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Japan Journal of Clinical & Medical Research最新文献

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People’s Responsibility towards Organ Donation an Unanswered Appeal 人们对器官捐献的责任:未获回应的呼吁
Japan Journal of Clinical & Medical Research Pub Date : 2021-12-31 DOI: 10.47363/jjcmr/2021(1)117
C. Félix
{"title":"People’s Responsibility towards Organ Donation an Unanswered Appeal","authors":"C. Félix","doi":"10.47363/jjcmr/2021(1)117","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)117","url":null,"abstract":"People easily agree with the principle of organ donation; nevertheless, when a person dies, their relatives often refuse to honour this agreement. Because of this persistent social conduct, organ shortage is responsible for the rising mortality of patients on organ waiting lists. This sad reality continues despite the ongoing education effort with the enduring slogan: “Organ donation is a gift of life”.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123838440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PD-1 /PD-L1 Adoptive Checkpoint Biosynthesis Separately Are Regulated By Gamma Common Which Regulate PD-1, Globin, and IFN-Gamma PD-1 /PD-L1过继性检查点生物合成分别由调节PD-1，球蛋白和ifn - γ的γ Common调节
Japan Journal of Clinical & Medical Research Pub Date : 2021-12-31 DOI: 10.47363/jjcmr/2021(1)119
Ashraf Marzouk El Tantawi
{"title":"PD-1 /PD-L1 Adoptive Checkpoint Biosynthesis Separately Are Regulated By Gamma Common Which Regulate PD-1, Globin, and IFN-Gamma","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jjcmr/2021(1)119","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)119","url":null,"abstract":"PD-1 /PD-L1 is adoptive checkpoint mechanism, where PD-1 is an adopting its PD-L1 ligand activities by presence of specific helical kinase proteins in its compositions: _gamma common chains,_LNK” lymphocyte adaptor protein, _or SH2B adaptor _protein “tyrosine kinases, and _”SOCS” suppressor of cytokine signaling, that specified for controlling PD-1 and PD-L1 bindings activity through temporary resting the PD-L1 and consequently T-cells activities then transform incoming signals to exogenous processes in favor the of proper immune functions, But the permanent inhibition of PD-1 /PD-L1 binding is due to breaking down or inhibition in one or more of the adaptors helical proteins (lymphocyte adaptor protein, or SH2B) with the presence of SOCS” suppressor of cytokine signaling that will increase stability of binding without adopting and without activities, but cells survival can still exist through presence of tyrosine kinases , interferon stimulate kinases ,and gamma common.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131444734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covid-19 and Dengue Coinfection: Case Report Covid-19和登革热合并感染:病例报告
Japan Journal of Clinical & Medical Research Pub Date : 2021-09-30 DOI: 10.47363/jjcmr/2021(1)113
Tatiana Betancur Pérez, J. Gómez
{"title":"Covid-19 and Dengue Coinfection: Case Report","authors":"Tatiana Betancur Pérez, J. Gómez","doi":"10.47363/jjcmr/2021(1)113","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)113","url":null,"abstract":"The concurrence of COVID-19 with dengue present a similarity in the early stages of both diseases could cause delays in the diagnosis of dengue infection,SARS-CoV-2 or both. This adds an additional difficulty to the diagnosis and suggests that a positive result of IgM or IgG serology would not be sufficient for the definitive confirmation of dengue. Clinical case: 13-year-old female patient in poor general condition who debuts with a clinical picture of 5 days of evolution consisting of fever, anosmia, ageusia, unquantified fever peaks, chills, abdominal pain and vomiting that does not stop.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130464343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healing Efficacy After Surgery and Intensity-Modulated Radiotherapy for Extremely Rare Maxillary Giant Cell Tumor 极为罕见的上颌巨细胞瘤手术及调强放疗后的愈合效果
Japan Journal of Clinical & Medical Research Pub Date : 2021-09-30 DOI: 10.47363/jjcmr/2021(1)114
L. Marinova, Radoslav Gieeorgv
