α-Bromoketone derivatives from lithocholic acid: a comprehensive evaluation of their antibacterial activity

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2025-07-10 DOI:10.1016/j.steroids.2025.109658

Mónica Díaz-Fernández , Jesús Ramón-Sierra , Elizabeth Ortiz-Vázquez , María A. Fernández-Herrera

引用次数: 0

Abstract

A series of six α-bromoketones derived from lithocholic acid was synthesized through an oxidative bromination reaction, with four of these compounds being reported for the first time. All products were characterized using NMR, IR spectroscopy, and mass spectrometry. The structures and crystalline packing of two α-bromoketones were further confirmed through X-ray diffraction analysis. The antibacterial activity of the compounds was evaluated against both Gram-negative and Gram-positive bacterial strains of clinical relevance.

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石胆酸α-溴酮衍生物抗菌活性的综合评价。

以石胆酸为原料，经氧化溴化反应合成了6个α-溴酮，其中4个为首次报道。所有的产物都用核磁共振、红外光谱和质谱进行了表征。通过x射线衍射分析进一步证实了两种α-溴酮的结构和晶体排列。化合物的抗菌活性被评估对革兰氏阴性和革兰氏阳性菌株的临床相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.