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Stem Cell Reviews and Reports最新文献

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The Invisible Variables: Why Clonal Systems are not Immune to Environmental Confounding. 看不见的变量：为什么克隆系统不能对环境混杂免疫。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-10 DOI: 10.1007/s12015-026-11239-w
Onishi Tatsuki
{"title":"The Invisible Variables: Why Clonal Systems are not Immune to Environmental Confounding.","authors":"Onishi Tatsuki","doi":"10.1007/s12015-026-11239-w","DOIUrl":"https://doi.org/10.1007/s12015-026-11239-w","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membrane-Bound and Dual-Source Nuclear β-Catenin in hESC Fate Control. 膜结合和双源核β-Catenin在hESC命运控制中的作用。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-10 DOI: 10.1007/s12015-026-11238-x
Yuanzheng Ma, Ziwei Luo, Liujiang Dai
{"title":"Membrane-Bound and Dual-Source Nuclear β-Catenin in hESC Fate Control.","authors":"Yuanzheng Ma, Ziwei Luo, Liujiang Dai","doi":"10.1007/s12015-026-11238-x","DOIUrl":"https://doi.org/10.1007/s12015-026-11238-x","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GDF15 and Skeletal Stromal-Cell Fate in Osteoporosis: Separating Systemic Stress Signaling from Local Causal Evidence. 骨质疏松症中的GDF15和骨骼基质细胞命运：从局部因果证据中分离系统应激信号。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-08 DOI: 10.1007/s12015-026-11224-3
Xueyang Wang, Weiyi Huang, Ruiqi Zhang, Zeping Li, Tianfu Ran, Ye Chen, Linglong Liu, Yuhuan Zhong
{"title":"GDF15 and Skeletal Stromal-Cell Fate in Osteoporosis: Separating Systemic Stress Signaling from Local Causal Evidence.","authors":"Xueyang Wang, Weiyi Huang, Ruiqi Zhang, Zeping Li, Tianfu Ran, Ye Chen, Linglong Liu, Yuhuan Zhong","doi":"10.1007/s12015-026-11224-3","DOIUrl":"https://doi.org/10.1007/s12015-026-11224-3","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation. 鼓包祖细胞：毛囊再生和临床转化的一个有前途的前沿。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-05 DOI: 10.1007/s12015-026-11232-3
Mamata Mishra, Rinky Kapoor, Maushmi S Kumar, Debraj Shome, Ashwin Prabhughate
{"title":"Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation.","authors":"Mamata Mishra, Rinky Kapoor, Maushmi S Kumar, Debraj Shome, Ashwin Prabhughate","doi":"10.1007/s12015-026-11232-3","DOIUrl":"https://doi.org/10.1007/s12015-026-11232-3","url":null,"abstract":"<p><strong>Highlight: </strong>• Bulge progenitors' cells (BPC) are multipotent cells that fuel hair follicle cycling, sebaceous turnover, and epidermal repair.• BPC activation from quiescence is governed by niche-derived Wnt/β-catenin (anagen entry), BMP antagonism (licensing transit), and TGF-β/Smad (catagen enforcement).• Preclinical models demonstrate de novo folliculogenesis using BPC- dermal papilla cell recombinants in 3D scaffolds, with > 70% graft viability and restored cyclic hair growth.• Early-phase clinical trials of autologous BPC-enriched micrografts report 20-30% increases in hair density in androgenetic alopecia, with minimal adverse events.• Translational realization demands GMP-compliant isolation, biomimetic niche engineering (hydrogels, bioprinting), and immunomodulatory strategies to ensure safety, scalability, and durability.</p>","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One Ligand, Two Messages: How JAG2 Reconciles Self-Renewal and Differentiation in Muscle Stem Cells. 一个配体，两个信息：JAG2如何协调肌肉干细胞的自我更新和分化。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-04 DOI: 10.1007/s12015-026-11230-5
Janitri Venkatachala Babu, Kandasamy Nagarajan ArulJothi, Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn
{"title":"One Ligand, Two Messages: How JAG2 Reconciles Self-Renewal and Differentiation in Muscle Stem Cells.","authors":"Janitri Venkatachala Babu, Kandasamy Nagarajan ArulJothi, Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn","doi":"10.1007/s12015-026-11230-5","DOIUrl":"https://doi.org/10.1007/s12015-026-11230-5","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Targeted Reconstitution of Follicular Signaling in Alopecia: Extending a Six-Factor Biomimetic Polypeptide Suite with BMP Antagonism, HGF, and SCF - the Zenith of Engineered Orchestration". 脱发中毛囊信号的靶向重建：扩展具有BMP拮抗、HGF和SCF的六因子仿生多肽套件——工程编排的顶峰。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-03 DOI: 10.1007/s12015-026-11223-4
Rinky Kapoor, Raji Patil, Debraj Shome, Prashant Anilkumar Singh, Sukesh M S, Imran Ali
{"title":"\"Targeted Reconstitution of Follicular Signaling in Alopecia: Extending a Six-Factor Biomimetic Polypeptide Suite with BMP Antagonism, HGF, and SCF - the Zenith of Engineered Orchestration\".","authors":"Rinky Kapoor, Raji Patil, Debraj Shome, Prashant Anilkumar Singh, Sukesh M S, Imran Ali","doi":"10.1007/s12015-026-11223-4","DOIUrl":"https://doi.org/10.1007/s12015-026-11223-4","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Growth Factor Abundance: Why Hair Regeneration Needs Pathway-Oriented Design? 超越生长因子丰度：为什么头发再生需要通路导向的设计？
