Substance Abuse: Research and Treatment最新文献

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Lean/Sizzurp Ingredients, Use, and Coping With Mental Health Symptoms. 精益/Sizzurp成分、使用和应对心理健康症状。
IF 2.1
Substance Abuse: Research and Treatment Pub Date : 2023-09-22 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231195226
Orrin D Ware
{"title":"Lean/Sizzurp Ingredients, Use, and Coping With Mental Health Symptoms.","authors":"Orrin D Ware","doi":"10.1177/11782218231195226","DOIUrl":"https://doi.org/10.1177/11782218231195226","url":null,"abstract":"<p><p>The substance combination of codeine and promethazine, commonly termed <i>lean</i>/<i>sizzurp</i>, has been identified as a method that some individuals use to cope with PTSD and other mental health symptomology. A sample of 1423 adults with self-reported past year lean use was recruited from substance-related Reddit pages to complete a survey about lean, including information about using lean to cope with emotions, thoughts, or feelings. To be included in the sample, persons needed to: (1) be ⩾18 years old, (2) report past year lean use, (3) complete lean use screeners, and (4) pass data quality checks (eg, bot detection). As Reddit is an online forum, no geographic restrictions were placed on study participation. Data on demographic characteristics, lean use, and mental health disorder symptomology were captured from participants. Logistic regression models included anxiety, depression, and trauma as independent variables along with covariates to examine using lean to cope with emotions, thoughts, or feelings in the past 30 days. Most participants were male (n = 1102; 77.4%), with an average age of 26.9 (SD = 5.2) years. Most participants used included codeine as an ingredient in lean (n = 1060; 74.5%); promethazine was added as an ingredient by 31.7% of the sample (n = 451), and the combination of codeine and promethazine was included as ingredients by 13.5% (n = 192) of the sample. Participants with anxiety, lifetime trauma exposure, and who were female had increased odds of using lean to cope with emotions, thoughts, or feelings in the past 30 days. Those with depression and unstable housing exhibited decreased odds of using lean to cope with emotions, thoughts, or feelings in the past 30 days. This study recruited persons via social media to learn more about lean use, especially lean use to cope with mental health symptoms; future population-level studies are needed.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231195226"},"PeriodicalIF":2.1,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/f0/10.1177_11782218231195226.PMC10517614.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the Shared Meaning of Recovery From Substance Use Disorders: New Findings From the What is Recovery? Study. 理解物质使用障碍康复的共同意义:《什么是康复?学习
IF 2
Substance Abuse: Research and Treatment Pub Date : 2023-09-15 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231199372
Sarah E Zemore, Kelly L Ziemer, Paul A Gilbert, Mitchell P Karno, Lee Ann Kaskutas
{"title":"Understanding the Shared Meaning of Recovery From Substance Use Disorders: New Findings From the What is Recovery? Study.","authors":"Sarah E Zemore, Kelly L Ziemer, Paul A Gilbert, Mitchell P Karno, Lee Ann Kaskutas","doi":"10.1177/11782218231199372","DOIUrl":"10.1177/11782218231199372","url":null,"abstract":"<p><strong>Background: </strong>Substance use disorder (SUD) resolution typically involves a long-term, comprehensive process of change now widely referred to as \"recovery.\" Yet, definitions of recovery vary substantially, producing significant confusion. To support formal recovery definitions, we aimed to systematically identify recovery elements that are central to those in recovery and shared regardless of subgroup/pathway.</p><p><strong>Methods: </strong>Data were from the What is Recovery? Study, involving a diverse, national, online survey of people in recovery (N = 9341). Surveys included a 35-item recovery measure reflecting 4 domains; participants reported whether or not each element definitely belonged in their recovery definitions. Analyses examined item endorsements overall and among 30 subgroups defined <i>a priori</i> (by sociodemographics, substance use characteristics, and help-seeking history) to determine where items met study-specific centrality thresholds (ie, endorsement by ⩾80% and top-10 ranking, by endorsement level). We then classified items as \"core\" if meeting centrality thresholds both overall and for all 30 subgroups, and \"prevalent\" if meeting centrality thresholds overall and for 26 to 29 subgroups.