Sexual Medicine最新文献

{"title":"Translation, cultural adaptation, and psychometric validation of the Female Sexual Function Index to Lebanese Arabic (FSFI-LB).","authors":"Stephanie Zakhour, Walter Gonçalves, Hugo Santos, Douglas Rodrigues, Nadine El Kassis, David Atallah, Antonio Egídio Nardi, Aline Sardinha","doi":"10.1093/sexmed/qfaf055","DOIUrl":"10.1093/sexmed/qfaf055","url":null,"abstract":"<p><strong>Background: </strong>The Female Sexual Function Index (FSFI) is widely used to assess female sexual function, but its applicability in Lebanon is limited due to linguistic and cultural barriers.</p><p><strong>Aim: </strong>This study aimed to develop and validate a Lebanese Arabic version of the FSFI (FSFI-LB) to improve accessibility for clinical and research use.</p><p><strong>Methods: </strong>A study was conducted with 119 Lebanese women between April 2023 and June 2024 at Hôtel-Dieu de France Hospital, Beirut. The FSFI was translated, back-translated, and psychometrically validated using exploratory factor analysis, Cronbach's alpha, test-retest reliability, and factor correlations.</p><p><strong>Outcomes: </strong>The FSFI-LB showed excellent internal consistency (Cronbach's alpha = 0.973) and test-retest reliability (<i>r</i> = 0.9997), with a Kaiser-Meyer-Olkin value of 0.925 and significant Bartlett's test of sphericity (<i>P</i> < .001). Test-retest reliability was assessed in a subsample of 42 participants after 4 weeks and demonstrated high consistency across all domains (<i>r</i> > 0.99) and total scale reliability (<i>r</i> = 0.9997).</p><p><strong>Results: </strong>A six-factor model was retained for the FSFI-LB, aligning with the original FSFI, with the pain domain showing the weakest correlations with other domains. The questionnaire included English translations alongside Arabic terms for improved comprehension.</p><p><strong>Clinical translation: </strong>The FSFI-LB is a reliable tool for assessing female sexual function in Lebanon, ensuring cultural and linguistic sensitivity for diverse populations.</p><p><strong>Strengths and limitations: </strong>The study's strengths include robust psychometric validation and the adaptation of a widely used instrument. The limitations include the focus on a specific Lebanese population, which may limit generalizability to other Arabic-speaking communities.</p><p><strong>Conclusion: </strong>The FSFI-LB is a valid and reliable tool for assessing female sexual function, contributing to the development of culturally appropriate measures in sexual health research and clinical practice.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 4","pages":"qfaf055"},"PeriodicalIF":2.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a single functional neurology session on thermography of the genital region and sexual function in patients with premature ejaculation.","authors":"Vicente Javier Clemente-Suárez, Jorge Rey-Mota, Guillermo Escribano-Colmena, Noelia Vanessa Marín, Jesús Fernandez-Lucas","doi":"10.1093/sexmed/qfaf046","DOIUrl":"10.1093/sexmed/qfaf046","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Premature ejaculation (PE) is a common male sexual dysfunction with limited long-term therapeutic options. Pharmacological and behavioral treatments often yield only temporary improvement, and alternative neuromodulatory strategies remain underexplored. Functional neurology, which targets autonomic and sensory-motor regulation, may offer a novel approach.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To evaluate the effect of a single functional neurology intervention on genital thermoregulation and ejaculatory latency in men with PE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Fifty-two men diagnosed with PE participated in a pre-post intervention study. Each underwent a single session of functional neurology aimed at modulating nociceptor and mechanoreceptor pathways. Genital thermoregulation was assessed using infrared thermography, and ejaculatory function was measured via intravaginal ejaculatory latency time (IELT) and self-report at baseline, after the first post-treatment sexual encounter, and at 1-month follow-up. Statistical analyses included repeated-measures ANOVA, paired &lt;i&gt;t&lt;/i&gt;-tests, Pearson correlation, and multiple regression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Significant improvements in IELT and genital temperature were expected following the intervention, supporting its role in enhancing autonomic regulation and microvascular circulation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Intravaginal ejaculatory latency time increased significantly from a baseline of 20.4 ± 11.5 seconds to 439.2 ± 214.5 seconds post-treatment, with sustained effects at 1 month (498.0 ± 171.6 seconds; &lt;i&gt;P&lt;/i&gt; &lt; .001). Infrared thermography revealed significant increases in temperature in the glans, testicles, and abdomen (all &lt;i&gt;P&lt;/i&gt; &lt; .001), indicating enhanced peripheral circulation. Glans temperature change was the strongest predictor of testicular thermoregulation (β = 0.513, &lt;i&gt;P&lt;/i&gt; &lt; .001). Principal component analysis highlighted that glans and testicular areas contributed most to thermal variance post-treatment. A ≥1 °C increase in genital temperature was observed in 60% of participants.