Stem Cells Translational Medicine最新文献

{"title":"Isolation and characterization of human multilineage-differentiating stress-enduring cells for use in tissue engineering: a systematic review.","authors":"Ingrid Garzón, Miguel Ángel Martín-Piedra, Luis Martínez-Girón, Miguel Alaminos, James J Yoo, Anthony Atala","doi":"10.1093/stcltm/szag039","DOIUrl":"10.1093/stcltm/szag039","url":null,"abstract":"<p><p>Human multilineage-differentiating stress-enduring (MUSE) cells represent a promising cell population for tissue engineering and translational medicine owing to their intrinsic pluripotency and stress resistance. MUSE cells express pluripotency markers such as SSEA-3, Nanog, Sox2, and Oct3/4, while maintaining their immunomodulatory capabilities. This systematic review (PROSPERO CRD42024532621) analyzed studies on human MUSE cell isolation, characterization, and translational potential through searches of the PubMed, Scopus, and Web of Science databases in April 2024. The TIDieR and SYRCLE checklists were used to assess the risk of bias. Our findings identified 34 studies that followed the PRISMA guidelines for assessing different tissue sources, isolation techniques, and characterization methods. MUSE cells are primarily obtained from bone marrow mesenchymal stem cells, and fluorescence-activated cell sorting is the predominant isolation method. Characterization was mainly performed using SSEA-3 immunodetection (positivity ranged from <1% to 6.30%) and was linked to the expression of pluripotency and mesenchymal markers. These findings highlight the relevance of MUSE cells in regenerative medicine as a distinct pluripotent subpopulation within adult mesenchymal tissues. In addition, SSEA-3-based isolation approaches complemented by functional assays has emerged as a key methodological approach for the reliable identification and characterization of MUSE cells. However, isolation efficiency varies depending on the cell source and method. Standardized protocols are, therefore, needed to improve reproducibility and facilitate the translational development of MUSE cell-based regenerative therapies.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 7","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of PDL1 in mesenchymal stromal cells from young-onset MDS-RAEB-1 promotes inflamm-aging through epigenetic dysregulation of H3K9me3.","authors":"Pengju Lv, Ranran Jin, Lei Sun, Yalong Li, Chaofei Cheng, Lifang Shi, Sining Shen, Haili Wang, Han Yue","doi":"10.1093/stcltm/szag025","DOIUrl":"10.1093/stcltm/szag025","url":null,"abstract":"<p><p>Myelodysplastic syndromes (MDS), an age-related hematological malignancy, involve dysfunctional bone marrow mesenchymal stromal cells (BM-MSCs). Our study reveals that BM-MSCs from young refractory anemia with excess of blasts-1 (RAEB-1)/MDS patients exhibit impaired proliferation, altered immunophenotype, and reduced immunosuppressive capacity compared to healthy donor (HD)-MSCs. Notably, MDS-MSCs display a senescent state, distinct morphology, and elevated secretion of senescence-associated secretory phenotype (SASP) cytokines. Mechanistically, loss of programmed cell death ligand 1 (PDL1) in MDS-MSCs correlates with decreased SETDB1 levels and reduced H3K9me3-marked heterochromatin, leading to a more open chromatin state. This SETDB1/H3K9me3 deficiency mediates the reduction in immunosuppressive function and the increase in SASP factors (e.g. IL-6, IL-8, MCP1), exacerbating inflamm-aging. Gene expression profiling showed stage-specific senescence and inflammation phenotypes across MDS-MSCs generations. Furthermore, H3K9me3 inhibition directly induced BM-MSC senescence. Our findings demonstrate that dysfunctional BM-MSCs, driven by PDL1-SETDB1-H3K9me3 axis disruption and consequent SASP, critically promote pathogenesis in young MDS-RAEB-1 patients.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 6","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting outcomes of intra-articular injection of autologous, culture-expanded, adipose-derived mesenchymal stem cells in knee osteoarthritis.","authors":"Jun Bum Park, Gi-Young Jang, Kye-Youl Cho, Hyobeom Lee, Kang-Il Kim","doi":"10.1093/stcltm/szag027","DOIUrl":"10.1093/stcltm/szag027","url":null,"abstract":"<p><strong>Background: </strong>This study aims to assess the outcomes of intra-articular injection of adipose-derived mesenchymal stem cells (ADMSC) in osteoarthritis (OA) of knee joint up to 3-year follow-up and evaluate possible factors related to the outcomes.