</p><p><strong>Results: </strong>Four \"core\" recovery elements emerged, including a process of growth or development; being honest with oneself; taking responsibility for the things one can change; and reacting in a more balanced way. Four \"prevalent\" recovery elements also emerged, referencing the ability to enjoy life and handle negative feelings without substance use; abstinence and/or nonproblematic substance use; and living a life that contributes. Subgroups differing most in their endorsements included those reporting mild/moderate SUD severity; non-abstinent recovery; and no specialty treatment or mutual-help group attendance.</p><p><strong>Conclusions: </strong>Recovery elements identified here partially reflect some stakeholder definitions, but offer greater specificity and include novel elements (eg, personal integrity). Elements may point to areas of functioning that are damaged in the addiction process and can support an addiction-free life. Findings should inform institutional recovery definitions; SUD services and research; and communications about recovery.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231199372"},"PeriodicalIF":2.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/91/10.1177_11782218231199372.PMC10508054.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41130143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Childhood Maltreatment, Internal Working Models, and Perinatal Substance Use: Is There a Role for Hyperkatifeia? A Systematic Review. 母婴虐待、内部工作模式和围产期药物使用:是否存在高卡替菲亚的作用?系统回顾。
IF 2.1
Substance Abuse: Research and Treatment Pub Date : 2023-07-18 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231186371
Aviva K Olsavsky, Isabella Chirico, Diab Ali, Hannah Christensen, Brianna Boggs, Lillian Svete, Katherine Ketcham, Kent Hutchison, Charles Zeanah, Nim Tottenham, Paula Riggs, C Neill Epperson
{"title":"Maternal Childhood Maltreatment, Internal Working Models, and Perinatal Substance Use: Is There a Role for Hyperkatifeia? A Systematic Review.","authors":"Aviva K Olsavsky,&nbsp;Isabella Chirico,&nbsp;Diab Ali,&nbsp;Hannah Christensen,&nbsp;Brianna Boggs,&nbsp;Lillian Svete,&nbsp;Katherine Ketcham,&nbsp;Kent Hutchison,&nbsp;Charles Zeanah,&nbsp;Nim Tottenham,&nbsp;Paula Riggs,&nbsp;C Neill Epperson","doi":"10.1177/11782218231186371","DOIUrl":"10.1177/11782218231186371","url":null,"abstract":"<p><p>The parent-infant relationship is critical for socioemotional development and is adversely impacted by perinatal substance use. This systematic review posits that the mechanisms underlying these risks to mother-infant relationships center on 3 primary processes: (1) mothers' childhood maltreatment experiences; (2) attachment styles and consequent internal working models of interpersonal relationships; and (3) perinatal substance use. Further, the review considers the role of hyperkatifeia, or hypersensitivity to negative affect which occurs when people with substance use disorders are not using substances, and which drives the negative reinforcement in addiction. The authors performed a systematic review of articles (published 2000-2022) related to these constructs and their impact on mother-infant relationships and offspring outcomes, including original clinical research articles addressing relationships between these constructs, and excluding case studies, reviews, non-human animal studies, intervention studies, studies with fewer than 30% female-sex participants, clinical guidelines, studies limited to obstetric outcomes, mechanistic/biological studies, and studies with methodological issues precluding interpretation. Overall 1844 articles were screened, 377 were selected for full text review, and data were extracted from 157 articles. Results revealed strong relationships between mothers' childhood maltreatment experiences, less optimal internal working models, and increased risk for perinatal substance use, and importantly, all of these predictors interacted with hyperkatifeia and exerted a marked impact on mother-infant relationships with less data available on offspring outcomes. These data strongly support the need for future studies addressing the additive impact of maternal childhood maltreatment experiences, suboptimal internal working models, and perinatal substance use, with hyperkatifeia as a potential moderator, and their interacting effects on mother-infant socioemotional outcomes.