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-03 DOI: 10.1007/s12015-026-11229-y
Monalisha Debnath, Rinky Kapoor, Raji Patil, Varad Saptarshi, Debraj Shome
{"title":"Beyond Growth Factor Abundance: Why Hair Regeneration Needs Pathway-Oriented Design?","authors":"Monalisha Debnath, Rinky Kapoor, Raji Patil, Varad Saptarshi, Debraj Shome","doi":"10.1007/s12015-026-11229-y","DOIUrl":"https://doi.org/10.1007/s12015-026-11229-y","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nitinol Stented Vessels: Integrating Pathological Triad of Inflammation, Hypoxia and Mechanical Stress to Rethink Endothelial Protection. 镍钛诺支架血管：结合炎症、缺氧和机械应力的病理三因素重新思考内皮保护。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-02 DOI: 10.1007/s12015-026-11226-1
Temur Nasibov, Anna Gorokhova, Igor Khlusov, Kristina Yurova, Larisa Litvinova, Alex Volinsky
{"title":"The Nitinol Stented Vessels: Integrating Pathological Triad of Inflammation, Hypoxia and Mechanical Stress to Rethink Endothelial Protection.","authors":"Temur Nasibov, Anna Gorokhova, Igor Khlusov, Kristina Yurova, Larisa Litvinova, Alex Volinsky","doi":"10.1007/s12015-026-11226-1","DOIUrl":"https://doi.org/10.1007/s12015-026-11226-1","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Remission: Risk-Adapted Maintenance and Mechanism-Guided Salvage After CAR T-Cell Therapy for Multiple Myeloma. 超过缓解：CAR - t细胞治疗多发性骨髓瘤后的风险适应性维持和机制引导的挽救。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-09-02 DOI: 10.1007/s12015-026-11228-z
Shuai Su, Sijia Yan, Jiaying Wu, Yi Xiao
{"title":"Beyond Remission: Risk-Adapted Maintenance and Mechanism-Guided Salvage After CAR T-Cell Therapy for Multiple Myeloma.","authors":"Shuai Su, Sijia Yan, Jiaying Wu, Yi Xiao","doi":"10.1007/s12015-026-11228-z","DOIUrl":"https://doi.org/10.1007/s12015-026-11228-z","url":null,"abstract":"<p><strong>Background: </strong>B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy can induce deep responses in relapsed or refractory multiple myeloma, yet relapse remains frequent. Neither post-infusion maintenance nor salvage after CAR T-cell failure has an established standard.</p><p><strong>Main text: </strong>This review synthesizes pivotal trials, real-world cohorts, and translational studies into a risk-adapted framework for longitudinal care. Relapse biology, target modulation, CAR T-cell persistence, immune reconstitution, measurable residual disease (MRD), and imaging are integrated to guide structured observation, time-limited maintenance, pre-emptive intervention, and salvage. Preventive treatment is defensible only when the estimated risk posed by residual disease exceeds the competing risks of infection, cytopenia, and delayed immune recovery. At relapse, treatment selection should begin with clinical tempo, disease compartment, contemporary expression of BCMA, G protein-coupled receptor class C group 5 member D (GPRC5D), and Fc receptor-homolog 5 (FcRH5), prior target pressure, and host immune fitness.</p><p><strong>Conclusions: </strong>Structured observation is appropriate for many patients with sustained MRD negativity, no extramedullary disease, and recovering immune function. Persistent or rising MRD, residual lesions, aggressive disease biology, or unfavorable CAR T-cell kinetics should prompt early trial referral rather than automatic chronic therapy. Salvage may involve BCMA retargeting, a switch to GPRC5D or FcRH5, conventional cytoreduction, radiotherapy, antibody-drug conjugates, bispecific antibodies, or a second cellular platform. Future trials should assess progression-free survival together with infection-free survival, treatment-free interval, immune recovery, quality of life, and responsiveness to subsequent salvage.</p>","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADSCs and ADSC-EVs for Female Stress Urinary Incontinence Repair: A Translational Framework Linking Potency, Local Exposure, and Recipient-Cell Networks. ADSCs和adsc - ev用于女性压力性尿失禁修复：连接效力、局部暴露和受体细胞网络的翻译框架。
IF 4.9 3区 医学
Stem Cell Reviews and Reports Pub Date : 2026-08-31 DOI: 10.1007/s12015-026-11227-0
Keqing Zhang, Mingmei Ding, Siqi Bai, Zhengyu Hua, Zhen Xiao
{"title":"ADSCs and ADSC-EVs for Female Stress Urinary Incontinence Repair: A Translational Framework Linking Potency, Local Exposure, and Recipient-Cell Networks.","authors":"Keqing Zhang, Mingmei Ding, Siqi Bai, Zhengyu Hua, Zhen Xiao","doi":"10.1007/s12015-026-11227-0","DOIUrl":"https://doi.org/10.1007/s12015-026-11227-0","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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