International Journal on Biological Sciences最新文献

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COMPUTATIONAL EVALUATION OF PHYTOCHEMICAL CONSTITUENTS FROM MALUS PUMILA (APPLE) FOR BREAST CANCER TREATMENT 苹果植物化学成分对乳腺癌治疗的计算评价
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v13i2.1
Suneetha Yeguvapalli, Durga Rathikota
{"title":"COMPUTATIONAL EVALUATION OF PHYTOCHEMICAL CONSTITUENTS FROM MALUS PUMILA (APPLE) FOR BREAST CANCER TREATMENT","authors":"Suneetha Yeguvapalli, Durga Rathikota","doi":"10.53390/ijbs.v13i2.1","DOIUrl":"https://doi.org/10.53390/ijbs.v13i2.1","url":null,"abstract":"Apple is a widely consumed fruit that is accessible throughout the year and is high in phytochemicals. The current study's major goal is to use computational methodologies to discover new anti-cancer medication candidates from plants. The ligands of the plant malus pumila were docked with protein EGFR (PDB ID:1M17) to predict novel potential inhibitors that could be employed as anticancer medicines for breast cancer. Breast cancer is a complex disease with no known single cause that continues to be a global killer and the leading cause of cancer-related death in women. One of the first key targets of these emerging anticancer drugs was the epidermal growth factor receptor (EGFR).The physicochemical, pharmacokinetic, and drug-like properties help in the selection of the best compound for breast cancer treatment. Furthermore, a substantial study suggests that phytochemicals, which are plant secondary compounds have oncopreventive Properties.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131851616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IN VITRO CYTOTOXIC AND APOPTOTIC EFFECT OF CONCANAVALINS FROM CANAVALIA spp.ON BREAST CARCINOMA CELLS 菜豆蛋白对乳腺癌细胞的体外细胞毒性和凋亡作用
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v11i1.2
G. Suvarna, A. Prabhu, K. Muhseena N, B. B. Sharma
{"title":"IN VITRO CYTOTOXIC AND APOPTOTIC EFFECT OF CONCANAVALINS FROM CANAVALIA spp.\u0000ON BREAST CARCINOMA CELLS","authors":"G. Suvarna, A. Prabhu, K. Muhseena N, B. B. Sharma","doi":"10.53390/ijbs.v11i1.2","DOIUrl":"https://doi.org/10.53390/ijbs.v11i1.2","url":null,"abstract":"Concanavalins from Canavalia spp. possess diverse bioactivities and exhibit potent anticancer effects. In this study we assessed the cytotoxic activity of concanavalins from Canavalia spp. on human breast carcinoma MCF-7 cells. The lectins concanavalin A (ConA), concanavalin C (ConC), concanavalin G (ConG) and concanavalin M (ConM) were\u0000isolated from seeds of C. ensiformis, C. cathartica, C. gladiata and C. rosea respectively. ConAand ConG demonstrated strong inhibitory effect on MCF-7 cell proliferation with IC values 81.66 µg/mLand 81.09 µg/mLrespectively, with no 50 significant effect in normal kidney HEK293T cells. MCF-7 cells treated with ConA and ConG showed apoptotic\u0000morphological changes and accumulation of sub-G /G proportion, suggesting stimulation of apoptotic pathway. These 0 1 results uphold the anticancer potential of concanavalins.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115498869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A STUDY ON THREE MAJOR FOREST INVASIVE SPECIES COMMON ALONG THE SHIVALIK BELT OF HIMACHAL PRADESH KASHMIR, PUNJAB AND UTTARAKHAND, INDIA 印度喜马偕尔邦克什米尔、旁遮普和北阿坎德邦shivalik带常见的三种主要森林入侵物种研究
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v12i2.4
P. Padmanabhan, Nidhi Srivastava, G. Kaur, A. Thakur
{"title":"A STUDY ON THREE MAJOR FOREST INVASIVE SPECIES COMMON ALONG THE SHIVALIK BELT OF HIMACHAL PRADESH KASHMIR, PUNJAB AND UTTARAKHAND, INDIA","authors":"P. Padmanabhan, Nidhi Srivastava, G. Kaur, A. Thakur","doi":"10.53390/ijbs.v12i2.4","DOIUrl":"https://doi.org/10.53390/ijbs.v12i2.4","url":null,"abstract":"Non-native/distant species that occur outside of their natural existence with good scattering ability are known as forest invasive species (FIS). Some alien species become invasive when they are introduced either purposely or accidentally, to a new environment where they exhibit an ability to conquer and dominatethe native species. There are ample literatures on such species in IHR (Indian Himalayan Region), when compared less is known in the Shivaliks. The present