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231186371"},"PeriodicalIF":2.1,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/3b/10.1177_11782218231186371.PMC10354827.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10665728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Compensation and Enhanced Contacts in Studies With Persons Who Use Drugs: Lessons From the COVID-19 Pandemic Demand a Reset. 研究补偿和加强与吸毒者研究的联系:新冠肺炎大流行需求重置的教训。
IF 2
Substance Abuse: Research and Treatment Pub Date : 2023-06-06 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231179039
Matthew G Lemansky, Anna K Martin, Judith A Bernstein, Sabrina A Assoumou
{"title":"Research Compensation and Enhanced Contacts in Studies With Persons Who Use Drugs: Lessons From the COVID-19 Pandemic Demand a Reset.","authors":"Matthew G Lemansky, Anna K Martin, Judith A Bernstein, Sabrina A Assoumou","doi":"10.1177/11782218231179039","DOIUrl":"10.1177/11782218231179039","url":null,"abstract":"<p><p>Policy changes resulting from the coronavirus 2019 (COVID-19) pandemic have had a substantial and positive impact on the clinical care of persons with opioid use disorder. These innovative paradigm shifts created a ripe environment for re-evaluating traditional approaches to recruiting and retaining persons who use drugs into research studies. For example, changes to methadone prescribing requirements and authorization of buprenorphine prescriptions via telehealth have both increased access to medications. In this commentary, we contribute to ongoing conversations about the ethics of compensation for participants in addiction-related clinical research and share methods of payment that proved successful in research performed during the pandemic. We also discuss approaches to enrollment and follow-up that were implemented during the height of COVID restrictions. These approaches may mutually benefit both participants and researchers in a post-pandemic era.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231179039"},"PeriodicalIF":2.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2b/1c/10.1177_11782218231179039.PMC10251077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10351427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Focused Screening and Clinical Intervention with Streamlined Outpatient Linkage for Hospitalized Patients with Opioid Use Disorder Experiencing Homelessness. 针对无家可归的阿片类药物使用障碍住院患者的重点筛查和临床干预,以及简化的门诊链接。
IF 2
Substance Abuse: Research and Treatment Pub Date : 2023-04-06 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231166382
Sandra Oreper, Allison Bond, Marilyn Bazinski, Matthew Tierney, Margaret Fang, Sujatha Sankaran, Aksharananda Rambachan
{"title":"A Focused Screening and Clinical Intervention with Streamlined Outpatient Linkage for Hospitalized Patients with Opioid Use Disorder Experiencing Homelessness.","authors":"Sandra Oreper, Allison Bond, Marilyn Bazinski, Matthew Tierney, Margaret Fang, Sujatha Sankaran, Aksharananda Rambachan","doi":"10.1177/11782218231166382","DOIUrl":"10.1177/11782218231166382","url":null,"abstract":"<p><strong>Background: </strong>Patients experiencing homelessness have higher rates of substance use and related mortality, often driven by opioid overdose. Conversely, opioid use disorder (OUD) is a leading risk factor for homelessness. Our goal was to test the efficacy of an electronic health record (EHR) screen in identifying this vulnerable population during hospitalization and to assess the feasibility of a bundled intervention in improving opioid safety.