Ryan Kaveh, Justin Doong, Andy Zhou, Carolyn Schwendeman, K. Gopalan, F. Burghardt, A. Arias, M. Maharbiz, R. Muller
{"title":"A Wireless, Multielectrode, User-generic Ear EEG Recording System","authors":"Ryan Kaveh, Justin Doong, Andy Zhou, Carolyn Schwendeman, K. Gopalan, F. Burghardt, A. Arias, M. Maharbiz, R. Muller","doi":"10.1109/BIOCAS.2019.8918700","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8918700","url":null,"abstract":"Recently it has been demonstrated that electroencephalography (EEG) can be recorded from the ear canal (in-ear EEG), opening the door to using discreet earpieces as wearable brain-computer interfaces (BCIs). We present, for the first time to our knowledge, a wireless neural recording platform for recording EEG from the ear canal with dry multielectrode, user-generic earpieces. A low-cost manufacturing process involving vacuum forming and spray coating was developed to improve ear canal contact in a range of users and combined with a 2.5 x 2.5 cm2 wireless recording system. System performance was evaluated through electrode-skin interface (ESI) impedance characterization and measurement of common EEG signals simultaneously with wet scalp EEG, including eye blinks, alpha waves, and the auditory steady-state response (ASSR) across multiple users. The user-generic ear EEG recorded a mean alpha modulation of 2.17, outperforming the state-of-the-art.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114494137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Current-Switching Communication Technique for Miniaturized Medical Implants","authors":"Weihao Wang, M. Tian, Hong Zhang, Bo Zhao","doi":"10.1109/BIOCAS.2019.8918683","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8918683","url":null,"abstract":"Miniaturization of the medical implants is a key requirement for minimally-invasive surgery, while battery and antenna are the main bottlenecks. Wireless power transfer (WPT) is required to minimize or eliminate the battery, but the conventional inductive or capacitive WPT needs to implant a large inductor or capacitor to realize a relatively high efficiency. Based on the WPT, backscattering communication is widely used in medical implants due to its low power and low hardware cost. In conventional backscattering, the inductive or capacitive antenna of the implant should be large to improve the signal-to-noise ratio (SNR). In this work, we propose a new current-switching technique for the communication of medical implants. To avoid the use of antennas, the body tissue is utilized as the power-transfer medium, where a current loop is formed between the implanted and the external electrode pairs. The data of the medical implant controls its input impedance, and then switches the current loop, resulting in a data-modulated current in the external device. In this way, the external device can sense the data, achieving a high communication SNR without implanted antenna. A prototype is implemented to validate the proposed technique, where the implanted electrodes are as small as 200µ×200µm. Operating at 406 MHz of the standard medical band, the measurement shows that the signal-to-blocker ratio (SBR) achieves -35.7 dB, resulting in a high communication SNR of 21.9 dB at a data rate of 10 Mbps.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116965697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Sasagawa, Kenji Sugie, Yasumi Ohta, Mamiko Kawahara, M. Haruta, J. Ohta
{"title":"Live Demonstration: Lensless Highly Sensitive Fluorescence Imaging","authors":"K. Sasagawa, Kenji Sugie, Yasumi Ohta, Mamiko Kawahara, M. Haruta, J. Ohta","doi":"10.1109/BIOCAS.2019.8918682","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8918682","url":null,"abstract":"This demonstration presents a small lensless fluorescence imaging device with a hybrid emission filter. The hybrid filter consists of interference and absorption filters and rejects excitation light effectively in a lensless setup.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115211944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thorben Schoepe, Daniel Gutierrez-Galan, J. P. Dominguez-Morales, A. Jiménez-Fernandez, A. Linares-Barranco, E. Chicca
