Tetrahedron, asymmetry最新文献_第7页

Asymmetric epoxidation of enones using cumyl hydroperoxide and in situ generated zinc complexes of chiral pyrrolidinyl alcohols 烯酮的不对称环氧化反应，使用过氧cumyl和原位生成的手性吡啶醇锌配合物

Tetrahedron, asymmetry Pub Date : 2017-11-15 DOI: 10.1016/j.tetasy.2017.09.004

Halide Sedef Karaman , Hamdullah Kılıç , Engin Şahin

引用次数: 3

Stereochemistry abstracts 立体化学文摘

Tetrahedron, asymmetry Pub Date : 2017-11-15 DOI: 10.1016/S0957-4166(17)30517-7

引用次数: 0

Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1 S ,2 R )-tranylcypromine 混合碳羧酸酰胺化羧酸及其在抗抑郁药(1s, 2r)-丙酰环丙胺合成中的应用

Tetrahedron, asymmetry Pub Date : 2017-11-06 DOI: 10.1016/J.TETASY.2017.10.015

Tetsuya Ezawa, Yuya Kawashima, Takuya Noguchi, Seunghee Jung, N. Imai

引用次数: 9

Corrigendum to “Advances on asymmetric organocatalytic 1,4-conjugate addition reactions in aqueous and semi-aqueous media” [Tetrahedron: Asymmetry 2017, 849–875] “水和半水介质中不对称有机催化1,4-共轭加成反应的进展”的勘误表[Tetrahedron: symmetry 2017, 849-875]

Tetrahedron, asymmetry Pub Date : 2017-11-03 DOI: 10.1016/J.TETASY.2017.10.009

Anirban Mondal, Sudipto Bhowmick, Ayndrila Ghosh, Tanmoy Chanda, K. C. Bhowmick

引用次数: 0

Asymmetric synthesis of tert-butyl ((1R,4aR,8R,8aR)-1-hydroxyoctahydro-1H-isochromen-8-yl)carbamate 不对称合成叔丁基((1r,4a R, 8r,8a R)-1-羟基辛氢-1 H -异色胺-8-基)氨基甲酸酯

Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.10.005

Alfonso G. Rubia , Mateo M. Salgado , Carlos T. Nieto , Alejandro Manchado , David Díez , Francisca Sanz , Narciso M. Garrido

引用次数: 2

Synthesis and crystal structure of a chiral lactam and three amino alcohols as potential protein tyrosine phosphates 1B inhibitors 一种手性内酰胺和三种氨基醇作为蛋白酪氨酸磷酸1B抑制剂的合成和晶体结构

Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.09.014

Şafak Özhan Kocakaya , Mehmet Karakaplan , Rosario Scopelliti

{"title":"Synthesis and crystal structure of a chiral lactam and three amino alcohols as potential protein tyrosine phosphates 1B inhibitors","authors":"Şafak Özhan Kocakaya , Mehmet Karakaplan , Rosario Scopelliti","doi":"10.1016/j.tetasy.2017.09.014","DOIUrl":"10.1016/j.tetasy.2017.09.014","url":null,"abstract":"<div>Chiral lactam 2 and three chiral β-amino alcohols 3–5 have been synthesized and characterized by spectroscopic techniques. Regioselective ring opening reaction of chiral styrene oxide by an amine nucleophile was confirmed by X-ray diffraction data. Ligand 2–4 crystallizes in the tetragonal, orthorhombic and tetragonal crystal lattice system respectively. Ligands 2–6 have been used as potential inhibitors for protein tyrosine phosphatase 1B enzyme (PTP1B). The potential inhibitor effect of these molecules to the target protein was investigated by Dock and molecular dynamics calculations. Dock score analysis and Lipinski parameters suggested that ligands 1, 2, 4–6 are potential inhibitors towards PTP1B, thus indicating that the residues Arg24, Arg254 and Met258, Asp29 in the second active site of PTP1B are essential for the high selectivity of inhibitors. The results indicate that the polar hydrogen bonding interacts with Asp29, Gln102, and the amino acid residues of PTP1B are responsible for governing inhibitory potency of ligands 1–6.</div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":"28 10","pages":"Pages 1342-1349"},"PeriodicalIF":0.0,"publicationDate":"2017-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.09.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90604643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

‘Double chiral’ new members of calixsalen family “双手性”卡利萨伦家族的新成员

Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.08.021

Małgorzata Petryk , Agnieszka Janiak , Marcin Kwit

引用次数: 1

Traceless chirality transfer from a norbornene β-amino acid to pyrimido[2,1-a]isoindole enantiomers 降冰片烯β-氨基酸到嘧啶[2,1-a]异吲哚对映体的无迹手性转移

Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.07.006

Ferenc Miklós , Kristóf Bozó , Zsolt Galla , Matti Haukka , Ferenc Fülöp

引用次数: 5

A versatile ternary ion pair complex of 2′-amino-1,1′-binaphthalen-2-ol for sensing enantiomers and assignment of absolute configuration 2 ' -氨基-1,1 ' -二萘-2-醇的多功能三元离子对配合物，用于感应对映体和绝对构型的分配

Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.09.016

Anamalagundam Lakshmipriya , Gaonkar Sumana , Nagaraja Rao Suryaprakash

引用次数: 3

Chiral benzimidazoles and their applications in stereodiscrimination processes 手性苯并咪唑及其在立体识别中的应用

Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.09.001

Vaibhav N. Khose, Marina E. John, Anita D. Pandey, Anil V. Karnik

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引用次数: 19