Sleep and Breathing最新文献

{"title":"Are noradrenergics combined with antimuscarinics the future pharmacologic treatment for obstructive sleep apnea? A systematic review and meta-analysis of randomized controlled trials.","authors":"Zeyad Bady, Hazem E Mohammed, Heba Aboeldahab, Mahmoud Samir, Mohamed Smail Aissani, Aliaë A R Mohamed-Hussein","doi":"10.1007/s11325-024-03227-6","DOIUrl":"10.1007/s11325-024-03227-6","url":null,"abstract":"<p><strong>Purpose: </strong>Noradrenergics and antimuscarinics have been proposed as future pharmacotherapy for obstructive sleep apnea (OSA). However, the available randomized controlled trials (RCTs) showed heterogeneous results regarding the safety and efficacy of the combined regimen in OSA. Therefore, we performed this meta-analysis from the published RCTs to clarify this conflicting evidence.</p><p><strong>Methods: </strong>A systematic search of four electronic databases was done till December 2023.</p><p><strong>Results: </strong>Thirteen RCTs (n = 345) were systematically reviewed and meta-analyzed. The combined regimen significantly reduced apnea-hypopnea index (AHI): AHI 3% [events/h; Mean difference (MD): - 6.30; 95% Confidence interval (CI) (- 9.74, - 2.87); P = 0.0003], AHI 4% [events/h; MD: - 6.50; 95% CI (- 8.74, - 4.26 events/h); P < 0.00001]. All gasometric measures significantly improved in the combined regimen group except mean SpO2. No difference was found in total sleep time between the treatment and placebo. However, compared to placebo, the combined regimen altered sleep architecture and decreased sleep efficiency. Regarding OSA endotypes, the combined regimen significantly improved loop gain, pharyngeal muscle compensation, pharyngeal muscle recruitment, and respiratory arousal threshold.</p><p><strong>Conclusion: </strong>The combined regimen effectively reduces AHI and OSA severity with improvement in almost all OSA endotypes. However, this regimen decreased sleep efficiency and altered sleep architecture. Short-term side effects can be confined to increased heart rate, dry mouth and urinary hesitancy. Therefore, noradrenergics and anti-muscarinics is a promising regimen for treating OSA, yet this optimism must be titrated by the lack of long-term effects of the regimen. Future RCTs with focus on the long-term efficacy of the regimen and cardiovascular outcomes is recommended.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"63"},"PeriodicalIF":2.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The deficiencies of epworth sleepiness scale in the evaluation of excessive daytime sleepiness in obstructive sleep apnea and related factors.","authors":"Canan Gunduz Gurkan, Sema Sarac, Ezgi Yukcu Memis, Fatma Ozbaki","doi":"10.1007/s11325-024-03233-8","DOIUrl":"https://doi.org/10.1007/s11325-024-03233-8","url":null,"abstract":"<p><strong>Background: </strong>Epworth Sleepiness Scale(ESS) is widely used in the assessment of excessive daytime sleepiness (EDS) despite certain deficiencies. It was aimed to evaluate the factors associated with low ESS scores in subjects investigated for OSA.</p><p><strong>Methods: </strong>In this cross sectional study, we recorded the ESS and Pittsburg sleep quality index (PSQI) scores of patients undergoing polysomnography in our sleep center between November 2022-January 2023. Additional questions regarding literacy, vehicle use, driver licence and travelling habits were asked. Sleep indices of patients with AHI ≥ 5 were recorded following PSG.</p><p><strong>Results: </strong>96 patients with mean age 51 ± 12, 68% male, median AHI 34.6 (7-105), ESS 7 (0-22), PSQI 9 (2-15) were included. Among moderate-severe OSA patients without EDS; 10% were illiterate, 67% performed reading only from cellular phone, 88% did not attend the social settings, 53% did not travel frequently and 40% did not use any vehicle. The listed factors were also associated with low ESS (p < 0.001). The sleep indices and PSQI scores of patient groups with and without EDS were similar. There was a correlation between ESS and total PSQI score (β = 0.31, p = 0.002) and subjective sleep quality (β = 0.21, p = 0.04), sleep disturbances (β = 0.29, p = 0.004) and daytime dysfunction (β = 0.49, p < 0.001) domains.</p><p><strong>Conclusion: </strong>ESS may be inadequate in the assessment of the demographical features and daily habits of patients from different sociocultural settings. Clinicians should be aware that the patients may have severe OSA and poor sleep quality despite low ESS scores and should evaluate each patient individually.