Skeletal Radiology最新文献

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Ultrasound and magnetic resonance imaging (MRI) assessment of piezogenic papules: A report of three cases. 超声和磁共振成像(MRI)评估压电性丘疹:三例报告。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI: 10.1007/s00256-025-04906-5
Antoine Moraux, Thomas Le Corroller
{"title":"Ultrasound and magnetic resonance imaging (MRI) assessment of piezogenic papules: A report of three cases.","authors":"Antoine Moraux, Thomas Le Corroller","doi":"10.1007/s00256-025-04906-5","DOIUrl":"10.1007/s00256-025-04906-5","url":null,"abstract":"<p><p>Piezogenic papules (PP) are protrusions of fat that form within the subcutaneous tissue, which are typically found on the heels. We herein describe the ultrasound (US) presentation (topography, echogenicity, shape, dynamic reducibility, and power Doppler activity) and magnetic resonance imaging features (topography, signal, and shape) of PP in three female patients who were referred to our institution for evaluation of soft tissue nodules of the heel. Then, we discuss the anatomy of the heel fat pad and its implication in the pathophysiology of PP. Because PP consist of herniations of subcutaneous fat from deep macrochambers to superficial microchambers through focal defects in the fibroconjunctive capsule of the heel fat pad, dynamic US can demonstrate the reducibility of PP under probe compression and therefore allows easy differentiation from other soft tissue tumors.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1779-1785"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance and reliability comparison: original vs. revised bone reporting and data system (Bone-RADS). 性能和可靠性比较:原始与修订骨报告和数据系统(bone - rads)。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-22 DOI: 10.1007/s00256-025-04865-x
Sara Haseli, Chankue Park, Arash Azhideh, Gita Karande, Majid Chalian
{"title":"Performance and reliability comparison: original vs. revised bone reporting and data system (Bone-RADS).","authors":"Sara Haseli, Chankue Park, Arash Azhideh, Gita Karande, Majid Chalian","doi":"10.1007/s00256-025-04865-x","DOIUrl":"10.1007/s00256-025-04865-x","url":null,"abstract":"<p><strong>Objective: </strong>To propose a revised bone reporting and data system (Bone-RADS) and evaluate its diagnostic performance and inter-reader reliability compared to the original Bone-RADS for solitary bone lesions on CT.</p><p><strong>Materials and methods: </strong>This retrospective study included 159 adult patients (mean age: 56 ± 19 years; 88 men) who underwent bone biopsy for solitary bone lesions between March 2005 and September 2021. Two radiologists (R1/2) independently categorized the lesions twice, once using the original Bone-RADS and once using the revised version. Lesions were classified as follows: (1, benign; 2, incompletely assessed; 3, indeterminate; 4, malignancy or requiring treatment). The revised Bone-RADS excluded the original criteria for lesion related pain and history of malignancy. Diagnostic performance was assessed using histopathology as the reference standard, and inter-reader reliability was analyzed.</p><p><strong>Results: </strong>The bone lesions included 96 lucent and 63 sclerotic/mixed lesions. Sensitivity showed no significant difference between the original and revised Bone-RADS for both readers across lucent and sclerotic/mixed lesions (all P ≥ .05). However, the specificity of the revised Bone-RADS was significantly higher than that of the original (lucent: 11% vs. 50% [R1], 11% vs. 46% [R2]; sclerotic/mixed: 32% vs. 92% [R1], 32% vs. 86% [R2]). Other performance metrics, including positive/negative predictive value and accuracy, were also higher in the revised Bone-RADS. Inter-reader reliability was higher for the revised Bone-RADS compared to the original (κ = .744 vs .854).</p><p><strong>Conclusion: </strong>The revised Bone-RADS significantly improved specificity while maintaining sensitivity compared to the original version.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1681-1688"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sacral tumors: a comprehensive review of imaging, diagnostic challenges, and tumor mimics. 骶骨肿瘤:影像学、诊断挑战和肿瘤模拟的综合综述。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-16 DOI: 10.1007/s00256-024-04862-6
