Japan Journal of Clinical & Medical Research最新文献

{"title":"A Contemporary Evaluation of Calculated and Directly Measured LDL","authors":"Lauer Cs, Loh Wj, Phua Sk","doi":"10.47363/jjcmr/2021(1)109","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)109","url":null,"abstract":"Background: There are few contemporary evaluations of directly measured LDL (dLDL) assays. We evaluated the performance of the Roche Gen.3 dLDL assay and compared it to the Friedewald LDL (cLDL) in a large cohort, tested on the Cobas c702 analyser. Methods: We evaluated assay precision, linearity, and limit of detection (LOD). To compare cLDL/dLDL, lipid panels (TC/TG/HDL/cLDL) from 2017- 2019 (n=117,090) were tested for dLDL. Samples with TG >400mg/dL (4.5mmol/L) (n=605) and negative cLDL (n=32) were excluded. We examined the difference between cLDL/dLDL (n=116,453), the influence of increasing levels of TG/LDL on their measurements, and how cLDL/dLDL classified cardiovascular risk by LDL levels. Results: The Roche dLDL assay has a CV of 1.0%/0.9% at 58.4/106.4mg/dL, is linear from 19.4-374mg/dL, and has a verified LOD of 4.2mg/dL. Despite close agreement between dLDL/cLDL [Pearson r=0.98 (95%CI 0.9795-0.9800)], cLDL underestimates dLDL in 98.5% (n=114,750) of subjects across all levels of LDL/TG. The underestimation increases with LDL/TG levels. cLDL classified more subjects (63.5%) as having a desirable LDL (<100mg/dL) than dLDL (46.9%). Conclusions: The Cobas c702 dLDL assay performs well, and contemporary cLDL results underestimate dLDL across all levels of TG/LDL. cLDL classifies more patients into lower cardiovascular risk categories than dLDL","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122119343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Hormonal Contraceptive Device with Multiple Uses: Increases The Effectiveness of Fertility Awareness Methods and Controls Stress Incontinence","authors":"Shihata Alfred, A BrodySteven, L. Birgit, Birgit Midwife Linderoth, in Falun Sweden","doi":"10.47363/jjcmr/2021(1)108","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)108","url":null,"abstract":"This article addresses three unmet women’s reproductive health needs, and how the FemCap can fulfill these needs. The FemCap is an FDA-approved, non-hormonal contraceptive device that can accommodate some deficient areas of women’s health: 1. A scarcity of hormone-free contraceptive methods. 2. Enhancement of fertility awareness method that is infrequently used but is the safest method. 3. Help Millions of women who suffer silently from stress urinary incontinence. The FemCap blocks sperm from entering the cervix. It is time-tested to be safe and effective for contraception. Using the FemCap directly at the cervix, it can collect the fertile cervical mucus without mixing it with any other vaginal fluid. Current pessaries used to treat stress urinary incontinence (SUI) have significant drawbacks, including displacement, erosion, ulceration, of the vagina and urethral blockage. The rim of the FemCap performs the same function as the ring pessary by supporting the bladder neck. The outward flared brim restores the urethra and vaginal anatomy. At the same time, the bowl of the FemCap keep the cervix from prolapsing further. The FemCap is a long-established barrier method of contraception, and pilot studies results show it can improve fertility awareness methods and manage Stress Urinary Incontinence. It would be ideal and cost-effective to have a single reusable device with several functions for contraceptives, increasing the acceptability and effectiveness of fertility awareness methods, and stress urinary incontinence control. The FemCap would be an ideal alternative to the condom.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131143166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Analysis and Study of Smecta in the Treatment of Rotavirus Enteritis in Children","authors":"Cheng Xiao","doi":"10.47363/jjcmr/2021(1)102","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)102","url":null,"abstract":"Objective: To explore the clinical effect of Smecta in treating rotavirus enteritis. Methods: 40 children with rotavirus enteritis treated in our hospital were randomly divided into observation group and control group. The observation group was treated with smecta plus routine treatment, while the control group was treated with routine treatment. The efficacy and adverse reactions of the two groups were compared. Results: The effect of smecta in observation group was not clear.