Spinal cord最新文献_第6页

Urodynamic evaluation of neurogenic bladder in patients with spinal cord injury within 6 months post-injury: a Retrospective Cross-Sectional Study 脊髓损伤后6个月内神经源性膀胱尿动力学评价：一项回顾性横断面研究。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-03-24 DOI: 10.1038/s41393-025-01074-0

Onyoo Kim, Lyekyung An, Byung Chan Lee

{"title":"Urodynamic evaluation of neurogenic bladder in patients with spinal cord injury within 6 months post-injury: a Retrospective Cross-Sectional Study","authors":"Onyoo Kim, Lyekyung An, Byung Chan Lee","doi":"10.1038/s41393-025-01074-0","DOIUrl":"10.1038/s41393-025-01074-0","url":null,"abstract":"Retrospective cross-sectional survey of Korean patients with spinal cord injury (SCI) within 6 months post-injury. To evaluate urodynamic parameters and identify unfavorable urodynamic findings in patients with neurogenic bladder due to SCI during the acute to subacute stages of the disease based on the post-injury time interval. National Rehabilitation Center, Seoul, Korea. Data from urodynamic tests performed on individuals with SCI within 6 months post-injury were collected. Based on the time interval from injury to testing, the recruited patients were divided into three groups: 0–90 days, 91–135 days, and 136–180 days. Based on these groups, urodynamic test parameters and incidence of high-risk findings (high detrusor pressure exceeding 40 cmH2O during the filling phase, low compliance of the bladder, and detrusor-sphincter dyssynergia [DSD]) and unfavorable urodynamic findings (detrusor overactivity [DO], underactive or acontractile bladder) were compared. Analysis of urodynamic study (UDS) findings in 191 individuals with acute to subacute SCI, revealed that unfavorable urodynamic findings were observed within 3 months after injury in both complete and incomplete SCI. The UDS test results and incidence of unfavorable outcomes based on the interval between injury and examination showed no significant statistical differences over time. The urodynamics of individuals with SCI suggest that high-risk or unfavorable urodynamic results are common in the acute to subacute stages of SCI.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 5","pages":"246-251"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical outcomes of cervical spinal cord tumor in elderly patients assessed by the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire 日本骨科协会颈椎病评估问卷评估老年患者颈脊髓肿瘤的手术效果。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-03-22 DOI: 10.1038/s41393-025-01075-z

Shuhei Ito, Narihito Nagoshi, Toshiki Okubo, Masahiro Ozaki, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

{"title":"Surgical outcomes of cervical spinal cord tumor in elderly patients assessed by the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire","authors":"Shuhei Ito, Narihito Nagoshi, Toshiki Okubo, Masahiro Ozaki, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Morio Matsumoto, Masaya Nakamura, Kota Watanabe","doi":"10.1038/s41393-025-01075-z","DOIUrl":"10.1038/s41393-025-01075-z","url":null,"abstract":"Single-institution retrospective study. To assess postoperative functional and quality of life (QOL) outcomes in elderly patients who underwent cervical spinal cord tumor surgery using the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). Single university hospital. This retrospective study included 97 patients who underwent surgery for cervical spinal cord tumors between 2000 and 2016. Patients were divided into two groups: a younger group (patients < 65 years old) and an elderly group (patients ≥ 65 years old). Surgical outcomes were evaluated using JOA scores and JOACMEQ, with statistical comparisons between age (younger vs. elderly) and tumor types (intramedullary vs. extramedullary). Preoperative JOA scores were significantly lower in the elderly group compared to the younger group. Postoperative recovery rates were similar between the two groups. Extramedullary tumor resections in the elderly showed notable functional improvements. Conversely, elderly patients with intramedullary tumors exhibited poorer outcomes in lower extremity function and QOL, as measured by the JOACMEQ. Surgical intervention for cervical spinal cord tumors in elderly patients can yield functional and QOL outcomes similar to those in younger patients, especially for extramedullary tumors. However, intramedullary tumor resections in the elderly may result in less favorable outcomes, particularly in lower limb function and QOL. These findings underscore the importance of thorough preoperative counseling for elderly patients, highlighting potential risks and benefits based on tumor type.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 5","pages":"239-245"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The critical threshold of blood flow associated with spinal cord ischemia in a modified rabbit model developed by ligation of lumbar arteries 通过腰椎动脉结扎建立的改良兔模型中与脊髓缺血相关的血流量临界阈值。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-03-18 DOI: 10.1038/s41393-025-01071-3

