Sleep SciencePub Date : 2021-04-14DOI: 10.5935/1984-0063.20220004
C. Salles, M. Freitas, M. M. E. Cruz
{"title":"Impact of L-carnitine in narcolepsy treatment: a systematic review on the effectiveness and safety","authors":"C. Salles, M. Freitas, M. M. E. Cruz","doi":"10.5935/1984-0063.20220004","DOIUrl":"https://doi.org/10.5935/1984-0063.20220004","url":null,"abstract":"Introduction Studies have shown that narcolepsy patients may present with low serum acylcarnitine levels, demonstrating a dysfunctional beta fatty acid oxidation pathway in these patients. Objective Evaluate the therapeutic efficacy of L-carnitine as a treatment for narcolepsy patients. Methods This study runned in form of systematic review. The terms used for the search: (“narcolepsy”[MeSH Terms] OR “narcolepsy”[All Fields]) AND (“carnitine”[MeSH Terms] OR “carnitine”[All Fields] OR “l carnitine”[All Fields]). Were included all surveys published until January 2021, with the diagnosis of narcolepsy, that performed drug treatment with I-carnitine. The clinical endpoints of interest were: excessive daytime sleepiness, dissociative REM sleep manifestations: cataplexy, sleep paralysis, hypnagogic hallucinations, and early REM sleep (REM sleep naps, SOREMP). Results L-carnitine was found to be well-tolerated and without side effects in all surveys, at dosages ranging from 500 to 510 mg/day. Newborns did not present complications during delivery. Conclusion This study corroborates the efficacy and good tolerability of L-carnitine therapy as a treatment for patients with narcolepsy, including during pregnancy.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"88 1","pages":"278 - 284"},"PeriodicalIF":1.6,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81237200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-04-13DOI: 10.5935/1984-0063.20220005
M. Sprajcer, Catherine O’Mullan, A. Reynolds, J. Paterson, Alysa Bachmann, M. Lastella
{"title":"Sleeping together: understanding the association between relationship type, sexual activity, and sleep","authors":"M. Sprajcer, Catherine O’Mullan, A. Reynolds, J. Paterson, Alysa Bachmann, M. Lastella","doi":"10.5935/1984-0063.20220005","DOIUrl":"https://doi.org/10.5935/1984-0063.20220005","url":null,"abstract":"Objective Insufficient sleep, and particularly difficulties initiating sleep, are prevalent in the community. Treatment for poor sleep typically consists of pharmacological intervention, or cognitive behavioural therapies - which can be both costly and time-consuming. Evidence suggests that sexual activities may positively impact sleep. However, little is known about relationship types, sexual activities, and perceived sleep outcomes. The aim of this study was to explore the association between relationship type (e.g., having a regular, occasional, or casual partner), sexual activity and satisfaction, and perceived sleep outcomes, to identify potential strategies to improve sleep. Methods Seven-hundred and seventy-eight participants aged 18 years and over (442 females, 336 males; mean age 34.5 ± 11.4 years) responded to a cross-sectional online anonymous survey at their convenience. Participants were asked about their sleep, sexual activity and satisfaction, and relationship type. Results Results from multiple regression analyses with age and gender covariates revealed that shorter sleep latencies were associated with regular relationships (p = 0.030), greater emotional satisfaction with sexual activity (p = 0.029), and increased frequency of orgasm (p < 0.001). Men reported a greater frequency of orgasm than women (p < 0.001). Discussion Findings indicate that relationship type may be associated with improved sleep outcomes, including sleep latency. Relationship type should therefore be taken into consideration by clinicians when developing treatment plans for individuals with poor sleep.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"25 7 1","pages":"80 - 88"},"PeriodicalIF":1.6,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83459862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-04-12DOI: 10.5935/1984-0063.20220013
Ramón Julio Huamán Olarte, Willy Ramos, Elydia Mujica-Albán, J. D. L. Cruz-Vargas
