Toll-Like Receptor-4 Synthesis is Regulated by Jnk Signaling by Three Glucocorticoids Isoforms And By Three Interferons Isoforms, Also Its Advantages in Activities Depending on The Containment From Arg, Proline, And Hydrophobic Amino Acids In Its Compositions

Abstract

Toll-like receptor-4 (TLR4), synthesis is regulated by JNK signaling, by three glucocorticoids isoforms, and by the three interferons isoforms, also depending on avaliablities of LPS & on long fatty acids chains with Arg and proline availabilities For performing and running the mitochondrial oxidative processes for producing fatty-acyl-CoA-synthetase followed by fatty-acyl-CoA-synthase followed by fatty-acyl-CoA-phospholipase productions for linear TLR4 active beta-subunits which will be transformed into TLR4-alpha upon phospholipase effects, which will follow phosphorylation process (alpha-oxidations) for generate Guanosine triphosphate cyclohydrolase (GTP-Chase) subunits which supposed to contain specific hydrophobic amino acids including Arg, Tyr, leu, proline…. Etc