Li-Feng Xing, Ding-Wen Zheng, Yan-Song Miao, Yu-Cai Hong, Wei Xiao

{"title":"The critical threshold of blood flow associated with spinal cord ischemia in a modified rabbit model developed by ligation of lumbar arteries","authors":"Li-Feng Xing, Ding-Wen Zheng, Yan-Song Miao, Yu-Cai Hong, Wei Xiao","doi":"10.1038/s41393-025-01071-3","DOIUrl":"10.1038/s41393-025-01071-3","url":null,"abstract":"Animal study. To investigate the influence of lumbar arteries ligation on spinal cord blood flow (SCBF), and to determine by what proportion the SCBF decrease would cause spinal cord ischemia (SCI) in rabbit model. Sir Run Run Shaw Hospital, Zhejiang University School of Medicine. SCI model was established by ligation of lumbar arteries in rabbits. 20 rabbits were divided into four groups: group A, sham surgery without ligation; group B, ligation at 3 levels; group C, ligation at 4 levels; group D, ligation at 5 levels. The SCBF was measured with laser doppler flowmetry, motor function was assessed using modified Tarlov grading system, and neurophysiological integrity was detected with motor-evoked potential (MEP), followed by histological observation on the seventh day after operation. Lumbar arteries ligation at 3 levels led to average 40% decrease of SCBF, and spinal cord remained functional, electrophysiological and histological normal. Lumbar arteries ligation at 4 levels resulted in average 50% decrease of SCBF, slight motor dysfunction, prolonged latency of MEP and decreased cell volume of neuron, rabbits presented mild spinal cord injury. Lumbar arteries ligation at 5 levels caused average 60% decrease of SCBF, complete paraplegia, loss of MEP waveform and neuron karyopyknosis, rabbits presented severe SCI. More ligation of bilateral lumbar arteries leads to lower SCBF and increase the risk of SCI in rabbits, SCBF decreased by more than 50% could cause SCI. MEP associated significantly with SCBF, suggesting the usefulness of MEP to monitoring SCBF in surgery.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 4","pages":"233-238"},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histology of neurogenic heterotopic ossification and comparison with its radiological expression in acute spinal cord injured patients 急性脊髓损伤患者神经源性异位骨化的组织学及影像学表现比较。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-03-13 DOI: 10.1038/s41393-025-01070-4

Eugen Ulrich, Alexis Brinkemper, Manfred Köller, Ingo Stricker, Astrid Gisevius, Thomas A. Schildhauer, Renate Meindl, Dennis Grasmücke, Sabrina Buche-Lyding, Volkmar Nicolas, Mirko Aach