</p><p><strong>Methods: </strong>This was a prospective observational follow-up of participants from the ADMSC treatment arm of a prior phase III clinical trial. A total of 104 patients were assessed through the follow-up study for 3 years after ADMSC injection. We assessed the WOMAC and VAS for pain at 1-, 2-, and 3-year post-injection and compared with baseline values. Minimal clinically important difference (MCID) was calculated, and the proportion of patients achieving MCID was evaluated at each time point. Finally, we assessed which factors may affect the outcome.</p><p><strong>Results: </strong>Significant improvements in WOMAC and VAS scores were observed after ADMSC injection, with these benefits sustained throughout the 1-, 2-, and 3-year follow-up. The proportion achieving MCID slightly decreased over time without statistical significance. Significant factors affecting the favorable outcomes were lower body mass index (BMI) (<25), higher baseline clinical scores up to 3 years after the injection. Other variables did not show the significant relation.</p><p><strong>Conclusions: </strong>Intra-articular injection of autologous, culture-expanded ADMSC in patient with knee OA was sustained improvements observed up to 3 years in terms of WOMAC and VAS values. Moreover, patient BMI and baseline WOMAC were related to the outcomes after a single injection. Patient condition including severity of pain may affect the effect of ADMSC injection in OA knee. Clinical trial registration number: NCT04427930. This study was retrospectively registered.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-culturing hiPSC-cardiomyocytes and cardiac fibroblasts enhances engineered heart tissue structure and function.","authors":"Yinhan Luo, Jeremy Parker, Armando Alcázar Magaña, Ardin Sacayanan, Kate Huang, Ian Fernandes, Gordon M Keller, Peter H Backx, Leonard J Foster, Zachary Laksman","doi":"10.1093/stcltm/szag041","DOIUrl":"10.1093/stcltm/szag041","url":null,"abstract":"<p><strong>Background: </strong>Engineered heart tissues (EHTs) are widely used for cardiac disease modeling and drug screening, but their lack of multicellularity limits translational relevance. Thus, it is essential to incorporate other cardiac cells to improve the reliability and accuracy of the model.</p><p><strong>Objectives: </strong>To develop a co-culture EHT model from human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) and cardiac fibroblasts (CFs) and assess its structural, contractile, electrophysiological and metabolic properties.</p><p><strong>Methods: </strong>hiPSCs were differentiated into CMs and CFs and combined at a ratio of 3:1 to generate co-culture EHTs. Structural, functional and metabolic features of CM-only and co-culture EHTs were evaluated and compared using immunofluorescence, force analysis, optical mapping and metabolomics.</p><p><strong>Results: </strong>Co-culture EHTs were more compact, generated higher force when stimulated, and displayed improved sarcomere organization compared to CM-only EHTs. They showed reduced hypoxia under high frequency pacing and a more mature, stress resistant metabolic profile, while maintaining stable electrophysiology and reduced arrhythmogenicity.</p><p><strong>Conclusions: </strong>Incorporating hiPSC-CFs into EHTs enhanced structural and functional properties, improved stress resistance, and reduced variability, making our co-culture EHTs a more physiological and predictive platform for cardiac disease modeling and drug screening.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 7","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13387363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on 18F-FDG PET/CT imaging assessment of the anti-aging efficacy of BMMSCs in the macaque brain.","authors":"Pinghui Li, Yaxi Jiang, Xinghua Pan, Xiangqing Zhu, Baoci Shan, Tingting Pan, Shici Yang, Qinghua Li, Ting Li, Jie Li, Lilin Chen, Rui He, Fei Xie, Gaohong Zhu","doi":"10.1093/stcltm/szag028","DOIUrl":"10.1093/stcltm/szag028","url":null,"abstract":"<p><strong>Objective: </strong>Aging is a pressing global challenge requiring urgent solutions, and the anti-aging potential of mesenchymal stem cells (MSCs) has drawn global attention. This study treated aged macaques with bone marrow mesenchymal stem cells (BMMSCs) and aimed to establish a non-invasive, reliable, specific, and reproducible imaging method for evaluating BMMSCs' therapeutic effects by combining 18F-FDG PET/CT imaging with texture analysis and Statistical Parametric Mapping 8.0 (SPM8.0).</p><p><strong>Methods: </strong>Sixteen healthy female macaques were split into three age groups: juvenile, young, and elderly. Baseline 18F-FDG PET/CT imaging was conducted, and only the elderly group received BMMSC transplantation. Brain PET/CT scans were repeated 3 and 6 months post-treatment. PET data were processed using PET Vcar (for metabolic analysis), LIFEx (for texture feature extraction), and SPM8.0 (for pixel-wise statistical mapping).