study is an attempt to review on three major FIS of the Shivalik belt of Himachal Pradesh, Kashmir, Punjab and Uttarakhand of North West India. Some of the plants that were intended to be beneficial have developed a notorious habit, as they are known for their adaptability, persistence, reproductive ability and exclusion of competition. It has drastically changed the composition of natural habitats, as well as the variety and dynamics of native flora. These species have become established outside of their native ranges and have learnt to thrive in this new ecological area. But with time, the situation has worsened as a result of a lack of knowledge, inadequate information about the species, its range and a large ecological amplitude.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122606304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LIFESTYLE AS RISK FACTOR FOR BREAST CANCER: A CASECONTROL STUDY IN CHENNAI, TAMIL NADU, INDIA 生活方式是乳腺癌的危险因素:印度泰米尔纳德邦金奈的病例对照研究
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v12.i1.3
K. Parvathy
{"title":"LIFESTYLE AS RISK FACTOR FOR BREAST CANCER: A CASECONTROL STUDY IN CHENNAI, TAMIL NADU, INDIA","authors":"K. Parvathy","doi":"10.53390/ijbs.v12.i1.3","DOIUrl":"https://doi.org/10.53390/ijbs.v12.i1.3","url":null,"abstract":"AIM: The present investigation was attempted to find out the possible life style risk factors for breast cancer among the breast cancer cases, using a case-control study in Chennai, Tamil Nadu, India.\u0000Methods: A total number of 512 breast cancer cases, from various hospitals of Chennai and 540 control women of same age group in same geographical area, were investigated using standard questionnaire that evaluated the various lifestyle risk factors for breast cancer such as BMI, physical exercise, psychological stress, abortion, lifestyle health problems and parity.\u0000Results: Karl Pearson's chi-square test was performed to determine the overall association between the lifestyle risk factors and breast cancer. The results revealed that all the lifestyle risk factors investigated were found to be highly significantly associated with breast cancer when compared with control women in Chennai.\u0000Conclusion: The lifestyle changes such as overall maintenance of BMI, increasing physical exercise, decreasing psychological stress using yoga, avoiding abortion, increasing parity and eating healthy traditional foods may reduce the\u0000risk of breast cancer","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130683526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
POPULATION DYNAMICS OF PROTOZOAN ECTOPARASITES IN SOME CAT FISHES INHABITING DOMRI RESERVOIR, BEED DISTRICT (M.S.) 蜂区多姆里水库几种猫鱼原生动物体外寄生虫种群动态(m.s。
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v12i2.1
P. Sirsat
{"title":"POPULATION DYNAMICS OF PROTOZOAN ECTOPARASITES IN SOME CAT FISHES INHABITING DOMRI RESERVOIR, BEED DISTRICT (M.S.)","authors":"P. Sirsat","doi":"10.53390/ijbs.v12i2.1","DOIUrl":"https://doi.org/10.53390/ijbs.v12i2.1","url":null,"abstract":"The present study was conducted to find out the prevalence and intensity of protozoan ectoparasites of freshwater catfishes. Total four species of protozoan parasites were collected from 294 fishes. Total three ectoparasites were observed during study period, July 2020 to June 2021. Among the ectoparasites, Ichthyoptherius is the most prevalent\u0000ectoparasites followed by Trichodina and Myxobolus. Among the infected fishes, Wallago attu (48.43%) harboured maximum number of ectoparasites followed by Ompok pabda (40.27%), Mystus cavasius (37.93%), and Mystus vittatus (32.78%). Due to the presence of these parasites, the physiological activities of the host fishes are hindered and their\u0000developmental growth is retarded which cause economic loss to the fishery industry","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114100634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AN APPRAISAL OF THE BIOLOGICAL DIVERSITY ACT, 2002 AND RULES, 2004 – STRENGTHS AND WEAKNESSES 对2002年《生物多样性法》和2004年《规则》的评价——优势和劣势
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v13i2.3
Jagtap Chandrashekhar, Charde Vaibhav, Babu Gajji