</p><p><strong>Methods: </strong>We assessed patients' housing status, substance use, previous MOUD treatment, barriers to MOUD treatment and readiness to take MOUD in and out of the hospital. For each post discharge follow up call, patients were asked about their MOUD status, barriers accessing treatment, current substance use, and housing status. We also assessed team members perceptions and experiences of the study.</p><p><strong>Results: </strong>We enrolled 32 patients with housing insecurity and OUD. The mean age was 44, the majority self-identified as male (78%), and mostly as White (56%) or Black (38%). At each follow up within the 6-months post-discharge, reach rates were low: 40% of enrollees answered at least 1 call and the highest reach rate (31% of patients) occurred at week 4. At the third and sixth-month follow ups, >50% of subjects still taking MOUD were also using opioids.</p><p><strong>Conclusion: </strong>Our clinician augmented EHR screen accurately identified inpatients experiencing OUD and PEH. This intervention showed high rates of attrition among enrolled patients, even after providing cellphones. The majority of patients who were reached remained adherent to MOUD though they reported significant barriers.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231166382"},"PeriodicalIF":2.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/f5/10.1177_11782218231166382.PMC10084569.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9304497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Occupation-Based Lifestyle Lecture Intervention as Part of Inpatient Addiction Recovery Treatment: Exploring Occupational Performance, Balance and Personal Recovery. 以职业为基础的生活方式讲座干预,作为住院戒毒治疗的一部分:探索职业表现、平衡和个人康复。
IF 2
Substance Abuse: Research and Treatment Pub Date : 2023-03-31 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231165123
Deirdre Ryan, Marie Naughton, Meabh de Faoite, Tara Dowd, Ann-Marie Morrissey
{"title":"An Occupation-Based Lifestyle Lecture Intervention as Part of Inpatient Addiction Recovery Treatment: Exploring Occupational Performance, Balance and Personal Recovery.","authors":"Deirdre Ryan, Marie Naughton, Meabh de Faoite, Tara Dowd, Ann-Marie Morrissey","doi":"10.1177/11782218231165123","DOIUrl":"10.1177/11782218231165123","url":null,"abstract":"<p><strong>Introduction: </strong>Substance use disorders (SUDs) and addictive behaviours are growing problems which negatively impact health and wellbeing. Occupational therapy can support recovery by facilitating engagement in everyday activities that promote health. To date, the inclusion of occupational therapy in addiction recovery is limited and the evidence base for occupation-focused interventions is lacking. This study explores the impact of an occupational therapy-led intervention on self-reported occupational performance and occupational balance issues for people living with SUDs within an inpatient addiction service.</p><p><strong>Methodology: </strong>A quantitative pre and post-test study was implemented. The Canadian Personal Recovery Outcome Measure (C-PROM) was the sole outcome measure. The C-PROM is a self-report measure which aims to measure personal views of recovery based on rating activity engagement. The cohort of participants were recruited from referrals into 2 inpatient addiction recovery treatment programmes using purposive sampling. Descriptive statistics were run, and a Wilcoxon Signed Rank Test was used to analyse pre and post-test scoring.</p><p><strong>Results: </strong>Sixteen participants (9 male and 7 female) completed the intervention and outcome measure. The majority of participants (31.3%, n = 5) were between 45 and 54 years old. 25% of the sample (n = 4) were in the 35 to 44 age bracket while 18.8% (n = 3) were aged 55 to 64. The majority of participants (68.8%, n = 11) reported substance misuse as their main healthcare concern. The mean score on the C-PROM was significantly higher after participants received the intervention when compared with baseline scoring.</p><p><strong>Conclusion: </strong>Following engagement with an occupational therapist-led intervention participants reported increased engagement in activities and occupational performance. Participants also reported improved occupational balance and increased awareness of personal recovery needs. Further research is required to explore the effectiveness of this intervention in larger samples and to explore the transferability and sustainability of skills post discharge.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231165123"},"PeriodicalIF":2.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/5a/10.1177_11782218231165123.PMC10068992.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing COVID-19-related Morbidity and Mortality Between Patients With and Without Substance Use Disorders: A Retrospective Cohort Study. 比较有药物滥用障碍和无药物滥用障碍患者的 COVID-19 相关发病率和死亡率:回顾性队列研究。
