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Novel forms of ventilation in neonates: Neurally adjusted ventilatory assist and proportional assist ventilation 新生儿通气的新形式：神经调节通气辅助和比例辅助通气。
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-03-01 DOI: 10.1016/j.semperi.2024.151889
R.L. McKinney , L. Wallström , S.E. Courtney , R. Sindelar
{"title":"Novel forms of ventilation in neonates: Neurally adjusted ventilatory assist and proportional assist ventilation","authors":"R.L. McKinney ,&nbsp;L. Wallström ,&nbsp;S.E. Courtney ,&nbsp;R. Sindelar","doi":"10.1016/j.semperi.2024.151889","DOIUrl":"10.1016/j.semperi.2024.151889","url":null,"abstract":"<div><p>Patient-triggered modes of ventilation are currently the standard of practice in the care of term and preterm infants. Maintaining spontaneous breathing during mechanical ventilation promotes earlier weaning and possibly reduces ventilator-induced diaphragmatic dysfunction. A further development of assisted ventilation provides support in proportion to the respiratory effort and enables the patient to have full control of their ventilatory cycle. In this paper we will review the literature on two of these modes of ventilation: neurally adjusted ventilatory assist (NAVA) and proportional assist ventilation (PAV), propose future studies and suggest clinical applications of these modes.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 2","pages":"Article 151889"},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVER (PMS 486 K) 封面（PMS 486 K）
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-03-01 DOI: 10.1053/S0146-0005(24)00018-1
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引用次数: 0
TOPICS 主题
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-03-01 DOI: 10.1053/S0146-0005(24)00020-X
{"title":"TOPICS","authors":"","doi":"10.1053/S0146-0005(24)00020-X","DOIUrl":"https://doi.org/10.1053/S0146-0005(24)00020-X","url":null,"abstract":"","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 2","pages":"Article 151894"},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volume-targeted ventilation 容积目标通气
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-03-01 DOI: 10.1016/j.semperi.2024.151886
Martin Keszler , M. Kabir Abubakar
{"title":"Volume-targeted ventilation","authors":"Martin Keszler ,&nbsp;M. Kabir Abubakar","doi":"10.1016/j.semperi.2024.151886","DOIUrl":"10.1016/j.semperi.2024.151886","url":null,"abstract":"<div><p>Despite strong evidence of important benefits of volume-targeted ventilation, many high-risk extremely preterm infants continue to receive traditional pressure-controlled ventilation in the United States and elesewhere. Reluctance to abandon one's comfort zone, lack of suitable equipment and a lack of understanding of the subtleties of volume-targeted ventilation appear to contribute to the relatively slow uptake of volume-targeted ventilation. This review will underscore the benefits of using tidal volume as the primary control variable, to improve clinicians’ understanding of the way volume-targeted ventilation interacts with the awake, breathing infant and to provide information about evidence-based tidal volume targets in various circmstances. Focus on underlying lung pathophysiology, individualized ventilator settings and tidal volume targets are essential to successful use of this approach thereby improving important clinical outcomes.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 2","pages":"Article 151886"},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The most painful estrangement: Death at birth 最痛苦的分离出生时的死亡
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-02-01 DOI: 10.1016/j.semperi.2023.151870
Joanne Cacciatore
{"title":"The most painful estrangement: Death at birth","authors":"Joanne Cacciatore","doi":"10.1016/j.semperi.2023.151870","DOIUrl":"10.1016/j.semperi.2023.151870","url":null,"abstract":"<div><p><span>More than two million babies a year die during or before birth around the world, evoking grief that is traumatic. Because the psychological, physical, social, and emotional ramifications of grief following a baby's death are so enduring and intense, social support is essential to helping families cope. In particular, emotional acts of caring and judicious use of language are crucial, avoiding the use of the terms that belittle the value of the baby's life and the importance of the baby as part of a family history. </span>Traumatic grief informed continuing education can aid providers in increasing sensitivity to the needs of grieving families and minimize additional trauma and suffering in the aftermath of such loss.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 1","pages":"Article 151870"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138744488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stillbirth and the placenta 死胎和胎盘
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-02-01 DOI: 10.1016/j.semperi.2023.151871
Jerri A Waller , George Saade
{"title":"Stillbirth and the placenta","authors":"Jerri A Waller ,&nbsp;George Saade","doi":"10.1016/j.semperi.2023.151871","DOIUrl":"10.1016/j.semperi.2023.151871","url":null,"abstract":"<div><p><span>Stillbirth affects a large proportion of pregnancies world-wide annually and continues to be a major </span>public health<span> concern. Several causes of stillbirth have been identified and include obstetrical complications, placental abnormalities, fetal malformations<span>, infections, and medical complications in pregnancy. Placental abnormalities such as placental abruption, chorioangioma, vasa previa<span>, and umbilical cord<span> abnormalities have been identified as causes of death for a significant proportion of stillbirths. In the absence of placental abnormalities, the gross and histologic changes in the placenta in stillbirth are found when secondary to other etiologies. Here we describe both gross and histologic changes of the placenta that are associated with stillbirth.</span></span></span></span></p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 1","pages":"Article 151871"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Racial and ethnic inequities in stillbirth in the US: Looking upstream to close the gap 美国死胎中的种族和民族不平等：逆流而上，缩小差距