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117046141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Umbilical Cord Blood Stem Cells on Coronary Artery Damage in Mice with Kawasaki Disease By High-Frequency Ultrasound","authors":"Na Zhao, Xue-Mei Zhang, Hua Guo","doi":"10.47363/jjcmr/2021(1)101","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)101","url":null,"abstract":"Objective: to use lactobacillus casein cell wall extract (LCWE) to induce Kawasaki disease (KD) mouse model, and analyse the process of coronary artery damage and effects of umbilical cord blood stem cells by high-frequency ultrasound in small animals. Methods: LCWE was prepared and 18 BALB/c pups were randomly divided into two groups: 15 in KD model group and 3 in the normal control group. KD model was induced by a single intraperitoneal injection of 0.5ml LCWE in the model group, and changes of the coronary artery were observed at 2d, 21d and 30d after the injection, respectively. From the 16th day of modeling, 300 μL PBS was injected intraperitoneally daily in the control group and model group. The hUC-MSCs 300 μL (105/mL) were intraperitoneally injected daily for 10 consecutive days in the stem cell group. The mice were sacrificed in batches on day 2, 15, 21 and 30, and the morphological changes of coronary arteries were observed by echocardiography and histopathology. Results: the change of coronary artery diameter could be accurately measured by high-frequency small animal ultrasound. At 21d, the coronary arteries of the model group were widened compared with those of the control group. At 30d, there was no significant difference between the model group and the previous model group. Histopathology showed slight swelling of the epicardium of aortic valve, mitral valve, right ventricle and atrium, scattered infiltration of a few neutrophils, dilatation of the coronary artery lumen, necrosis and disintegration of a small number of myocardial cells, and significant hyperplasia of local fibrous connective tissue accompanied by solid calcium salt deposits. After hUC-MSCs intervention treatment, B-ultrasound showed a decrease in the main coronary artery diameter, histopathology showed multiple lymphocytes, eosinophilic granulocytes, and mononuclear cell infiltration in the left atrial appendage of mice, and no obvious vascular inflammatory reaction or other obvious abnormalities were observed. Conclusion: high-frequency ultrasound can be used to clearly obtain the coronary artery image of KD mice and dynamically observe the evolution process of coronary artery diameter, which provides more diagnostic basis for the treatment of clinical KD. And hUC-MSCs intervention reduced the pathological lesion of coronary artery inflammation in mice compared with the model group.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133749228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Diagnostic Confirmed by Cerebral Simple Proton Emission Computed Tomography (SPECT)","authors":"Roberto Levi Cavalcanti Jales, Tirol Natal Rn Brasil Clínica Nuclear de Natal, S. Santos-Filho, Petrópolis Natal Rn Brasil Clínica Serviço de Imagem Médica","doi":"10.47363/jjcmr/2021(1)104","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)104","url":null,"abstract":"It is usual in psychiatric clinic arise diagnostic hypothesis for the same patient. Take for example the schizophrenia, the classic definition was of a disease of the thoughts, and that no machine explored the thoughts. The advent of cerebral SPECT (single photon emission computed tomography) made it possible the formation of Data Bank. The SPECT when made cerebral images is known as cerebral perfusion scintigraphy, it is done with a drug that in minute fraction is extracted of blood to the interior of the neurons, through the haemato-encephalic barrier, still there for hours. The psychiatry is one of the more needy medical specialities, in terms of complementary examinations, and the cerebral SPECT done with HMPAO could be used to help the clinician in doubt cases. In this work we present two clinical cases where the cerebral SPECT produce a confinable diagnostic about schizophrenia. The mathematical language used by nuclear medicine inform that the obtained image belongs to a psychiatric specific group of diseases.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128778821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication Skills and Pain Assessment with Case History","authors":"M. J. Hossain","doi":"10.47363/jjcmr/2021(1)103","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)103","url":null,"abstract":"IntroductionCommunication with the patient must be important skills for a doctor or medical practitioner in practising field. Without good communication with the patient it is difficult to help that patient properly. In most developed and developing countries in the world health system is changing; political and economic forces are behind the growth of profit driven medicine, managed care and increasingly technological focus. Good communication skills improve the doctor – patient relationship and decrease the dissatisfaction by the patient and relatives. It offers numerous benefits to the patient. Communication skills is an interactive process, patient will also need knowledge to take part in decision making and can raised question about the quality of life. Doctors have a moral and social responsibility towards the community as well as medical responsibility and must preserve their patients’ trust.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130135752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}