IF 2
Substance Abuse: Research and Treatment Pub Date : 2023-03-22 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231160014
Angela McLaughlin, Rebecca Burns, Morgan Ryan, Wafaa Abbasi, Leah Harvey, Jacqueline Hicks, Pranay Sinha, Sabrina A Assoumou
{"title":"Comparing COVID-19-related Morbidity and Mortality Between Patients With and Without Substance Use Disorders: A Retrospective Cohort Study.","authors":"Angela McLaughlin, Rebecca Burns, Morgan Ryan, Wafaa Abbasi, Leah Harvey, Jacqueline Hicks, Pranay Sinha, Sabrina A Assoumou","doi":"10.1177/11782218231160014","DOIUrl":"10.1177/11782218231160014","url":null,"abstract":"<p><strong>Objectives: </strong>People with substance use disorders (SUD) are suggested to have higher risk of hospitalization, intubation, or death from coronavirus disease 2019 (COVID-19), although data are mixed. Little is known about other COVID-19-related complications in this group. We compared morbidity and mortality among individuals with and without SUD who were admitted to an urban safety net hospital with COVID-19 early in the pandemic, contemporaneous to other published studies on this subject.</p><p><strong>Methods: </strong>We performed a retrospective study of patients ⩾18 years old admitted with COVID-19 from March 16th to April 8th, 2020. SUD included alcohol, opioid, cocaine, amphetamine, and benzodiazepine use disorders and was identified using diagnostic codes, free text clinical documentation, and urine drug screens. The primary outcome was inpatient mortality. Secondary outcomes included clinical complications (eg, secondary infections, venous thromboembolism) and resource utilization (eg, mechanical ventilation, length of stay). We used multivariable regression to assess the relationship between SUD and mortality.</p><p><strong>Results: </strong>Of 409 patients, the mean age was 56 years and 13.7% had SUD. Those with SUD were more likely to be male, have experienced homelessness, have pulmonary disease or hepatitis C, or use tobacco or cannabis. After multivariable analysis, SUD was not associated with mortality (aOR 1.03; 95% CI, 0.31-3.10). Secondary outcomes were also similar between groups.</p><p><strong>Conclusions: </strong>Our findings suggest that persons with and without SUD have similar COVID-19-related outcomes. Previously reported increased COVID-19 complications may be from medical comorbidities.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231160014"},"PeriodicalIF":2.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/77/10.1177_11782218231160014.PMC10034287.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9560577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Buprenorphine Dose and the Urine "Norbuprenorphine" to "Creatinine" Ratio: Revised. 丁丙诺啡剂量和尿“诺丙诺啡”与“肌酐”比值之间的关系:修订。
IF 2.1
Substance Abuse: Research and Treatment Pub Date : 2023-03-13 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231153748
Hiroko Furo, Timothy Wiegand, Meenakshi Rani, Diane G Schwartz, Ross W Sullivan, Peter L Elkin
