulated by using Fluent software. By simulating the cooling process in the bottom reflector it was obtained differences in temperature and pressure drop of each model. As a result of pressure drop, it was found that a model with a hot gas plenum height of 250 mm has the lowest pressure drop. Meanwhile, the average temperature of the outlet channel of all simulation model is not significantly different.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79154455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoelectrochemical measurement of Epstein-Barr virus DNA in peripheral blood serum of nasopharyngeal carcinoma patients 鼻咽癌患者外周血eb病毒DNA的光电化学测定
K. Kusmardi, A. Tedjo, Y. H. Midoen, M. Adrian
{"title":"Photoelectrochemical measurement of Epstein-Barr virus DNA in peripheral blood serum of nasopharyngeal carcinoma patients","authors":"K. Kusmardi, A. Tedjo, Y. H. Midoen, M. Adrian","doi":"10.1063/1.5139371","DOIUrl":"https://doi.org/10.1063/1.5139371","url":null,"abstract":"Epstein-Barr Virus (EBV) DNA presents in the serum of nasopharyngeal carcinoma (NPC) patients indicates the existence of the viral DNA in the circulation and may be used as an early marker in NPC diagnosis. EBV DNA isolated from the serum and then amplified by using polymerase chain reaction (PCR) could be used to assess the response of the DNA to various NPC therapies. This study compares the results of EBV DNA measurement in the serum of NPC patients using photoelectrochemical technique and PCR. The presence of a specific oligonucleotide sequence of a standard DNA (EBNA-1) may be detected by photoelectrochemical hybridization of the standard with a DNA probe immobilized on TiO2 electrode, in which the DNA is intercalated by an electrochromic material. The purpose of this study is to obtain a photoelectrochemical system with a relatively good response and sensitivity to the changes in the concentration of EBV DNA in the peripheral blood serum of NPC patients. This research attempts to provide a device and methods that are simple, relatively inexpensive and easy to use, yet sensitive enough to see the prognosis of NPC patients. This study also attempts to develop the measurement instrumentation technology in the field of biomedical research. The photoelectrochemical system of this research used anthocyanin as DNA intercalator. The anthocyanin was isolated from purple cabbage leaves (also known as red cabbage), strawberries, and grapes and the extractant of these anthocyanins were ethanol and water. The best extraction with the highest level of total anthocyanin was achieved by alcohol as extractant. Alcohol gave higher yield of anthocyanin compared to water and ethyl acetate. Purple cabbage leaves have the highest level of anthocyanin compared to strawberry fruits and grapes. Anthocyanins contained in the extract of purple cabbage, strawberries, and grapes may function as DNA intercalators. Electrochromic substance used as DNA intercalator produces difference between the current strength generated by photoelectrochemical system with light and without light. There is a very strong correlation between diluted concentration of DNA and current strength shown by the electrochemical system of this study. There is also correlation between EBV EBNA-1 DNA concentration readings by using photoelectrochemical system and PCR. The sensitivity and specificity to EBV DNA in the serum of NPC patients of photoelectrochemical techniques are significantly higher compared to PCR.Epstein-Barr Virus (EBV) DNA presents in the serum of nasopharyngeal carcinoma (NPC) patients indicates the existence of the viral DNA in the circulation and may be used as an early marker in NPC diagnosis. EBV DNA isolated from the serum and then amplified by using polymerase chain reaction (PCR) could be used to assess the response of the DNA to various NPC therapies. This study compares the results of EBV DNA measurement in the serum of NPC patients using photoelectrochemical technique an","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85511952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and analysis for vibration assisted micro milling 振动辅助微铣削的设计与分析
Wina Libyawati, G. Kiswanto, Poly Poly
