Stroke Research and Treatment最新文献_第8页

Geographic Variations of Stroke Hospitalization across France: A Diachronic Cluster Analysis. 法国中风住院的地理差异:历时聚类分析。

IF 1.5

Stroke Research and Treatment Pub Date : 2018-07-18 eCollection Date: 2018-01-01 DOI: 10.1155/2018/1897569

Yacine Lachkhem, Étienne Minvielle, Stéphane Rican

{"title":"Geographic Variations of Stroke Hospitalization across France: A Diachronic Cluster Analysis.","authors":"Yacine Lachkhem, Étienne Minvielle, Stéphane Rican","doi":"10.1155/2018/1897569","DOIUrl":"https://doi.org/10.1155/2018/1897569","url":null,"abstract":"Background: This study evaluates the clustering of hospitalization rates for stroke and compares this clustering with two different time intervals 2009-2010 and 2012-2013, corresponding to the beginning of the French National Stroke Plan 2010-2014. In addition, these data will be compared with the deployment of stroke units as well as socioeconomic and healthcare characteristics at zip code level.Methods: We used the PMSI data from 2009 to 2013, which lists all hospitalizations for stroke between 2009 and 2013, identified on the most detailed geographic scale allowed by this database. We identify statistically significant clusters with high or low rates in the zip code level using the Getis-Ord statistics. Each of the significant clusters is monitored over time and evaluated according to the nearest stroke unit distance and the socioeconomic profile.Results: We identified clusters of low and high rate of stroke hospitalization (23.7% of all geographic codes). Most of these clusters are maintained over time (81%) but we also observed clusters in transition. Geographic codes with persistent high rates of stroke hospitalizations were mainly rural (78% versus 17%, P < .0001) and had a least favorable socioeconomic and healthcare profile.Conclusion: Our study reveals that high-stroke hospitalization rates cluster remains the same during our study period. While access to the stroke unit has increased overall, it remains low for these clusters. The socioeconomic and healthcare profile of these clusters are poor but variations were observed. These results are valuable tools to implement more targeted strategies to improve stroke care accessibility and reduce geographic disparities.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"1897569"},"PeriodicalIF":1.5,"publicationDate":"2018-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/1897569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36401641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Relationship of Serum Uric Acid Level with Demographic Features, Risk Factors, Severity, Prognosis, Serum Levels of Vitamin D, Calcium, and Magnesium in Stroke. 卒中患者血清尿酸水平与人口学特征、危险因素、严重程度、预后、血清维生素D、钙、镁水平的关系

IF 1.5

Stroke Research and Treatment Pub Date : 2018-07-02 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6580178

Payam Saadat, Alijan Ahmadi Ahangar, Mansor Babaei, Mandana Kalantar, Mohammad Ali Bayani, Hiva Barzegar, Hemmat Gholinia, Farbod Zahedi Tajrishi, Sekineh Faraji, Fatemeh Frajzadeh