{"title":"Association Between Buprenorphine Dose and the Urine \"Norbuprenorphine\" to \"Creatinine\" Ratio: Revised.","authors":"Hiroko Furo,&nbsp;Timothy Wiegand,&nbsp;Meenakshi Rani,&nbsp;Diane G Schwartz,&nbsp;Ross W Sullivan,&nbsp;Peter L Elkin","doi":"10.1177/11782218231153748","DOIUrl":"10.1177/11782218231153748","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Utilizing a 1-year chart review as the data, Furo et al. conducted a research study on an association between buprenorphine dose and the urine \"norbuprenorphine\" to \"creatinine\" ratio and found significant differences in the ratio among 8-, 12-, and 16-mg/day groups with an analysis of variance (ANOVA) test. This study expands the data for a 2-year chart review and is intended to delineate an association between buprenorphine dose and the urine \"norbuprenorphine\" to \"creatinine\" ratio with a higher statistical power.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study performed a 2-year chart review of data for the patients living in a halfway house setting, where their drug administration was closely monitored. The patients were on buprenorphine prescribed at an outpatient clinic for opioid use disorder (OUD), and their buprenorphine prescription and dispensing information were confirmed by the New York Prescription Drug Monitoring Program (PDMP). Urine test results in the electronic health record (EHR) were reviewed, focusing on the \"buprenorphine,\" \"norbuprenorphine,\" and \"creatinine\" levels. The Kruskal-Wallis &lt;i&gt;H&lt;/i&gt; and Mann-Whitney &lt;i&gt;U&lt;/i&gt; tests were performed to examine an association between buprenorphine dose and the \"norbuprenorphine\" to \"creatinine\" ratio.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This study included 371 urine samples from 61 consecutive patients and analyzed the data in a manner similar to that described in the study by Furo et al. This study had similar findings with the following exceptions: (1) a mean buprenorphine dose of 11.0 ± 3.8 mg/day with a range of 2 to 20 mg/day; (2) exclusion of 6 urine samples with \"creatinine\" level &lt;20 mg/dL; (3) minimum \"norbuprenorphine\" to \"creatinine\" ratios in the 8-, 12-, and 16-mg/day groups of 0.44 × 10&lt;sup&gt;-4&lt;/sup&gt; (n = 68), 0.1 × 10&lt;sup&gt;-4&lt;/sup&gt; (n = 133), and 1.37 × 10&lt;sup&gt;-4&lt;/sup&gt; (n = 82), respectively; however, after removing the 2 lowest outliers, the minimum \"norbuprenorphine\" to \"creatinine\" ratio in the 12-mg/day group was 1.6 × 10&lt;sup&gt;-4&lt;/sup&gt;, similar to the findings in the previous study; and (4) a significant association between buprenorphine dose and the urine \"norbuprenorphine\" to \"creatinine\" ratios from the Kruskal-Wallis test (&lt;i&gt;P&lt;/i&gt; &lt; .01). In addition, the median \"norbuprenorphine\" to \"creatinine\" ratio had a strong association with buprenorphine dose, and this association could be formulated as: [y = 2.266 ln(&lt;i&gt;x&lt;/i&gt;) + 0.8211]. In other words, the median ratios in 8-, 12-, and 16-mg/day groups were 5.53 × 10&lt;sup&gt;-4&lt;/sup&gt;, 6.45 × 10&lt;sup&gt;-4&lt;/sup&gt;, and 7.10 × 10&lt;sup&gt;-4&lt;/sup&gt;, respectively. Therefore, any of the following features should alert providers to further investigate patient treatment compliance: (1) inappropriate substance(s) in urine sample; (2) \"creatinine\" level &lt;20 mg/dL; (3) \"buprenorphine\" to \"norbuprenorphine\" ratio &gt;50:1; (4) buprenorphine dose &gt;24 mg/day; or (5) \"norbuprenorphine\" to \"creatinine\" ratios &lt;0.5 × 10&lt;sup&gt;-4&lt;/","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231153748"},"PeriodicalIF":2.1,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/88/10.1177_11782218231153748.PMC10014968.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9499456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychoactive Substance Use Disorder in HIV-Infected Adolescents in Botswana: A Comparison Between the Congenitally Infected and Behaviorally Infected Adolescents. 博茨瓦纳感染艾滋病毒青少年的精神活性物质使用障碍:先天感染和行为感染青少年的比较。
IF 2
Substance Abuse: Research and Treatment Pub Date : 2023-02-27 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231152818
Anthony A Olashore, Saeeda Paruk, Merrian Brooks, Bonginkosi Chiliza
