Steroids最新文献

{"title":"Veratrum-derived steroidal alkaloids: from scaffold to pharmacological leads.","authors":"Burçin Özüpek, Sultan Pekacar, Ömer Furkan Güverti, Didem Deliorman Orhan, Vaibhavkumar Patel","doi":"10.1016/j.steroids.2026.109793","DOIUrl":"https://doi.org/10.1016/j.steroids.2026.109793","url":null,"abstract":"<p><p>Veratrum species (Melanthiaceae) have a long history of medical usage throughout Europe, Asia, and North America. However, they are well-known for their toxicity. Their pharmacological significance stems from a number of steroidal alkaloids with unique C-nor-d-homosteroidal and isosteroidal structures. This review provides an overview of the Veratrum-derived steroidal alkaloids. It focuses on their structural diversity, manufacturing processes, isolation methods, biological activity, and potential as new therapeutic leads. Nearly 185 steroidal alkaloids have been found in Veratrum species. They are usually classified as cevanine, veratramine, jervine, verazine, and solanidine. Improvements in chromatographic and spectroscopic technologies, particularly HPLC-MS/MS and multidimensional NMR, allow for a more detailed understanding of the structures of these complex substances and ensure quality control. Biosynthetic studies suggest that cholesterol is an important starting point for their synthesis, but various late-stage enzymatic processes remain unknown. Veratrum alkaloids have a diverse biological activity. Notably, they inhibit the Hedgehog/SMO pathway, as seen in cyclopamine and its derivatives, and impact voltage-gated sodium channels, such as veratridine. This emphasizes both their medicinal potential and hazardous hazards. Semi-synthetic alterations and research into the link between structure and activity have resulted in derivatives with increased potency, stability, and solubility, including prominent cyclopamine analogs such as patidegib. In conclusion, this review identifies Veratrum steroidal alkaloids as essential natural structures that link traditional medicine and modern drug research. It also emphasizes the importance of carefully evaluating their toxicity, as well as further research into their production and pharmacological properties, in order to realize their full therapeutic value.</p>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":" ","pages":"109793"},"PeriodicalIF":2.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alteration of bile acid metabolism in mice under thermoneutral conditions.","authors":"Hinata Soma, Ryo Yoshida, Satoshi Ishizuka","doi":"10.1016/j.steroids.2026.109794","DOIUrl":"https://doi.org/10.1016/j.steroids.2026.109794","url":null,"abstract":"<p><p>Metabolic responses in mice at thermoneutrality (TN; 30°C) closely reflect those in humans rather than at conventional ambient temperature (CT; 22°C). However, the effect of TN on bile acid (BA) metabolism remains unclear. In this study, mice were maintained at CT or TN for 6 weeks, and BA profiles were quantitatively assessed at several sites, including enterohepatic and systemic circulation. TN markedly increased feed efficiency, adipose tissue mass, and hepatic and circulating triglyceride levels. Moreover, the ratio of 12-hydroxylated to non-12-hydroxylated BAs was elevated in the liver, small intestinal contents, and feces in mice maintained at TN. The ratios of primary to secondary BAs and of conjugated to unconjugated BAs were consistently reduced across sites, suggesting enhanced microbiota-dependent BA metabolism at TN. Collectively, these findings indicate that TN shifts murine BA composition toward a more human-like profile, highlighting the significance of TN models in terms of BA metabolism.</p>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":" ","pages":"109794"},"PeriodicalIF":2.