{"title":"Factors associated with excessive daytime sleepiness in informal drivers of buses on a high-altitude road","authors":"Ramón Julio Huamán Olarte, Willy Ramos, Elydia Mujica-Albán, J. D. L. Cruz-Vargas","doi":"10.5935/1984-0063.20220013","DOIUrl":"https://doi.org/10.5935/1984-0063.20220013","url":null,"abstract":"Objective To determine the factors associated with excessive daytime sleepiness (EDS) in informal interprovincial transport drivers of the Lima-Huancayo central highway (Peru) from January to March 2018. Methods Cross-sectional study. The drivers were weighed and measured, then individual, sociodemographic, and occupational data were obtained which were recorded in a data collection form, then the Epworth Sleepiness Scale (ESS) was applied to the drivers. The prevalence and EDS-associated factors in drivers were obtained from this data. The multivariate analysis of the possible associated factors for EDS was performed with binary logistic regression, obtaining the adjusted odds ratio (AOR). Results 162 drivers participated in the study. The average age was 42.0 ± 10.2 years (Range of 21-62 years), all the participants were male. 55. 6% had a technical degree, 42.0% were married and 55.6% had two to three children. The mean time of experience as a driver was 17.0 ± 6.8 years, 54.9% were overweight, and 32.1% were obese. 27.8% of drivers had EDS, the multivariate analysis found that the EDS-associated factors of the drivers were obesity (AOR=3.8, 95% CI: 1.422- 10.233), having 10 or more years of experience as a driver (AOR=3.1, 95% CI: 1.342-7.189) and overweight (AOR=2.9 CI 95%: 1.216-7.096). Conclusion There is a high prevalence of EDS in informal drivers of interprovincial transport of the central high-altitude highway studied. Obesity was the main factor associated with EDS, along with being overweight and having 10 or more years of experience as a driver.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"78 1","pages":"143 - 148"},"PeriodicalIF":1.6,"publicationDate":"2021-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90247202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-04-02DOI: 10.5935/1984-0063.20220032
M. Bezerra, R. N. Rodrigues, Ricardo Oliveira Souza
{"title":"The hypothalamic-pituitary-adrenal axis and the central monoaminergic systems: a pathophysiological link to insomnia with clinical implications","authors":"M. Bezerra, R. N. Rodrigues, Ricardo Oliveira Souza","doi":"10.5935/1984-0063.20220032","DOIUrl":"https://doi.org/10.5935/1984-0063.20220032","url":null,"abstract":"ABSTRACT The authors present a theoretical overview of the hypothalamic-pituitary-adrenal axis and the central monoaminergic systems, focusing on a putative pathophysiological relationship to insomnia complaints. Insomnia is an independent and self-perpetuating disorder that requires diagnostic and therapeutic attention in the presence of concomitant disorders, likely with bidirectional influence. An adequate understanding of such mechanisms can help for a better understanding of the interplay between clinical features, neurotransmitters, and the adrenal hypothalamic-pituitary axis may help clinicians to better manage insomnia patients","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"23 1","pages":"128 - 135"},"PeriodicalIF":1.6,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88456508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-03-30DOI: 10.5935/1984-0063.20220023
Papan Thaipisuttikul, Thongthai Theansukont, Ratima Boonmueng, Pattarabhorn Wisajun
{"title":"Sleep quality problems in Thai medical students","authors":"Papan Thaipisuttikul, Thongthai Theansukont, Ratima Boonmueng, Pattarabhorn Wisajun","doi":"10.5935/1984-0063.20220023","DOIUrl":"https://doi.org/10.5935/1984-0063.20220023","url":null,"abstract":"Objective To explore sleep quality and daytime sleepiness problems in medical students at Ramathibodi Hospital. Methods This was a cross-sectional study. Data were collected using questionnaires. The questionnaires included (1) Demographic and personal data, (2) The Pittsburgh Sleep Quality Index (PSQI) for sleep quality problem assessment and (3) The Epworth Sleepiness Scale (ESS) for daytime sleepiness assessment. Results Of 691 medical students, 165 (23.9%) completed questionnaires. The prevalence of poor sleep quality and daytime sleepiness were 63.6% and 41.8%, respectively. After adjusted for age and relationship concern, academic concern (prevalence ratio 1.46) and nighttime activity without screen (prevalence ratio 1.43) were associated significantly with sleep quality problem. No factor was associated with daytime sleepiness. Discussion Interventions to reduce academic burdens should be promoted to improve sleep problems in medical students. Further studies in larger groups of medical students using both subjective and objective measurements should be done in the future.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"31 1","pages":"244 - 248"},"PeriodicalIF":1.6,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88183995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-03-29DOI: 10.5935/1984-0063.20210030
J. P. Rosa, D. F. Rodrigues, R. Viana, R. Vancini, M. Andrade, Claudio Andre Barbosa de-Lira
