Karnataka Pediatric Journal最新文献

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The company that one keeps: An interplay between growth hormone and other pituitary hormones 伴侣:生长激素和其他垂体激素之间的相互作用
Karnataka Pediatric Journal Pub Date : 2022-06-20 DOI: 10.25259/kpj_3_2022
Diksha Shirodkar, Najya Nasrin, Safeena Ansari Suhara, Prakash M Saldanha
{"title":"The company that one keeps: An interplay between growth hormone and other pituitary hormones","authors":"Diksha Shirodkar, Najya Nasrin, Safeena Ansari Suhara, Prakash M Saldanha","doi":"10.25259/kpj_3_2022","DOIUrl":"https://doi.org/10.25259/kpj_3_2022","url":null,"abstract":"Short stature is defined as a height <2 SD from the mean height for a child of the same sex, ethnicity and chronological age. We present a case series of proportionate short stature whose associated endocrinological deficits left us intrigued. A 9 ½-year-old boy presented with poor growth-velocity (GV) for 5 years and central diabetes insipidus (on the treatment for 1 year). His height was 118 cm (−2.6 SD) and his weight was 20 kg (−2.03 SD). MRI brain showed hypoplastic anterior pituitary with absent bright spot and growth hormone (GH) dynamics proved GH deficiency. A 10-year-4-month-old girl presented with poor GV. Her height was 106 cm (−4.44 SD) and her weight was 15 kg (−3.74 SD). Targeted investigations revealed multiple pituitary hormone deficiencies (central hypothyroidism, secondary adrenal insufficiency and GH deficiency). MRI brain showed reduced pituitary height with ectopic posterior pituitary. GH therapy commenced only after coverage with hydrocortisone. A 1-year-old boy was admitted with failure to gain weight and height for 4 months of age. His length was 57 cm (−7.89 SD) and weight: was 4.6 kg (−5.86 SD) with immature facies, frontal bossing and midfacial hypoplasia. Low GH values at the time of critical sample (blood glucose = 36 mg/dl) revealed GH deficiency. MRI brain demonstrated a hypoplastic pituitary gland. All proportionate short-statured children without obvious dysmorphism need detailed evaluation. GH deficiency can present as a spectrum from isolated deficiency to multiple pituitary (anterior and posterior) deficiencies and so the order of correction of the deficiencies is equally important.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121758280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incontinentia pigmenti with ocular, cutaneous and CNS manifestation 有眼部、皮肤和中枢神经系统表现的色素失禁
Karnataka Pediatric Journal Pub Date : 2022-06-16 DOI: 10.25259/kpj_19_2020
N. Varghese, Venugopalan Nettiyath
{"title":"Incontinentia pigmenti with ocular, cutaneous and CNS manifestation","authors":"N. Varghese, Venugopalan Nettiyath","doi":"10.25259/kpj_19_2020","DOIUrl":"https://doi.org/10.25259/kpj_19_2020","url":null,"abstract":"Incontinentia Pigmenti (IP) is an uncommon X-linked genodermatosis, with an estimated prevalence at birth of 0.7/100,000, caused by mutations in the NEMO gene. Ectodermic and mesodermic origin of tissue is seen in this systemic disease including cutaneous tissue, teeth, eyes, and the central nervous system. Herein, we present a case of a female newborn with inflammatory vesiculopustular lesions all over the body. This baby also had ocular, and CNS manifestations as well. The importance of a detailed diagnostic workup for the newborns with pustular skin disease has been highlighted in this case. IP is a rare, x-linked dominant genodermatosis with the involvement of multiple organs. Dermatological abnormalities are the most prominent manifestation. The diagnosis is based on the clinical findings of skin lesion brain imaging and biopsy. The skin lesions do not require specific treatment and prognosis depend on other organ involvement.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116756713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All about scrub typhus 都是关于恙虫病的
Karnataka Pediatric Journal Pub Date : 2022-06-16 DOI: 10.25259/kpj_13_2020
S. Agarwalla
{"title":"All about scrub typhus","authors":"S. Agarwalla","doi":"10.25259/kpj_13_2020","DOIUrl":"https://doi.org/10.25259/kpj_13_2020","url":null,"abstract":"\u0000\u0000Rickettsia is Gram-negative, non-motile, obligate intracellular proteobacteria. They stay in various forms such as coccus, bacillus, and threads. At times, they are regarded as coccobacilli. No human-to-human transmission is there. They always need a vector such as fleas, lice, mite, and ticks for transmission. Rickettsiae species were classically divided into spotted fever and typhus groups. Scrub typhus also known as bush typhus is an important cause of acute febrile illness in South and East Asia and Pacific. It is caused by the intracellular parasite Orientia tsutsugamushi, a gram negative alpha proteobacterium of family Rickettsiaceae which was first isolated and identified in 1930 in Japan. It is distinct from other Rickettsiae in that it lacks both peptidoglycan and lipopolysaccharide in its cell wall. Like other vasculotropic rickettsiae, it affects vascular endothelial cells causing vasculitis. It also affects macrophages and cardiac myocytes.