揭开表观遗传交响乐的神秘面纱：骨重塑与疾病中的组蛋白乙酰化协调

IF 4.5 3区医学 Q2 CELL & TISSUE ENGINEERING

Stem Cell Reviews and Reports Pub Date : 2024-11-04 DOI:10.1007/s12015-024-10807-2

Jingyi Cai, Yudi Deng, Ziyang Min, Chaoyuan Li, Zhihe Zhao, Jianru Yi, Dian Jing

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引用次数: 0

摘要

组蛋白乙酰化是基因表达的复杂交响乐，控制着细胞的命运和活动，包括骨重塑的复杂过程。尽管组蛋白乙酰化的重要性已得到证实，但由于其复杂性，一直缺乏对这一过程的系统阐述，从而阻碍了临床应用。在这篇综述中，我们将深入研究组蛋白乙酰化的核心调控因子，揭示它们在调节骨生理过程中的多方面作用。我们探讨了这些调控因子之间相互矛盾和重叠的作用，并评估了它们作为各种骨骼疾病治疗靶点的潜力。此外，我们还强调了目前的应用，并讨论了在骨病中更有效地利用表观遗传疗法的潜在问题，旨在解决知识和临床实践方面的差距。通过全景式地展示组蛋白乙酰化对骨骼健康和疾病的影响，这篇综述揭示了有希望的治疗干预途径，并加深了我们对骨骼生理学的理解，这对提高治疗效果和患者生活质量至关重要。

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Unlocking the Epigenetic Symphony: Histone Acetylation Orchestration in Bone Remodeling and Diseases.

Histone acetylation orchestrates a complex symphony of gene expression that controls cellular fate and activities, including the intricate processes of bone remodeling. Despite its proven significance, a systematic illustration of this process has been lacking due to its complexity, impeding clinical application. In this review, we delve into the central regulators of histone acetylation, unveiling their multifaceted roles in modulating bone physiology. We explore both contradictory and overlapping roles among these regulators and assess their potential as therapeutic targets for various bone disorders. Furthermore, we highlight current applications and discuss looming questions for a more effective use of epigenetic therapy in bone diseases, aiming to address gaps in knowledge and clinical practice. By providing a panoramic view of histone acetylation's impact on bone health and disease, this review unveils promising avenues for therapeutic intervention and enhances our understanding of skeletal physiology, crucial for improving therapeutical outcomes and quality of patients' life.

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.