</p><p><strong>Results: </strong>The elderly group had a higher metabolic volume (MTV) than the juvenile group, which declined after BMMSC treatment. However, no significant differences in SUVmax, SUVmean, or TLG were found in the elderly group post-treatment. Texture analysis identified SHAPE_Surface and GLZLM_LZLGE as strong classification markers, with ROC curve AUC values of 0.833 and 0.75, respectively. SPM 8.0 analysis showed BMMSCs improved glucose metabolism in the entorhinal and auditory cortices of aged macaques.</p><p><strong>Conclusions: </strong>BMMSC treatment improved glucose metabolism in specific functional brain regions (auditory processing, motor ability, cognitive memory, vision, taste, and reproductive systems) of aged macaques. 18F-FDG PET/CT plus texture analysis and SPM8.0 is a credible, accurate quantitative methods for assessing BMMSC efficacy.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imbalance in WNT: retinoic acid signaling dysregulates HOX gene expression: implications for cancer stem cell heterogeneity and CRC patient survival.","authors":"Brian Osmond, Chi Zhang, Pascal K Kataboh, Caroline O B Facey, Lynn M Opdenaker, Bruce M Boman","doi":"10.1093/stcltm/szag043","DOIUrl":"10.1093/stcltm/szag043","url":null,"abstract":"<p><p>How HOX transcription factors play a role in the stem cell (SC) origin of cancer is unclear. Our goal is to determine how dysregulation of HOX gene expression promotes colorectal cancer (CRC) development through aberrant SC regulatory mechanisms. We investigated retinoic acid (RA) and WNT signaling because they regulate HOX expression and both pathways are dysregulated in cancer. Previously, we reported WNT and RA pathways are functionally linked, and in CRC, APC mutation generates a WNT:RA imbalance leading to incomplete differentiation and SC overpopulation. We hypothesize that aberrant WNT- and RA-signaling dysregulates HOX expression that contributes to the SC origin of CRC. We discovered a HOX expression signature of eight genes (six-upregulated, two-downregulated) that are significantly altered in CRC, and that predict poor CRC patient survival. NanoString profiling of fluorescence activated cell sorted SC subpopulations, bioinformatics studies, and RNA-seq analysis of fresh colon tissues revealed: (1). The six-upregulated genes are regulated by RA signaling; (2). ATRA-treatment of CRC cells, but not wt-APC induction or RARA knockout, leads to a HOX expression pattern matching the HOX signature; (3). Mid-cluster (group 3) HOXB gene expression characterizes normal colon, but increased group 3 HOXC expression occurs in CRC; (4). LGR5+ SCs selectively express group 3 HOXB genes while ALDH+ SCs express group 3 HOXC genes; (5). HOXA13 and HOXB13 which are downregulated and predict poor patient survival likely possess tumor-suppressor activity and function by retro-inhibition of earlier HOX genes. Given HOX expression predicts survival and identifies SC phenotype, this indicates dysregulated HOX expression contributes to SC origin of CRC.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism.","authors":"Seok Won Chung, Jong Pil Yoon, Sung-Jin Park","doi":"10.1093/stcltm/szag023","DOIUrl":"10.1093/stcltm/szag023","url":null,"abstract":"<p><p>Rotator cuff (RC) tears are commonly associated with progressive muscle atrophy, fatty infiltration, and fibrosis, which often persist despite successful tendon repair and remain major barriers to functional recovery and structural integrity. These degenerative muscle changes are not sufficiently addressed by tendon-focused surgical approaches and contribute significantly to poor clinical outcomes and high retear rates. In response, biologically targeted therapies have emerged to directly modulate the cellular and molecular mechanisms underlying muscle degeneration. Current strategies focus on 3 major approaches: regenerative cell-based therapies that promote muscle regeneration and suppress fibrosis; signaling pathway modulation to disrupt pathological tissue remodeling; and metabolic interventions aimed at restoring mitochondrial function and correcting lipid metabolism. Central to these strategies is the regulation of dysfunctional cellular populations within the muscle microenvironment, particularly those responsible for fibrotic and adipogenic changes. This article is a narrative literature review summarizing recent preclinical and early clinical evidence, incorporating representative quantitative findings, and acknowledging key limitations of the available studies. By integrating these emerging biologic approaches, this review provides an updated perspective on therapeutic strategies for RC muscle degeneration and evaluates their translational potential for future clinical applications.