\u0000\u0000\u0000\u0000This review will give a way forward regarding all information about scrub typhus in detail.\u0000\u0000\u0000\u0000Various clinical profile especially clinical features, presence or absence of ESCHAR, organ invovement, investigations, treatment and final outcome was studied in detail.\u0000\u0000\u0000\u0000Clinical results, investigations were analysed to stamp the diagnosis. Different modalities of management has interpreted well.\u0000\u0000\u0000\u0000Among all rickettsial infections, scrub typhus being most common is seen all over Indian states and UTs. A child presenting to ER with fever of unknown origin, nephropathy, acute encephalitic syndrome, hepatosplenomegaly, lymphadenopathy, and also hypotension pointing toward possibility of scrub, hence, a detailed search for ESCHAR being essential in clinical examination.\u0000","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126106519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune thyroiditis in adolescents: Two different presentations 青少年自身免疫性甲状腺炎:两种不同的表现
Karnataka Pediatric Journal Pub Date : 2022-06-16 DOI: 10.25259/kpj_19_2021
Pratibha Manjunath Patagar, S. Rudrappa
{"title":"Autoimmune thyroiditis in adolescents: Two different presentations","authors":"Pratibha Manjunath Patagar, S. Rudrappa","doi":"10.25259/kpj_19_2021","DOIUrl":"https://doi.org/10.25259/kpj_19_2021","url":null,"abstract":"Autoimmune thyroiditis is one of the most common causes of acquired hypothyroidism in children and adolescents. Both genetic susceptibility and environmental factors play a role in etiopathogenesis. We report two cases of autoimmune thyroiditis here with varied presentation. Both of them had different clinical features of hypothyroidism at presentation. On investigation, both of them had elevated thyroid-stimulating hormone (TSH), low T4 and elevated anti-Thyroid peroxidase (TPO) antibodies. Case 1 also had elevated anti-TG antibody level. Based on these findings, diagnosis of autoimmune thyroiditis was made and started on levothyroxine tablet, for which both of them showed both clinical and biochemical improvements.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133871557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thiamine-responsive megaloblastic anaemia syndrome – A case report 硫胺素反应性巨幼细胞贫血综合征1例报告
Karnataka Pediatric Journal Pub Date : 2022-06-14 DOI: 10.25259/kpj_18_2021
S. Shubha, S. Rudrappa
{"title":"Thiamine-responsive megaloblastic anaemia syndrome – A case report","authors":"S. Shubha, S. Rudrappa","doi":"10.25259/kpj_18_2021","DOIUrl":"https://doi.org/10.25259/kpj_18_2021","url":null,"abstract":"Thiamine is a water-soluble vitamin which is helpful for tissue growth and development. Thiamine-responsive megaloblastic anaemia (TRMA), also known as Rogers syndrome, is caused by the mutation of a gene SLC19A2 which encodes for a thiamine transporter protein. TRMA is characterised by the triad of megaloblastic anaemia, progressive sensorineural hearing loss and diabetes mellitus. The onset of megaloblastic anaemia is between the extremes of infancy and adolescence, which can be corrected with pharmacological doses of thiamine. Progressive sensorineural hearing loss is generally early in onset, irreversible and may not be prevented by thiamine treatment.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123406523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paediatric journal article watch 儿科期刊文章观看
Karnataka Pediatric Journal Pub Date : 2022-05-10 DOI: 10.25259/kpj_4_2022
V. S. Kumar
{"title":"Paediatric journal article watch","authors":"V. S. Kumar","doi":"10.25259/kpj_4_2022","DOIUrl":"https://doi.org/10.25259/kpj_4_2022","url":null,"abstract":"","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120951544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patenting the innovation and regulatory considerations 专利创新和监管方面的考虑
Karnataka Pediatric Journal Pub Date : 2022-05-09 DOI: 10.25259/kpj_12_2021
Bindu Sharma
{"title":"Patenting the innovation and regulatory considerations","authors":"Bindu Sharma","doi":"10.25259/kpj_12_2021","DOIUrl":"https://doi.org/10.25259/kpj_12_2021","url":null,"abstract":"Bringing a medical product in the market is far more complicated compared to any other product due to its sensitivity and direct implication to human life. On one hand, legal protection in the form of patent may be needed and on the other hand the approval to manufacture and sell product should be obtained. In this article, we will discuss the role of Intellectual Property Rights in protecting innovations as well as regulatory requirements, specifically in case of medical products.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130067720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A non-invasive novel approach for managing digestive tract foreign body ingestion in children 一种处理儿童消化道异物摄入的非侵入性新方法