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Functional neurology may be a non-invasive, fast-acting intervention for improving ejaculatory control in PE by promoting autonomic balance and vascular function. Thermography proved useful as a biomarker for physiological changes and treatment efficacy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;This study is the first to evaluate thermographic and ejaculatory outcomes after a functional neurology intervention in PE. Strengths include objective and subjective measures, while limitations involve the lack of a control group, small sample size, and short-term follow-up. These results should be confirmed through randomized controlled trials.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;A single session of functional neurology significantly improved both genital thermoregulation and ejaculatory latency in men with PE. These find","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf046"},"PeriodicalIF":2.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitation to the capacity to love and hypersexual behavior in their relationship with psychoticism and paranoid ideation.","authors":"Giulia Origlia, Davide Doroldi, Gabriele Lo Buglio, Tommaso Boldrini, Antonio Del Casale, Grazia Spitoni, Erika Limoncin, Giacomo Ciocca","doi":"10.1093/sexmed/qfaf050","DOIUrl":"10.1093/sexmed/qfaf050","url":null,"abstract":"<p><strong>Background: </strong>Limitation to the Capacity to Love (CTL) and problematic sexuality could be considered as indicators of psychopathological suffering.</p><p><strong>Aim: </strong>We aimed to investigate the relationship between problematic sexuality, specifically hypersexuality, and the symptom dimensions of psychoticism and paranoid ideation, with a focus on the role of the CTL, in a non-clinical sample.</p><p><strong>Methods: </strong>Through an online platform, we recruited a convenience sample of 521 subjects (390 females and 131 males; age span: 18-50).</p><p><strong>Outcomes: </strong>Recruited subjects completed a psychometric protocol that included completion of the following measurement tools: (1) the Capacity to Love Inventory, (2) the Hypersexual Behavior Inventory, (3) the Brief Symptom Inventory.</p><p><strong>Results: </strong>Results indicated a significant inverse correlation between CTL and both paranoid ideation and psychoticism, with hypersexuality positively correlated with these symptoms. Linear regression analysis revealed that CTL acts as a protective factor, while hypersexuality is a predictive factor for both psychoticism and paranoid ideation.</p><p><strong>Clinical implications: </strong>The study highlights the importance of evaluating sexual behavior and subclinical symptomatology in non-clinical populations, and it underscores the potential role of CTL as an indicator of relational functioning.</p><p><strong>Strengths and limitations: </strong>The strength of this research lies undoubtedly in its innovative inclusion of the construct of CTL in studying the relationship between sexuality, paranoid ideation, and psychoticism.However, the research design reveals a gender imbalance that may limit the significance of the findings. Moreover, the study was conducted on a sample primarily composed of students and individuals from Italian cultural backgrounds, which should be considered when generalizing the results.</p><p><strong>Conclusion: </strong>The relationship between the limitation of the CTL, hypersexuality and paranoid ideation and psychoticism (assessed with the SCL-90) sheds light on the importance of integrating the assessment of a central aspect of human life, that is, the CTL, with problematic sexuality and psychopathological symptoms, in the clinical practice of prevention of sexual and psychological problems.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf050"},"PeriodicalIF":2.