Sustainable Chemistry and Pharmacy最新文献

{"title":"Preparation and characterization of n-octadecane @ bio-based polyurea microcapsules","authors":"Xinrui Lu ,&nbsp;Xianfeng Wang ,&nbsp;Dong Xue ,&nbsp;Tao Zhao","doi":"10.1016/j.scp.2025.102002","DOIUrl":"10.1016/j.scp.2025.102002","url":null,"abstract":"<div><div>The phase change microcapsules for thermal energy storage have wide applications in various fields. However, only a small portion of the wall materials used for phase change materials are sourcing from biology, which puts a lot of pressure on the environment. In this paper, we prepared a bio-based polyurea microcapsule. It was prepared by the interfacial polymerization method using HMDI as an oily monomer and bio-based 1,5-pentanediamine as an aqueous monomer. The method is convenient and the optimum process conditions for microcapsule preparation were explored experimentally. The results showed that the prepared bio-based polyurea phase change microcapsules present a spherical appearance and uniform size distribution, with an average particle size of 3 μm or more. Under the optimal conditions, the microcapsules with an encapsulation efficiency of 80.9 %, showing a high enthalpy of melting of 194.2 J/g. Compared with the pure n-octadecane, the obtained microcapsules exhibit good heat-resistance. Based on the addition of 1,5-pentanediamine, the obtained microcapsules are environmentally friendly and have better prospects for energy storage. The thermoregulated fabrics were prepared using bio-based microcapsules,which have good temperature regulation and water washing resistance.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102002"},"PeriodicalIF":5.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supercritical CO2 extraction of lipids from coffee silverskin: From laboratory optimization to industrial scale-up","authors":"Chiara Scapuzzi ,&nbsp;Tamara Chwojnik ,&nbsp;Luisella Verotta ,&nbsp;Giangiacomo Beretta ,&nbsp;Luciano Navarini ,&nbsp;Stefania Lupinelli ,&nbsp;Stefania Marzorati","doi":"10.1016/j.scp.2025.102001","DOIUrl":"10.1016/j.scp.2025.102001","url":null,"abstract":"<div><div>Coffee is one of the most important food commodities worldwide. During the production of green coffee beans, the outer layers of coffee cherries are discarded generating wastes. Coffee silverskin (CS), the thin tegument covering green coffee beans, is the sole by-product of coffee roasting and is generated in importing countries. CS could be reused in other productive processes due to its interesting chemical composition. In particular, the lipidic fraction of CS presents potentialities in pharmaceutical, packaging, and cosmetic applications. In this work, the supercritical CO₂ extraction of lipids from CS has been optimized at lab-scale using response surface methodology, for the first time. Design of experiment (DoE) and Principal Component Analysis were employed to investigate the effect of pressure and temperature on the extraction yield and on the composition of the extract in the range 100–500 bar and 40–80 °C. In particular, the different effect of temperature above and below the crossover pressure has been highlighted.</div><div>Based on DoE results, the optimal extraction conditions were set at 400 bar in a temperature range between 50 and 60 °C, applied at industrial scale. As expected, the industrial scale extraction yields resulted higher compared to those obtained in laboratory (3.4 % ± 0.3 and 2.54 % ± 0.06, respectively), while the composition of the extracts did not show significant differences in term of fatty acids. These findings demonstrate the feasibility of scaling up supercritical CO₂ extraction of lipids from coffee silverskin, offering a sustainable approach to valorise this by-product for high-value applications in various industries.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102001"},"PeriodicalIF":5.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing phytosterols extraction from Codium tomentosum using bio-based molecular solvents and accelerated solvent extraction","authors":"Judite Resende,&nbsp;João Rocha,&nbsp;Armando J.D. Silvestre,&nbsp;Sónia A.O. Santos","doi":"10.1016/j.scp.2025.101987","DOIUrl":"10.1016/j.scp.2025.101987","url":null,"abstract":"<div><div>In the present work, a new approach comprising the use of accelerated solvent extraction (ASE) with bio-based molecular solvents for extracting phytosterols from the macroalga <em>Codium tomentosum</em> was developed. Preliminarily, four different solvents (ethanol, ethyl acetate, 2-methyltetrahydrofuran and propan-2-ol) at two distinct temperatures (40 and 100 °C) were tested, with ethyl acetate at 40 °C yielding the highest phytosterol content (63.0 ± 0.14 mg phytosterols/g extract). Subsequently, the extraction conditions, namely the temperature (40–100 °C), time of extraction (15–75 min) and biomass weight (0.2–0.7 g) were optimized using a Box-Behnken design