Mehmet Emin Adin, Graham Woolf, Rahul Hegde, Aladine A Elsamadicy, Ehud Mendel, William B Zucconi, Darko Pucar, Nafi Aygün
{"title":"Sacral tumors: a comprehensive review of imaging, diagnostic challenges, and tumor mimics.","authors":"Mehmet Emin Adin, Graham Woolf, Rahul Hegde, Aladine A Elsamadicy, Ehud Mendel, William B Zucconi, Darko Pucar, Nafi Aygün","doi":"10.1007/s00256-024-04862-6","DOIUrl":"10.1007/s00256-024-04862-6","url":null,"abstract":"<p><p>The sacrum can harbor a diverse group of both benign and malignant tumors, including metastases. Primary tumors of the sacrum can arise from bone, cartilage, marrow, notochordal remnants, or surrounding nerves and vessels. Among a variety of primary tumors of the spine, chordoma, germ cell tumors and Ewing's sarcoma are recognized for their propensity to occur in the sacrum. Imaging is essential in diagnosis, pretreatment evaluation, and assessment of response to treatment. Radiography, CT and MRI are the primary modalities in assessing morphology and tumor extent whereas PET/CT is crucial in the evaluation of systemic disease in the setting of myeloma, lymphoproliferative disease, and metastasis. A definitive diagnosis is not always achievable by imaging as some tumors lack specific imaging features. However, as we detail in this comprehensive review, many entities have characteristic clinical and epidemiological factors as well as typical imaging findings that can help make either a confident diagnosis or offer a narrow list of differentials. We discuss a wide range of benign and malignant, primary, and secondary tumors that can involve the sacrum, highlighting the pertinent clinical details and typical imaging findings of these entities, enabling the reader to develop and apply a systematic approach to evaluating sacral masses on imaging. We also briefly describe non-neoplastic tumor mimics, which include developmental entities, infections, and insufficiency fractures.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1581-1606"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI grading using the neuropathy score-reporting and data system with electrodiagnostic correlation in radial neuropathy around the elbow: a 13-year retrospective review. 使用神经病变评分报告和数据系统与电诊断相关的MRI分级肘部周围桡神经病变:13年回顾性回顾。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-06 DOI: 10.1007/s00256-024-04861-7
Benjamin Abiri, David Kopylov, Mohammad Samim, William Walter, Jan Fritz, Iman Khodarahmi, Christopher J Burke
{"title":"MRI grading using the neuropathy score-reporting and data system with electrodiagnostic correlation in radial neuropathy around the elbow: a 13-year retrospective review.","authors":"Benjamin Abiri, David Kopylov, Mohammad Samim, William Walter, Jan Fritz, Iman Khodarahmi, Christopher J Burke","doi":"10.1007/s00256-024-04861-7","DOIUrl":"10.1007/s00256-024-04861-7","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the Neuropathy Score-Reporting and Data System (NS-RADS) MRI grading system in conjunction with electrodiagnostic (EDx) testing for radial neuropathy at the elbow.</p><p><strong>Materials and methods: </strong>Patients presenting between 2010 and 2023 with suspected radial neuropathy who underwent both EDx testing in the form of electromyography and nerve conduction studies and MRI within a 12-month period were evaluated. Three blinded radiologists used the NS-RADS grading system to evaluate nerve entrapment (E grades), muscle denervation (M grades) proximally within the supinator/extensor carpi radialis brevis (ECRB), and more distally within the forearm extensor muscles. These grades and the presence of lateral epicondylitis were then correlated with EDx abnormalities.