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship and sexual satisfaction among patients with bipolar disorder and partners.","authors":"Lærke Helene Andreasen, Vita Djamilla Sandeman, Helle B Krogh, Julie Ravneberg Stokholm, Caroline Fussing Bruun, Jeff Zarp, Lars Vedel Kessing, Annamaria Giraldi, Maj Vinberg","doi":"10.1093/sexmed/qfaf051","DOIUrl":"10.1093/sexmed/qfaf051","url":null,"abstract":"<p><strong>Objectives: </strong>Good interpersonal relationships are associated with improved functioning, quality of life, and a better prognosis in patients with bipolar disorder (BD). Little information is available regarding relationship satisfaction and sexual satisfaction within couples where 1 partner has BD.</p><p><strong>Aim: </strong>This cross-sectional study aimed to examine relationship and sexual satisfaction in patients with BD and partners to patients with BD.</p><p><strong>Methods: </strong>Patients with BD and partners to patients with BD were included, and outcomes were assessed using semi-structured interviews and questionnaires.</p><p><strong>Outcomes: </strong>Couple satisfaction was measured by the self-reported questionnaire Couple Satisfaction Index (CSI-4), and sexual satisfaction was measured by 3 self-reported questions. Multiple regression analyses were used to compare the groups adjusting for sex, age, mood symptoms, overall functioning, and stress symptoms. The results were compared to general populations.</p><p><strong>Results: </strong>One hundred eleven patients with BD and 74 partners were included. We found a significant difference between patients with BD and partners concerning relationship satisfaction measured with the CSI, with partners being less satisfied (<i>P</i> = .050). Comparing relationship satisfaction in patients with BD and partners to the general population, we found that the general population was more satisfied in each CSI item (<i>P</i> < .050). In multiple regression analyses adjusted for sex, age, mood symptoms, stress, and function, patients with BD were more satisfied with their sexual life over the last year compared to partners (<i>P</i> = .039). They further rated the importance of a good sexual life higher than partners (<i>P</i> = .006). Finally, more patients with BD and partners rated their sex life the last year as being bad to extremely bad compared to the control group from the general population (partners = 21.1%, BD = 23.4%, general population = 16%).</p><p><strong>Clinical implications: </strong>In clinical practice, it is essential to focus on relationships including sexual life in patients with BD and partners as both groups have a lower degree of relationship and sexual satisfaction compared to the general population.</p><p><strong>Strengths and limitations: </strong>The use of validated questionnaires and clinical ratings is a strength, albeit the cross-sectional design is a limitation.</p><p><strong>Conclusions: </strong>Patients with BD reported a higher degree of satisfaction with their relationship and sexual life compared to their partners. Compared to the general population, both groups expressed lower degree of relationship and sexual satisfaction.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf051"},"PeriodicalIF":2.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptome analyses reveal the mechanism of mitochondrial activity in erectile dysfunction.","authors":"Biao Xiao, Qiangrong He, Jianbin Wang, Xun Zhou","doi":"10.1093/sexmed/qfaf049","DOIUrl":"10.1093/sexmed/qfaf049","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a multifactorial disorder, with mitochondrial dysfunction increasingly recognized as an important contributor to its pathogenesis.</p><p><strong>Aim: </strong>This study aimed to characterize the single-cell landscape of ED and investigate the impact of mitochondrial function on cellular heterogeneity.</p><p><strong>Methods: </strong>We performed single-cell RNA sequencing analysis on ED samples (GSE206528), screened for ED-related mitochondrial genes, evaluated mitochondrial activity using area under the curve cell scoring at the single-cell level, and conducted subclustering, cell-cell communication, pseudotime trajectory, and pathway enrichment analyses to systematically characterize key cell populations.</p><p><strong>Outcomes: </strong>The principal finding is that fibroblasts (FB) and endothelial cells (EC) display significant mitochondrial heterogeneity associated with ED.