{"title":"Histology of neurogenic heterotopic ossification and comparison with its radiological expression in acute spinal cord injured patients","authors":"Eugen Ulrich, Alexis Brinkemper, Manfred Köller, Ingo Stricker, Astrid Gisevius, Thomas A. Schildhauer, Renate Meindl, Dennis Grasmücke, Sabrina Buche-Lyding, Volkmar Nicolas, Mirko Aach","doi":"10.1038/s41393-025-01070-4","DOIUrl":"10.1038/s41393-025-01070-4","url":null,"abstract":"Clinical prospective study. To histologically examine puncture biopsies of early neurogenic heterotopic ossification (NHO) in spinal cord injured individuals. University of Bochum, Germany. After acute spinal trauma, participants underwent a sonographic examination of the hip joints and a routine laboratory examination. Magnetic resonance imaging (MRI) or computed tomography (CT) of the pelvis was performed if there were clinical and laboratory signs of NHO and sonographic evidence of edema and/or calcifications in the tissue around the hip joint. If NHO were detected, tissue was obtained and preserved for histological examination from the involved tissue around the hip joint affected by NHO and from an unaffected calf as control. Nine participants with a complete spinal cord lesion American Spinal Injury Association Impairment Scale (AIS) grade A and evidence of an acute NHO in the hip joint muscles were recruited for the study. In all sonographic examinations of the hip joint, edematous changes could be detected. In one case, calcifications were detected sonographically. In MRI/CT in six participants, ossification could already be detected. All histological specimens from the NHO-affected gluteal region showed varying degrees of tissue deformation. The unaffected reference samples showed regular muscular structure microscopically. It was possible to show and compare histological changes in NHO-affected tissue with MRI/CT imaging, depending on the stage of NHO. DRKS, DRKS00034049. Registered 12 April 2024 - Retrospectively registered, https://www.drks.de/DRKS00034049 .","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 4","pages":"227-232"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatments of fatigue after spinal cord injury: a systematic review and meta-analysis 脊髓损伤后疲劳的治疗：系统回顾和荟萃分析。

IF 2.1 4区医学

Spinal cord Pub Date : 2025-03-06 DOI: 10.1038/s41393-025-01067-z

Carlos Leonardo Cano-Herrera, Gita Manhas, Matthew Querée, Bob Hoogenes, Emma A. Bateman, Eldon Loh, William C. Miller, W. Ben Mortenson, Andrea Townson, Janice J. Eng, the SCIRE Research Team

{"title":"Treatments of fatigue after spinal cord injury: a systematic review and meta-analysis","authors":"Carlos Leonardo Cano-Herrera, Gita Manhas, Matthew Querée, Bob Hoogenes, Emma A. Bateman, Eldon Loh, William C. Miller, W. Ben Mortenson, Andrea Townson, Janice J. Eng, the SCIRE Research Team","doi":"10.1038/s41393-025-01067-z","DOIUrl":"10.1038/s41393-025-01067-z","url":null,"abstract":"Systematic Review and Meta-analysis. Canada. Fatigue is one of the most common consequences of spinal cord injury (SCI). In this systematic review and meta-analysis, we examined interventions for fatigue in SCI and evaluated their effectiveness. MEDLINE, EMBASE, CINAHL, and PsycINFO databases were searched up to January 2024 inclusive. Randomized controlled trials (RCTs) that assessed any intervention for at least one fatigue outcome in people with SCI were included. Study quality was assessed using the Cochrane Risk of Bias Tool. Initial screening identified 282 studies from which six RCTs were included in the review (N = 249). One study found that moderate-intensity arm-crank exercise significantly improved fatigue compared to a control group (p = 0.036) with a large effect size (standard mean difference [SMD] = 1.05; 95% confidence interval [CI], 0.10–2.00). Two studies assessing behavioral interventions found a moderate effect on fatigue (SMD = 0.46; 95% CI, −0.00–0.92; p = 0.05). Two studies did not find an effect of massage therapy on fatigue (SMD = 0.06; 95% CI, −0.38–0.50; p = 0.80). The risk of bias was classified as High for all but two of the RCTs. These findings suggest that exercise and behavioral interventions promoting an active lifestyle may have a positive effect on fatigue. More research with larger sample sizes, including controls for co-morbid conditions like pain and depression, is needed to establish evidence-based treatments for reducing fatigue in people with SCI.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 3","pages":"149-158"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mindfulness- and acceptance-based interventions for people with spinal cord injury: a scoping review 对脊髓损伤患者的正念和接受干预：范围综述。

IF 2.1 4区医学

Spinal cord Pub Date : 2025-02-26 DOI: 10.1038/s41393-025-01068-y

Mengqi Li, Wing Yiu Lo, Yule Hu, Shanshan Wang, Tsz-Ching Sun, Worku Animaw Temesgen, Mengting He, Yan Li

