{"title":"COMPUTATIONAL EVALUATION OF PHYTOCHEMICAL CONSTITUENTS FROM MALUS PUMILA (APPLE) FOR BREAST CANCER TREATMENT","authors":"Suneetha Yeguvapalli, Durga Rathikota","doi":"10.53390/ijbs.v13i2.1","DOIUrl":"https://doi.org/10.53390/ijbs.v13i2.1","url":null,"abstract":"Apple is a widely consumed fruit that is accessible throughout the year and is high in phytochemicals. The current study's major goal is to use computational methodologies to discover new anti-cancer medication candidates from plants. The ligands of the plant malus pumila were docked with protein EGFR (PDB ID:1M17) to predict novel potential inhibitors that could be employed as anticancer medicines for breast cancer. Breast cancer is a complex disease with no known single cause that continues to be a global killer and the leading cause of cancer-related death in women. One of the first key targets of these emerging anticancer drugs was the epidermal growth factor receptor (EGFR).The physicochemical, pharmacokinetic, and drug-like properties help in the selection of the best compound for breast cancer treatment. Furthermore, a substantial study suggests that phytochemicals, which are plant secondary compounds have oncopreventive Properties.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131851616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Suvarna, A. Prabhu, K. Muhseena N, B. B. Sharma
{"title":"IN VITRO CYTOTOXIC AND APOPTOTIC EFFECT OF CONCANAVALINS FROM CANAVALIA spp.\u0000ON BREAST CARCINOMA CELLS","authors":"G. Suvarna, A. Prabhu, K. Muhseena N, B. B. Sharma","doi":"10.53390/ijbs.v11i1.2","DOIUrl":"https://doi.org/10.53390/ijbs.v11i1.2","url":null,"abstract":"Concanavalins from Canavalia spp. possess diverse bioactivities and exhibit potent anticancer effects. In this study we assessed the cytotoxic activity of concanavalins from Canavalia spp. on human breast carcinoma MCF-7 cells. The lectins concanavalin A (ConA), concanavalin C (ConC), concanavalin G (ConG) and concanavalin M (ConM) were\u0000isolated from seeds of C. ensiformis, C. cathartica, C. gladiata and C. rosea respectively. ConAand ConG demonstrated strong inhibitory effect on MCF-7 cell proliferation with IC values 81.66 µg/mLand 81.09 µg/mLrespectively, with no 50 significant effect in normal kidney HEK293T cells. MCF-7 cells treated with ConA and ConG showed apoptotic\u0000morphological changes and accumulation of sub-G /G proportion, suggesting stimulation of apoptotic pathway. These 0 1 results uphold the anticancer potential of concanavalins.","PeriodicalId":219235,"journal":{"name":"International Journal on Biological Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115498869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}