{"title":"Healing Efficacy After Surgery and Intensity-Modulated Radiotherapy for Extremely Rare Maxillary Giant Cell Tumor","authors":"L. Marinova, Radoslav Gieeorgv","doi":"10.47363/jjcmr/2021(1)114","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)114","url":null,"abstract":"Giant cell tumors are rare benign borderline tumors, and maxillary localization is extremely rare. Because of the few clinical cases, healing behavior is very different, although the primary is the surgery. We present a 72-year-old man in which, on the occasion of difficulty left nasal breathing with four months of length, in January 2021 an operation was carried out on a left maxillary sinus. Histological diagnosis is a giant cell tumor (GCT) of the maxillary sinus.The patient is targeted for post-operative radiotherapy (RT).","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125298196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granular Cell Tumor of the Tongue: A Rare Case Presentation of a 14 Years Old Girl 舌颗粒细胞瘤:一例罕见的14岁女孩
Japan Journal of Clinical & Medical Research Pub Date : 2021-09-30 DOI: 10.47363/jjcmr/2021(1)111
M. Nacouzi
{"title":"Granular Cell Tumor of the Tongue: A Rare Case Presentation of a 14 Years Old Girl","authors":"M. Nacouzi","doi":"10.47363/jjcmr/2021(1)111","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)111","url":null,"abstract":"Granular cell tumor or Abrikossoff ’s tumor is an infrequent tumor that can arise in most organs, and especially in the ENT area. It is a usually benign neoplasm, that can lead to a misdiagnose of malignancy. It affects both sex, between the fourth and the sixth decade. We present in this report a case of a 14 years old girl with a slowly growing lesion on the right lateral border of the mobile tongue. The biopsy showed a proliferation of large cells with a granular cytoplasm that expressed two immunohistochemistry markers: CD68 and S100 antibodies. Surgical resection was completed with a one centimeter margin.The rare issue about this case is the age of presentation: the age of the patient is 14, whereas this tumor usually affects adult patients.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115916633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An In-Depth Study of TCA cycles, OPA1, S6K1, ATPase, TLR4, MHC-class-I, GCs, and IFNs Bio-Synthesis, and Their Roles of Deficiency in Diabetes, Asthma, Cancer, etc and the NAD Roles in Their Activities TCA循环、OPA1、S6K1、ATPase、TLR4、mhc - 1类、GCs、IFNs的生物合成及其在糖尿病、哮喘、癌症等疾病缺乏中的作用及NAD在其活性中的作用的深入研究
Japan Journal of Clinical & Medical Research Pub Date : 2021-09-30 DOI: 10.47363/jjcmr/2021(1)115
Ashraf Marzouk El Tantawi
{"title":"An In-Depth Study of TCA cycles, OPA1, S6K1, ATPase, TLR4, MHC-class-I, GCs, and IFNs Bio-Synthesis, and Their Roles of Deficiency in Diabetes, Asthma, Cancer, etc and the NAD Roles in Their Activities","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jjcmr/2021(1)115","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)115","url":null,"abstract":"The roles of S6K1 is regulating ATPase, and GTPase synthesis, and consequently the endocytic proliferations including endocytic soluble MHC class II synthesis which regulate both SIRPα1 and TLR4 synthesis , where diabetes reflect deficiency in Ser amino acids that reflect deficiency in pyrimidines synthesis consequently deficiency in Estrogen and reflect increasing in androgen synthesis with increasing in consuming in purines (A&G) that lead to decreasing in anabolic processes which depends on presence of adenosine and guanosine stored in ribosimes.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129457311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Toll-Like Receptor-4 Synthesis is Regulated by Jnk Signaling by Three Glucocorticoids Isoforms And By Three Interferons Isoforms, Also Its Advantages in Activities Depending on The Containment From Arg, Proline, And Hydrophobic Amino Acids In Its Compositions toll样受体-4的合成受Jnk信号的调控，受三种糖皮质激素同工型和三种干扰素同工型的调控，其活性的优势也取决于其成分中精氨酸、脯氨酸和疏水氨基酸的抑制
Japan Journal of Clinical & Medical Research Pub Date : 2021-08-31 DOI: 10.47363/jjcmr/2021(1)112
Ashraf Marzouk El Tantawi