</p><p><strong>Results: </strong>A total of 64 993 high-quality cells were classified into seven major cell types. Among these, FB and EC exhibited significant mitochondrial heterogeneity. Seventy-three ED-related mitochondrial genes were identified, with 11 and six mitochondrial activity-associated genes in FB and EC, respectively. Subclustering analysis revealed six FB and four EC subpopulations, with distinct functional pathways. Cell-cell communication analysis indicated increased tumor necrosis factor, TNF-related apoptosis-inducing ligand, and wingless/integrated signaling in high-mitochondrial-activity groups. Pseudotime analysis suggested FB0 and EC1 as progenitor states, progressing toward FB4 and EC0, respectively. Pathway enrichment highlighted shared metabolic and stress-response pathways in FB and EC.</p><p><strong>Clinical implications: </strong>These results suggest that targeting mitochondrial dysfunction in FB and EC may offer novel therapeutic approaches for ED.</p><p><strong>Strengths & limitations: </strong>The study's strengths lie in its comprehensive single-cell characterization and functional annotation, while limitations include sample representativeness and the lack of direct experimental validation.</p><p><strong>Conclusion: </strong>This study provides a comprehensive single-cell landscape of ED, identifying mitochondrial dysfunction as a key contributor to cellular heterogeneity. FB and EC emerged as critical regulators, with potential implications for targeted therapeutic strategies.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf049"},"PeriodicalIF":2.6,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anorgasmia following initiation of GLP-1 agonist.","authors":"Vidya Visvabharathy, Sally MacPhedran, Katie Shupp, Benjamin King","doi":"10.1093/sexmed/qfaf047","DOIUrl":"10.1093/sexmed/qfaf047","url":null,"abstract":"<p><strong>Introduction: </strong>According to the Obesity Medicine Association, obesity is a chronic, progressive, relapsing, multifactorial and treatable neurobehavioral disease. A small number of drugs have been approved by the Food & Drug Administration (FDA) for weight loss. Liraglutide, Tirzepatide, and Semaglutide are GLP-1 agonists and anti-diabetic drugs, and are some of the latest FDA-approved medications for weight loss. Up to 50% of patients experience gastrointestinal (GI) distress, a common side effect, while taking these medications. Other side effects include tachycardia, antibody-mediated angioedema, anaphylaxis, irritation at the injection site, and hypoglycemia. However, very little is known regarding sexual dysfunction as a side effect of GLP-1 agonists. The following case report discusses the potential negative impact on sexual function of these widely prescribed anti-diabetic, weight loss medications. The case report also discusses a proposed mechanism of action of GLP-1 agonists on sexual function.</p><p><strong>Aims: </strong>To report the sexual side effects and plausible mechanism of female anorgasmia from GLP-1 agonists.</p><p><strong>Methods: </strong>Chart review of the patient case was conducted. Consultation with a Doctor of Pharmacy was also requested for additional guidance on possible mechanisms of action of GLP-1 agonists on sexual function.</p><p><strong>Results: </strong>Several proposed mechanisms causing anorgasmia were theorized, the most likely being GLP-1 agonist vasoconstriction of smooth muscle, which results in reduced oxygen delivery and blood flow to the genitals. This may hinder genital engorgement and arousal, in addition to causing impairment of smooth muscle contractions essential for orgasms. Other mechanisms of GLP-1 agonist-induced anorgasmia may involve their signaling in the brain due to their presence in the hypothalamus. GLP-1 receptor modulation in the hypothalamus may decrease dopamine and norepinephrine signaling, which are neurotransmitters crucial for motivation, pleasure, and orgasm as well as disrupt pathways involved in sexual desire and arousal.</p><p><strong>Conclusion: </strong>Further investigation on the prevalence of sexual dysfunction with GLP-1 agonists and their mechanism of action is needed.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf047"},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of surgical complications and risk factors in genital feminization surgery: a retrospective cohort study of 407 transgender women.","authors":"Fériel Ferchichi, Nicolas Morel-Journel, Damien Carnicelli, Lucas Freton, Lucie Jurek, Alain Ruffion, François-Xavier Madec, Paul Neuville","doi":"10.1093/sexmed/qfaf045","DOIUrl":"10.1093/sexmed/qfaf045","url":null,"abstract":"<p><strong>Background: </strong>Penile inversion vulvo-vaginoplasty with addition of a scrotal skin graft is a widely used technique in genital feminizing surgery for trans women.