Stem Cell Reviews and Reports最新文献_第3页

Single cell, Label free Characterisation of Human Mesenchymal Stromal cell Stemness and Future Growth Potential by Autofluorescence Multispectral Imaging. 通过自发荧光多光谱成像技术对人间质基质细胞干性和未来生长潜力进行单细胞、无标记表征。

IF 5.4 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.1007/s12015-024-10778-4

Jared M Campbell, Abbas Habibalahi, Adnan Agha, Shannon Handley, Aline Knab, Xiaohu Xu, Akanksha Bhargava, Zhilin Lei, Max Mackevicius, Yuan Tian, Saabah B Mahbub, Ayad G Anwer, Stan Gronthos, Sharon Paton, Shane T Grey, Lindsay Wu, Robert B Gilchrist, Ewa M Goldys

{"title":"Single cell, Label free Characterisation of Human Mesenchymal Stromal cell Stemness and Future Growth Potential by Autofluorescence Multispectral Imaging.","authors":"Jared M Campbell, Abbas Habibalahi, Adnan Agha, Shannon Handley, Aline Knab, Xiaohu Xu, Akanksha Bhargava, Zhilin Lei, Max Mackevicius, Yuan Tian, Saabah B Mahbub, Ayad G Anwer, Stan Gronthos, Sharon Paton, Shane T Grey, Lindsay Wu, Robert B Gilchrist, Ewa M Goldys","doi":"10.1007/s12015-024-10778-4","DOIUrl":"10.1007/s12015-024-10778-4","url":null,"abstract":"Aim: To use autofluorescence multispectral imaging (AFMI) to develop a non-invasive assay for the in-depth characterisation of human bone marrow derived mesenchymal stromal cells (hBM-MSCs).Methods: hBM-MSCs were imaged by AFMI on gridded dishes, stained for endpoints of interest (STRO-1 positivity, alkaline phosphatase, beta galactosidase, DNA content) then relocated and results correlated. Intensity, texture and morphological features were used to characterise the colour distribution of regions of interest, and canonical discriminant analysis was used to separate groups. Additionally, hBM-MSC lines were cultured to arrest, with AFMI images taken after each passage to investigate whether an assay could be developed for growth potential.Results: STRO-1 positivity could be predicted with a receiver operator characteristic area under the curve (AUC) of 0.67. For spontaneous differentiation this was 0.66, for entry to the cell-cycle it was 0.77 and for senescence it was 0.77. Growth potential (population doublings remaining) was estimated with an RMSPE = 2.296. The Mean Absolute Error of the final prediction model indicated that growth potential could be predicted with an error of ± 1.86 doublings remaining.Conclusions: This non-invasive methodology enabled the in-depth characterisation of hBM-MSCs from a single assay. This approach is advantageous for clinical applications as well as research and stands out for the characterisation of both present status as well as future behaviour. The use of data from five MSC lines with heterogenous AFMI profiles supports potential generalisability.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2283-2292"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Conventional Treatments: Exploring CAR-T Cell Therapy for Cancer Stem Cell Eradication. 超越传统疗法：探索消除癌症干细胞的 CAR-T 细胞疗法。

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-09-23 DOI: 10.1007/s12015-024-10786-4

Lobna E Rabie, Ahmed A Mohran, Kholoud A Gaber, Nour M Ali, Asmaa M Abd El Naby, Eman A Ghoniem, Basmala A Abd Elmaksod, Ahmed N Abdallah