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “In silico analysis of Moringaceae derived potential drug-like compounds against Newcastle disease virus” [Steroids 219 (2025) 109628]","authors":"Muhammad Hammad Mustafa ,&nbsp;Fayyaz-ur Rehman ,&nbsp;Muhammad Ali ,&nbsp;Mohsin Javed ,&nbsp;Nazir Ahmad ,&nbsp;Tayyaba Shafique ,&nbsp;Ammar Zidan ,&nbsp;Ali Bahadur ,&nbsp;Shahid Iqbal ,&nbsp;Sajid Mahmood ,&nbsp;Abd-ElAziem Farouk ,&nbsp;Ibrahim Jafri","doi":"10.1016/j.steroids.2026.109750","DOIUrl":"10.1016/j.steroids.2026.109750","url":null,"abstract":"","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"228 ","pages":"Article 109750"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donepezil enhances the testicular protective effect of metformin in diabetic rats by modulating steroidogenic signaling and Bax/Bcl-2/Caspase-3 pathway","authors":"Roland Eghoghosoa Akhigbe ,&nbsp;Joseph Chimezie ,&nbsp;Ajibola Ayomide Odeyemi ,&nbsp;Stella Olamide Oyesode ,&nbsp;Favour Adesogan ,&nbsp;Abimbola Ayoola Oladipo ,&nbsp;Precious Jesutofunmi Ashonibare ,&nbsp;Tunmise Maryanne Akhigbe ,&nbsp;Ebenezer Adeola Ashamu ,&nbsp;Michael A. Olamoyegun","doi":"10.1016/j.steroids.2026.109748","DOIUrl":"10.1016/j.steroids.2026.109748","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 diabetes mellitus (T2DM) induces testicular damage through xanthine oxidase (XO)/uric acid (UA)/caspase-3-driven oxidative stress and apoptosis. Although metformin is effective in managing diabetes, combined therapy is more effective. Though donepezil protects against neuronal and retinal damage in diabetic rats, its role in diabetes-induced testicular damage is yet to be reported.</div></div><div><h3>Aim</h3><div>This study investigated the protective effects of combined metformin and donepezil treatment on testicular dysfunction in a high-fat diet/streptozotocin-induced T2DM rat model. Also, the involvement of XO/UA and Bax/Bcl-2/caspase signaling was examined.</div></div><div><h3>Methods</h3><div>Forty-eight 8-week-old male Wistar rats were randomly assigned into six equal groups: control, diabetes (DM), DM+metformin, donepezil, DM+donepezil, and DM+metformin+donepezil groups.</div></div><div><h3>Results</h3><div>T2DM caused testicular inflammation and oxidative stress, evidenced by elevated pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), activation of NF-κB signaling, increased oxidative markers (MDA), and reduced antioxidant enzymes. T2DM also led to testicular apoptosis (increased Bax and caspase-3 and reduced Bcl-2). More so, T2DM repressed serum testosterone, FSH, and LH, and caused morphological disorganization of the testes, including germ cell loss and Leydig cell degeneration. Treatment with metformin and donepezil, singly or in combination, significantly mitigated these adverse effects, with the combined therapy demonstrating superior efficacy. The intervention suppressed XO/uric acid signaling, oxidative stress, and inflammatory responses via downregulation of NF-κB and apoptotic cascades. These results imply that donepezil and metformin work in concert to provide a potentially effective treatment strategy for reducing testicular damage caused by diabetes through modulation of oxidative, inflammatory, and apoptotic pathways, ultimately restoring testicular structure and function.</div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"228 ","pages":"Article 109748"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LCA and 3-oxo-LCA mitigate dietary oxysterols-induced loss of barrier function in intestinal epithelial cells","authors":"Gayatri Reghu ,&nbsp;Ashna Fathima ,&nbsp;Narendran Swaminathan ,&nbsp;Rajeev Sakhuja ,&nbsp;Trinath Jamma","doi":"10.1016/j.steroids.2026.109749","DOIUrl":"10.1016/j.steroids.2026.109749","url":null,"abstract":"<div><div>Loss of intestinal barrier integrity is a hallmark of many intestinal inflammations and associated diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). One of the primary factors contributing to intestinal epithelial barrier damage is a diet high in cholesterol. The non-enzymatically oxidized forms of dietary cholesterol, collectively known as oxysterols, have recently gained attention as mediators of various inflammatory conditions. In addition, oxysterols have been found to cause intestinal barrier damage via the loss of tight junction protein expression and promote inflammation. Secondary bile acids of host-gut microbial