</p><p><strong>Aim: </strong>To identify the types and frequencies of complications following genital feminizing surgery and assess associated risk factors.</p><p><strong>Methods: </strong>A retrospective review was conducted on all trans women who underwent primary genital feminizing surgery at Lyon Sud University Hospital between 2008 and 2022. Inclusion criteria were age over 18 and a minimum follow-up of 1 year. Data were collected from electronic medical records and included demographic and clinical characteristics, surgical details, intraoperative events, postoperative complications, and revision procedures.</p><p><strong>Outcomes: </strong>The study focused on the incidence of intraoperative, early, and late postoperative complications, as well as the frequency and types of surgical revisions.</p><p><strong>Results: </strong>Among 407 patients (mean (SD) age of 38.6 (12.7) years, mean (SD) BMI of 24.7), intra-operative rectal injury occurred in 5 patients (1.2%). Early graft failure requiring revision was seen in 1%, and 23.1% underwent secondary revisions. Late complications included recto-neovaginal fistula (0.5%) and vaginal stenosis requiring revision (3.4%). Labiaplasty was the most frequent revision procedure (<i>n</i> = 68). Younger age was associated with increased early revisions, while BMI and smoking were not.</p><p><strong>Clinical implications: </strong>Clear, individualized preoperative counseling is essential to prepare patients for the potential need for revision surgery.</p><p><strong>Strengths & limitations: </strong>This study benefits from a large sample size and long follow-up but is limited by its retrospective design and reliance on electronic records.</p><p><strong>Conclusion: </strong>Penile inversion vulvo-vaginoplasty with scrotal skin graft is a generally safe procedure; detailed knowledge of complications supports better patient counseling and informed decision-making.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf045"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Chinese herbal medicine in the treatment of anxiety and depression in male sexual dysfunction: a systematic review and meta-analysis.","authors":"Zhaozhan Xie, Jinxian Lu, Xuecheng Zhang, Hongling Jia, Yongchen Zhang","doi":"10.1093/sexmed/qfaf048","DOIUrl":"10.1093/sexmed/qfaf048","url":null,"abstract":"<p><strong>Background: </strong>Male Sexual Dysfunction (MSD), comprising erectile dysfunction (ED) and premature ejaculation (PE), exhibits an age-related prevalence affecting 50% of males beyond their fourth decade. Beyond physiological manifestations, MSD with comorbid anxiety and depression exerts profound psychosocial impacts. Emerging evidence suggests Chinese Herbal Medicine (CHM) may offer therapeutic potential for addressing this clinical intersection.</p><p><strong>Aim: </strong>To systematically assess the efficacy of CHM on alleviating anxiety and depression in patients with MSD via a comprehensive systematic review and meta-analysis.</p><p><strong>Methods: </strong>This study systematically searched four Chinese databases (China National Knowledge Infrastructure, Wanfang Database, China Biomedical Database, and VIP Database) and four international databases (PubMed, Web of Science, EMBASE, and Cochrane Library). Randomized controlled trials (RCTs) investigating CHM interventions for MSD with comorbid anxiety and depression were identified.</p><p><strong>Outcomes: </strong>The primary outcome focused on changes in symptoms of anxiety and depression, while secondary outcomes encompassed overall male sexual function improvement.</p><p><strong>Results: </strong>By synthesizing data from 12 RCTs involving 1050 participants, our findings provide the first robust evidence that CHM significantly alleviates anxiety and depression in MSD, while concurrently improving core symptoms of MSD, such as PE and ED. Notably, CHM formulations demonstrated superior efficacy over SSRIs in improving both psychological scales, including Self-Rating Anxiety Scale [MD = -9.11, 95% CI (-11.53, -6.70), <i>P</i> < .05], Self-Rating Depression Scale [MD = -9.85, 95% CI (-14.07, -5.63), <i>P</i> < .05], the Hamilton Depression Rating Scale (HAMD) [MD = -5.30, 95% CI (-11.61, 1.01), <i>P</i> > .05], and the Hamilton Anxiety Rating Scale [MD = -3.89, 95% CI (-4.52,-3.27), <i>P</i> < .05], as well as MSD-specific metrics, such as International Index of Erectile Function-5 [MD = 3.26, 95% CI (1.98, 4.53), <i>P</i> < .05] and intravaginal ejaculation latency time [MD = 1.60, 95% CI (0.82, 2.37), <i>P</i> < .05]. Importantly, the lack of statistical significance in HAMD scores in our analysis may be attributed to the differences in treatment responses between the PE and ED populations.