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.","authors":"Christine Hum, Jessica Poliwoda, Manoj Lalu, Duncan J Stewart, Shirley H J Mei, Keith R Walley, John Marshall, Asher A Mendelson, Dean A Fergusson, Shane English, Brent W Winston, John Granton, Claudia C Dos Santos, Josee Champagne, Lauralyn McIntyre","doi":"10.1093/stcltm/szag029","DOIUrl":"10.1093/stcltm/szag029","url":null,"abstract":"<p><strong>Background: </strong>Mesenchymal stromal cells (MSCs) have the capacity to self-renew and exert immunomodulatory and paracrine effects. Our previously published systematic review of 55 randomized controlled trials (RCTs) of all MSC sources found an overall favorable safety profile for MSCs aside from more frequent fever in the MSC group.</p><p><strong>Objective: </strong>Umbilical cord MSCs (UC-MSCs) possess potential biological and economic advantages over other MSC sources. Since several UC-MSC RCTs have been recently published in a heterogenous group of disorders, we performed a systematic review to specifically examine the safety profile of adult UC-MSC RCTs, while also providing quantitative syntheses (meta-analyses) of prespecified adverse events.</p><p><strong>Methods: </strong>A systematic search was performed up to August 2025. RCTs were identified that compared intravascular delivery of UC-MSCs in adults to a control group. The primary outcome was safety categorized by the following prespecified adverse events with potential relevance to UC-MSCs: (1) fever and (2) non-fever acute infusional toxicity within 24 hours of study product administration, (3) infection, (4) death, (5) malignancy/ectopic tissue formation, (6) thrombotic/thromboembolic events, and (7) mycotic aneurysms. Prespecified adverse events were pooled and meta-analyzed.</p><p><strong>Results: </strong>A total of 9160 studies were screened and 42 UC-MSC RCTs (n = 2280 patients) were included. UC-MSCs were associated with increased risk for fever (relative risk [RR] =2.34, 95% confidence interval [CI] =1.02-5.35). None of the other prespecified adverse events were associated with signals for harm. No included trials were stopped early due to safety concerns.</p><p><strong>Conclusions: </strong>UC-MSC therapy appears safe for study in heterogeneous patient populations.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction of: Oral Progenitor Cell Line-Derived Small Extracellular Vesicles as a Treatment for Preferential Wound Healing Outcome.","authors":"","doi":"10.1093/stcltm/szag044","DOIUrl":"10.1093/stcltm/szag044","url":null,"abstract":"","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 6","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient and robust generation of functional hematopoietic cells from human pluripotent stem cells in albumin-free conditions.","authors":"Byung Woo Kim, Linyi Zhang, Mo Liu, Supreet Khanal, Ye Eun Jeong, Ge Zheng, Nirjal Bhattarai, Zhaohui Ye","doi":"10.1093/stcltm/szag020","DOIUrl":"10.1093/stcltm/szag020","url":null,"abstract":"<p><p>Generation of human hematopoietic stem and progenitor cells (HSPCs) from pluripotent stem cells (PSCs) holds significant promise in disease modeling, drug screening, and the development of cell and gene therapies for various hematologic and nonhematologic disorders. However, efficient and consistent derivation of functional HSPCs remains a major challenge hindering their practical use in biomedical research and applications. One of the contributing factors is the use of human serum albumin (HSA), which has been widely regarded as essential for supporting ex vivo maintenance, expansion, and differentiation of human stem cells and their derivatives. The lot-to-lot variation of this critical reagent can contribute to inconsistent laboratory results and high manufacturing costs. In this study, we address the manufacturing and regulatory challenges associated with using HSA in HSPC differentiation and propose an approach using a caprolactam-based polymer as an alternative. Our differentiation method demonstrates robust HSPC generation across various embryonic and induced PSC lines and culture conditions, highlighting its adaptability and reliability. Importantly, PSC-derived HSPCs exhibit functional versatility in differentiation capacity into myeloid and lymphoid lineages, as validated through colony-forming assays as well as directed red blood cell and NK cell differentiations. These findings suggest that HSA is dispensable in HSPC differentiation and replacing it with synthetic polymers has the potential to mitigate lot-to-lot reagent variation, improve HSPC production consistency, lower manufacturing costs, and expedite clinical applications.</p>","PeriodicalId":21986,"journal":{"name":"Stem Cells Translational Medicine","volume":"15 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}