{"title":"Relationship of Serum Uric Acid Level with Demographic Features, Risk Factors, Severity, Prognosis, Serum Levels of Vitamin D, Calcium, and Magnesium in Stroke.","authors":"Payam Saadat, Alijan Ahmadi Ahangar, Mansor Babaei, Mandana Kalantar, Mohammad Ali Bayani, Hiva Barzegar, Hemmat Gholinia, Farbod Zahedi Tajrishi, Sekineh Faraji, Fatemeh Frajzadeh","doi":"10.1155/2018/6580178","DOIUrl":"https://doi.org/10.1155/2018/6580178","url":null,"abstract":"Introduction: Stroke is one of the most common neurological disorders with high mortality rates. A large financial burden is imposed on the families and health systems of countries in addition to the problems related to the disabilities caused by the disease for the patients. Extensive research is being conducted on the disease, including studies seeking possible relationships between some biomarkers such as uric acid and stroke.Methods: This descriptive-analytic cross-sectional study was conducted on 170 stroke patients at Babol Ayatollah Rohani Hospital during 2015-2016. Serum uric acid (SUA) levels were measured and recorded at admission time. Patients' demographic data as well as the stroke type and some of their risk factors were entered in a checklist. The data were analyzed by SPSS.v.23 using chi-square and logistic regression tests. P < 0.05 was considered as significant in all analyses.Results: Of the total 170 included patients, 57% had normal, 25% had low, and the remaining patients (18%) had high SUA levels. There was no significant difference in SUA levels in different types of stroke in both genders. Diabetic ischemic embolic patients had higher levels of SUA than diabetic ischemic thrombotic cases. Patients with low magnesium levels had higher rate of low levels of SUA in ischemic stroke.Conclusion: Serum uric acid levels are not associated with stroke types and gender. Diabetic embolic ischemic stroke cases had high SUA levels than thrombotic types and in ischemic stroke patients with low serum levels of magnesium, SUA levels were also lower.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"6580178"},"PeriodicalIF":1.5,"publicationDate":"2018-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6580178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36354434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Enhanced Upper Extremity Functions with a Single Session of Action-Observation-Execution and Accelerated Skill Acquisition Program in Subacute Stroke. 亚急性中风患者通过单次 "动作观察-执行 "和 "加速技能习得 "课程增强上肢功能

IF 1.8

Stroke Research and Treatment Pub Date : 2018-06-12 eCollection Date: 2018-01-01 DOI: 10.1155/2018/1490692

Shambhu Prasad Adhikari, Jarugool Tretriluxana, Pakaratee Chaiyawat, Chutima Jalayondeja

{"title":"Enhanced Upper Extremity Functions with a Single Session of Action-Observation-Execution and Accelerated Skill Acquisition Program in Subacute Stroke.","authors":"Shambhu Prasad Adhikari, Jarugool Tretriluxana, Pakaratee Chaiyawat, Chutima Jalayondeja","doi":"10.1155/2018/1490692","DOIUrl":"10.1155/2018/1490692","url":null,"abstract":"Background: Action-observation-execution (AOE) primes physical training. We examined the immediate effect of AOE with accelerated skill acquisition program (ASAP) on dexterity in subacute stroke.Methods: Twelve individuals from 1 to 6 months after stroke were allocated into two groups by matching age and side of stroke. After AOE of 30 minutes, the experimental group received ASAP for 60 minutes whereas the control group received dose-equivalent usual care. The movement time (MT) and functional ability (FA) of hand items of the Wolf motor function test (WMFT), hand functions and global recovery of stroke impact scale (SIS), and intrinsic motivation items of stroke rehabilitation motivation scale were assessed at baseline, after training, and during one-week follow-up. Data were analyzed within and between the groups.Results: AOE significantly decreased MT of flipping cards of WMFT and hand functions of SIS. Total MT was markedly reduced. AOE with ASAP demonstrated significant group-by-time interactions on MT of lifting pencil of WMFT, total MT, and global recovery. Grip strength, FA, and hand functions were significantly improved only in the experimental group. Both groups improved motivation significantly.Conclusions: The AOE with ASAP enhanced dexterity, which persisted for at least a week. This intervention might improve dexterity in subacute stroke.Trial registration number: This trial is registered with TCTR20161007001.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"1490692"},"PeriodicalIF":1.8,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36312982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Best Practices for The Interdisciplinary Rehabilitation Team: A Review of Mental Health Issues in Mild Stroke Survivors. 跨学科康复团队的最佳实践:轻度中风幸存者的心理健康问题综述

IF 1.5

Stroke Research and Treatment Pub Date : 2018-06-04 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6187328

Alexandra L Terrill, Jaclyn K Schwartz, Samir R Belagaje

引用次数: 16

Dual-Task Walking in Challenging Environments in People with Stroke: Cognitive-Motor Interference and Task Prioritization. 中风患者在具有挑战性的环境中进行双任务行走：认知-运动干扰和任务优先级。