{"title":"Beyond Conventional Treatments: Exploring CAR-T Cell Therapy for Cancer Stem Cell Eradication.","authors":"Lobna E Rabie, Ahmed A Mohran, Kholoud A Gaber, Nour M Ali, Asmaa M Abd El Naby, Eman A Ghoniem, Basmala A Abd Elmaksod, Ahmed N Abdallah","doi":"10.1007/s12015-024-10786-4","DOIUrl":"10.1007/s12015-024-10786-4","url":null,"abstract":"Background: For decades cancer remained the center of attention in the scientific community as its survival rates are low. Researchers from all around the world wanted to know the core of the problem as to what initiates cancer in a patient and helps with its progression. Many postulations came to light, but Cancer Stem Cells (CSC) was the most appealing and convincing.Main body: In this review, we shed light on a potential solution to the problem by reviewing CAR-T cells (Chimeric antigen receptor T cells). These specialized T cells are designed to detect specific antigens on cancer cells. We analyse the steps of their formation from the collection of T cells from the patient's bloodstream and modifying it to exhibit specific CAR structures on their surfaces, to reinjecting them back and evaluating their efficacy. We thoroughly investigate the structure of the CAR design with improvements across different generations. The focus extends to the unique properties of CSCs as in how targeting specific markers on them can enhance the precision of cancer therapy.Conclusion: Despite the successes, the review discusses the existing limitations and toxicities associated with CAR-derived therapies, highlighting the ongoing need for research and refinement. Looking ahead, we explore proposed strategies aimed at optimizing CAR-T cell therapy to mitigate adverse effects for improved cancer treatments.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2001-2015"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Replicative Senescence of Human Chorionic MSCs on their EV-miRNA Profile. 人绒毛膜间充质干细胞复制衰老对其 EV-miRNA 图谱的影响

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-09-21 DOI: 10.1007/s12015-024-10790-8

Hedviga Košuthová, Lívia K Fecskeová, Jana Matejová, Lucia Slovinská, Marko Morávek, Zuzana Bártová, Denisa Harvanová

{"title":"Effects of Replicative Senescence of Human Chorionic MSCs on their EV-miRNA Profile.","authors":"Hedviga Košuthová, Lívia K Fecskeová, Jana Matejová, Lucia Slovinská, Marko Morávek, Zuzana Bártová, Denisa Harvanová","doi":"10.1007/s12015-024-10790-8","DOIUrl":"10.1007/s12015-024-10790-8","url":null,"abstract":"Chorionic mesenchymal stromal cells (CHO-MSCs) and their extracellular vesicles (EVs) are becoming increasingly popular, since chorion is ethically harmless and an easily accessible source of MSCs. However, until now there is only a limited number of studies with a thorough characterization of CHO-MSCs derived EVs and their miRNA profile. In this study, we monitored changes in the EV-miRNA profile between early and late passage of human CHO-MSCs. First, senescence of CHO-MSCs was induced by serial passaging and confirmed by morphological changes, shortened telomeres and changes in the expression of selected genes. The expression of MSCs-specific surface markers CD73, CD90, CD105 did not change with increasing passages. Next, EVs and their miRNA profiles were compared between early vs late passage cells. Number of EVs and their size were not significantly changed. Seven of the top 10 most expressed EV-miRNAs were common to both early and late passages. A differential expression study between early and late passages identified 37 significantly differentially expressed EV-miRNAs, out of which 23 were found to be associated with pathways of cellular senescence based on KEGG pathway analysis. A set of 9 miRNAs were identified as the most frequently associated with senescence and/or with the most altered expression between early and late passages, out of which miR-145-5p, miR-335-5p and miR-199b-3p were the most significant downregulated miRNAs in late passages. The most upregulated EV-miRNAs were miR-1307-3p, miR-3615 and miR320b. Targeting these miRNAs in future experiments may prolong the therapeutic potential of CHO-MSCs and their EVs.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2318-2335"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Tube Organoids: A Novel System to Study Developmental Timing. 神经管有机体：研究发育时间的新系统

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1007/s12015-024-10785-5

Alexa Rabeling, Amy van der Hoven, Nathalie Andersen, Mubeen Goolam

引用次数: 0

Mesenchymal Stem Cells Increase Resistance Against Ventricular Arrhythmias Provoked in Rats with Myocardial Infarction. 间充质干细胞增强心肌梗死大鼠对室性心律失常的抵抗力

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-08-22 DOI: 10.1007/s12015-024-10773-9

Larissa Emília Seibt, Ednei Luiz Antonio, Ighor Luiz AzevedoTeixeira, Helenita Antonia de Oliveira, André Rodrigues Lourenço Dias, Luis Felipe Neves Dos Santos, Andrey Jorge Serra