</p><p><strong>Results: </strong>Forty-nine participants were included. Inter-reader reliability for M grades in the forearm extensor muscles was good (ICC = 0.90 [95% CI = 0.83 - 0.94], p < 0.001), as was reliability for the supinator/ECRB muscles (ICC = 0.91 [95% CI = 0.86-0.95], p < 0.001). Inter-reader reliability for E grades was moderate (ICC = 0.83 [95% CI = 0.69-0.90], p < 0.001). Patients with positive EDx studies had a significantly different distribution of M grades for the forearm extensors and supinator/ECRB than those with negative studies (all p values < 0.001). However, overall consensus reads showed no significant difference in the distribution of E grades between patients with positive and negative EDx studies.</p><p><strong>Conclusion: </strong>Muscle grading strongly correlated with EDx positivity, with a high level of inter-reader agreement for muscle denervation-related alterations. Nerve grading, however, did not show a statistical correlation.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1621-1630"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Question: New onset right hip pain. 问:新发右髋关节疼痛。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-03-05 DOI: 10.1007/s00256-025-04893-7
Hila Yashar, Ashley Flaman, Adam Frost, Mara Caragea, Bashiar Thejeel
{"title":"Question: New onset right hip pain.","authors":"Hila Yashar, Ashley Flaman, Adam Frost, Mara Caragea, Bashiar Thejeel","doi":"10.1007/s00256-025-04893-7","DOIUrl":"10.1007/s00256-025-04893-7","url":null,"abstract":"","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1749-1752"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are we underestimating pathological fracture risk in malignant bone lesions of the proximal humerus? 我们是否低估了肱骨近端恶性骨病变的病理性骨折风险?
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-18 DOI: 10.1007/s00256-025-04875-9
Wolfram Weschenfelder, Friederike Weschenfelder, Christian Spiegel, Karin Gabriela Schrenk, Gunther Olaf Hofmann
{"title":"Are we underestimating pathological fracture risk in malignant bone lesions of the proximal humerus?","authors":"Wolfram Weschenfelder, Friederike Weschenfelder, Christian Spiegel, Karin Gabriela Schrenk, Gunther Olaf Hofmann","doi":"10.1007/s00256-025-04875-9","DOIUrl":"10.1007/s00256-025-04875-9","url":null,"abstract":"<p><strong>Objective: </strong>This study is aimed at evaluating the distribution of metastatic bone disease (MBD), with a particular focus on the humerus, and its association with pathological fractures. Factors for contributing to the underestimation of fracture risk were assessed, including their impact on surgical management.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed patient records of patients undergoing surgical treatment for MBD at our institution between 2005 and 2023. The analysis included factors such as medical history, tumour type, metastatic status, surgical method, lesion location, and imaging. The images of local and staging studies (CT chest/abdomen/pelvis, CT skeleton body, bone scan, PET/CT) were reviewed by two observers. Group comparisons were made based on lesion localisation.</p><p><strong>Results: </strong>The two most affected bone regions were the proximal femur (39.4%), followed by the proximal humerus (13.5%). Lesions of the proximal humerus were significantly more likely to be associated with pathological fractures compared to those of the proximal femur and other localisations (p < 0.01). Identified potential causes include less frequent depiction of the proximal humerus during staging (29% vs. 79% and 51%; p < 0.01) and overall lower Mirel's scores despite the number of fractures (8 vs. 10 and 9; p < 0.01).</p><p><strong>Conclusion: </strong>Metastatic bone disease (MBD) in the proximal humerus is less frequently captured in current staging imaging, particularly CT chest/abdomen/pelvis. Additionally, fracture prediction using Mirel's scoring often underestimates the actual risk. Staging investigations should include this region more comprehensively, and even when correctly imaged, better tools are needed to evaluate bone metastases effectively.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1653-1660"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant transformation of osteochondroma to chondrosarcoma: a challenging case. 骨软骨瘤向软骨肉瘤的恶性转化:一个具有挑战性的病例。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-02-26 DOI: 10.1007/s00256-025-04898-2