{"title":"Mindfulness- and acceptance-based interventions for people with spinal cord injury: a scoping review","authors":"Mengqi Li, Wing Yiu Lo, Yule Hu, Shanshan Wang, Tsz-Ching Sun, Worku Animaw Temesgen, Mengting He, Yan Li","doi":"10.1038/s41393-025-01068-y","DOIUrl":"10.1038/s41393-025-01068-y","url":null,"abstract":"Scoping review. To synthesize the effects of mindfulness- and acceptance-based interventions (MABIs) on health-related outcomes of individuals with spinal cord injury. The included studies were conducted across four countries: The United States, Iran, China, and The United Kingdom. This review followed the Arksey and O’Malley framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guideline. Seven databases were searched until November 2024 to identify studies published in English-language that evaluated MABIs’ effects on health-related outcomes in people with spinal cord injury. Literature screening, data extraction, and quality assessment were conducted by two reviewers independently. A narrative data synthesis was conducted. Of 2389 records, nine studies were included with designs of randomized controlled trials (n = 4), quasi-experimental studies (n = 3), and case studies (n = 2). Acceptance commitment therapy (n = 4) and mindfulness-based interventions (n = 5) were employed. MABIs demonstrated significant improvements in psychological health outcomes (depression, n = 3; anxiety, n = 3; stress, n = 2) with medium-to-large effect sizes ( $${{{{rm{eta }}}}}_{{{{rm{p}}}}}^{2}=0.112-0.223$$ ) and other health-related outcomes (chronic pain, n = 1; functional independence, n = 1; engagement in meaningful activities, n = 1; and quality of life, n = 1). Participants found the MABIs to be acceptable and satisfactory. Study quality varied from weak (n = 6) to strong (n = 2). The findings generally support the acceptability and effectiveness of MABIs for improving the overall well-being of individuals with SCI. Future research directions regarding designing MABIs and exploring effectiveness mechanisms were recommended for maximizing its benefits.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 3","pages":"159-170"},"PeriodicalIF":2.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical signs and symptoms for degenerative cervical myelopathy: a scoping review of case-control studies to facilitate early diagnosis among healthcare professionals with stakeholder engagement 退行性颈椎病的临床体征和症状：病例对照研究的范围审查，以促进与利益相关者参与的医疗保健专业人员的早期诊断。

IF 2.1 4区医学

Spinal cord Pub Date : 2025-02-26 DOI: 10.1038/s41393-025-01065-1

Suhani Sharma, Alisha Sial, Stone Sima, Ashish Diwan

{"title":"Clinical signs and symptoms for degenerative cervical myelopathy: a scoping review of case-control studies to facilitate early diagnosis among healthcare professionals with stakeholder engagement","authors":"Suhani Sharma, Alisha Sial, Stone Sima, Ashish Diwan","doi":"10.1038/s41393-025-01065-1","DOIUrl":"10.1038/s41393-025-01065-1","url":null,"abstract":"Scoping Review. Degenerative cervical myelopathy (DCM) is a leading cause of chronic spinal cord dysfunction, with diverse clinical presentations that complicate diagnosis. Therefore, it is important to identify the signs and symptoms of DCM that demonstrate high diagnostic accuracy. This review aims to evaluate the sensitivity and specificity of signs and symptoms in diagnosing DCM. Articles up to June 2024 were retrieved from PubMed, EMBASE, and Cochrane databases using search terms like “degenerative cervical myelopathy”, “cervical spondylotic myelopathy”, “sensitivity”, “specificity”, and related signs and symptoms. Studies were screened based on selection criteria assessing the sensitivity and specificity of signs or symptoms using an appropriate control group. Sixteen studies were included. The most sensitive signs were Tromner sign (93–97%) and hyperreflexia (15–85%). Specific signs included the Babinski sign (93–100%), Tromner sign (79–100%), clonus (96–99%), and inverted supinator sign (78–99%). Neck pain had a sensitivity of 76–94% and specificity of 11–73%. Hand incoordination showed 52% sensitivity and 92% specificity. Altered hand sensation had 76% sensitivity and 90% specificity. Upper extremity weakness had 51–75% sensitivity and 18–95% specificity. Gait imbalance exhibited 56–63% sensitivity and 52–95% specificity. Sensitive signs like the Tromner sign and hyperreflexia are useful for screening, while specific signs such as Babinski, clonus, and the inverted supinator sign aid in confirmation of DCM. Symptoms like neck pain, hand incoordination, and altered hand sensation should heighten suspicion and guide differential diagnosis. Early and accurate diagnosis using these indicators can improve patient outcomes and reduce diagnostic delays.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 3","pages":"171-180"},"PeriodicalIF":2.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-025-01065-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity and reliability of the Turkish version of the Spinal Cord Independence Measure (SCIM III) self-report 土耳其版脊髓独立测量（SCIM III）自我报告的效度和信度。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-02-25 DOI: 10.1038/s41393-025-01069-x

