Synthesis of 25-hydroxycholesterol from bisnoralcohol

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2025-06-02 DOI:10.1016/j.steroids.2025.109640

Bu-Luan Liang , Yan-Xin Yue , De-Jie Zhang , Hao-Jie Ni , Xiang-Zhong Gu , Wen-Wei Qiu , Chen-Chen Li

引用次数: 0

Abstract

25-Hydroxycholesterol not only exhibits various important biological activities but also plays a crucial role in the synthesis of 25-hydroxyvitamin D₃. To date, researchers have proposed multiple synthetic routes for 25-hydroxycholesterol. Herein, a novel synthetic method for 25-hydroxycholesterol is described, involving a seven-step reaction that starts from economical and commercially available plant-derived bisnoralcohol, with an overall yield of up to 43.4%. Key reaction conditions, including solvents, reaction temperatures, bases and catalysts, were thoroughly investigated and optimized. This novel synthetic route provides a cost-effective strategy for the potential large-scale production of plant-derived 25-hydroxycholesterol.

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双诺醇合成25-羟基胆固醇

25-羟基胆固醇不仅具有多种重要的生物活性，而且在25-羟基维生素D3的合成中起着至关重要的作用。迄今为止，研究人员已经提出了多种合成25-羟基胆固醇的途径。本文描述了一种新的合成25-羟基胆固醇的方法，包括从经济和商业上可用的植物衍生的双去甲醇开始的七步反应，总收率高达43.4%。对溶剂、反应温度、碱和催化剂等关键反应条件进行了研究和优化。这种新的合成路线为大规模生产植物源性25-羟基胆固醇提供了一种具有成本效益的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.