{"title":"Neuromorphic Sensory Integration for Combining Sound Source Localization and Collision Avoidance","authors":"Thorben Schoepe, Daniel Gutierrez-Galan, J. P. Dominguez-Morales, A. Jiménez-Fernandez, A. Linares-Barranco, E. Chicca","doi":"10.1109/BIOCAS.2019.8919202","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8919202","url":null,"abstract":"Animals combine various sensory cues with previously acquired knowledge to safely travel towards a target destination. In close analogy to biological systems, we propose a neuromorphic system which decides, based on auditory and visual input, how to reach a sound source without collisions. The development of this sensory integration system, which identifies the shortest possible path, is a key achievement towards autonomous robotics. The proposed neuromorphic system comprises two event based sensors (the eDVS for vision and the NAS for audition) and the SpiNNaker processor. Open loop experiments were performed to evaluate the system performances. In the presence of acoustic stimulation alone, the heading direction points to the direction of the sound source with a Pearson correlation coefficient of 0.89. When visual input is introduced into the network the heading direction always points at the direction of null optical flow closest to the sound source. Hence, the sensory integration network is able to find the shortest path to the sound source while avoiding obstacles. This work shows that a simple, task dependent mapping of sensory information can lead to highly complex and robust decisions.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122659313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Williams, Adrien Rapeaux, Jack Pearson, K. Nazarpour, E. Brunton, Song Luan, Yan Liu, T. Constandinou
{"title":"SenseBack – Implant considerations for an implantable neural stimulation and recording device","authors":"I. Williams, Adrien Rapeaux, Jack Pearson, K. Nazarpour, E. Brunton, Song Luan, Yan Liu, T. Constandinou","doi":"10.1109/BIOCAS.2019.8919046","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8919046","url":null,"abstract":"This paper describes a fully implantable and highly compact neural interface platform for chronic (> 6 month) rat and small rodent experiments. It provides 32 channels of highly flexible neural stimulation and recording with wireless control and data readout, as well as wireless transcutaneous power (although power waste remains a challenge). All the system firmware is fully upgradeable over the air (even after implantation) allowing future enhancements such as closed loop operation or data filtering. This paper focuses on the implant considerations – i.e. design and manufacture of the physical platform, encapsulation, wireless connections and testing.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124822987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bathiya Senevirathna, Sheung Lu, E. Smela, P. Abshire
{"title":"An Imaging Platform for Real-Time In Vitro Microscopic Imaging for Lab-on-CMOS Systems","authors":"Bathiya Senevirathna, Sheung Lu, E. Smela, P. Abshire","doi":"10.1109/BIOCAS.2019.8919023","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8919023","url":null,"abstract":"CMOS-based microelectronic sensors have great potential in the development of biosensors for medical and life science applications. Validating these lab-on-CMOS systems is a challenging task due to the difficulties in obtaining simultaneous ground-truth imaging and sensor data. In this work, we report a real-time imaging platform that generates high-quality images of lab-on-CMOS systems within cell culture environments. The platform was used to validate a CMOS capacitance sensor that monitors cell viability, proliferation, and death. In vitro experiments were performed with human ovarian cancer cell lines, in which time-lapse images and capacitance recordings were acquired simultaneously over three days. The images corroborate the temporal changes in capacitance recordings as the cells proliferate, and unambiguously confirm the sensor’s ability to detect single-cell binding events, track cell morphology changes, identify cell division events, and monitor cell motility.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129828943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Novák, Kamila Konopińska, M. Meyerhoff, Richard B. Brown
{"title":"Portable Bluetooth Microsystem for Electrochemically Modulated Nitric Oxide-Releasing Catheters","authors":"O. Novák, Kamila Konopińska, M. Meyerhoff, Richard B. Brown","doi":"10.1109/BIOCAS.2019.8919232","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8919232","url":null,"abstract":"In this paper, an emerging technology for preventing thrombosis and bacterial infections associated with medical implants is presented. A prototype of a battery-powered microsystem facilitating the release of nitric oxide (NO) from intravenous catheters is demonstrated. Results of an animal study showing the efficacy of the antimicrobial/thromboresistant catheters are presented. The next generation microsystem with a wireless interface is also introduced.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127539052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boyu Shui, Daniel De Dorigo, A. S. Herbawi, P. Ruther, O. Paul, Y. Manoli, M. Kuhl