IF 1.5

Stroke Research and Treatment Pub Date : 2018-05-02 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7928597

Celine Timmermans, Melvyn Roerdink, Thomas W J Janssen, Carel G M Meskers, Peter J Beek

{"title":"Dual-Task Walking in Challenging Environments in People with Stroke: Cognitive-Motor Interference and Task Prioritization.","authors":"Celine Timmermans, Melvyn Roerdink, Thomas W J Janssen, Carel G M Meskers, Peter J Beek","doi":"10.1155/2018/7928597","DOIUrl":"10.1155/2018/7928597","url":null,"abstract":"Cognitive-motor interference may contribute to the risk of falling in people with stroke, as may be the associated phenomenon of inappropriate task prioritization. Examining dual-task walking could provide valuable insights as to how to best evaluate and treat walking in people with stroke. This study aimed to examine the effect of different walking environments on cognitive-motor interference and task prioritization in dual-task walking in people with stroke. Using a repeated-measures design, cognitive-motor interference and task prioritization were assessed in 30 stroke survivors, while walking in a plain environment and in two challenging environments that were enriched with either stationary physical context or suddenly appearing projector-augmented context. All three walking environment conditions were performed with and without a concurrent serial-3 subtraction task. We found stronger cognitive-motor interference for the two challenging environments than for the plain walking environment. Cognitive-motor interference did not differ between challenging walking environments, but task prioritization did: motor performance was prioritized more in the environment with physical context than in the environment with projector-augmented context and vice versa for cognitive-task performance. In conclusion, walking environment strongly influenced cognitive-motor interference and task prioritization during dual-task walking in people with stroke.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"7928597"},"PeriodicalIF":1.5,"publicationDate":"2018-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36182567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin. 组织源性非血栓性栓塞性中风的病因和治疗的系统综述。

IF 1.5

Stroke Research and Treatment Pub Date : 2018-04-24 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8092862

Sarah Mello, Ciaran Judge, Roisin Kelly, David Bradley, Joseph Harbison

{"title":"A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin.","authors":"Sarah Mello, Ciaran Judge, Roisin Kelly, David Bradley, Joseph Harbison","doi":"10.1155/2018/8092862","DOIUrl":"https://doi.org/10.1155/2018/8092862","url":null,"abstract":"Introduction: Various bodily tissues have been reported to enter the arterial circulation and embolize to the brain resulting in ischemic stroke. Most frequently nonthrombotic embolic stroke (NTES) of tissue origin is iatrogenic or related to an underlying disease process. With the increase in elective surgery and intravascular procedures, NTES may increase in prevalence.Aim: To compile a summary of the background, incidence, presentation, and treatment of NTES of tissue origin, by conducting a systematic review of the current literature.Summary of review: We searched EMBASE and MEDLINE for articles on NTES of tissue origin published in English with no restriction on publication date (search date June 2017). 800 articles were identified and screened and 159 articles were ultimately reviewed in full text and included in qualitative analysis. Articles deemed relevant were assessed by a second reviewer to confirm compatibility with the inclusion criteria. References of included articles were reviewed for relevant publications. We categorized the pathology of the emboli into the following groups: amniotic fluid (4 publications), tumour (60 publications), fat (43 publications), cholesterol (19 publications), and intravascular debris (12 publications). We then summarized the available literature on each cause of NTES.Conclusions: NTES of tissue origin is an uncommon but important diagnosis to consider particularly in younger stroke patients and in certain clinical settings. Treatment for NTES is currently anecdotal and based on small case series. Embolectomy may emerge as the therapy of choice due to the longer treatment timeframe and heterogeneity of the emboli.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"8092862"},"PeriodicalIF":1.5,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8092862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36182569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Validity of Multisensor Array for Measuring Energy Expenditure of an Activity Bout in Early Stroke Survivors. 多传感器阵列测量早期脑卒中幸存者活动回合能量消耗的有效性。