{"title":"Design and analysis for vibration assisted micro milling","authors":"Wina Libyawati, G. Kiswanto, Poly Poly","doi":"10.1063/1.5138343","DOIUrl":"https://doi.org/10.1063/1.5138343","url":null,"abstract":"Vibration Assisted Machining is an example of sustainable manufacturing concept application and as an alternative machining process, to improve machine performance and machined surface quality. Machine construction and system respond toward the applied active vibration, actuator selection with a function to generate vibration, the direction, and placement of vibration on to the machine, workpiece properties, and product complexity of the required product, are the main aspects to design Vibration Assisted Machining for machining process especially in microscale. VAM design had been introduced and investigated by many researchers for many types of machine and manufacturing process, thru the structural static and dynamic load on to machine structure due to the vibration additional at its resonant frequency toward the machined surface quality, by conducted simulation or experimental or comparison of both. Nevertheless, the research about VAM design development for the miniaturized machine for milling was still limited. Thus this paper would like to introduce VAM mechanism in which the workpiece would be positioned and customized for miniaturized milling machine, by implementing product development evaluation and finite element method to obtain the stress and displacement plot. Piezoelectric actuator and flexure combination was chosen as the most compatible design in comparison to the application of mechanical and vibration motor system. Finite element simulation showed VAM able to uphold the targeted machining forces and to vibrate workpiece with displacement within several micrometers.Vibration Assisted Machining is an example of sustainable manufacturing concept application and as an alternative machining process, to improve machine performance and machined surface quality. Machine construction and system respond toward the applied active vibration, actuator selection with a function to generate vibration, the direction, and placement of vibration on to the machine, workpiece properties, and product complexity of the required product, are the main aspects to design Vibration Assisted Machining for machining process especially in microscale. VAM design had been introduced and investigated by many researchers for many types of machine and manufacturing process, thru the structural static and dynamic load on to machine structure due to the vibration additional at its resonant frequency toward the machined surface quality, by conducted simulation or experimental or comparison of both. Nevertheless, the research about VAM design development for the miniaturized machine for milling was stil...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84303594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature profile analysis on cryogenic activated carbon column of helium purification testing facility 氦气净化试验装置低温活性炭柱温度分布分析
S. Sriyono, R. Kusumastuti, A. Hafid, D. H. Salimy, M. Pancoko, I. Irianto, M. Subekti, Febrianto, G. R. Sunaryo
{"title":"Temperature profile analysis on cryogenic activated carbon column of helium purification testing facility","authors":"S. Sriyono, R. Kusumastuti, A. Hafid, D. H. Salimy, M. Pancoko, I. Irianto, M. Subekti, Febrianto, G. R. Sunaryo","doi":"10.1063/1.5135555","DOIUrl":"https://doi.org/10.1063/1.5135555","url":null,"abstract":"Cryogenic activated carbon testing facility (CACTF) is an apparatus built to purify helium gas from impurities such as oxygen, nitrogen, and gas of fission products. Because of oxygen and nitrogen have a small molecular size, the cryogenic (very low temperature) condition is needed. CACTF has a cryogenic vessel, activated carbon column, liquid nitrogen storage tank, and helium storage tank (pure and dirty). This paper discusses the investigation of temperature changes in the activated carbon column that installed inside a cryogenic vessel. The objective of research is find out the lowest temperature can be achieved in the inner of the activated carbon column so the optimum purification process can be done. The methodology used was modeling with ChemCAD software and CACTF experiments. CACTF has been modeled and simulated with ChemCAD software. Cryogenic model simulation by ChemCAD showed that the lowest temperature of - 190°C will be achieved by 300 kg/hour of liquid nitrogen injection, while the laboratory experiment resulted -160°C of temperature as well. The inside vessel temperature differences it caused by heat losses to the environment during the apparatus experiment. By using ChemCAD, the optimum pressure of the cryogenic carbon column is 30 bars based on the adsorption simulation process of the cryogenic carbon column model.Cryogenic activated carbon testing facility (CACTF) is an apparatus built to purify helium gas from impurities such as oxygen, nitrogen, and gas of fission products. Because of oxygen and nitrogen have a small molecular size, the cryogenic (very low temperature) condition is needed. CACTF has a cryogenic vessel, activated