{"title":"A Slim Needle Neural Probe with 160 Active Recording Sites and Selectable ADCs","authors":"Boyu Shui, Daniel De Dorigo, A. S. Herbawi, P. Ruther, O. Paul, Y. Manoli, M. Kuhl","doi":"10.1109/BIOCAS.2019.8919180","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8919180","url":null,"abstract":"In order to provide active neural needle probes with a large number of recordings sites integrated on a single shank, a high degree of miniaturization of the probe shank and its electronics is required. This work presents a probe which comprises 160 recording sites each combined with a low-noise amplifier integrated under each electrode in an area of only 50×80 µm2. In total, 32 channels can be monitored simultaneously by means of 32 12-bit incremental Delta-Sigma ADCs each requiring an area of 120×40 µm2. The selection of the 32 channels is performed by means of a digital controller. The average input referred noise for AP signals (300 Hz to 10 kHz) is extracted to 20.87 µVrms in in-vitro measurements. The design competes well with the state of the art due to a maximum shank width of 200 µm, an area of 0.032 mm2, and a power consumption of 26.5 µW per channel.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"121 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124514318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhanwei Zhong, Haodong Zhu, Peiran Zhang, J. Morizio, T. Huang, K. Chakrabarty
{"title":"Hardware Design and Experimental Demonstrations for Digital Acoustofluidic Biochips","authors":"Zhanwei Zhong, Haodong Zhu, Peiran Zhang, J. Morizio, T. Huang, K. Chakrabarty","doi":"10.1109/BIOCAS.2019.8919148","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8919148","url":null,"abstract":"A digital microfluidic biochip (DMB) is an attractive platform for automating laboratory procedures in microbiology. To overcome the problem of cross-contamination due to fouling of the electrode surface in traditional DMBs, a contactless liquid-handling biochip technology, referred to as acoustofluidics, has recently been proposed. A major challenge in operating this platform is the need for a control signal of frequency 24 MHz and voltage range ±10/ ±20 V to activate the inter-digital-transducer (IDT) units in the biochip. A preliminary solution based on amplifiers, mechanical relays, and jump wires introduces signal loss (at least 6dB), signal coupling, and waveform distortion. In this paper, we present a new IDT-driver design that offers three major advantages: smaller form factor and lower cost, effective and high-quality signal generation and transmission, and fully-automated and flexible biochip control. Experimental demonstrations of droplet routing and a simple bioassay highlight the effectiveness of our hardware design.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116351656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Loai Danial, Kanishka Sharma, Shivanshu Dwivedi, Shahar Kvatinsky
{"title":"Logarithmic Neural Network Data Converters using Memristors for Biomedical Applications","authors":"Loai Danial, Kanishka Sharma, Shivanshu Dwivedi, Shahar Kvatinsky","doi":"10.1109/BIOCAS.2019.8919068","DOIUrl":"https://doi.org/10.1109/BIOCAS.2019.8919068","url":null,"abstract":"Data converters are ubiquitous in electrical data driven systems, where they are heterogeneously distributed across the analog-digital interface. Unfortunately, conventional data converters trade off speed, power, and accuracy. Logarithmic analog-to-digital/digital-to-analog converters (ADC/DACs) are employed in biomedical applications where signals with high dynamic range are recorded. For the same input dynamic range of a linear ADC/DAC, a logarithmic one can efficiently quantize the sampled data by reducing the number of resolution bits, sampling rate, and power consumption, albeit with reduced accuracy for high amplitudes. Previously, we employed novel neural network architectures to design smart data converters that could be trained in real-time for general purpose applications, breaking through the speed-power-accuracy tradeoff, and using machine learning techniques and memristors for synaptic realization. In this paper, we report the results of SPICE simulations performed to train our converters to perform logarithmic quantization. The proposed architecture achieved a 77.19 pJ/conv FOM, 2.55 ENOB, 0.26 LSB INL, and 0.62 LSB DNL. These promising features will pave the way towards adaptive human-machine interfaces with continuous varying conditions for precision medicine applications.","PeriodicalId":222264,"journal":{"name":"2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122596803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}