Seminars in perinatologyPub Date : 2025-12-01Epub Date: 2025-12-04DOI: 10.1016/j.semperi.2025.152163
Aisling Fanning , Elisabetta Pegorer , Andreea M Pavel , Sean R Mathieson , Brian H Walsh , Geraldine B Boylan
{"title":"Background EEG grading for the assessment of neonatal encephalopathy in full term neonates","authors":"Aisling Fanning , Elisabetta Pegorer , Andreea M Pavel , Sean R Mathieson , Brian H Walsh , Geraldine B Boylan","doi":"10.1016/j.semperi.2025.152163","DOIUrl":"10.1016/j.semperi.2025.152163","url":null,"abstract":"<div><div>Multichannel electroencephalography (EEG) is a well-established tool for detecting neonatal seizures and for the assessment of global brain function. Numerous classification and grading schemes for neonatal EEG in full term neonates have been proposed but no universally accepted framework exists, hindering international multicentre research and complicating clinical interpretation. This review summarises widely used classification schemes, compares their key features and argues for a consensus-based classification system.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 8","pages":"Article 152163"},"PeriodicalIF":3.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-10-28DOI: 10.1016/j.semperi.2025.152154
Samudragupta Bora
{"title":"Systems framework for post-hospital follow-up care of small and/or sick newborns: A pathway to sustainable and scalable quality care in low-resource, high-burden countries","authors":"Samudragupta Bora","doi":"10.1016/j.semperi.2025.152154","DOIUrl":"10.1016/j.semperi.2025.152154","url":null,"abstract":"<div><div>South Asian and Sub-Saharan African countries, disproportionately overrepresented in the World Bank’s low- and middle-income categories, bear a high burden of small and/or sick newborns. It is important to acknowledge that, in addition to reducing mortality, creating opportunities to enhance their health and well-being, thereby improving quality of life, is an essential metric for evaluating neonatal care success. With increased survival rates for small and/or sick newborns in most high-burden, resource-constrained settings, developing and strengthening specialized, structured neonatal follow-up programs to provide high-quality post-hospital care is imperative for optimizing outcomes and quality of life. This paper proposes a Systems Framework for Neonatal Follow-Up of small and/or sick newborns. While this framework applies to all settings, it is particularly pertinent in low-resource, high-burden countries, considering their unique contextual settings. This framework will provide a significant opportunity to foster meaningful engagement and partnership with a wide range of relevant local stakeholders, including families with small and/or sick newborns, as well as to identify areas for increased strategic investment. Furthermore, a multidimensional checklist aligned with the proposed framework provides a comprehensive tool for assessing neonatal follow-up readiness in health systems. The goal is to accelerate progress by transforming the delivery and accessibility of neonatal follow-up for small and/or sick newborns, thus improving the prospects for favorable long-term outcomes in this highly vulnerable population.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152154"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145393040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-09-22DOI: 10.1016/j.semperi.2025.152156
Mary Lauren Neel , Kristen L Benninger
{"title":"Perception of neonatal outcomes: lessons learned from positive health","authors":"Mary Lauren Neel , Kristen L Benninger","doi":"10.1016/j.semperi.2025.152156","DOIUrl":"10.1016/j.semperi.2025.152156","url":null,"abstract":"<div><div>Traditional measures of neurodevelopmental outcomes in preterm children are deficit focused and not informed by parent and family perspectives. Parents care less about medical classification of severity of disability and more about the child’s ability to function and participate. Positive health encompasses a broad and dynamic perspective on health that goes beyond the absence of disease and focuses on physical, mental, and social well-being, life-satisfaction, and goal attainment. Measuring positive health as an outcome in children at high risk of disability is challenging but possible. Further exploration of positive health as an outcome may meet the needs of both families and researchers.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152156"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-09-13DOI: 10.1016/j.semperi.2025.152147
Nathalie L. Maitre , Kanishka S. Baduni
