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Role of Angiogenesis and Its Biomarkers in Development of Targeted Tumor Therapies 血管生成及其生物标志物在开发肿瘤靶向治疗中的作用
IF 4.3 3区 医学
Stem Cells International Pub Date : 2024-01-04 DOI: 10.1155/2024/9077926
Anchal Pathak, Ajay Kumar Pal, Subhadeep Roy, Mukesh Nandave, Keerti Jain
{"title":"Role of Angiogenesis and Its Biomarkers in Development of Targeted Tumor Therapies","authors":"Anchal Pathak, Ajay Kumar Pal, Subhadeep Roy, Mukesh Nandave, Keerti Jain","doi":"10.1155/2024/9077926","DOIUrl":"https://doi.org/10.1155/2024/9077926","url":null,"abstract":"Angiogenesis plays a significant role in the human body, from wound healing to tumor progression. “Angiogenic switch” indicates a time-restricted event where the imbalance between pro- and antiangiogenic factors results in the transition from prevascular hyperplasia to outgrowing vascularized tumor, which eventually leads to the malignant cancer progression. In the last decade, molecular players, i.e., angiogenic biomarkers and underlying molecular pathways involved in tumorigenesis, have been intensely investigated. Disrupting the initiation and halting the progression of angiogenesis by targeting these biomarkers and molecular pathways has been considered as a potential treatment approach for tumor angiogenesis. This review discusses the currently known biomarkers and available antiangiogenic therapies in cancer, i.e., monoclonal antibodies, aptamers, small molecular inhibitors, miRNAs, siRNAs, angiostatin, endostatin, and melatonin analogues, either approved by the U.S. Food and Drug Administration or currently under clinical and preclinical investigations.","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139096467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Stem Cells Accelerate Recovery of Acetic Acid-Induced Chronic Gastric Ulcer by Regulating Ekt/Akt/TRIM29 Axis 间充质干细胞通过调节 Ekt/Akt/TRIM29 轴加速醋酸诱导的慢性胃溃疡的恢复
IF 4.3 3区 医学
Stem Cells International Pub Date : 2024-01-03 DOI: 10.1155/2024/6202123
Feiyue Zhao, Zhibin Fan, Ruikang Jia, Qichao Liu, Menglei Wang, Jianliang Sui, Huiyun Liu
{"title":"Mesenchymal Stem Cells Accelerate Recovery of Acetic Acid-Induced Chronic Gastric Ulcer by Regulating Ekt/Akt/TRIM29 Axis","authors":"Feiyue Zhao, Zhibin Fan, Ruikang Jia, Qichao Liu, Menglei Wang, Jianliang Sui, Huiyun Liu","doi":"10.1155/2024/6202123","DOIUrl":"https://doi.org/10.1155/2024/6202123","url":null,"abstract":"Chronic gastric ulcer (CGU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Mesenchymal stem cells (MSCs) have been proven to have beneficial therapeutic effects in many human diseases. Here, a CGU model induced by acetic acid in mice was used to evaluate the repair effects and potential mechanism of human umbilical cord-derived MSCs (hUC-MSCs) and hUC-MSCs derived conditioned medium (hUC-MSC-CM). We found that hUC-MSCs and hUC-MSC-CM treatment significantly repaired morphological characteristics of CGU, improved proliferation and decreased apoptosis of gastric cells, and promoted the generation of new blood vessels in granulation tissues. In addition, we could detect the homing of MSCs in gastric tissue, and MSCs may differentiate into Lgr5-positive cells. As well as this, in vitro experiments showed that hUC-MSC-CM could promote cell proliferation, stimulate cell cycle progression, and reduce the incidence of apoptosis. The transcriptome of cells and the iTRAQ proteome of gastric tissues suggest that MSCs may play a therapeutic role by increasing the expression of TRIM29. Additionally, it was found that knocking down TRIM29 significantly decreased the ameliorative effects of hUC-MSC-CM on cell apoptosis. As a result of further molecular experiments, it was found that TRIM29 is capable of phosphorylating Erk/Akt in specific cell type. As a whole, it appears that hUC-MSCs can be an effective therapeutic approach for promoting gastric ulcer healing and may exert therapeutic effects in the form of paracrine and differentiation into gastric cells.","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"207 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139082617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose Tissue-Derived Extracellular Vesicles: A Promising Biomarker and Therapeutic Strategy for Metabolic Disorders 脂肪组织衍生的细胞外囊泡：代谢紊乱的有望生物标记物和治疗策略