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"62"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening moderate to severe obstructive sleep apnea with wearable device.","authors":"James Tisyakorn, Narongkorn Saiphoklang, Tunlanut Sapankaew, Kristina Thapa, Chutiporn Anutariya, Aekavute Sujarae, Chatkarin Tepwimonpetkun","doi":"10.1007/s11325-024-03232-9","DOIUrl":"https://doi.org/10.1007/s11325-024-03232-9","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder usually diagnosed through polysomnography (PSG). Moderate to severe OSA can significantly increase morbidity and mortality. Existing screening tools have limited accuracy. This study aimed to evaluate the Wellue O₂ ring, a commercial pulse oximeter ring, for screening moderate to severe OSA.</p><p><strong>Methods: </strong>A cross-sectional study included adults aged 18 and older suspected of having OSA who underwent PSG while wearing the Wellue O2 ring on their thumb. The oxygen desaturation index (ODI) from both the O2 ring and PSG was recorded. Sensitivity, specificity, and receiver operating characteristic (ROC) curves were calculated to determine the optimal ODI cutoff value for predicting moderate to severe OSA.</p><p><strong>Results: </strong>The study included 190 participants (53.2% male) with an average age of 43 years and an average apnea-hypopnea index (AHI) of 50.4 events per hour. Among the participants, 84.7% had moderate to severe OSA. The optimal cutoff value for 11% ODI was 1.25 events per hour lasting 20 s, with a sensitivity of 87.30% and a specificity of 78.70%. The area under the ROC curve for identifying moderate to severe OSA was 0.91.</p><p><strong>Conclusions: </strong>The Wellue O2 ring demonstrated high accuracy in detecting moderate to severe OSA and could be a viable alternative for screening in clinical settings due to its accessibility and ease of use. However, larger studies are required to validate its clinical utility for diagnosing and managing moderate to severe OSA.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"61"},"PeriodicalIF":2.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic profile of surgical approaches to obstructive sleep apnea in the United States from 2004 to 2020: a descriptive study.","authors":"Thomaz A Fleury Curado, Mohamed Abdelwahab, Allen Huang, Flavio T P Oliveira, Ahmed El Abany, Lucas Diniz, Patrícia Dos Santos Cé, N Scott Howard, Sandro Marques, Robson Capasso","doi":"10.1007/s11325-024-03197-9","DOIUrl":"10.1007/s11325-024-03197-9","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the quantity, types, and trends of surgical procedures used to treat obstructive sleep apnea (OSA) within a diverse national population, utilizing a comprehensive proprietary healthcare database.</p><p><strong>Methods: </strong>This descriptive observational study analyzed longitudinal data from the Optum Clinformatics® Data Mart databases, covering the period from January 2004 to December 2020. The study included patients aged 18 to 89 years, both male and female, with a confirmed diagnosis of OSA. These patients were either treated with continuous positive airway pressure (CPAP) or underwent surgical interventions.</p><p><strong>Results: </strong>Throughout the study period, 1,250,273 individuals were diagnosed with OSA. The average age at diagnosis was 62 years (SD = 16), with a male predominance of 62.3%, and 75% of the patients were identified as Caucasian. The most frequently performed surgical procedure for OSA was Uvulopalatopharyngoplasty (UPPP). However, the implantable hypoglossal nerve stimulator was more commonly utilized among older patients.</p><p><strong>Conclusions: </strong>This study provides essential insights into the prevalence and characteristics of surgical procedures used in OSA treatment across a diverse national population. The findings underscore the significance of understanding surgical intervention patterns and trends to enhance patient care and outcomes.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"60"},"PeriodicalIF":2.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the impact of obstructive sleep apnea on cognitive function in severe COPD.","authors":"Kristina Kock Hansen, Anders Løkke, Hanne Irene Jensen, Eline Kirstine Gantzhorn, Ingeborg Farver-Vestergaard, Ole Hilberg","doi":"10.1007/s11325-024-03228-5","DOIUrl":"10.1007/s11325-024-03228-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the association between obstructive sleep apnea (OSA) and cognitive function in patients with severe chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>Patients with severe COPD, who had not previously been diagnosed with OSA, were recruited between January 2021 and January 2023. To evaluate cognitive function, the Montreal Cognitive Assessment (MoCA), a continuous reaction time test (CRT) and a driving simulator were used. OSA was identified using a CardioRespiratory Monitor (CRM). Cognitive tests were repeated for patients who were identified with and received treatment for OSA, to determine whether treatment improved cognitive function.