Seyyed Mohammad Ata Sharifi Dalooei, Behzad Aminzadeh, Naime Ataei, Farzaneh Khoroushi, Mohsen Saberifar
{"title":"Malignant transformation of osteochondroma to chondrosarcoma: a challenging case.","authors":"Seyyed Mohammad Ata Sharifi Dalooei, Behzad Aminzadeh, Naime Ataei, Farzaneh Khoroushi, Mohsen Saberifar","doi":"10.1007/s00256-025-04898-2","DOIUrl":"10.1007/s00256-025-04898-2","url":null,"abstract":"<p><p>A 50-year-old female presented with a large palpable mass in the right buttock and proximal thigh, accompanied by sciatic paresthesia. She reported intermittent thigh and knee pain for 5 years, worsening over the previous 6 months. Plain radiography images revealed a pedunculated osteochondroma on the posterolateral aspect of the femur with extensive soft tissue involvement and soft tissue calcifications. A computed tomography (CT) scan showed an osteochondroma with a large adjacent bursa containing multiple foci of calcifications with a \"snowstorm\" appearance. A diagnostic dilemma arose regarding whether the condition represented reactive bursitis secondary to osteochondroma or a malignant transformation to chondrosarcoma with intra-bursal invasion. Magnetic resonance imaging (MRI) indicated a thick cartilage cap of osteochondroma measuring 53 mm and multiple cartilage nodules in the bursa along with heterogeneous enhancement in cartilage islands. Moreover, evidence of adjacent muscle invasion and sciatic nerve encasement was noted. These findings suggested an unusual diagnosis of malignant transformation of the osteochondroma to chondrosarcoma with intra-bursal invasion. The patient underwent wide-margin resection of the proximal femur and tumoral soft tissue, reconstructed with a proximal femoral mega prosthesis. Histologic evaluation confirmed a well-differentiated chondrosarcoma with intra-bursal invasion. This case highlights the critical role of diagnostic imaging in differentiating between benign and malignant complications associated with osteochondroma.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1767-1772"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis: Phosphaturic mesenchymal tumor. 诊断:磷化间充质瘤。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-02-13 DOI: 10.1007/s00256-025-04894-6
Hila Yashar, Ashley Flaman, Adam Frost, Mara Caragea, Bashiar Thejeel
{"title":"Diagnosis: Phosphaturic mesenchymal tumor.","authors":"Hila Yashar, Ashley Flaman, Adam Frost, Mara Caragea, Bashiar Thejeel","doi":"10.1007/s00256-025-04894-6","DOIUrl":"10.1007/s00256-025-04894-6","url":null,"abstract":"","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1787-1788"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study. 他汀类药物的使用和纵向骨髓病变负担:来自骨关节炎倡议研究的无骨关节炎膝关节的分析。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-31 DOI: 10.1007/s00256-025-04878-6
Kamyar Moradi, Bahram Mohajer, Ali Guermazi, Roham Hadidchi, Soheil Mohammadi, Xu Cao, Mei Wan, Frank W Roemer, Shadpour Demehri
{"title":"Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study.","authors":"Kamyar Moradi, Bahram Mohajer, Ali Guermazi, Roham Hadidchi, Soheil Mohammadi, Xu Cao, Mei Wan, Frank W Roemer, Shadpour Demehri","doi":"10.1007/s00256-025-04878-6","DOIUrl":"10.1007/s00256-025-04878-6","url":null,"abstract":"<p><strong>Objectives: </strong>Knee subchondral bone marrow lesions (BMLs) are one of the hallmark features of structural osteoarthritis (OA) and are potential targets for statins' disease-modifying effect. We aimed to determine the association between statin use and longitudinal changes in magnetic resonance imaging (MRI)-based BML volume in participants without radiographic knee OA at baseline.