IF 1.5

Stroke Research and Treatment Pub Date : 2018-03-07 eCollection Date: 2018-01-01 DOI: 10.1155/2018/9134547

Sharon Flora Kramer, Liam Johnson, Julie Bernhardt, Toby Cumming

{"title":"Validity of Multisensor Array for Measuring Energy Expenditure of an Activity Bout in Early Stroke Survivors.","authors":"Sharon Flora Kramer, Liam Johnson, Julie Bernhardt, Toby Cumming","doi":"10.1155/2018/9134547","DOIUrl":"https://doi.org/10.1155/2018/9134547","url":null,"abstract":"Introduction. Stroke survivors use more energy than healthy people during activities such as walking, which has consequences for the way exercise is prescribed for stroke survivors. There is a need for wearable device that can validly measure energy expenditure (EE) of activity to inform exercise prescription early after stroke. We aimed to determine the validity and reliability of the SenseWear-Armband (SWA) to measure EE and step-counts during activity <1 month after stroke. Materials and Methods. EE was measured using the SWA and metabolic cart and steps-counts were measured using the SWA and direct observation. Based on walking ability, participants performed 2x six-minute walks or repeated sit-to-stands. Concurrent validity and test-retest reliability were determined by calculating intraclass and concordance correlation coefficients. Results and Discussion. Thirteen participants walked; nine performed sit-to-stands. Validity of the SWA measuring EE for both activities was poor (ICC/CCC < 0.40). The SWA overestimates EE during walking and underestimated EE during sit-to-stands. Test-retest agreement showed an ICC/CCC of <0.40 and >0.75 for walking and sit-to-stand, respectively. However, agreement levels changed with increasing EE levels (i.e., proportional bias). The SWA did not accurately measure step-counts. Conclusion. The SWA should be used with caution to measure EE of activity of mild to moderate stroke survivors <1 month after stroke.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"9134547"},"PeriodicalIF":1.5,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/9134547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36053109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Increased Zinc Serum Level: New Clues in Babol Stroke Patients, Northern Iran. 血清锌水平升高:伊朗北部巴博尔中风患者的新线索。

IF 1.5

Stroke Research and Treatment Pub Date : 2018-02-27 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7681682

Alijan Ahmadi Ahangar, Payam Saadat, Sona Niroomand, Shayan Alijanpour, Reza Sohrabnezhad, Alireza Firozejahi, Mohamad Ali Biani, Fatemeh Arab, Hamed Hosseinzadeh, Sekine Faraji, Jalal Niroomand

{"title":"Increased Zinc Serum Level: New Clues in Babol Stroke Patients, Northern Iran.","authors":"Alijan Ahmadi Ahangar, Payam Saadat, Sona Niroomand, Shayan Alijanpour, Reza Sohrabnezhad, Alireza Firozejahi, Mohamad Ali Biani, Fatemeh Arab, Hamed Hosseinzadeh, Sekine Faraji, Jalal Niroomand","doi":"10.1155/2018/7681682","DOIUrl":"https://doi.org/10.1155/2018/7681682","url":null,"abstract":"Background: Stroke is the second leading cause of death worldwide. The role of zinc as a new predictor of stroke was considered.Methods: This prospective study was conducted in Ayatollah Rouhani Hospital within a year on 100 stroke and 100 control patients.Findings: The difference in zinc serum level in two groups was significant (deficiency: 3 (3%) in patients versus 20 (20%) in control group, normal: 25 (25%) versus 54 (54%), and increased level: 72 (72%) versus 26 (26%); p < 0.001). Difference in zinc serum levels was statistically significant with ischemic heart disease (deficiency: 0 cases (0%), normal: 8 cases (24%), increased level: 24 cases (75%), p = 0.003). Increases in zinc serum level were significantly correlated with the frequency of hemorrhagic and ischemic patients (deficiency: 3 (3.3%) hemorrhagic versus 0 (0%) ischemic; normal: 19 (21%) versus 6 (60%), increased level: 68 (75.6%) versus 4 (40%); p = 0.025). Regression logistics showed that ischemic heart disease (p < 0.001; OR = 28.29, %95 CI: 5.53; 144.87), hyperlipidemia (p < 0.001; OR = 0.26, %95 CI: 0.12; 0.56), and zinc serum level (p < 0.001, OR = 15.53, %95 CI: 4.03; 59.83) each had a significant role.Conclusions: Babol stroke patients are prone to increased zinc serum level as a new parameter. Ischemic heart disease, increased levels of zinc, and hyperlipidemia were found to be probable predictor factors for stroke in Babol.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"7681682"},"PeriodicalIF":1.5,"publicationDate":"2018-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7681682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36032132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The Importance of Assessing Nutritional Status to Ensure Optimal Recovery during the Chronic Phase of Stroke. 评估营养状况对确保中风慢性期最佳康复的重要性。