origin, and several other gut-microbiota-derived metabolites, are known to modulate intestinal inflammation. Here, we have studied the roles of two secondary bile acids in restoring barrier integrity and reducing the extent of dietary oxysterol-induced damage in intestinal epithelial cells. We found that oxysterols exert their damaging effects by inducing matrix metalloproteinases (MMP-2 and MMP-9) and activating NF-κB, which is coupled with the production of pro-inflammatory cytokines and chemokines (CCL2, CCL5, &amp; IL-8). Additionally, we also show that the secondary bile acids lithocholic acid (LCA) and dehydrolithocholic acid (3-oxo-LCA) counteract dietary oxysterol-induced loss of barrier function (TEER &amp; FITC-dextran flux). Overall, these findings provide supportive evidence for the potential role for secondary bile acids in maintaining barrier integrity and modulating inflammation in intestinal epithelial cells exposed to dietary oxysterols in vitro.</div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"228 ","pages":"Article 109749"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-acetyl-cysteine alleviates nandrolone decanoate-induced hippocampal cell apoptosis in rats via reversing protein expressions of S1P1, Akt and FOXO3a signaling pathway","authors":"Alireza Shirpoor ,&nbsp;Zahra Zarrini ,&nbsp;Roya Naderi","doi":"10.1016/j.steroids.2026.109759","DOIUrl":"10.1016/j.steroids.2026.109759","url":null,"abstract":"<div><div>Illicit use of nandrolone can result in apoptosis in the hippocampus tissue but the underlying mechanism is unknown. The present study evaluated the role of S1P1/Akt/FOXO3a pathway in hippocampus cell apoptosis following exposure to nandrolone decanoate either alone or in combination with <em>N</em>-acetyl-cysteine. Twenty-four male Wistar rats were randomly divided into three groups (n = 8): control, nandrolone (10 mg/kg; intramuscularly; three times per week), and nandrolone + <em>N</em>-acetyl-cysteine (150 mg/kg; intraperitoneally). After six weeks of treatment, the number of apoptotic cells was significantly increased in the nandrolone treated group compared with the control group. Compared to control group, nandrolone group showed significant upregulation of NOX2, iNOS, 8-OHdG, P-FOXO3a/FOXO3a and lactate dehydrogenase (LDH) protein expression in rat hippocampus cells. Conversely, the protein expressions of P-Akt/Akt and S1P1 were significantly downregulated in hippocampus tissue of rats treated with nandrolone compared with control rats. Co-administration of <em>N</em>-acetyl-cysteine with nandrolone significantly reduced the apoptotic index and reversed the expressions of S1P1, P-Akt/Akt and P-FOXO3a/FOXO3a in the hippocampus neurons compared with the nandrolone group. These findings suggest that S1P1/Akt/FOXO3a signaling pathway may at least in part play an important role in the progression of apoptosis induced by nandrolone exposure, providing new insights into the pathogenesis and potential treatment of nandrolone-induced hippocampal damage.</div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"228 ","pages":"Article 109759"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146081684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroidal alkaloids: Exploring new therapeutic frontiers in cardiovascular diseases","authors":"Madhura Bapat,&nbsp;Kalyani Barve","doi":"10.1016/j.steroids.2026.109758","DOIUrl":"10.1016/j.steroids.2026.109758","url":null,"abstract":"<div><div>Cardiovascular diseases (CVDs) still remain one of the leading causes of mortality worldwide, requiring novel therapeutic approaches. Steroidal alkaloids, a unique class of naturally bioactive compounds, have showcased promising pharmacological qualities in cardiovascular health. This review article explores the structural classification, pharmacokinetics, and pharmacodynamics properties of such alkaloids, emphasizing their potential therapeutic effects in CVDs. Key cardiovascular activities of these alkaloids include antihypertensive, vasodilatory, antiarrhythmic, and lipid-lowering effects, primarily mediated through