{"title":"Mesenchymal Stem Cells Increase Resistance Against Ventricular Arrhythmias Provoked in Rats with Myocardial Infarction.","authors":"Larissa Emília Seibt, Ednei Luiz Antonio, Ighor Luiz AzevedoTeixeira, Helenita Antonia de Oliveira, André Rodrigues Lourenço Dias, Luis Felipe Neves Dos Santos, Andrey Jorge Serra","doi":"10.1007/s12015-024-10773-9","DOIUrl":"10.1007/s12015-024-10773-9","url":null,"abstract":"This study evaluated the role of the mesenchymal stem cells derived from adipose tissue (MSCs) in provoked ventricular arrhythmias (VAs) in animals with myocardial infarction (MI). The experimental groups were: sham, subjected to sham surgery and intramyocardial saline injection; MIV, infarcted rats subjected to intramyocardial saline injection; MI + MSCs, infarcted rats subjected to intramyocardial MSCs injection. Injections were performed two days after infarction and the arrhythmogenic inducibility experiment was performed the next day. Only 35% of the MI + MSCs group developed VAs, while the one in the MIV group was 65%. The proportion of nonsustained ventricular tachycardia, sustained tachycardia, and ventricular fibrillation was similar between the infarcted groups, but MSCs animals had shorter duration of nonsustained ventricular tachycardia. However, MSCs increased connexin 43 content in the remote area, even above the levels found in the sham group. MSCs prevented the increase of IL-1β in the different areas of the myocardium. There was higher carbonylation and content of 4-hydroxynonenal (4-HNE, a marker of lipoperoxidation) in the myocardium of infarcted rats, but MSCs attenuated the increase of 4-HNE in the infarcted area. In conclusion, MSCs have a protective effect against the development of arrhythmias, but do not imply a significant benefit for animals that have developed VAs. It is possible to think that the cardioprotection of MSCs involves anti-inflammatory/oxidative actions and improvement in the formation of communicating junctions.Graphical abstract.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2293-2302"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group. 合并症和血管生成调节因子会影响健康志愿者对照组的内皮祖细胞亚型数量。

IF 5.4 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.1007/s12015-024-10777-5

Kamini Rakkar, Rais Reskiawan A Kadir, Othman A Othman, Nikola Sprigg, Philip M Bath, Ulvi Bayraktutan

{"title":"Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group.","authors":"Kamini Rakkar, Rais Reskiawan A Kadir, Othman A Othman, Nikola Sprigg, Philip M Bath, Ulvi Bayraktutan","doi":"10.1007/s12015-024-10777-5","DOIUrl":"10.1007/s12015-024-10777-5","url":null,"abstract":"Endothelial progenitor cells (EPCs) are stem cells that can repair injured blood vessels through neovascularisation. This is achieved through secretion of growth factors and endothelial maturation. EPC numbers and function have been studied to determine their diagnostic, prognostic and therapeutic potential in many ischaemic diseases such as stroke. However their activation homing and migration is not definitively understood in stroke patients. In this study, we profiled the non-stroke control group recruited into the Dunhill Medical Trust Endothelial Progenitor Cell Study. Demographic, clinical and plasma levels of angiogenic regulators of participants were analysed to determine if there was any correlation with EPC numbers, subtypes and function. Participants with diabetes had significantly supressed EPC numbers (CD45-CD34 + CD133 + KDR+) and CD34 + KDR + and KDR + EPC subtypes. Male participants had significantly lower EPC numbers compared to female participants and the proliferative capacity of endothelial colony forming cells significantly decreased with increasing participant age. Pro-angiogenic proteins such as granulocyte colony-stimulating factor and stromal cell-derived factor were positively correlated with both undifferentiated and endothelial-committed EPC subtype numbers (CD133+, KDR+, CD34 + CD133+, CD34 + KDR+), whereas anti-angiogenic proteins such as thrombospondin-1 showed a negative correlation with undifferentiated EPC subtypes (CD133+, CD34 + CD133+) but a positive correlation with endothelial-committed EPC subtype numbers (KDR+, CD34 + KDR+). These results show that EPC numbers and subtypes are affected by many factors and larger studies which can analyse and deconvolute the interactions between comorbidities, plasma biomarker levels and EPC are needed.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2336-2344"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Non-Surgical Curative Regenerative Therapies for Knee Osteoarthritis. 目前治疗膝关节骨性关节炎的非手术治疗性再生疗法。