{"title":"Early detection of cerebral palsy in community settings: current state and a pathway forward","authors":"Nathalie L. Maitre , Kanishka S. Baduni","doi":"10.1016/j.semperi.2025.152147","DOIUrl":"10.1016/j.semperi.2025.152147","url":null,"abstract":"<div><div>We explore how and why early detection of cerebral palsy (CP) should occur in community settings across low and middle income countries (LMICs) and high income countries (HICs). Early diagnosis is best clinical practice and can happen in the first year of life using evidence-based tools such as the General Movements Assessment (GMA) and the Hammersmith Infant Neurological Examination (HINE). In HICs, primary care surveillance guided by published motor “red flags” can identify children who need prompt referral, yet uptake remains uneven. In LMICs, clinicians demonstrate high diagnostic accuracy when tools are available, but the main barrier is health system reach rather than clinical capability. Across settings, caregiver studies show that delayed diagnosis reduces empowerment, increases mental health burden, and erodes trust in services. The central implementation task is to build reliable pathways that connect families from home to timely diagnosis, aligning community surveillance with referral networks, provider training, and policy support. Strengthening these pathways is essential to improve participation, reduce comorbidity burden, and enhance wellbeing for children with CP and their families.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152147"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-09-27DOI: 10.1016/j.semperi.2025.152150
Joanna Parga-Belinkie , Benjamin Courchia , Daphna Yasova Barbeau
{"title":"Using media to transform education and public health messaging in the neonatal intensive care unit","authors":"Joanna Parga-Belinkie , Benjamin Courchia , Daphna Yasova Barbeau","doi":"10.1016/j.semperi.2025.152150","DOIUrl":"10.1016/j.semperi.2025.152150","url":null,"abstract":"<div><div>In this era of rapid digital transformation, media has become an essential tool for education, communication, collaboration, and advocacy in neonatal-perinatal care. This article explores the evolving media ecosystem within the neonatal intensive care unit (NICU), highlighting how healthcare professionals are using traditional media, video content, blogs, podcasts, and social media to connect with one another, share the latest research, educate peers and families, improve clinical practice, and amplify public health messaging. Drawing on diverse examples and expert commentary, the authors argue that strategic engagement in media enhances family-centered care, bridges the gap between research and bedside application, and fosters a connected, informed, and empowered neonatal community. The article presents a framework for assessing media engagement and invites clinicians to consider how media integration can shape their professional identity and expand their impact beyond their units.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152150"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-09-18DOI: 10.1016/j.semperi.2025.152148
Matthew J. Kielt , Lauren A. Sanlorenzo
{"title":"Interdisciplinary collaboration and innovation in established bronchopulmonary dysplasia","authors":"Matthew J. Kielt , Lauren A. Sanlorenzo","doi":"10.1016/j.semperi.2025.152148","DOIUrl":"10.1016/j.semperi.2025.152148","url":null,"abstract":"<div><div>Bronchopulmonary dysplasia (BPD) is the most common morbidity experienced by infants born extremely preterm. With improved survival of extremely preterm infants, rates of BPD have increased and the number of infants with established BPD being cared for in neonatal intensive care units (NICU) is increasing. To address the complex clinical needs of infants with established BPD, interdisciplinary BPD programs have been developed at level-IV NICUs throughout the United States. Interdisciplinary BPD programs adopt the principles of chronic care models that differ in size, scope, and practices when compared to traditional acute care NICU’s clinical programs. The purpose of this review is to summarize the collaborative and innovative features of interdisciplinary BPD clinical care programs.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152148"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-10-07DOI: 10.1016/j.semperi.2025.152155
Leeann Pavlek , Debra Armbruster , Cecilie Halling , Kaitlyn Hipp , Maria Jebbia , Susan Lopata , Matthew Rysavy , Rebecca Saliga , Sheria Wilson , Claire Beaullieu
{"title":"Transforming preterm care: The power of small baby guidelines in enhancing outcomes","authors":"Leeann Pavlek , Debra Armbruster , Cecilie Halling , Kaitlyn Hipp , Maria Jebbia , Susan Lopata , Matthew Rysavy , Rebecca Saliga , Sheria Wilson , Claire Beaullieu","doi":"10.1016/j.semperi.2025.152155","DOIUrl":"10.1016/j.semperi.2025.152155","url":null,"abstract":"<div><div>As survival rates of extremely preterm (EPT) infants continue to improve, focus has shifted to reduce morbidity and complications in these vulnerable patients. Management of EPT infants presents significant clinical, logistical, and sometimes ethical challenges. Outcomes across centers are highly variable and strongly influenced by the care provided in the early neonatal period. Standardized guidelines, based on published literature and center-specific experiences, play an important role in improving outcomes for EPT infants. Multidisciplinary guidelines provide a framework for clinical management and support a consistent care approach. Guidelines can improve care throughout the entire neonatal intensive care unit (NICU) course, beginning prior to delivery during antenatal counseling, delivery room management, golden hour, and throughout the NICU stay as infants’ needs evolve based on physiologic changes.