</p><p><strong>Results: </strong>In total, 80 patients participated in the study and 50 patients (63%) were diagnosed with OSA, with or without nocturnal desaturation (ND), and six patients (8%) with ND only. Thirty-two patients (40%) had mild OSA and 18 (23%) had moderate/severe OSA. We found no statistically significant difference in the prevalence of cognitive impairment (CI) between patients with and without OSA and/or ND. However, a multiple regression analysis showed that patients with moderate/severe OSA had a significant lower CRT-index, indicating a decrease in attention and reaction time, compared to patients with mild OSA.</p><p><strong>Conclusion: </strong>In patients with COPD and OSA, the degree of CI may depend on the severity of OSA. The 23% prevalence of moderate/severe OSA emphasizes the importance of OSA screening in severe COPD. The study was registered at www.</p><p><strong>Clinicaltrials: </strong>gov in March 2020, with the identification number NCT04458038.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"59"},"PeriodicalIF":2.1,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine for obstructive sleep apnoea: a systematic review with meta-analysis.","authors":"Yoann Birling, Yu Wu, Matthew Rahimi","doi":"10.1007/s11325-024-03194-y","DOIUrl":"10.1007/s11325-024-03194-y","url":null,"abstract":"<p><strong>Purpose: </strong>Chinese Herbal Medicine (CHM) may have a place in the treatment of obstructive sleep apnoea (OSA), but the evidence has not been systematically assessed. The objective of this study is to evaluate the evidence for the effectiveness of CHM for OSA.</p><p><strong>Methods: </strong>CENTRAL, EMBase, PubMed, CINAHL, CNKI, Wanfang and Chongqing VIP were searched from database inception to the 13th of August 2023. Randomised-controlled trials in which the effect of CHM on sleep variables was tested in the treatment of OSA were selected. The primary outcomes of this review and meta-analysis were the apnoea hypopnoea index (AHI) measured with polysomnography.</p><p><strong>Results: </strong>A total of 58 studies, involving 4,590 participants, were included. The meta-analysis showed that CHM reduced AHI more significantly than placebo (mean difference = -7.10 events/hour, 95% CI = -11.95, -2.25, P < 0.01, 7 studies, 583 participants) and the combination of CHM and Continuous Positive Airway Pressure (CPAP) more effective than CPAP alone (mean difference = -4.71 events/hour, 95% CI = -5.62, -3.80, P < 0.001, 28 studies, 2,267 participants). CHM improved sleepiness, quality of life, body weight, oxidative biomarkers, inflammatory biomarkers, cognitive function, blood pressure and respiratory function.</p><p><strong>Conclusion: </strong>Our results suggest that CHM, alone and as an adjunct treatment, can improve various aspects of OSA and its comorbidities and is therefore a viable therapeutic option for OSA.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"56"},"PeriodicalIF":2.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memoriam Professor Karl Heinz Rühle MD-An early pulmonary sleep medicine pioneer: an obituary and short historical review.","authors":"Nikolaus C Netzer, Georg Nilius","doi":"10.1007/s11325-024-03224-9","DOIUrl":"https://doi.org/10.1007/s11325-024-03224-9","url":null,"abstract":"","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"57"},"PeriodicalIF":2.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between obstructive sleep apnea and serum markers HIF-1, IL-6 and iNOS after lung transplantation.","authors":"Qi Li, Huaqing Yu, Chao Wang, Jingxiao Gu, Hang Yang, Rongrong Wan, Yunyun Zhang, Chunxiao Hu, Xiaochuan Cui","doi":"10.1007/s11325-024-03229-4","DOIUrl":"https://doi.org/10.1007/s11325-024-03229-4","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the correlation between obstructive sleep apnea (OSA) and hypoxia-inducible factor (HIF)-1, interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) in patients complicated with OSA after lung transplantation. To identify serum markers of OSA after lung transplantation.</p><p><strong>Methods: </strong>We retrospectively selected patients who planned to undergo lung transplantation between 2018 and 2020, including 25 without OSA before lung transplantation (group A), 20 with OSA after lung transplantation (group B), and 15 patients without OSA after lung transplantation (group C). Sleep monitoring was performed, general information collection and hematological samples were collected. HIF-1, IL-6 and iNOS were detected by ELISA.</p><p><strong>Results: </strong>Group B were older [59.2 ± 10.1 (B) vs. 49.8 ± 15.1 (A), 58.2 ± 3.3 (C), yrs.], had a bigger neck circumference [38.1 ± 4.7 (B) vs. 34.6 ± 4.2 (A),35.7 ± 4.2 (C), cm], and a greater abdominal circumference [88.2 ± 12.5 (B) vs. 76.2 ± 7.9 (A), 82.5 ± 6.5 (C), cm] compared with Groups A and C (P < 0.05). iNOS in group B (4784.8 ± 1365.2 (B) vs. 1925.2 ± 1868.5 (A), 2838.7 ± 3015.5 (C), pg/mL) was significantly increased compared to groups A and C (P < 0.05). iNOS was positively correlated with AHI.