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-08-15 DOI: 10.1007/s12015-024-10768-6

Ali Bahari Golamkaboudi, Elham Vojoudi, Kosar Babaeian Roshani, Pejman Porouhan, David Houshangi, Zahra Barabadi

{"title":"Current Non-Surgical Curative Regenerative Therapies for Knee Osteoarthritis.","authors":"Ali Bahari Golamkaboudi, Elham Vojoudi, Kosar Babaeian Roshani, Pejman Porouhan, David Houshangi, Zahra Barabadi","doi":"10.1007/s12015-024-10768-6","DOIUrl":"10.1007/s12015-024-10768-6","url":null,"abstract":"Osteoarthritis (OA) is a prevalent musculoskeletal disease affecting middle-aged and elderly individuals, with knee pain as a common complaint. Standard therapy approaches generally attempt to alleviate pain and inflammation, using various pharmacological and non-pharmacological options. However, the efficacy of these therapies in long-term tissue repair remains debated. As an alternative, regenerative medicine offers a promising strategy, with decreased adverse event rates and increasing evidence of safety and efficacy. This review will outline current advances in regenerative medicine for knee OA, emphasizing outpatient clinic-based therapies that use orthobiological and non-biological products. Different strategies based on orthobiologics are discussed as potential regenerative options for the management of knee OA. Cell-free therapies including platelet-rich plasma, autologous anti-inflammatories, exosomes, human placenta extract, and mitochondrial transplantation are discussed, focusing on their potential for cartilage regeneration. Additionally, cell-based therapies with regenerative properties including bone marrow aspirate concentrate, adipose stromal vascular fraction, microfat, nanofat, stem cell therapy, and genetically modified cells as part of orthobiologics, are being investigated. Also, this study is looking into non-biological approaches such as using gold-induced cytokines, extracorporeal shockwave therapy, and ozone therapy. The mechanisms of action, effectiveness, and clinical applications of each therapy are being explored, providing insights into their role in the management of knee OA.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2104-2123"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Applications of Engineered Mesenchymal Stromal Cells for Enhanced Angiogenesis in Cardiac and Cerebral Ischemia. 工程间充质基质细胞在心脑缺血中促进血管生成的治疗应用。

IF 5.4 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-09-21 DOI: 10.1007/s12015-024-10787-3

Madhavi Hegde, Abhishek Kumar Singh, Suresh Kannan, Udaykumar Kolkundkar, Raviraja N Seetharam

{"title":"Therapeutic Applications of Engineered Mesenchymal Stromal Cells for Enhanced Angiogenesis in Cardiac and Cerebral Ischemia.","authors":"Madhavi Hegde, Abhishek Kumar Singh, Suresh Kannan, Udaykumar Kolkundkar, Raviraja N Seetharam","doi":"10.1007/s12015-024-10787-3","DOIUrl":"10.1007/s12015-024-10787-3","url":null,"abstract":"Ischemic diseases are characterized by obstruction of blood flow to the respective organs, of which ischemia of the heart and brain are the most prominent manifestations with shared pathophysiological mechanisms and risk factors. While most revascularization therapies aim to restore blood flow, this can be challenging due to the limited therapeutic window available for treatment approaches. For a very long time, mesenchymal stromal cells have been used to treat cerebral and cardiac ischemia. However, their application is restricted either by inefficient mode of delivery or the low cell survival rates following implantation into the ischemic microenvironment. Nonetheless, several studies are currently focusing on using of mesenchymal stromal cells engineered to overexpress therapeutic genes as a cell-based gene therapy to restore angiogenesis. This review delves into the utilization of MSCs for angiogenesis and the applications of engineered MSCs for the treatment of cardiac and cerebral ischemia. Moreover, the safety issues related to the genetic modification of MSCs have also been discussed.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2138-2154"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage. 牙源性干细胞疗法及其衍生的细胞外小泡在 COVID-19 综合征后组织损伤中的作用

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI: 10.1007/s12015-024-10770-y