{"title":"Psychoactive Substance Use Disorder in HIV-Infected Adolescents in Botswana: A Comparison Between the Congenitally Infected and Behaviorally Infected Adolescents.","authors":"Anthony A Olashore, Saeeda Paruk, Merrian Brooks, Bonginkosi Chiliza","doi":"10.1177/11782218231152818","DOIUrl":"10.1177/11782218231152818","url":null,"abstract":"<p><p>Substance use is a major obstacle to preventing and managing HIV among adolescents, who account for 30% of new infections in many parts of the world, including Botswana. Unfortunately, there is a paucity of data on adolescent substance use, especially in the region. Therefore, this study aimed to determine the pattern of psychoactive substance use in adolescents living with HIV (ALWHIV). It also aimed to compare and explore the pattern of substance use disorders and associated factors between congenitally infected adolescents (CIAs) and behaviorally infected adolescents (BIAs). Six hundred and thirty-four ALWHIV were interviewed using a sociodemographic questionnaire, the WHO drug questionnaire, and DSM-5 criteria for substance use disorder. The participants' mean age (SD) was 17.69 (1.6) years, with a male predominance (n = 336, 53%), and the majority (n = 411, 64.8%) were CIAs. Alcohol was the most used substance among the participants, with 15.8% admitting to its current use. The BIAs were more likely to have SUD (χ<sup>2</sup> = 17.2, <i>P</i> < .01), use more than one substance (χ<sup>2</sup> = 20.3, <i>P</i> < .01), and more likely to use all psychoactive substances except for inhalants. In the CIAs, regular participation in religious activities was negatively associated with SUD (AOR = 0.36; 95% CI: 0.17-0.77), while struggling with HIV status acceptance was positively associated with SUD (AOR = 2.54; 95% CI: 1.15-5.61) in the BIAs. This study showed a huge burden and similar pattern of substance use disorders among the ALWHIV in Botswana, as reported elsewhere. It also identified the dissimilarities between the BIAs and CIAs regarding substance-related issues and suggested the need for differentiated care.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231152818"},"PeriodicalIF":2.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/4a/10.1177_11782218231152818.PMC9974603.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9395929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Habits and Routines of Adults in Early Recovery From Substance Use Disorder: Clinical and Research Implications From a Mixed Methodology Exploratory Study. 药物使用障碍早期康复成人的习惯和常规:一项混合方法探索性研究的临床和研究意义。
IF 2
Substance Abuse: Research and Treatment Pub Date : 2023-02-11 eCollection Date: 2023-01-01 DOI: 10.1177/11782218231153843
Robert H Kitzinger, Jennifer A Gardner, Mariann Moran, Carly Celkos, Nicole Fasano, Eric Linares, Joyce Muthee, Gabby Royzner
{"title":"Habits and Routines of Adults in Early Recovery From Substance Use Disorder: Clinical and Research Implications From a Mixed Methodology Exploratory Study.","authors":"Robert H Kitzinger, Jennifer A Gardner, Mariann Moran, Carly Celkos, Nicole Fasano, Eric Linares, Joyce Muthee, Gabby Royzner","doi":"10.1177/11782218231153843","DOIUrl":"10.1177/11782218231153843","url":null,"abstract":"<p><p>The purpose of this exploratory, non-experimental mixed methods study was to analyze the habits and routines of adults in early recovery (>3 months) from substance use disorder (SUD). Participants (N = 14) were recruited from an intensive outpatient treatment (IOP) program for substance use disorders. Data collection consisted of a demographic survey, a researcher developed Daily Occupational Questionnaire (DOQ), and follow-up semi-structured interviews with 5 randomly selected participants. Quantitative results indicate rest as the most frequently engaged in activity on the most busy (31.0%) and least busy day (36.6%). There was no significant difference, t(13) = 0.117, P = .909, between newly established activities on the most busy and least busy day. Qualitative themes included <i>1. The most difficult time of day is often related to patterns of unused time. 2. When there is a lack of structure or unoccupied time, they return to their previously established positive supports. 3. There is a need for consistency and structure for developing anticipated/perceived routines</i>. Implications for all healthcare and clinical providers working with this population, as well as research suggestions, are outlined.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":"17 ","pages":"11782218231153843"},"PeriodicalIF":2.0,"publicationDate":"2023-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/b6/10.1177_11782218231153843.PMC9926005.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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