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-02-01 DOI: 10.1016/j.semperi.2023.151865
Michelle P Debbink , Kaitlyn K. Stanhope , Carol J.R. Hogue
{"title":"Racial and ethnic inequities in stillbirth in the US: Looking upstream to close the gap","authors":"Michelle P Debbink ,&nbsp;Kaitlyn K. Stanhope ,&nbsp;Carol J.R. Hogue","doi":"10.1016/j.semperi.2023.151865","DOIUrl":"10.1016/j.semperi.2023.151865","url":null,"abstract":"<div><p>Though stillbirth<span> rates in the United States improved over the previous decades, inequities in stillbirth by race and ethnicity have persisted nearly unchanged since data collection began. Black and Indigenous pregnant people face a two-fold greater risk of experiencing the devastating consequences of stillbirth compared to their White counterparts. Because race is a social rather than biological construct, inequities in stillbirth rates are a downstream consequence of structural, institutional, and interpersonal racism which shape a landscape of differential access to opportunities for health. These downstream consequences can include differences in the prevalence of chronic health conditions as well as structural differences in the quality of health care or healthy neighborhood conditions, each of which likely plays a role in racial and ethnic inequities in stillbirth. Research and intervention approaches that utilize an equity lens may identify ways to close gaps in stillbirth incidence or in responding to the health and socioemotional consequences of stillbirth. A community-engaged approach that incorporates experiential wisdom will be necessary to create a full picture of the causes and consequences of inequity in stillbirth outcomes. Investigators working in tandem with community partners, utilizing a combination of qualitative, quantitative, and implementation science approaches, may more fully elucidate the underpinnings of racial and ethnic inequities in stillbirth outcomes.</span></p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 1","pages":"Article 151865"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138993341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomics of stillbirth 死胎基因组学
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-02-01 DOI: 10.1016/j.semperi.2023.151866
Jessica L. Giordano, Ronald J. Wapner
{"title":"Genomics of stillbirth","authors":"Jessica L. Giordano,&nbsp;Ronald J. Wapner","doi":"10.1016/j.semperi.2023.151866","DOIUrl":"10.1016/j.semperi.2023.151866","url":null,"abstract":"<div><p><span><span>Stillbirth<span>, defined as fetal death at 20 weeks gestation or later, is a devastating pregnancy outcome affecting 1 in 175 pregnancies in the United States. Although efforts to understand the etiology of stillbirth have expanded, 25 % of cases remain unexplained and some cases previously thought to be explained may have additional unknown causative factors. Determining an etiology for stillbirth is important for clinical management and for grieving families to obtain closure, to find meaning, and to understand recurrence risks. However, the evaluation of stillbirth is not completed uniformly despite American College of </span></span>Obstetrics and </span>Gynecology<span><span> (ACOG) guidelines and stillbirth data is frequently incomplete due to lack of genomic analysis, fetal autopsy, and placental pathology. </span>Karyotype<span><span> and chromosomal microarray have been the gold standard in genetic analysis in perinatal medicine for many years, but </span>next generation sequencing holds promise towards improving diagnostic yields and providing clarity for both clinicians and patients.</span></span></p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 1","pages":"Article 151866"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138744611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stillbirth risk factors, causes and evaluation 死产风险因素、原因和评估
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-02-01 DOI: 10.1016/j.semperi.2023.151867
Christy Gandhi , Jessica Page
{"title":"Stillbirth risk factors, causes and evaluation","authors":"Christy Gandhi ,&nbsp;Jessica Page","doi":"10.1016/j.semperi.2023.151867","DOIUrl":"10.1016/j.semperi.2023.151867","url":null,"abstract":"<div><p><span>Stillbirth<span> impacts 5.73 per 1,000 births in the United States and this rate exceeds that of contemporary high-resource countries.</span></span><span><sup>1</sup></span><sup>,</sup><span><sup>2</sup></span><span> Risk factors include both demographic and medical characteristics. There are also numerous pathophysiologic mechanisms that can lead to stillbirth. Unfortunately, these risk factors are fairly common, making stillbirth risk stratification and prevention challenging. This is due in part to a large number of unexplained stillbirths. In a large, multi-center study of stillbirths, approximately 24% of stillbirths remained unexplained following thorough, standardized evaluation.</span><span><sup>3</sup></span> The number of unexplained stillbirths is unquestionably larger outside of a rigorous study protocol, but real-world data are lacking. This large proportion of unexplained stillbirth cases makes achieving further decreases in the stillbirth rate difficult given lack of understanding of underlying causes in this population. Cause of death identification can be improved with adoption of an evidence-based, comprehensive stillbirth evaluation.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 1","pages":"Article 151867"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138820940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVER (PMS 486 K) 封面（PMS 486 K）
IF 3.4 3区 医学
Seminars in perinatology Pub Date : 2024-02-01 DOI: 10.1053/S0146-0005(24)00001-6
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引用次数: 0
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