Mitra Rostami, Pouria Farahani, Samar Esmaelian, Zahra Bahman, Abbas Fadel Hussein, Hareth A Alrikabi, Mohammad Hosseini Hooshiar, Saman Yasamineh

{"title":"The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage.","authors":"Mitra Rostami, Pouria Farahani, Samar Esmaelian, Zahra Bahman, Abbas Fadel Hussein, Hareth A Alrikabi, Mohammad Hosseini Hooshiar, Saman Yasamineh","doi":"10.1007/s12015-024-10770-y","DOIUrl":"10.1007/s12015-024-10770-y","url":null,"abstract":"Long coronavirus disease 2019 (COVID-19) is linked to an increased risk of post-acute sequelae affecting the pulmonary and extrapulmonary organ systems. Up to 20% of COVID-19 patients may proceed to a more serious form, such as severe pneumonia, acute respiratory distress syndrome (ARDS), or pulmonary fibrosis. Still, the majority of patients may only have mild, self-limiting sickness. Of particular concern is the possibility of parenchymal fibrosis and lung dysfunction in long-term COVID-19 patients. Furthermore, it has been observed that up to 43% of individuals hospitalized with COVID-19 also had acute renal injury (AKI). Care for kidney, brain, lung, cardiovascular, liver, ocular, and tissue injuries should be included in post-acute COVID-19 treatment. As a powerful immunomodulatory tool in regenerative medicine, dental stem cells (DSCs) have drawn much interest. Numerous immune cells and cytokines are involved in the excessive inflammatory response, which also has a significant effect on tissue regeneration. A unique reservoir of stem cells (SCs) for treating acute lung injury (ALI), liver damage, neurological diseases, cardiovascular issues, and renal damage may be found in tooth tissue, according to much research. Moreover, a growing corpus of in vivo research is connecting DSC-derived extracellular vesicles (DSC-EVs), which are essential paracrine effectors, to the beneficial effects of DSCs. DSC-EVs, which contain bioactive components and therapeutic potential in certain disorders, have been shown as potentially effective therapies for tissue damage after COVID-19. Consequently, we explore the properties of DSCs in this work. Next, we'll look at how SARS-CoV-2 affects tissue damage. Lastly, we have looked at the use of DSCs and DSC-EVs in managing COVID-19 and chronic tissue damage, such as injury to the heart, brain, lung, and other tissues.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2062-2103"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Basic Studies of Low-Intensity Pulsed Ultrasound in Periodontal Tissue Regeneration: A Systematic Review. 低强度脉冲超声在牙周组织再生中的基础研究最新进展：系统回顾

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1007/s12015-024-10769-5

Facai Li, Yujiao Li, Yuan Zhu, Xiaomei Bao, Lei Wang

{"title":"Recent Advances in Basic Studies of Low-Intensity Pulsed Ultrasound in Periodontal Tissue Regeneration: A Systematic Review.","authors":"Facai Li, Yujiao Li, Yuan Zhu, Xiaomei Bao, Lei Wang","doi":"10.1007/s12015-024-10769-5","DOIUrl":"10.1007/s12015-024-10769-5","url":null,"abstract":"Approximately half of the adult population is suffering from periodontal disease, and conventional periodontal treatment strategies can only slow the progression of the disease. As a kind of tissue engineering, periodontal regeneration brings hope for the treatment of periodontal disease. Low-intensity pulsed ultrasound (LIPUS) is a form of ultrasound with a frequency of 1-3 MHz and a much lower intensity (< 1W/cm2) than traditional ultrasound energy and output. LIPUS has been adopted for a variety of therapeutic purposes due to its bioeffects such as thermal, mechanical, and cavitation effects, which induce intracellular biochemical effects and lead to tissue repair and regeneration ultimately. In this systematic review, we summarize the basic research of LIPUS in the treatment of periodontal disease in periodontal disease animal models and the influence of LIPUS on the biological behavior (including promoting osteogenic differentiation of stem cells and inhibiting inflammatory response) and potential mechanism of periodontal ligament stem cells (PDLSCs), hoping to provide new ideas for the treatment of periodontal disease. We believe that LIPUS can be used as an auxiliary strategy in the treatment of periodontal disease and play an exciting and positive role in periodontal regeneration.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"2124-2137"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0