宫颈脂肪组织体积是中度至重度OSA的预测指标

IF 1.8 Q4 CLINICAL NEUROLOGY
Glenda Ernst, Pablo Dalzotto, Melina Saban, Fernando M. Ferraro, Alejandro Salvado, Eduardo Enrique Borsini
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引用次数: 0

摘要

【摘要】目的阻塞性睡眠呼吸暂停(OSA)是一种以睡眠时反复咽部梗阻为特征的疾病,其发病机制与上呼吸道解剖结构密切相关。本研究的目的是描述通过计算机断层扫描(CT)头测术获得的颈椎脂肪组织体积(CFTV)的量化是否与OSA的严重程度有关。方法回顾性研究2018 ~ 2020年住院患者;18岁,诊断为阻塞性睡眠呼吸暂停,并进行了脑容量成像。对图像进行三维重建,并测量CFTV。结果本研究共纳入91例患者,其中:无OSA(7例)、轻度OSA(19例)、中度OSA(39例)、重度OSA(26例)。我们观察到与OSA严重程度相关的CFTV进行性增加(无OSA: 58.9 ml(47.9-87.5),轻度:59.1ml(48.4-78.3),中度:71 ml(42.6-127.1),重度OSA 103.6 ml (81-153);p & lt;0.01);然而,在气道体积和颈部面积上没有发现差异。CFTV与OSA指标AHI、ODI、T90有显著相关性(Sp r: 0.48;0.38和0.36;p & lt;0.01分别)。CFTV鉴别AHI >15 ev/h的敏感性-特异性关系最佳的临界值为64.1 ml,曲线下面积为0.6±0.06。多因素分析显示,CFTV是中重度OSA的预测因子(OR:3.05, IC95%: 1.14-8.17)。结论CT头位测量法定量宫颈脂肪与成人OSA严重程度相关。脂肪量>64.1毫升使患中度至重度OSA的风险增加三倍以上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
Abstract Objective Obstructive sleep apnea (OSA) is a disorder characterized by recurrent pharyngeal obstruction during sleep, in which upper airway anatomy plays a key role in its pathogenesis. The aim of this study was to describe whether the quantification of cervical fat tissue volume (CFTV) obtained by Computed Tomography (CT)cephalometry is related to the severity of OSA. Methods Retrospective study between 2018 and 2020 in those patients > 18 years old, with diagnosis of OSA who performed a volumetric cephalometric imaging. Three-dimensional reconstruction of the images was performed and CFTV was measured. Results 91 patients were included in this study of which: without OSA (n: 7), mild (n: 19), moderate (n: 39) and severe OSA (n: 26). We observed a progressive increase of CFTV related to OSA severity has been observed (without OSA: 58.9 ml (47.9-87.5), mild: 59.1ml (48.4-78.3), moderate: 71 ml (42.6-127.1) and severe OSA 103.6 ml (81-153); p < 0.01); nevertheless, no differences were found in the airway volume and neck area. It was showed a significant correlation between CFTV and OSA indicators: AHI, ODI and T90 (Sp r: 0.48; 0.38 and 0.36; p < 0.01 respectively). CFTV cut-off value to discriminate AHI >15 ev/h with best sensitivity-specificity relationship was 64.1 ml with an area under the curve of 0.6 ± 0.06. Multivariate analysis showed that CFTV is a predictor for moderate to severe OSA (OR:3.05, IC95%: 1.14-8.17). Conclusion Cervical fat quantification by CT cephalometry correlates with OSA severity in adults. Fat volume > 64.1 ml increased more than three times the risk of OSA moderate to severe.
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来源期刊
Sleep Science
Sleep Science CLINICAL NEUROLOGY-
CiteScore
2.50
自引率
12.50%
发文量
124
审稿时长
10 weeks
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