receptor interactions, ion channel modulation, and enzyme inhibition. Clinical and preclinical research studies provide preliminary proof of efficacy, though significant research gaps still remain, including very clinical trials and incomplete mechanistic understanding. Furthermore, safety concerns regarding dose–response relationships, toxicity, and drug interactions must be addressed before clinical translation. Novel trends such as, targeted delivery systems, synthetic derivatives and multi-targeted approaches throw light upon the future potential of alkaloids in cardiovascular therapy. This review establishes the need for well-designed clinical trials and structure–activity relationship (SAR) studies to optimize these molecules for cardiovascular drug development. Further research studies integrating omics technologies and exploring the role of steroidal alkaloids in rare cardiovascular disorders could increase their therapeutic applicability.</div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"228 ","pages":"Article 109758"},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effects of luteolin and oleuropein against dexamethasone-induced hyperlipidemia","authors":"Lourin Nasr Aziz,&nbsp;Mohamed Omar Mahmoud,&nbsp;Ibrahim Taha Ibrahim","doi":"10.1016/j.steroids.2026.109746","DOIUrl":"10.1016/j.steroids.2026.109746","url":null,"abstract":"<div><h3>Background</h3><div>Dexamethasone-induced hyperlipidemia is a well-documented metabolic complication associated with prolonged glucocorticoid therapy. The present study aims to investigate the potential protective effects of the selected natural antioxidants luteolin and oleuropein against dexamethasone-induced hyperlipidemia.</div></div><div><h3>Methodology</h3><div>The study was conducted on five groups of female Wistar rats, including a normal control group, a dexamethasone-induced hyperlipidemia group, and three treatment groups. The treatment groups consisted of dexamethasone-administered rats receiving luteolin or oleuropein (100 mg/kg BW) individually or in combination (luteolin + oleuropein) for a duration of one month.</div></div><div><h3>Results</h3><div>Dexamethasone induced hyperlipidemia, hepatic injury, and oxidative stress, as evidenced by increased levels of aspartate aminotransferase (AST; +154%), alanine aminotransferase (ALT; +121%), total cholesterol (TC; +75%), triglycerides (+132%), and malondialdehyde (+85%), while reducing catalase and glutathione by approximately 50.5% and 62%, respectively, compared with the control group. Treatment with either luteolin or oleuropein individually mitigated these changes (AST: −47.0% and − 46.4%; ALT: −37.2% and − 36.4%; TC: −34.8% and − 33.1%; triglycerides: −41.7% and − 40.5%; malondialdehyde: −28.4% and − 26.0%; catalase: +79.2% and + 74.8%; and glutathione: +104.8% and + 102.3%, respectively). Combined treatment provided the greatest protection, and histological examination revealed partial restoration of normal hepatic architecture.</div></div><div><h3>Conclusion</h3><div>The study suggests that luteolin and oleuropein help counteract dexamethasone-induced hyperlipidemia. Their administration reduced oxidative stress and liver enzyme levels (AST, ALT, and ALP) and improved lipid profiles, indicating their potential as therapeutic agents against glucocorticoid-related metabolic disturbances. The enhanced effectiveness observed in the combined treatment groups likely reflects synergistic activity between these compounds<strong>.</strong></div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"227 ","pages":"Article 109746"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of multiple cardiotonic steroids in faecal material of untreated humans and rat strains","authors":"Zelie F. Masso ,&nbsp;Hannah Bint Ebrahim Mullah ,&nbsp;Anza Thiba ,&nbsp;Sarhana Dinat ,&nbsp;Ekene E. Nweke ,&nbsp;Gavin R. Norton ,&nbsp;Angela J. Woodiwiss ,&nbsp;A. Duncan Cromarty ,&nbsp;Geoffrey P. Candy","doi":"10.1016/j.steroids.2026.109747","DOIUrl":"10.1016/j.steroids.2026.109747","url":null,"abstract":"<div><div>Endogenous cardiotonic steroid (CTS) concentrations are raised in cardiovascular diseases. CTSs undergo gastro-hepatobiliary recirculation, with the gut being an important route of elimination, yet the presence of CTSs in faecal material is seldom reported. This study investigated methods to extract and identify the presence of CTSs in faecal material of rats and humans without prior treatment.