{"title":"Are exergames an option to cope with sleep disorders during the COVID-19 outbreak?","authors":"J. P. Rosa, D. F. Rodrigues, R. Viana, R. Vancini, M. Andrade, Claudio Andre Barbosa de-Lira","doi":"10.5935/1984-0063.20210030","DOIUrl":"https://doi.org/10.5935/1984-0063.20210030","url":null,"abstract":"ABSTRACT During the COVID-19 pandemic, factors related to the isolation and quarantine period increased psychobiological distress in the general population around the world, increasing anxiety, emotional stress, and depression, as well as worsening of the quality of sleep. Seeking alternatives to provide support for the implementation of some interventions for well-being and health under pandemic conditions, exergames (active video games) seem to be a feasible alternative to keep people physically active and to positively impact sleep health. In this overview article, we discussed the feasibility of exergames as an option to cope with sleep disorders and improve sleep quality during the COVID-19 outbreak through increasing physical exercise and physical fitness levels.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"16 1","pages":"393 - 397"},"PeriodicalIF":1.6,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87798061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-03-28DOI: 10.5935/1984-0063.20220011
M. Fujii, Masayuki Hayashi, C. Teng
{"title":"Nap patterns of children in kindergartens and childcare transit facility: a study in northern Peninsular Malaysia","authors":"M. Fujii, Masayuki Hayashi, C. Teng","doi":"10.5935/1984-0063.20220011","DOIUrl":"https://doi.org/10.5935/1984-0063.20220011","url":null,"abstract":"Objective The purpose of this study was to compare the duration of sleep and nap patterns between children in private kindergartens and those in a tabika -transit facility, in Malaysia. Methods The sleep duration of children aged 3-6, who attended either a kindergarten or a childcare transit facility ( tabika -transit in Malay) was investigated. Observational sleeping records were maintained for 24 hours, over 14 consecutive days. A self-administered questionnaire for caregivers investigated the children’s lifestyles. Naps were optional at kindergartens but mandatory at the tabika -transit. Results Of 35 participating children, data from 33 were analyzed. All respondents belonged to the Malay ethnicity, with 16 boys (48.5%) and 17 girls (51.5%). The average age of the children was 5.4 years; 11 of them were from kindergartens and 22 from a tabika -transit. The children slept longer and woke up later on weekends than on weekdays. There was a significant difference in the naptaking rate between the two groups; it was 100% in the tabika -transit, and 30% in the kindergartens during weekdays. However, on weekends, 19 of 22 tabika - transit children did not nap on any of the days (86.4%). The kindergarten group’s naps showed no outstanding differences between weekdays and weekends. Concerning the bedtime and wake-up times, no differences were found between the two groups. Discussion During weekdays, all children in the tabika -transit took naps, whereas one-third of them did in the kindergartens. Larger study is needed to assess how this mandatory napping style affects children’s lifestyle and development.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"45 1","pages":"128 - 134"},"PeriodicalIF":1.6,"publicationDate":"2021-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77273690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-03-21DOI: 10.5935/1984-0063.20210032
I. Manetta, D. Ettlin, P. M. Sanz, Isabel Rocha, M. Meira e Cruz
{"title":"Mandibular advancement devices in obstructive sleep apnea: an updated review","authors":"I. Manetta, D. Ettlin, P. M. Sanz, Isabel Rocha, M. Meira e Cruz","doi":"10.5935/1984-0063.20210032","DOIUrl":"https://doi.org/10.5935/1984-0063.20210032","url":null,"abstract":"ABSTRACT Obstructive sleep apnea (OSA) is the most prevalent sleep-disordered breathing in the adult population and if untreated remains a significant cause of morbidity and mortality. Continuous positive airway pressure (CPAP) therapy is still the gold standard treatment for OSA, but patient acceptance and adherence are often poor due to a multitude of factors, thereby compromising treatment success. Mandibular advancement devices (MADs) have been proposed not only as a first line therapy for symptomatic snoring patients, but also for those suffering from mild to moderate OSA, or those who refuse or do not tolerate CPAP. Yet, improved understanding of MAD regarding design, construction, and mechanisms of action is an important requirement to successfully implement MAD as a therapeutic tool. Therefore, the main focus of this paper is to focus on the general concepts and mechanisms of action of MAD, while highlighting important characteristics in the context of their use as a viable and effective treatment option for OSA patients.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"37 1","pages":"398 - 405"},"PeriodicalIF":1.6,"publicationDate":"2021-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81087235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-03-08DOI: 10.5935/1984-0063.20210013