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-26 DOI: 10.1155/2023/9517826
Wenhui Liu, Tianyan Liu, Qingyu Zhao, Junqiu Ma, Jiajia Jiang, Hui Shi
{"title":"Adipose Tissue-Derived Extracellular Vesicles: A Promising Biomarker and Therapeutic Strategy for Metabolic Disorders","authors":"Wenhui Liu, Tianyan Liu, Qingyu Zhao, Junqiu Ma, Jiajia Jiang, Hui Shi","doi":"10.1155/2023/9517826","DOIUrl":"https://doi.org/10.1155/2023/9517826","url":null,"abstract":"Adipose tissue plays an important role in systemic energy metabolism, and its dysfunction can lead to severe metabolic disorders. Various cells in adipose tissue communicate with each other to maintain metabolic homeostasis. Extracellular vesicles (EVs) are recognized as novel medium for remote intercellular communication by transferring various bioactive molecules from parental cells to distant target cells. Increasing evidence suggests that the endocrine functions of adipose tissue and even the metabolic homeostasis are largely affected by different cell-derived EVs, such as insulin signaling, lipolysis, and metabolically triggered inflammation regulations. Here, we provide an overview focused on the role of EVs released by different cell types of adipose tissue in metabolic diseases and their possible molecular mechanisms and highlight the potential applications of EVs as biomarkers and therapeutic targets. Moreover, the current EVs-based therapeutic strategies have also been discussed. This trial is registered with NCT05475418.","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"42 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139054858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats 撤回：负载在超可塑纳米脂质体黄芩苷 EDTMP（S-UNL-E）上的黄芩苷促进骨质疏松大鼠的骨生成
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-20 DOI: 10.1155/2023/9851693
Stem Cells International
{"title":"Retracted: Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats","authors":"Stem Cells International","doi":"10.1155/2023/9851693","DOIUrl":"https://doi.org/10.1155/2023/9851693","url":null,"abstract":"<jats:p />","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"76 18","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138956804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Exploring the Mechanism of Wenshen Huatan Quyu Decotion for PCOS Based on Network Pharmacology and Molecular Docking Verification. 撤回：基于网络药理学和分子对接验证的温神化瘀解毒丸治疗多囊卵巢综合征的机制探索
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-20 eCollection Date: 2023-01-01 DOI: 10.1155/2023/9872685
Stem Cells International
{"title":"Retracted: Exploring the Mechanism of Wenshen Huatan Quyu Decotion for PCOS Based on Network Pharmacology and Molecular Docking Verification.","authors":"Stem Cells International","doi":"10.1155/2023/9872685","DOIUrl":"10.1155/2023/9872685","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/3299091.].</p>","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"2023 ","pages":"9872685"},"PeriodicalIF":4.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10752714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Study of the Structure and Properties of ZnS Utilized in a Fluorescence Biosensor 撤回：荧光生物传感器中使用的 ZnS 的结构和特性研究
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-20 DOI: 10.1155/2023/9830605
Stem Cells International
{"title":"Retracted: Study of the Structure and Properties of ZnS Utilized in a Fluorescence Biosensor","authors":"Stem Cells International","doi":"10.1155/2023/9830605","DOIUrl":"https://doi.org/10.1155/2023/9830605","url":null,"abstract":"<jats:p />","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"19 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: miR-100-5p Is a Novel Biomarker That Suppresses the Proliferation, Migration, and Invasion in Skin Cutaneous Melanoma 撤稿：miR-100-5p 是一种抑制皮肤黑色素瘤增殖、迁移和侵袭的新型生物标记物
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-20 DOI: 10.1155/2023/9861375
Stem Cells International
{"title":"Retracted: miR-100-5p Is a Novel Biomarker That Suppresses the Proliferation, Migration, and Invasion in Skin Cutaneous Melanoma","authors":"Stem Cells International","doi":"10.1155/2023/9861375","DOIUrl":"https://doi.org/10.1155/2023/9861375","url":null,"abstract":"<jats:p />","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"34 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: miR-4780 Derived from N2-Like Neutrophil Exosome Aggravates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer. 撤稿：N2样中性粒细胞外泌体衍生的miR-4780会加剧结直肠癌的上皮-间充质转化和血管生成