</p><p><strong>Methods: </strong>Using the Osteoarthritis Initiative (OAI) cohort, we classified participants' knees into two categories: statin users (those who consistently used statins from baseline to the fourth year of the cohort) and non-users. We employed a 1:1 ratio propensity score (PS) matching method, adjusting for factors including age, sex, race, BMI, smoking, alcohol use, physical activity, abdominal obesity, and diabetes mellitus. We measured quantitative BML volume using a validated deep learning (DL) algorithm, applied to baseline, year-2, and year-4 intermediate-weighted fat-saturated knee MRIs. The outcome was determined by the differences in the BML volume change between statin users and non-users over the 4-year period.</p><p><strong>Results: </strong>After adjusting for potential confounders, 1502 knees were included (751 statin users and 751 non-users; mean age 63.5 ± 8.7 years, 44.5% female). A Multilevel linear mixed-effects regression model showed that statin use is associated with a smaller increase in BML volume over 4 years (time-treatment interaction effect estimates, 95% confidence interval (CI) - 14.88 mm<sup>3</sup>/year, - 23.04 to - 6.72, P < 0.001).</p><p><strong>Conclusion: </strong>In participants without baseline knee OA, continuous statin use is associated with a reduced longitudinal worsening of BML volume in the tibiofemoral joint, a known structural damage marker linked to downstream OA incidence.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1707-1714"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Image-guided cryoablation for palliation of painful bone metastases: a systematic review and meta-analysis. 图像引导冷冻消融缓解骨转移疼痛:系统回顾和荟萃分析。
IF 1.9 3区 医学
Skeletal Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-31 DOI: 10.1007/s00256-025-04877-7
Sarah Torabi, Mohadese Ahmadzade, Hamed Ghorani, Masoumeh Sarvari, Hamidreza Rouientan, Kelly Trinh, Gita Manzari Tavakoli, Mahshad Afsharzadeh, Raul Nirmal Uppot, Mohammad Ghasemi-Rad
{"title":"Image-guided cryoablation for palliation of painful bone metastases: a systematic review and meta-analysis.","authors":"Sarah Torabi, Mohadese Ahmadzade, Hamed Ghorani, Masoumeh Sarvari, Hamidreza Rouientan, Kelly Trinh, Gita Manzari Tavakoli, Mahshad Afsharzadeh, Raul Nirmal Uppot, Mohammad Ghasemi-Rad","doi":"10.1007/s00256-025-04877-7","DOIUrl":"10.1007/s00256-025-04877-7","url":null,"abstract":"<p><strong>Objective: </strong>To assess the efficacy of cryoablation in controlling pain from metastatic bone lesions.</p><p><strong>Materials and methods: </strong>A systematic search of PubMed, Embase, Scopus, Cochrane library, and Web of Science was conducted from inception to April 2024, focusing on cryoablation for palliation of painful bone metastases. The inclusion criteria were as follows: studies involving patients over 18 years of age who were affected by bone metastases; bone metastases treated with stand-alone cryoablation; studies reporting patients' pain levels before and at least at one time point after cryoablation; and studies published in English.</p><p><strong>Results: </strong>A total of 844 articles were initially screened, resulting in 12 articles involving 309 patients included. Pain assessments were conducted at various time points ranging from 1 day to 6 months after the cryoablation procedure. Included studies reported significant improvements in pain scores based on the visual analog scale (VAS), the numeric rating scale (NRS) and brief pain inventory-short form (BPI-SF) following treatment at 1, 4, 8 and 12 weeks. The most notable mean difference between pre- and post-procedure pain scores was observed at 12 weeks, with a standardized mean difference of -3.71 (95% confidence interval [CI]: -5.29 to -2.00; p < 0.001). Regarding pain relief outcomes, by the fourth week, the proportion of patients experiencing pain relief was 0.69 (95% CI: 0.62 to 0.75; p < 0.001).</p><p><strong>Conclusions: </strong>Cryoablation could be an effective method for palliation of painful bone metastases. Further studies are needed to compare its efficacy with other palliative methods and to define its role in cancer management.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"1715-1727"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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