Yelda Soluk Özdemir, Cansın Medin Ceylan, Nurdan Paker, Veysel Korkut, Burak Kütük, Kadriye Öneş, Derya Buğdaycı, Fatma N. Kesiktaş

{"title":"Validity and reliability of the Turkish version of the Spinal Cord Independence Measure (SCIM III) self-report","authors":"Yelda Soluk Özdemir, Cansın Medin Ceylan, Nurdan Paker, Veysel Korkut, Burak Kütük, Kadriye Öneş, Derya Buğdaycı, Fatma N. Kesiktaş","doi":"10.1038/s41393-025-01069-x","DOIUrl":"10.1038/s41393-025-01069-x","url":null,"abstract":"A cross-sectional validation study. The aim of the study was to create a Turkish version of the Spinal Cord Independence Measure Self-Report (SCIM-SR) scale and verify its validity and reliability. Rehabilitation Department at Istanbul Physical Medicine and Rehabilitation and Training Research Hospital. The Turkish version of SCIM-SR was translated from English using forward and backward translation in accordance with standard guidelines and 90 participants completed the SCIM-SR Turkish form. At the same time, a Spinal Cord Independence Measure III (SCIM III) was administered to the participants by a health professional through observation. Cronbach’s alpha, Pearson and Spearman correlation coefficients were used to evaluate the internal consistency and concurrent validity. The Cronbach’s α coefficients for the total scale was 0.883. For the subscales, it was 0.929 for self-care, 0.571 for respiration and sphincter management and 0.885 for mobility. Test-retest reliability after two weeks yielded Spearman coefficients above 0.92 for the total scale and all subscales. When analyzing the correlation between SCIM-SR and SCIM III, the intraclass correlation average and its lower and upper bound values were as follows: 0.984 (0.976–0.990) for self-care; 0.970 (0.955–0.980) for respiration and sphincter management; 0.968 (0.951–0.979) for mobility and 0.980 (0.969–0.987) for the total. There was good agreement between SCIM-SR and SCIM III when evaluating the total score in Bland-Altman graphs. The Bland–Altman analysis revealed no significant proportional bias (0.76; 95% CI [−21.34, 22.87]), but a significant fixed bias was observed. The Turkish version of SCIM-SR demonstrated excellent internal consistency and good validity in Turkish individuals with spinal cord injury.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 4","pages":"222-226"},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of melatonin administration on motor recovery after spinal cord injury in animal models: a systematic review and meta-analysis 褪黑素对动物脊髓损伤后运动恢复的影响：系统回顾和荟萃分析。