{"title":"Toll-Like Receptor-4 Synthesis is Regulated by Jnk Signaling by Three Glucocorticoids Isoforms And By Three Interferons Isoforms, Also Its Advantages in Activities Depending on The Containment From Arg, Proline, And Hydrophobic Amino Acids In Its Compositions","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jjcmr/2021(1)112","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)112","url":null,"abstract":"Toll-like receptor-4 (TLR4), synthesis is regulated by JNK signaling, by three glucocorticoids isoforms, and by the three interferons isoforms, also depending on avaliablities of LPS & on long fatty acids chains with Arg and proline availabilities For performing and running the mitochondrial oxidative processes for producing fatty-acyl-CoA-synthetase followed by fatty-acyl-CoA-synthase followed by fatty-acyl-CoA-phospholipase productions for linear TLR4 active beta-subunits which will be transformed into TLR4-alpha upon phospholipase effects, which will follow phosphorylation process (alpha-oxidations) for generate Guanosine triphosphate cyclohydrolase (GTP-Chase) subunits which supposed to contain specific hydrophobic amino acids including Arg, Tyr, leu, proline…. Etc","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122003281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Proteins and Cancer Therapy-A Complicated Duet 蛋白质和癌症治疗——一个复杂的二重唱
Japan Journal of Clinical & Medical Research Pub Date : 2021-08-13 DOI: 10.47363/jjcmr/2021(1)110
Priyanka Ray
{"title":"Proteins and Cancer Therapy-A Complicated Duet","authors":"Priyanka Ray","doi":"10.47363/jjcmr/2021(1)110","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)110","url":null,"abstract":"Cancer is a leading cause of death worldwide, with some forms of exhibiting low survival rates due to poor prognosis and absence of early diagnosis. To effectively treat cancer, various interactions governing cellular subdivision and growth must be investigated","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132076939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myofacial Release for the Management of Cervical Compressive Myelopathy – Case Study 肌面松解术治疗颈压迫性脊髓病-个案研究
Japan Journal of Clinical & Medical Research Pub Date : 2021-06-30 DOI: 10.47363/jjcmr/2021(1)105
P. Mohanty
{"title":"Myofacial Release for the Management of Cervical Compressive Myelopathy – Case Study","authors":"P. Mohanty","doi":"10.47363/jjcmr/2021(1)105","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)105","url":null,"abstract":"Cervical compressive myelopathy commonly occurs due to degeneration or disc herniation. The persons with cervical meylopathy are usually advised for surgical decompression. Person with signs of cervical cord compression was treated with myofacial release and found to be improved in signs as well as the symptoms. Total 34 numbers of similar cases (31 males and 3 females) age ranging from 25 to 61 years were treated by myofascial release of periscapular soft tissue structures over last 2 & ½ years (2017 to 2020) and found to return back to their activities after 6 months of follow up.","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"11 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114403249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Constitution of a Failed Antitumor Immune Response as Carcinogenesis Sustainment 一个失败的抗肿瘤免疫反应的构成作为癌变的维持
Japan Journal of Clinical & Medical Research Pub Date : 2021-06-30 DOI: 10.47363/jjcmr/2021(1)106
L. Agius
{"title":"Constitution of a Failed Antitumor Immune Response as Carcinogenesis Sustainment","authors":"L. Agius","doi":"10.47363/jjcmr/2021(1)106","DOIUrl":"https://doi.org/10.47363/jjcmr/2021(1)106","url":null,"abstract":"The constitutive provocations of an immature DC governing enhanced tumor cell proliferation and spread constitute effective further carcinogenesis as projected by systems of tumor cell derivation and progression. The developmental dynamics of an ineffective antitumor immune response constitute the elements for further progression of neoplastic growth that derives sustained stimulation in terms of the genesis of various tumor derived growth factors such as vascular endothelial growth factor. The involvement of vascular leukocytes is inciting element within the encompassed derivation of a lesion whose growth and spread is actively enhanced by the immature DC and as further proposed by systems of multilayers of DC dysfunctionality","PeriodicalId":221951,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128787318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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