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-20 eCollection Date: 2023-01-01 DOI: 10.1155/2023/9875371
Stem Cells International
{"title":"Retracted: miR-4780 Derived from N2-Like Neutrophil Exosome Aggravates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer.","authors":"Stem Cells International","doi":"10.1155/2023/9875371","DOIUrl":"10.1155/2023/9875371","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2023/2759679.].</p>","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"2023 ","pages":"9875371"},"PeriodicalIF":4.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10752705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Effects of Fibulin-5 Gene Silencing on Proliferation and Apoptosis of IgG4-ROD Lacrimal Gland Fibroblasts 撤回：Fibulin-5基因沉默对IgG4-ROD泪腺成纤维细胞增殖和凋亡的影响
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-20 DOI: 10.1155/2023/9856916
Stem Cells International
{"title":"Retracted: Effects of Fibulin-5 Gene Silencing on Proliferation and Apoptosis of IgG4-ROD Lacrimal Gland Fibroblasts","authors":"Stem Cells International","doi":"10.1155/2023/9856916","DOIUrl":"https://doi.org/10.1155/2023/9856916","url":null,"abstract":"<jats:p />","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"76 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination Therapy with Platelet-Rich Plasma and Epidermal Neural Crest Stem Cells Increases Treatment Efficacy in Vascular Dementia 富血小板血浆和表皮神经干细胞联合疗法可提高血管性痴呆症的疗效
IF 4.3 3区 医学
Stem Cells International Pub Date : 2023-12-18 DOI: 10.1155/2023/3784843
Somayeh Akbari, Masoud Haghani, Mojtaba Ghobadi, Etrat Hooshmandi, Afshin Borhani Haghighi, Mohammad Saied Salehi, Sareh Pandamooz, Negar Azarpira, Afsoon Afshari, Shahrbanoo Zabihi, Marzieh Nemati, Mahnaz Bayat
{"title":"Combination Therapy with Platelet-Rich Plasma and Epidermal Neural Crest Stem Cells Increases Treatment Efficacy in Vascular Dementia","authors":"Somayeh Akbari, Masoud Haghani, Mojtaba Ghobadi, Etrat Hooshmandi, Afshin Borhani Haghighi, Mohammad Saied Salehi, Sareh Pandamooz, Negar Azarpira, Afsoon Afshari, Shahrbanoo Zabihi, Marzieh Nemati, Mahnaz Bayat","doi":"10.1155/2023/3784843","DOIUrl":"https://doi.org/10.1155/2023/3784843","url":null,"abstract":"This study aimed to evaluate the efficacy and treatment mechanism of platelet-rich plasma (PRP) and neural crest-derived epidermal stem cells (ESCs) in their administration alone and combination in vascular dementia (VaD) model by two-vessel occlusion (2VO). <i>Methods</i>. Sixty-six rats were divided into six groups: the control, sham, 2VO + vehicle, 2VO + PRP, 2VO + ESC, and 2VO + ESC + PRP. The treated groups received 1 million cells on days 4, 14, and 21 with or without 500 <i>µ</i>l PRP (twice a week) after 2VO. The memory performance and anxiety were evaluated by behavioral tests including open field, passive avoidance, and Morris water maze. The basal-synaptic transmission (BST) and long-term potentiation (LTP) were assessed through field-potential recordings of the CA1. The mRNA expression levels of IGF-1, TGF-<i>β</i>1, PSD-95, and GSk-3<i>β</i> were measured in the rat hippocampus by quantitative reverse transcription polymerase chain reaction. <i>Results</i>. The results demonstrated impaired learning, memory, and synaptic plasticity in the 2VO rats, along with a significant decrease in the expression of IGF-1, TGF-<i>β</i>1, PSD-95, and upregulation of GSK-3<i>β</i>. Treatment with ESC alone and ESC + PRP showed similar improvements in spatial memory and LTP induction, with associated upregulation of PSD-95 and downregulation of GSK-3<i>β</i>. However, only the ESC + PRP group showed recovery in BST. Furthermore, combination therapy was more effective than PRP monotherapy for LTP and memory. <i>Conclusions</i>. The transplantation of ESC showed better effects than PRP alone, and combination therapy increased the treatment efficacy with the recovery of BST. This finding may be a clue for the combination therapy of ESC and PRP for VaD.","PeriodicalId":21962,"journal":{"name":"Stem Cells International","volume":"1 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138715553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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