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152155"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measuring family-important outcomes in large neonatal networks: where we are and where we need to go","authors":"Catherine Demers , Thuy Mai Luu , Stephanie Glegg , Jehier Afifi , Rebecca Pearce , Émilie Thivierge , Annie Janvier","doi":"10.1016/j.semperi.2025.152149","DOIUrl":"10.1016/j.semperi.2025.152149","url":null,"abstract":"<div><div>Neonatal follow-up programs are critical in monitoring the long-term outcomes of infants born preterm. The current focus is on neurodevelopmental impairment (NDI). However, such deficit-based outcomes often exclude parental perspectives, failing to capture what matters the most to families: function and quality of life over diagnoses. This paper explores the integration of new family-important outcomes (FIO) measures into neonatal follow-up using patient-reported outcome measures. FIO measures are patient-completed questionnaires that assess a range of health outcomes such as health status, functional ability, and quality of life. We discuss the importance and ethical imperative of integrating FIO measures into neonatal follow-up programs to better align care with family priorities and challenges in bringing practice changes. We propose using an implementation science approach to successfully embed FIO measures into practice and research, enhancing the relevance, equity, and quality of neonatal follow-up care.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152149"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-09-19DOI: 10.1016/j.semperi.2025.152153
Marliese Dion Nist, Nicole Cistone, Rita H. Pickler
{"title":"Improving outcomes for preterm infants: Mitigating stress exposure","authors":"Marliese Dion Nist, Nicole Cistone, Rita H. Pickler","doi":"10.1016/j.semperi.2025.152153","DOIUrl":"10.1016/j.semperi.2025.152153","url":null,"abstract":"<div><div>Stress exposure in the neonatal intensive care unit (NICU) is ubiquitous and affects long-term outcomes for preterm infants. The NICU hospitalization occurs during a critical period of experience-dependent and experience-expectant development when the immature brain is particularly sensitive to environmental exposures, but the experiences of preterm infants are often poorly matched to their neurologic expectations. The mismatch between preterm infants’ experiences and neurologic expectations may cause abnormal brain development and programming of the stress response systems. Routine nursing care and parental separation are two neurologically unexpected experiences that, while often overlooked, may be amenable to interventions, including system-level changes. To guide the development and implementation of effective interventions, it is necessary to understand how nurse caregiving practices and parental separation specifically contribute to the preterm infant’s stress burden. The purpose of this paper is to provide an overview of the effects of routine nursing care and parental separation, two persistent NICU stressors, and offer recommendations for interventions that nurses and other care providers can use to mitigate the negative effects of these exposures.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152153"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in perinatologyPub Date : 2025-11-01Epub Date: 2025-09-18DOI: 10.1016/j.semperi.2025.152144
Robert Barrett , Brooke Lawler , Star Liu , Woo Yeon Park , Marjan Davoodi , Ben Martin , Sai Manasa Kalyanam , Kartikeya Makker , Jordan R. Kuiper , Khyzer B. Aziz
{"title":"Transforming neonatal care through informatics: A review of artificial intelligence, data, and implementation considerations","authors":"Robert Barrett , Brooke Lawler , Star Liu , Woo Yeon Park , Marjan Davoodi , Ben Martin , Sai Manasa Kalyanam , Kartikeya Makker , Jordan R. Kuiper , Khyzer B. Aziz","doi":"10.1016/j.semperi.2025.152144","DOIUrl":"10.1016/j.semperi.2025.152144","url":null,"abstract":"<div><div>Significant strides have been made in utilizing data, information, and knowledge to enhance neonatal outcomes. This review examines how data informatics, encompassing electronic health records (EHRs), data standards, and artificial intelligence (AI), has facilitated advancements in neonatal care and research. Vast amounts of data, structured and unstructured, have been produced from clinical care. In turn AI stands to improve patient care, safety, and quality improvement initiatives. Facilitated by AI, clinicians’ interaction with neonatal informatic tools is transitioning from reactive to real-time, proactive care. Historically, necrotizing enterocolitis, sepsis, medical imaging, and neonatal mortality have been the targets of AI-integrated neonatal care. While much progress has been made in developing state-of-the-art AI tools, their development and implementation must consider optimization of patient care, clinical workflows, and aim to decrease clinician burnout. Employing a sociotechnical framework to assess both technical and human factors is key to effectively evaluating clinical utility, promoting adoption, and facilitating successful deployment. Beyond technical concerns, ethical considerations such as trust in AI, data security, and model transparency are critical to the responsible deployment of informatics tools. Ongoing advancements in neonatal care coupled with informatics, multi-omics, AI, and federated learning expands the possibilities of personalized care for neonates.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 7","pages":"Article 152144"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}