Raiza Aranha Nascimento, Virgínia Capistrano Fajardo, Luiz Antônio Alves de Menezes Júnior, Pedro Mendonça, Maria Cristina Veiga Aranha Nascimento, Pedro Marques Oliveira Tristão, F. Oliveira, R. N. Nascimento Neto
{"title":"Work hours as a risk factor for SARS-CoV-2 infections: cardiometabolic and sleep characteristics in rotating shift workers","authors":"Raiza Aranha Nascimento, Virgínia Capistrano Fajardo, Luiz Antônio Alves de Menezes Júnior, Pedro Mendonça, Maria Cristina Veiga Aranha Nascimento, Pedro Marques Oliveira Tristão, F. Oliveira, R. N. Nascimento Neto","doi":"10.5935/1984-0063.20210013","DOIUrl":"https://doi.org/10.5935/1984-0063.20210013","url":null,"abstract":"ABSTRACT Objective: This study aims to describe the health characteristics of rotating shift mining workers that may be related to a worse course scenario for COVID-19, according to literature data. Methods: Is a cross-sectional from three studies with 1478 shift workers. Social, demographic, clinical, and biochemical variables were analyzed. Risk factors for COVID-19 analyzed: hyperglycemia, altered blood pressure, dyslipidemia, hypovitaminosis D, obesity, presence of pre-existing cardiovascular diseases, and smokers. Results: Evaluating the grouped risk factors for an unfavorable evolution of COVID-19 most workers (91.0%) presented at least one risk factor. Discussion: With coronavirus in pandemic circulation, we noticed that mineworkers are in a vulnerable position. Their exposure to occupational risk factors, to the shift system, which directly affects sleep and negatively influences immunity, added to the conditions of favorable transmissibility by the flow of people from the mines leads us to believe in their greater susceptibility to acquiring the most serious forms of the disease.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"7 1","pages":"380 - 387"},"PeriodicalIF":1.6,"publicationDate":"2021-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91032234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2021-03-05DOI: 10.5935/1984-0063.20210036
Y. Hacımusalar, Ozgul Karaaslan, E. Mısır, O. Amuk, Goknur Hacimusalar
{"title":"Sleep quality impairments in schizophrenia and bipolar affective disorder patients continue during periods of remission: a case-controlled study","authors":"Y. Hacımusalar, Ozgul Karaaslan, E. Mısır, O. Amuk, Goknur Hacimusalar","doi":"10.5935/1984-0063.20210036","DOIUrl":"https://doi.org/10.5935/1984-0063.20210036","url":null,"abstract":"ABSTRACT Objective: Bipolar disorder (BD) and schizophrenia are chronic psychiatric disorders in which sleep disorders are commonly seen. In mental disorders, residual symptoms may persist even if symptoms are greatly reduced overall. The aim of this study was to compare the sleep quality of schizophrenia and BD patients in remission with that of healthy controls. Methods: Forty-three patients with schizophrenia, 46 BD patients in remission for at least 3 months, and 51 healthy controls were included the study. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Young Mania Rating Scale (YMRS) and Pittsburgh Sleep Quality Index (PSQI) were administered to all participants and the Positive and Negative Syndrome Scale (PANSS) was administered to patients with schizophrenia. Results: Poor sleep quality was more frequent in the patient groups than the control group ( p =0.009). PSQI score was positively correlated with duration of disease ( r =0.236; p =0.026), number of cigarettes smoked per day ( r =0.430; p <0.001), body mass index ( r =0.189; p =0.025), and negatively correlated with duration of remission ( r =-0.224; p =0.0359). Conclusion: Schizophrenia and BD patients in remission had worse sleep quality than a control group. Sleep quality was worst in the patients with schizophrenia. The severity of sleep disorder symptoms was positively associated with disease duration and negatively associated with duration of remission. Schizophrenia and BD patients should be carefully evaluated for symptoms of sleep disorders even when they are in clinical remission and should be offered additional treatment for sleep disorder symptoms when necessary.","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"1053 1","pages":"47 - 54"},"PeriodicalIF":1.6,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86469561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}