IF 1.8

Stroke Research and Treatment Pub Date : 2018-01-11 eCollection Date: 2018-01-01 DOI: 10.1155/2018/1297846

Monica C Serra

{"title":"The Importance of Assessing Nutritional Status to Ensure Optimal Recovery during the Chronic Phase of Stroke.","authors":"Monica C Serra","doi":"10.1155/2018/1297846","DOIUrl":"10.1155/2018/1297846","url":null,"abstract":"Background: Despite evidence that many of the consequences of stroke that hinder recovery (i.e., obesity, muscle atrophy, and functional declines) have nutritionally modifiable behavior components, little attention has been focused on the significance of nutrition beyond the acute phase of stroke.Objective: This literature review summarizes the evidence for and against the influence of nutrition on optimal recovery and rehabilitation in chronic (>6 months) stroke.Results: The literature, which is mainly limited to cross-sectional studies, suggests that a suboptimal nutritional status, including an excess caloric intake, reduced protein intake, and micronutrient deficiencies, particularly the B-vitamins, vitamin D, and omega 3 fatty acids, may have deleterious effects on metabolic, physical, and psychological functioning in chronic stroke survivors.Conclusions: Careful evaluation of dietary intake, especially among those with eating disabilities and preexisting malnutrition, may aid in the identification of individuals at increased nutritional risk through which early intervention may benefit recovery and rehabilitation and prevent further complications after stroke.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2018 ","pages":"1297846"},"PeriodicalIF":1.8,"publicationDate":"2018-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35939677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value 肾功能障碍是急性缺血性脑卒中患者静脉溶栓治疗预后不良的独立危险因素:一个新的临界值

IF 1.5

Stroke Research and Treatment Pub Date : 2017-01-03 DOI: 10.1155/2017/2371956

Elyar Sadeghi-Hokmabadi, D. Baş, M. Farhoudi, A. Taheraghdam, Daryoush Savadi Oskouei, M. Yazdchi, M. Hashemilar, N. Uzuner, Reshad Mirnour, E. Çolak, A. Özdemi̇r

{"title":"Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value","authors":"Elyar Sadeghi-Hokmabadi, D. Baş, M. Farhoudi, A. Taheraghdam, Daryoush Savadi Oskouei, M. Yazdchi, M. Hashemilar, N. Uzuner, Reshad Mirnour, E. Çolak, A. Özdemi̇r","doi":"10.1155/2017/2371956","DOIUrl":"https://doi.org/10.1155/2017/2371956","url":null,"abstract":"Objective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m2 and (2) low GFR group with GFR < 45 mL/min/1.73 m2. Outcome measurements were poor outcome (mRS 3–6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24–36 hours. Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs). Results. Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m2 significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09–1.30, p < 0.001) and mortality (OR 1.18, 95% CI 1.06–1.32, p = 0.002). In multivariate regression, adjusted for all variables with p value < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01–4.56, p = 0.045). Conclusion. In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m2 before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m2.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"23 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2017-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74780745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11