G. Suvarna, A. Prabhu, K. Muhseena N, B. B. Sharma
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IN VITRO CYTOTOXIC AND APOPTOTIC EFFECT OF CONCANAVALINS FROM CANAVALIA spp.
ON BREAST CARCINOMA CELLS
Concanavalins from Canavalia spp. possess diverse bioactivities and exhibit potent anticancer effects. In this study we assessed the cytotoxic activity of concanavalins from Canavalia spp. on human breast carcinoma MCF-7 cells. The lectins concanavalin A (ConA), concanavalin C (ConC), concanavalin G (ConG) and concanavalin M (ConM) were
isolated from seeds of C. ensiformis, C. cathartica, C. gladiata and C. rosea respectively. ConAand ConG demonstrated strong inhibitory effect on MCF-7 cell proliferation with IC values 81.66 µg/mLand 81.09 µg/mLrespectively, with no 50 significant effect in normal kidney HEK293T cells. MCF-7 cells treated with ConA and ConG showed apoptotic
morphological changes and accumulation of sub-G /G proportion, suggesting stimulation of apoptotic pathway. These 0 1 results uphold the anticancer potential of concanavalins.
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