and response surface methodology (RSM). The optimal extraction conditions to maximize the phytosterols content were determined to be time of 15 min, temperature of 40 °C and biomass weight of 0.4 g biomass, for which the experimental phytosterol content was achieved to be 70.3 ± 0.20 mg of phytosterols/g of extract. The extract obtained at the optimal ASE conditions was further compared with extracts obtained by two conventional extraction procedures. Finally, the environmental analysis footprint of the ASE process compared to conventional methods was carried out using the EcoScale methodology. Overall, our process resulted in a more enriched-phytosterols extract compared to Soxhlet and solid-liquid extractions, while at the same time significantly reducing the extraction time.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 101987"},"PeriodicalIF":5.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic impact of plant essential oil based microemulsion on lychee preservation in comparison to Prochloraz","authors":"Yujie Shen ,&nbsp;Xin Zhou ,&nbsp;Jupeng Zhao ,&nbsp;Zhe Wang ,&nbsp;Dandan Zhang ,&nbsp;Lingrong Wen ,&nbsp;Yueming Jiang ,&nbsp;Liang Gong","doi":"10.1016/j.scp.2025.102003","DOIUrl":"10.1016/j.scp.2025.102003","url":null,"abstract":"<div><div>Citral (Cit) and cinnamaldehyde (Cin) presented a synergistic coefficient of 2.74 at a mass fraction ratio of 1:3 against <em>Phytophthora litchi</em> to effectively prevent the post-harvest pericarp browning and decay of lychee fruit. Plant essential oil-based microemulsion was prepared by utilizing a surfactant (Tween 80) and co-surfactant (anhydrous ethanol) based on the pseudo-ternary phase diagrams (Km value of 3). The size distribution (10 nm) and Zeta potential (−11.6 mV) were measured using a nanoparticle sizer spectrometer, which coincided with the cryo-electron microscopy observations. Infrared spectroscopy revealed an abundance of H bonds. Nanoscale size and strong H bond interaction established the stability of the microemulsion. The impact of the microemulsion on lychee fruit preservation at room temperature was evaluated and compared with the chemical fungicide prochloraz. The microemulsion treatment efficiently prevented the browning of lychee pericarp and extended its shelf life for 2–4 days. Microemulsion treatment also retained higher levels of anthocyanin and vitamin C in the lychee fruit. Furthermore, the microemulsion treatment reduced the peroxidative damage to membranes and maintained catalase and superoxide dismutase activities. We propose that microemulsions could efficiently replace the chemical preservatives for post-harvest lychee preservation.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102003"},"PeriodicalIF":5.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algicidal strain of Bacillus velezensis IMV B-7571 for controlling harmful algal blooms","authors":"Nataliia Rybalchenko ,&nbsp;Maksym Kharkhota ,&nbsp;Liliya Avdeeva ,&nbsp;Maksym Kharchuk ,&nbsp;Taras Rybalchenko ,&nbsp;Nataliia Matviienko","doi":"10.1016/j.scp.2025.101990","DOIUrl":"10.1016/j.scp.2025.101990","url":null,"abstract":"<div><div>Microorganisms and their metabolites hold promise as bioagents for controlling harmful algal blooms (HABs), providing an alternative to traditional chemical and physical methods. A strain of <em>Bacillus velezensis</em> with algіcidal activity against various cyanobacterial strains, particularly those from the genera <em>Microcystis</em> and <em>Anabena</em> was previously isolated from soil. This study aims to identify the metabolites responsible for the algicidal effectiveness of <em>B. velezensis</em> IMV B-7571. Transmission electron microscopy (TEM) analysis revealed significant morphological changes in the cells of <em>Microcystis aeruginosa</em> and <em>M. pulverea</em> after treatment with the supernatant from <em>Bacillus velezensis</em>. Notable alterations included the loss of cytoplasmic granularity, carboxysomes, and polyphosphate granules disappeared. However, the cell membrane remained intact, maintaining its integrity and reducing the risk of cyanotoxin release into the environment. Chlorophyll-a (Chl-a), a key marker for cyanobacterial growth, significantly decreased after treatment with <em>B. velezensis</em> supernatant compared to Ch-a levelin the control group. The algicidal ratio reached 74 %, demonstrating a strong inhibitory effect on photosynthesis after 48 h. <em>B. velezensis</em> IMV B-7571 was found to produce 21 different metabolites, including 11 cyclic dipeptides, with Cyclo-(Leu-Pro) and Cyclo-(Phe-Pro) being the most prominent. The purified metabolites fraction exhibited potent algicidal activity against <em>M. aeruginosa</em>, <em>M. pulverea</em>, and <em>A. hassalii</em>. These findings support using of <em>B. velezensis</em> IMV B-7571 as a sustainable and eco-friendly approach to managing harmful algal blooms.