IF 2.1 4区医学

Spinal cord Pub Date : 2025-02-20 DOI: 10.1038/s41393-025-01063-3

Ali Khodabakhshi Korelaei, Arash Fallahi, Michael R. Hamblin, Fatemeh Ramezani

{"title":"The effect of melatonin administration on motor recovery after spinal cord injury in animal models: a systematic review and meta-analysis","authors":"Ali Khodabakhshi Korelaei, Arash Fallahi, Michael R. Hamblin, Fatemeh Ramezani","doi":"10.1038/s41393-025-01063-3","DOIUrl":"10.1038/s41393-025-01063-3","url":null,"abstract":"Systematic review and meta-analysis. In this study, the effects of the antioxidant melatonin on motor function after spinal cord injury were investigated in preclinical studies. IRAN The search strategy was designed based on keywords related to melatonin and spinal cord injury. The primary screening was based on title and abstract, and the secondary screening was based on the full text of the articles. After extracting data from the articles, statistical analysis was performed using STATA software. Standardized mean differences were used to analyze the results of the included studies. Subgroup analysis and quality control of articles were also performed. Based on the results of 29 separate experiments, melatonin showed a significant strong effect compared to the untreated group. The results showed that IP injection and multiple administrations days had the strong effect in the first three days as well as after 3–4 weeks. But more studies are needed to draw conclusions about its longer term effects. The analysis of MDA, SOD and GSH redox factors showed that the amount of MDA decreased and the amount of GSH increased in the treated animals. Also, the inflammatory factors IL-1Β and TNF-α as well as apoptosis and the rate of neuronal cell death, were reduced in animals that received melatonin, while the number of viable neurons was increased in melatonin treated animals. Melatonin is an antioxidant supplement, which can be considered for clinical trials in human SCI patients. IRAN University of medical sciences","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 3","pages":"135-148"},"PeriodicalIF":2.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nerve transfers to anterior interosseous nerve for restoration of finger flexion in spinal cord and brachial plexus injury: a systematic Review and individual-patient-data meta-analysis 神经转移至前骨间神经修复脊髓和臂丛损伤手指屈曲：系统回顾和个体患者数据荟萃分析。

IF 2.1 4区医学

Spinal cord Pub Date : 2025-02-17 DOI: 10.1038/s41393-025-01066-0

Pavlos Texakalidis, Stavros Matsoukas, Nikhil Murthy, Adenike A. Adewuyi, Nader S. Dahdaleh, Colin K. Franz, Kevin Swong

{"title":"Nerve transfers to anterior interosseous nerve for restoration of finger flexion in spinal cord and brachial plexus injury: a systematic Review and individual-patient-data meta-analysis","authors":"Pavlos Texakalidis, Stavros Matsoukas, Nikhil Murthy, Adenike A. Adewuyi, Nader S. Dahdaleh, Colin K. Franz, Kevin Swong","doi":"10.1038/s41393-025-01066-0","DOIUrl":"10.1038/s41393-025-01066-0","url":null,"abstract":"Systematic review and meta-analysis. Cervical spinal cord injury (SCI) and brachial plexus injury (BPI) can result in hand paralysis. Reconstruction of hand motion is associated with improved functionality and quality of life. We synthesized the outcomes of finger and thumb flexion after various nerve transfers to the anterior interosseous nerve (AIN). A systematic literature review and meta-analysis was performed according to the PRISMA guidelines. Successful finger and thumb flexion recovery was defined as Medical research council (MRC) grade ≥3. In total, 23 studies with 99 patients and 120 nerve transfers to the AIN were performed. The mean interval from injury to surgery was 12.8 months and mean follow-up duration was 24 months. Overall, 81/120 (67.5%) and 68/102 (66.7%) hands achieved successful finger and thumb flexion recovery, respectively. Individual-patient-data were available for 94 nerve transfers. Type of injury (SCI vs BPI/peripheral) did not affect finger flexion outcomes (OR 1.92, 95%CI 0.74–5.0, p = 0.17). On multivariate analysis adjusted for mechanism of injury, timing of injury to surgery and duration of follow-up, utilization of the brachioradialis (BR) branch (25%, 1/4, OR 0.01, 95%CI 0.0006–0.44, p = 0.01) and brachialis (BA) branch (59%, 30/51, OR 0.06, 95%CI 0.006–0.68, p = 0.02) as donors, were associated with statistically significant lower odds of successful finger flexion recovery compared to extensor carpi radialis brevis (ECRB) use (95%, 19/20). Similar outcomes were observed with SCI and BPI/peripheral type injuries. ECRB utilization as a donor was superior to BA or BR branch in terms of successful finger flexion recovery.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 3","pages":"127-134"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0