</div></div><div><h3>Methods</h3><div>Freeze-dried faecal material from different untreated rat strains was extracted using various solvents, with separation and identification of CTSs using HPLC/MS. Preliminary results were obtained from human faecal material.</div></div><div><h3>Results</h3><div>Multiple CTSs were identified in faecal material, with marinobufagenin (MBG) predominant. Telocinobufagin was only detected in certain rat strains, whereas the extraction methods used did not recover ouabain. MBG and digoxin were elevated in Dahl salt sensitive rats fed supplementary salt. Bufalin was present in most spontaneously hypertensive rats (SHRs) but was not detectable in Wistar Kyoto rats (WKY). Conversely, digitoxin was detected in most WKYs but only few SHRs. Levels of digitoxin and bufalin remained relatively constant over 24 days in untreated rats. Solvent selection was critical in determining the CTSs extracted from human faecal material.</div></div><div><h3>Conclusions</h3><div>Multiple CTSs were detected in faecal material of untreated rats and humans. Steroids varied between rat strains and aligned with phenotype. Extraction requires further solvent optimisation and the use of tandem MS/MS is essential to reliably detect the profile of CTSs present. Analysis of CTSs present in readily available faecal material will enable studies to determine relationships between CTSs, the microbiome and disease progression.</div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"227 ","pages":"Article 109747"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"l-arginine mitigates endocrine and spermatogenesis disruptions in cisplatin-exposed male Wistar rats by modulating iNOS/NO/NF-kB and Nrf2/HO-1 signaling","authors":"O.O. Obembe ,&nbsp;G.A. Oyeniyi ,&nbsp;P.J. Ashonibare ,&nbsp;T.M. Akhigbe ,&nbsp;E.A. Ashamu ,&nbsp;R.E. Akhigbe","doi":"10.1016/j.steroids.2025.109738","DOIUrl":"10.1016/j.steroids.2025.109738","url":null,"abstract":"<div><h3>Background</h3><div>Even though cisplatin is highly effective in cancer treatment, its toxicity to non-target organs, such as the testes, remains a concern. Studies have shown that cisplatin induces testicular toxicity by activating an oxido-inflammatory response. Conversely, arginine exerts antioxidant and anti-inflammatory properties. Aim: Hence, the current study assessed the impact of arginine on cisplatin-induced testicular toxicity. In addition, the involvements of iNOS/NO/NF-kB and Nrf2/HO-1 signaling, which are key pathways in cisplatin toxicity, were probed. Materials and methods: Twenty-four male Wistar rats were acclimatized for two weeks and then randomized into 4 equal groups; control, arginine-treated, cisplatin-treated, and cisplatin + arginine-treated. Results: Arginine significantly attenuated cisplatin-induced reductions in sperm concentration, motility, and viability and increased the percentage of abnormal sperm morphology. More so, arginine markedly suppressed cisplatin-induced reductions in daily and total spermatid production, and circulating levels of GnRH, FSH, LH, and testosterone. Additionally, arginine improved cisplatin-induced distortion in testicular histology. These findings were associated with arginine-driven mitigation of cisplatin-induced rise in MDA, TNF-α, IL-6, IL-1β, iNOS, and NF-kB and cisplatin-induced decline in GSH, TAC, IL-10, NO, and Nrf2 levels and GR, SOD, catalase, and HO-1 activities. Conclusion: Summing up, arginine mitigated cisplatin-induced testicular endocrine and spermatogenesis disruption via the modulation of iNOS/NO/NF-kB and Nrf2/HO-1 signaling.</div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"226 ","pages":"Article 109738"},"PeriodicalIF":2.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}