Karnataka Pediatric Journal Pub Date : 2022-05-06 DOI: 10.25259/kpj_2_2022
Sayanthan Balasubramaniam, Sanjaya Abeygunasekara, Ganeshrajah Arunasalam, T. Suwaminathan
{"title":"A non-invasive novel approach for managing digestive tract foreign body ingestion in children","authors":"Sayanthan Balasubramaniam, Sanjaya Abeygunasekara, Ganeshrajah Arunasalam, T. Suwaminathan","doi":"10.25259/kpj_2_2022","DOIUrl":"https://doi.org/10.25259/kpj_2_2022","url":null,"abstract":"\u0000\u0000The phenomenon of foreign body ingestion (FB) is considered a common scenario in children’s tertiary care clinical settings. This study aimed to assess the sociodemographic factors of ingested FB, and its details and find the efficient clinical outcomes of a novel non-invasive interventional approach for removing FB in children.\u0000\u0000\u0000\u0000This was a prospective study of 55 patients in a tertiary care centre, Sri Lanka for 1 year from 2019. The univariate, bivariate analysis, and the Chi-squared test were used to check the relationship between two categorical variables as this study dataset comprises more than 50 observations, where 5% was used as the significance level.\u0000\u0000\u0000\u0000This study’s mean age was 5.18 ± 3.1 years and the median 5 years. The higher number of ingested FB was metal (88.5%) among this coin (33.3%) recorded the highest contribution and round shape was 62% whereas the ratio between sharp edge and none sharp edge was 1:4. A greater number of children both males (58.3%) and females (30.6%) were managed spontaneously to pass the FB through stool while vomiting (2.78%) was observed only in males. In comparison, the endoscopy removal cases were female (5.56%) and their mean age was 7.7 years.\u0000\u0000\u0000\u0000There are a number of studies that claim that the management of FB ingestion relatively depends on children’s age, developmental stage, the type of the ingested object, and clinical presentation. However, our study contends that the majority of FB ingestion can be moved spontaneously through stool by applying the noninvasive therapeutic approach without causing clinical complications.\u0000","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131681910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare association of esophageal atresia and tracheoesophageal fistula with microgastria: A case report 食管闭锁、气管食管瘘合并小胃症1例
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_26_2021
Prashant K. Zulpi, Anil B. Halgeri, B. A. Kalavant, V. Kulkarni
{"title":"A rare association of esophageal atresia and tracheoesophageal fistula with microgastria: A case report","authors":"Prashant K. Zulpi, Anil B. Halgeri, B. A. Kalavant, V. Kulkarni","doi":"10.25259/kpj_26_2021","DOIUrl":"https://doi.org/10.25259/kpj_26_2021","url":null,"abstract":"We present a case of esophageal atresia with tracheoesophageal fistula which was associated with microgastria. Following primary esophageal anastamosis developed leak and went into severe sepsis and died.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114975935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nursing professional’s understanding and screening practices in the identification of children with autism spectrum disorder: A scoping review 护理专业人员对自闭症谱系障碍儿童识别的理解和筛查实践:范围回顾
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_34_2021
Rajalakshmi Ramu, Radhakrishnan Govindan
{"title":"Nursing professional’s understanding and screening practices in the identification of children with autism spectrum disorder: A scoping review","authors":"Rajalakshmi Ramu, Radhakrishnan Govindan","doi":"10.25259/kpj_34_2021","DOIUrl":"https://doi.org/10.25259/kpj_34_2021","url":null,"abstract":"\u0000\u0000Early identification and intervention of childhood autism spectrum disorder (ASD) is recognised to have a valuable impact on a child’s life. Nurses who are adequately prepared with the necessary screening practices to do early identification of the children with risk for ASD and knowledge surrounding ASD may enhance the screening practices in the child care delivery system.\u0000\u0000\u0000\u0000This study was to discuss nurses’ knowledge and understanding about childhood ASD and its’ screening practices among nurses.\u0000\u0000\u0000\u0000The scoping review approach was adopted for the present study utilised by reviewing electronic databases from inception to 2021.\u0000\u0000\u0000\u0000The authors have searched 160 related studies from above-said database and found only 10 full-text studies based on the objective and research question. Based on the review, researchers understood that the Nursing Professionals have scant to moderate knowledge and understanding on childhood ASD and its ‘Screening Practices.’ Effective training programmes and continuing nursing education would hasten the early identification and intervention process in this arena.\u0000","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133072107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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