{"title":"AN APPRAISAL OF THE BIOLOGICAL DIVERSITY ACT, 2002 AND RULES, 2004 – STRENGTHS AND WEAKNESSES","authors":"Jagtap Chandrashekhar, Charde Vaibhav, Babu Gajji","doi":"10.53390/ijbs.v13i2.3","DOIUrl":"https://doi.org/10.53390/ijbs.v13i2.3","url":null,"abstract":"Aim: To create basic understanding of the Biological Diversity Act, 2002 and Rules 2004, along with their strengths, weaknesses, complexities, incongruities and provide some suggestions in them. Background: Biodiversity is the 'variety, variability, between genes, species and ecosystems'. It is very important for the survival of the human beings because it has direct consumptive value in food, medicine, agriculture, industry. Being one of the world's 'mega diversity' countries India, in order to ensure compliance with the Convention of Biological Diversity, 1992, enacted Biological Diversity Act in 2002 and the Biological Diversity Rules in April 2004. They are considered necessary for the conservation and sustainable use of biological diversity and regulate the access to biological resources of the country with the purpose of ensuring equitable share in benefits arising out of the uses of bioresources and associated knowledge to prevent the biopiracy. Review results: Though the objectives of the act are noble it has created confusions amongst the most biologists, researchers, herbal industry, raw drug suppliers and start up entrepreneurs. Along with certain strengths, there are some drawbacks like inadequate access to local communities, non-inclusion of genetic resources and complexities in access benefit sharing and equitable benefit sharing etc. Conclusion: Though the Act and Rules have some salient features there are some drawbacks and weaknesses which need to be rectified. Incorporation of the suggestions mentioned in this article can help in successfully dealing with the loopholes in the Biodiversity Act and Rules. However, till the next amendments in the legislation it is absolutely necessary for everybody in the fields related with the use of biological resources and traditional knowledge related to them to be apprised of the act.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"10862 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122718917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DETERMINATION OF MEDIAN TOLERANCE LIMIT (LC50) OF CHANNA PUNCTATA (BLOCH) FOR CADMIUM CHLORIDE 斑点鱼对氯化镉的中位容忍极限lc50的测定
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v12i2.9
A. Chandra, A. Verma
{"title":"DETERMINATION OF MEDIAN TOLERANCE LIMIT (LC50) OF CHANNA PUNCTATA (BLOCH) FOR CADMIUM CHLORIDE","authors":"A. Chandra, A. Verma","doi":"10.53390/ijbs.v12i2.9","DOIUrl":"https://doi.org/10.53390/ijbs.v12i2.9","url":null,"abstract":"The present investigation was undertaken to investigate the acute toxicity of cadmium, a heavy metal widely detected in the aquatic environment due to natural effects and anthropogenic activities, in freshwater teleost, Channa punctata (Bloch). The experiments for the bioassay were performed in semi-static test condition according to the standard\u0000guidelines. The behavioural changes in the fish were observed for all tested concentrations of the metal. The data obtained for bioassay were analyzed for median lethal concentrations (LC50) of the metal by SPSS computer software. The LC50\u0000values, estimated by SPSS, with 95% confidence level were found to be:20.589 (18.326-23.221), 17.133 (14.840- 19.734), 11.815 (9.696 – 13.850) mg/L and 9.908 (7.635-12381) mg/L for cadmium chloride at 24, 48, 72 and 96 h exposure, respectively.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"11 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125011502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
POSSIBLE TREATMENT APPROACHES FOR HEPATOCELLULAR CARCINOMA 肝细胞癌可能的治疗方法
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v12.i1.7
N. Yadav