</p><p><strong>Clinical implications: </strong>It provides evidence-based support to address the limitations of separating physical and mental symptoms in traditional treatment, further substantiates its application value within the integrated medical model, and explores new research avenues for designing personalized treatment plans for patients.</p><p><strong>Strengths and limitations: </strong>A first-of-its-kind systematic evaluation was conducted to assess the comprehensive efficacy of traditional CHM in alleviating anxiety and depression symptoms while improving sexual function indic","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf048"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practices and attitudes of Israeli obstetrician-gynecologists regarding female sexual health: results from a national survey.","authors":"Inshirah Sgayer, Yacov Reisman, Chen Nusbaum, Rola Farah-Khamisy, Ala Aiob, Lior Lowenstein","doi":"10.1093/sexmed/qfaf044","DOIUrl":"10.1093/sexmed/qfaf044","url":null,"abstract":"<p><strong>Background: </strong>Sexual health is an often-overlooked component of clinical care that has significant implications for patients' quality of life.</p><p><strong>Aim: </strong>To evaluate the practices, attitudes, and barriers faced by Israeli obstetrician-gynecologists (OB-GYNs) in addressing female sexual health, and to identify factors that influence engagement.</p><p><strong>Methods: </strong>During April-December 2024, a cross-sectional survey was conducted that assessed Israeli OB-GYNs' socio-demographics, frequency of initiating discussions, perceived training adequacy, and barriers to addressing sexual health.</p><p><strong>Outcomes: </strong>The primary outcomes were the frequency of initiating discussions on sexual health and the perceived adequacy of training in addressing sexual dysfunction.</p><p><strong>Results: </strong>Among 504 participants, 19.1% routinely initiated discussions on sexual health, while 45.8% rarely did. Female compared to male OB-GYNs (<i>P</i> = 0.002), and infertility compared to other specialists (<i>P</i> = 0.003) were more likely to engage in these discussions. Barriers included limited clinic time (57.5%), insufficient knowledge of treatment options (48.2%), a lack of strategies for initiating discussions (27.0%), and discomfort discussing these issues (15.9%). OB-GYNs aged 60 years and older, compared to 20-29 years, and those who graduated in Israel, rather than abroad (<i>P</i> < 0.001 for both), were more likely to report feeling comfortable addressing sexual health topics. OB-GYNs in central Israel and Jewish participants were more likely to feel comfortable, compared to their southern and Muslim counterparts (<i>P</i> < 0.001 for both). Training was rated as poor or very poor by 43.2% for discussing sexual health and 60.2% for treating sexual dysfunction. Compared to their counterparts, poor training was reported by OB-GYNs under age 60 years, with degrees from abroad, and with less experience. The respective odds ratios were 2.70 (95% CI 1.47-4.96, <i>P</i> = 0.001), 1.799 (95% CI 1.24-2.60, <i>P</i> = 0.002), and 1.72 (95% CI 1.04-2.82, <i>P</i> = 0.033). Most respondents supported integrating sexual health education into medical curricula (69.5%) and OB-GYN residency programs (89.1%).</p><p><strong>Clinical implications: </strong>Significant gaps in the training and practices of Israeli OB-GYNs underscore the need for enhanced education tailored to address cultural and demographic factors.</p><p><strong>Strengths and limitations: </strong>The large, diverse sample provides valuable insights. However, the self-reported data may have introduced bias, and the cultural diversity may limit generalizability.</p><p><strong>Conclusion: </strong>Substantial gaps were reported in the training and practices of Israeli OB-GYNs regarding female sexual health. These findings underscore the need for enhanced education and structured training programs, tailored also to address cultural and demographic","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf044"},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Continuous education in sexology: the International Online Sexology Supervisors (IOSS) conceptual framework and roadmap.","authors":"","doi":"10.1093/sexmed/qfaf053","DOIUrl":"https://doi.org/10.1093/sexmed/qfaf053","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sexmed/qfaf036.].</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 3","pages":"qfaf053"},"PeriodicalIF":2.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}