carbon column, liquid nitrogen storage tank, and helium storage tank (pure and dirty). This paper discusses the investigation of temperature changes in the activated carbon column that installed inside a cryogenic vessel. The objective of research is find out the lowest temperature can be achieved in the inner of the activated carbon column so the optimum purification process can be done. The methodology used was modeling with ChemCAD software and CACTF experiments. CACTF has been modeled and simulated with ChemCAD software. Cryogenic model simulation by ChemCAD showed that the lowest temperature of - 190°C will be achieved by 300 kg/hour of liquid nitrogen injection, while the laborator...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91231013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Centella asiatica as a potential plaque stabilizer: Future preventive therapy for cardiovascular disease 积雪草作为潜在的斑块稳定剂:未来心血管疾病的预防治疗
Nindya P. B. S. Utami, Siti Farida
{"title":"Centella asiatica as a potential plaque stabilizer: Future preventive therapy for cardiovascular disease","authors":"Nindya P. B. S. Utami, Siti Farida","doi":"10.1063/1.5139370","DOIUrl":"https://doi.org/10.1063/1.5139370","url":null,"abstract":"WHO states that cardiovascular disease (CVD) is the cause of 31% of deaths worldwide, reaching 17.7 million deaths per year. Causes of CVD, including smoking, unbalanced food intake, low physical activity, and excessive alcohol consumption. The common pathophysiology of CVD is the formation of atherosclerotic plaques. It begins with endothelial dysfunction that is closely related to diabetes mellitus (DM). Existing treatment focus on preventing the formation of atherosclerotic plaques by lowering blood cholesterol levels and blood viscosity. It prevents the formation of shear strength that can damage the endothelial layer. Centella asiatica (CA) is a well-known herb used as an oxidative-stress remedy. Literature review was conducted by searching two journal databases, PubMed and Ebscohost. The search was carried out using Boolean Operator as follows: cardiovascular AND therapy AND “Centella asiatica”. Sources are not year-limited and include animal studies, randomized-controlled trial reports or related reviews. Based on the literature review, various studies are linking the protective effect of CA on CVD. Ramachandran et al. conducted an in vivo study by using mice with DM. Lipid profiles of DM mice were given asiatic acid shifted towards normalcy, which reduces the risk of atherosclerotic plaque formation. Cesarone et al. conducted Randomized Controlled Trial (RCT) studies by using the group given CA therapy for 12 months. The study showed an increase in Gray-Scale median (GSM) parameters and an improvement in the texture of atherosclerotic plaques, which showed the formation of a stable with low risk for thrombus. Luzzi et al. conducted RCT study on high-oxidative stress asymptomatic patients given Pycnogenol and CA extract. It showed an increase in the stability of atherosclerotic plaque as indicated by an increase in plaque density, a decrease in the number and size of plaques. These results indicate the potential of CA as a good preventive cardiovascular therapy.WHO states that cardiovascular disease (CVD) is the cause of 31% of deaths worldwide, reaching 17.7 million deaths per year. Causes of CVD, including smoking, unbalanced food intake, low physical activity, and excessive alcohol consumption. The common pathophysiology of CVD is the formation of atherosclerotic plaques. It begins with endothelial dysfunction that is closely related to diabetes mellitus (DM). Existing treatment focus on preventing the formation of atherosclerotic plaques by lowering blood cholesterol levels and blood viscosity. It prevents the formation of shear strength that can damage the endothelial layer. Centella asiatica (CA) is a well-known herb used as an oxidative-stress remedy. Literature review was conducted by searching two journal databases, PubMed and Ebscohost. The search was carried out using Boolean Operator as follows: cardiovascular AND therapy AND “Centella asiatica”. Sources are not year-limited and include animal studies, randomized-controlled tri","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91259218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short circuit analysis on electrical power supply building # 71 BATAN for case reliability study of nuclear power plant electrical protection system 核电厂电气保护系统案例可靠性研究中BATAN 71号供电楼的短路分析
K. Handono, Tukiman, I. M. Putra, L. Subekti
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引用次数: 2
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