{"title":"POSSIBLE TREATMENT APPROACHES FOR HEPATOCELLULAR CARCINOMA","authors":"N. Yadav","doi":"10.53390/ijbs.v12.i1.7","DOIUrl":"https://doi.org/10.53390/ijbs.v12.i1.7","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide. HCC patients are diagnosed in advanced stages, due to its poor prognosis. Currently, immunotherapy and chemotherapy are the best treatment options in >90 cases of liver cancer. Therefore, new treatment options are urgently needed for the cure of liver cancer. Use of nanotechnology and/or some natural compounds may become better options for liver cancer patients with minimum side effects and lower toxicity. This review focuses on present available treatment approaches for the management of liver cancer in patients.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126007636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TOXICOLOGICAL EFFICACY OF PINUSROXBURGHII SARG. AGAINST WATER BORNE PATHOGENS 刺梨松的毒理学效应。抵抗水媒病原体
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v12i2.6
R. Singh, R. C. Mishra, Bhasker Jyoti, R. K. Mishra, M. Agrawal
{"title":"TOXICOLOGICAL EFFICACY OF PINUSROXBURGHII SARG. AGAINST WATER BORNE PATHOGENS","authors":"R. Singh, R. C. Mishra, Bhasker Jyoti, R. K. Mishra, M. Agrawal","doi":"10.53390/ijbs.v12i2.6","DOIUrl":"https://doi.org/10.53390/ijbs.v12i2.6","url":null,"abstract":"The present investigation focused on the toxicological efficacy of essential oil of Pinus roxburghii Sarg. The oils were extracted from the leaves using hydro-distillation method. Further its toxicological efficacy was evaluated against Escherichia coli (MTCC-723),Klebsiella pneumoniae(MTCC No. 4032),Salmonella typhimurium (MTCC-3231) and\u0000Vibrio cholerae (MTCC-3906). Toxicological efficacy of essential oil was found highest against S. typhimurium. Inhibiting activity was also found against K. pneumoniae and E. coli (MTCC-723). Least activity was recorded against V. cholerae. Hence, essential oil from leaves of P. roxburghii exhibit great potential for the development of eco-friendly, nontoxic, cost-effective anti-bacterial herbal drug formulations.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114839259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NUTRITIONAL STATUS OF TEENAGERS IN URBAN AREA IN BAGHPAT, U.P. 巴格帕特市区青少年营养状况。
International Journal on Biological Sciences Pub Date : 1900-01-01 DOI: 10.53390/ijbs.v12i2.8
Prachi Singh, R. Mishra, O. P. Chauhan, A. Verma
{"title":"NUTRITIONAL STATUS OF TEENAGERS IN URBAN AREA IN BAGHPAT, U.P.","authors":"Prachi Singh, R. Mishra, O. P. Chauhan, A. Verma","doi":"10.53390/ijbs.v12i2.8","DOIUrl":"https://doi.org/10.53390/ijbs.v12i2.8","url":null,"abstract":"The active rising stage of childhood is referred to as school age. Children's malnutrition is one of India's most significant problems. This issue is still being addressed throughout the country. Malnutrition, which is caused by insufficient nutrition, weakens the immune system and causes significant developmental delays. The key metric for determining a child's nutritional and health condition, as well as an indirect indication of well-being for adults, is development assessment. We used a predesigned and pre-tested questionnaire, anthropometric assessments, and clinical analysis to\u0000conduct a cross-sectional study in urban slums of Baghpat, U.P. India, from August 2021 to October 2021 to investigate nutritional status in school-age slum children and examine factors associated with malnutrition. The mean height and weight of boys and girls in the sample population were lower below the CDC 2000 (Centers for Disease Control and Prevention) guidelines in all age groups. In terms of nutritional status, the age group 11 to 13 years had the highest incidence of stunting and underweight, whereas the age group 5 to 7 years had the highest prevalence of wasting.\u0000However, all illnesses are more common in children with refractive defects, although only anaemia and rickets have a statistically significant gender disparity. Malnutrition was shown to be substantially greater among children born in communal homes, infants whose mothers' training was [below or comparable to] 6th grade, and infants of working moms. The majority of our impoverished school-aged children were found malnourished. Food and nutrition knowledge based on skills, nutritional fortification, proactive infection prevention, public healthcare staff preparation, and delivery of\u0000comprehensive services are all encouraged.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124492320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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