</p><p><strong>Conclusions: </strong>iNOS is significantly increased in OSA after lung transplantation, and maybe an important indicator of OSA.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"58"},"PeriodicalIF":2.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urges to move and struggles to breathe: restless legs syndrome/WillisEkbom disease in adult patients with obstructive sleep apnea.","authors":"Fernando Gustavo Stelzer, Ygor Arzeno Ferrão, Debora Palma Maia, Liselotte Menke Barea, Helena Maria Tahnnauser Barros, Álan Luiz Éckeli","doi":"10.1007/s11325-024-03230-x","DOIUrl":"https://doi.org/10.1007/s11325-024-03230-x","url":null,"abstract":"<p><strong>Purpose: </strong>Recent evidences pointed out that the prevalence of comorbidity of restless legs syndrome/Willis-Ekbom disease (RLS/WED) and obstructive sleep apnea (OSA) is around 20%. Nonetheless its association factors have not been extensively evaluated after the recent modification in diagnostic criteria. We aimed to estimate the prevalence of RLS/WED and its association factors with OSA in an adult sample.</p><p><strong>Methods: </strong>This was a prospective, cross-sectional study including 490 adult patients with OSA diagnosis (apnea-hypopnea index ≥ 5 obstructive events/hour associated to clinical picture). RLS/WED diagnosis was established by the 2014 International Restless Legs Syndrome Study Group (IRLSSG) criteria established by face-to-face interview with a neurologist.</p><p><strong>Results: </strong>The prevalence of RLS/WED was 18.6% (n = 91) and its diagnosis was previously established in 13.2% (n = 12/91). The mean IRLSSG severity score was 17.0 (standard deviation 6.8). RLS/WED was associated with female sex, chronic insomnia symptoms, greater anxiety, and depression severity scores, and with mild obstructive sleep apnea severity. On the other hand, severe obstructive sleep apnea was negatively associated to RLS/WED.</p><p><strong>Conclusions: </strong>Despite being relatively prevalent among patients with OSA, RLS/WED is previously underrecognized in our sample. RLS/WED severity correlated with higher scores on anxiety and depression scales. Chronic insomnia symptoms were the main RLS/WED association factor.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"52"},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum 25(OH)D levels and obstructive sleep apnea syndrome severity in patients without comorbidities: a systematic review and meta-analysis.","authors":"Marco Serafin, Martina Vaninetti, Ismahan Mohamed, Luigi Ferini Strambi, Alberto Caprioglio","doi":"10.1007/s11325-024-03167-1","DOIUrl":"10.1007/s11325-024-03167-1","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the present systematic review was to corroborate existing evidence on how serum25(OH)D levels affect obstructive sleep apnea syndrome (OSAS) severity in the absence of comorbidities.</p><p><strong>Methods: </strong>From inception to May 2024, PubMed, Scopus, and Embase electronic databases were systematically screened to identify randomized controlled trials (RCTs), quasi-RCTs, prospective, and retrospective studies. A strict search protocol was applied following the application of PROSPERO, under the registration number CRD42023468744. The formulated question based on PICO process was: \"how do serum25(OH)D levels affect the severity of OSAS or result in enhanced sleep function?\". Collected results were finally reviewed for meta-analysis and quality assessment according to the ROBINS-I tool.</p><p><strong>Results: </strong>Data from 24 studies were pooled and divided into 15 case-control studies and 9 cross-sectional studies. All studies involved a total of 2640 OSAS subjects and 933 healthy subjects. All studies underwent qualitative analysis whereas only 20 were collected for meta-analysis. Mild OSAS showed 25(OH)D levels non-statistically significant (P = 0.12) than the healthy patients whereas moderate OSAS (P = 0.004) and severe OSAS (P < 0.001) differed significantly from control groups. Meta-regression suggested that OSAS severity correlated inversely to the deficiency of 25(OH)D serum levels. Qualitative assessment and Egger's test revealed an elevated risk of bias but low presence of publication bias, respectively.</p><p><strong>Conclusion: </strong>Serum levels of 25(OH)D were observed to be inversely proportional to OSAS severity in patients without coexisting morbidities. 25(OH)D levels in mild OSAS patients were not significantly different from non-OSAS patients, suggesting vitamin supplementation to improve potential sleep disorders.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"53"},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}