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 101990"},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring polymer architectures to drive molecular sieving in protein-polymer hybrids","authors":"Kriti Kapil ,&nbsp;Hironobu Murata ,&nbsp;Lucca Trachsel ,&nbsp;Krzysztof Matyjaszewski","doi":"10.1016/j.scp.2025.101988","DOIUrl":"10.1016/j.scp.2025.101988","url":null,"abstract":"<div><div>Protein-polymer hybrids (PPHs) exemplify a transformative intersection of biotechnology and materials science, offering innovative solutions to complex biomedical and engineering challenges. These hybrids synergistically combine the functional specificity of proteins with the structural adaptability of synthetic polymers, resulting in materials with enhanced stability, bioactivity, and responsiveness to environmental stimuli. Advances in reversible deactivation radical polymerization techniques, including atom transfer radical polymerization and reversible addition-fragmentation chain transfer polymerization, have enabled precise control over polymer architecture, molecular weight, and functionality. This precision has facilitated the creation of sophisticated polymer architectures such as block copolymers and complex polymer architectures, tailored for applications including molecular sieving and selective separation. Molecular sieving in PPHs, governed by polymer morphology and protein interactions, holds potential for applications ranging from size-selective separations and enzymatic pathway activation to next-generation therapeutic delivery systems. However, critical challenges remain, including preserving protein activity during synthesis, achieving biocompatibility under physiological conditions, and ensuring long-term stability against proteolytic degradation and pH fluctuations.</div><div>This review discusses recent advancements in PPHs design, emphasizing synthetic methodologies, advanced characterization techniques, and predictive modeling approaches for achieving varying polymer topologies. It highlights the pivotal role of computational tools, including molecular dynamics simulations and machine learning algorithms, in guiding the design and optimization of these hybrids. Future research should prioritize interdisciplinary approaches to expand protein-polymer interaction datasets, refine predictive models, and enable high-throughput synthesis. Addressing these challenges will accelerate the development of next-generation PPHs for transformative applications in drug delivery, biocatalysis, and molecular separation technologies.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 101988"},"PeriodicalIF":5.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced characterization of hemp biomass pyrolysis: Bioenergy recovery and environmental implications","authors":"Rashid Minhas ,&nbsp;Asif Hussain Khoja ,&nbsp;Hajirah Kanwal ,&nbsp;Muhammad Hassan ,&nbsp;Arslan Khan ,&nbsp;Syed Sheraz Daood ,&nbsp;Israf Ud din ,&nbsp;Ali Bahadar","doi":"10.1016/j.scp.2025.101989","DOIUrl":"10.1016/j.scp.2025.101989","url":null,"abstract":"<div><div>This paper investigates the high-temperature pyrolysis of wild hemp, focusing on converting into valuable gaseous products, bio-oil (BO) and biochar (BC), which can be explored for energy and environmental applications. The pyrolysis products were characterized through various advanced techniques to identify the product composition, physicochemical properties and their suitability in further applications. The yield of the pyrolysis process resulted in 55.68 % gaseous products, 11.11 % BO and 31.86 % BC. The composition of gaseous products include hydrogen (H₂), methane (CH₄), and carbon monoxide (CO). Whereas, the BO contains phthalates and fatty acid esters that are relatively in higher quantity. The physicochemical properties of BC revealed the d-spacing of graphitic (d₀₀₂ = 3.0 Å) and calcite peaks (d₁₀₁ = 2.12 Å), as well as exhibiting the porous structure. Moreover, the Density Functional Theory (DFT) of BC revealed that the sum of Mulliken charges is 0.00 in the armchair model. Given that all free-edge carbon atoms have negative charges, they were particularly susceptible to the chemisorption of oxygen atoms and molecules from the reactant gas, leading to the formation of the semi-quinone structure, which contains oxygen content. Finally, based on the characterization and DFT, the potential application of BC in energy and environmental prospects is revealed.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 101989"},"PeriodicalIF":5.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of highly loaded meperfluthrin microemulsions with green sugar-based surfactants","authors":"Zhihui Zhang,&nbsp;Yuan Zhou,&nbsp;Xiuquan Yang,&nbsp;Ziyu Qin,&nbsp;Zhiyu Wu","doi":"10.1016/j.scp.2025.101958","DOIUrl":"10.1016/j.scp.2025.101958","url":null,"abstract":"<div><div>In this study, we report the formulation of sustainable pesticide microemulsions using green surfactants and solvents. Sugar-based surfactant was selected as emulsifiers, and biomass-based ethyl lactate served as the co-solvent, with a low-energy emulsification method employed to produce high-efficiency meperfluthrin microemulsions. The results showed that the microemulsions had a particle size ranging from 30 to 60 nm, with a maximum meperfluthrin loading of 32.4% and an encapsulation rate exceeding 90%. The microemulsions had good stability under various environmental conditions. Compared to commercially available meperfluthrin products, the microemulsions had a lower organic solvent content and a higher loading capacity, due to pyrethroid pesticides having better solubility in ethyl lactate. Furthermore, the toxicity of microemulsions was significantly reduced and met environmental protection standards. This study provides a new solution and practical basis for the green and sustainable development of pesticide formulations.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 101958"},"PeriodicalIF":5.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe and sustainable-by-design (SSbD): Calling for efficient metrics, biophysical benchmarks, and broader application","authors":"Peter Fantke","doi":"10.1016/j.scp.2025.101986","DOIUrl":"10.1016/j.scp.2025.101986","url":null,"abstract":"<div><div>The European Commission is investing in the development and application of the emerging concept of safe and sustainable-by-design (SSbD) through proposing and testing an initial methodological framework as well as through financing a wide range of multi-partner projects via dedicated Horizon Europe funding programme calls. However, SSbD currently faces both methodological and practical challenges that need to be addressed. Evaluating the initial SSbD framework's ambition and the focus areas across EU-funded SSbD projects yields various suggestions to foster the methodological advancement and more feasible application of SSbD as ambitious yet operational innovation tool in Europe and beyond. Specific recommendations are made for a more balanced distribution of funding related to applying SSbD approaches as well as for an increased innovation in developing the underlying methodological aspects of SSbD. This includes covering a broader set of economic sectors, materials/processes and substances in future case studies beyond what is already funded in existing SSbD projects, exploring a wider range of assessment metrics that allow for aggregation and comparison of results across assessment steps, streamline existing methods using more efficient metrics and tools especially for sustainability assessment aspects, and a stronger focus on defining and integrating biophysical benchmarks in the environmental sustainability component of SSbD, especially with respect to chemical pollution.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 101986"},"PeriodicalIF":5.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of pKa values of some proton pump inhibitors in water-organic solvent mixtures: Conventional and green RPLC methods","authors":"Y. Doğan Daldal ,&nbsp;Ebru Çubuk Demiralay","doi":"10.1016/j.scp.2025.101983","DOIUrl":"10.1016/j.scp.2025.101983","url":null,"abstract":"<div><div>In this study, the ionization/protonation constants (pK_a) of commonly used proton pump inhibitors (PPIs), omeprazole, pantoprazole, rabeprazole and lansoprazole, were determined using green reversed phase liquid chromatography (green RPLC) and conventional RPLC methods. Qualitative determination of the compounds was carried out on a Gemini NX C18 (250 × 3.0 mm I.D., 5 μm) column at 37 °C column temperature and 1 mL/min flow rate. To determine this physicochemical parameter, liquid chromatographic analyzes of PPIs were carried out in water-organic solvent binary mixtures containing 20%, 25%, 30%, and 35% (v/v) of organic solvent (acetonitrile, methanol, ethanol). The effects of substituents on the pyridine and benzimidazole rings in the structures of these compounds on the pK_a values were also investigated. The pK_a <span><math><mrow><mo>(</mo><mmultiscripts><msub><mrow><mi>p</mi><mi>K</mi></mrow><mi>a</mi></msub><mprescripts></mprescripts><mi>w</mi><mi>w</mi></mmultiscripts><mo>)</mo></mrow></math></span> values of the compounds in water environment were calculated and compared using the <span><math><mrow><mmultiscripts><msub><mrow><mi>p</mi><mi>K</mi></mrow><mi>a</mi></msub><mprescripts></mprescripts><mi>s</mi><mi>s</mi></mmultiscripts></mrow></math></span> values in water-organic solvent mixtures and solvent macroscopic constants. The obtained data were evaluated with AGREE and GAPI software programs that give the greenness profile, and the optimum separation condition for the green RPLC approach based on the 12 principles of green chemistry was determined.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 101983"},"PeriodicalIF":5.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}