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The immunogenetics of subacute sclerosing panencephalitis: A comprehensive review 亚急性硬化性全脑炎的免疫遗传学研究综述
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_39_2021
A. Kocaaga
{"title":"The immunogenetics of subacute sclerosing panencephalitis: A comprehensive review","authors":"A. Kocaaga","doi":"10.25259/kpj_39_2021","DOIUrl":"https://doi.org/10.25259/kpj_39_2021","url":null,"abstract":"\u0000\u0000Subacute sclerosing panencephalitis (SSPE) is a rare devastating complication of measles virus (MV) involving the central nervous system (CNS). SSPE occurs 4–11/100,000 cases of the measles.\u0000\u0000\u0000\u0000A poor cellular immune response seems to predispose individuals to the development of SSPE. The presence of mutations that may lead to MV persistence has also been demonstrated in samples obtained from SSPE patients. However, no study to date has definitively revealed the pathogenesis of SSPE caused by persistent infection in the CNS of MV.\u0000\u0000\u0000\u0000In this review, we provide a brief overview of SSPE from both an immunological and genetic perspective. We will try to focus on the mechanisms underlying the pathogenesis of SSPE that results in MV persistence. Clarifying the pathogenesis of SSPE will enable both the expansion of therapeutic options and the prediction of disease prognosis.\u0000","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131266842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Unusual manifestation of the central hypothyroidism 中枢性甲状腺功能减退症的不寻常表现
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_33_2021
H. Tara, V. Ratageri, Vishal B. Patil
{"title":"Unusual manifestation of the central hypothyroidism","authors":"H. Tara, V. Ratageri, Vishal B. Patil","doi":"10.25259/kpj_33_2021","DOIUrl":"https://doi.org/10.25259/kpj_33_2021","url":null,"abstract":"The central hypothyroidism occurs in one in 16,000–30,000 infants. The common presentations include lethargy, sluggishness, hoarse cry, and feeding. Seizure and apnea are a rare manifestations. Herein, we describe the case of an infant with the central hypothyroidism who presented with seizures.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129024287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal outcome in COVID-19 pregnant women in District Hospital, Ballari 巴拉里地区医院COVID-19孕妇的新生儿结局
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_8_2021
Bhavana Damala, M. Shankar, M. Rao, N. Jayalakshmi, P. S. Kumar, M. Venkatesh, S. Sanjay, Y. Ganesh, M. Sampath
{"title":"Neonatal outcome in COVID-19 pregnant women in District Hospital, Ballari","authors":"Bhavana Damala, M. Shankar, M. Rao, N. Jayalakshmi, P. S. Kumar, M. Venkatesh, S. Sanjay, Y. Ganesh, M. Sampath","doi":"10.25259/kpj_8_2021","DOIUrl":"https://doi.org/10.25259/kpj_8_2021","url":null,"abstract":"\u0000\u0000This study aims to study the neonatal COVID-19 incidence and outcome in District Hospital, Ballari.\u0000\u0000\u0000\u0000This is a retrospective analytic study of 171 neonates born to COVID-19-positive pregnant women delivered at District Hospital, Ballari, Karnataka, during the period of April 2020–September 2020.\u0000\u0000\u0000\u0000The study was conducted among 171 babies delivered to COVID-19-positive pregnant women delivered in District Hospital, Ballari. Out of which, 62 babies were admitted in SNCU for various indications such as respiratory distress syndrome (4), meconium aspiration syndrome (8), other causes of respiratory distress (13), birth asphyxia (8), neonatal jaundice (14), hypoglycemia (1), preterm care (8), and neonatal COVID-19 (1). Out of 171 neonates born to COVID-19-positive mothers, only 7 (4%) neonates were tested positive for reverse transcription-polymerase chain reaction. A total of three babies were symptomatic, among those, two had refusal of feeds and one had respiratory distress and hypernatremic dehydration.\u0000\u0000\u0000\u0000In this study, COVID-19-positive neonates had milder manifestation with transmission rate of 4%. All symptomatic babies got cured and discharged successfully with average length of stay for 4 days. Although our conclusions are limited, the findings conclude that neonatal COVID-19 outcome is not as severe as seen in adults.\u0000","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":" 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131978170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anaphylaxis – A white elephant in the emergency room 过敏反应——急诊室里的白象
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_24_2021
Nikhita Sawhney, Neeraj Gupta
{"title":"Anaphylaxis – A white elephant in the emergency room","authors":"Nikhita Sawhney, Neeraj Gupta","doi":"10.25259/kpj_24_2021","DOIUrl":"https://doi.org/10.25259/kpj_24_2021","url":null,"abstract":"","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132017666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kikuchi – Fujimoto disease presenting as FUO in an adolescent girl 菊地-藤本病在青春期女孩中表现为FUO
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_31_2021
B. Sahana, V. Ratageri, Purushotham Reddy
{"title":"Kikuchi – Fujimoto disease presenting as FUO in an adolescent girl","authors":"B. Sahana, V. Ratageri, Purushotham Reddy","doi":"10.25259/kpj_31_2021","DOIUrl":"https://doi.org/10.25259/kpj_31_2021","url":null,"abstract":"Kikuchi – Fujimoto disease is a rare usually self-limiting disease mainly reported in Asian population. Herein we are reporting same disease in a 16-year-old child who presented with FUO.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"421 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126709294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid status in children with severe acute malnutrition 严重急性营养不良儿童的甲状腺状况
Karnataka Pediatric Journal Pub Date : 2022-03-08 DOI: 10.25259/kpj_13_2021
Shilpa Chandrashekaraiah, V. Ratageri, Laxminarayana Kamath
{"title":"Thyroid status in children with severe acute malnutrition","authors":"Shilpa Chandrashekaraiah, V. Ratageri, Laxminarayana Kamath","doi":"10.25259/kpj_13_2021","DOIUrl":"https://doi.org/10.25259/kpj_13_2021","url":null,"abstract":"\u0000\u0000The objective of the study is to study thyroid hormone levels in children with severe acute malnutrition (SAM) and its correlation with serum total protein and albumin levels.\u0000\u0000\u0000\u0000A prospective cross-sectional study was carried out at Nutritional Rehabilitation Centre, Hubli, from Dec 2018 to Nov 2019. Inclusion criteria: All children in the age group of 6–59 months with SAM. Exclusion criteria: (i) Children suffering from metabolic disorders, tuberculosis, urinary tract infection, malabsorption syndrome (celiac disease), protein losing enteropathy, and nephrotic syndrome; (ii) Children with major congenital anomalies; and (iii) Children with chronic liver and kidney diseases. All enrolled children’s details of demography, clinical history, and examination were entered in a predesigned pro forma. Total triiodothyronine (TT3), total thyroxine (TT4), thyroid-stimulating hormone (TSH), and serum total protein and albumin were estimated. Data were analyzed using SPSS Version 16.\u0000\u0000\u0000\u0000Total of 50 children fulfilled criteria during study period. Mean age of presentation was 18 ± 2.1 months with male-to-female ratio 0.8:1. The mean TT3 (ng/dl), TT4 (mcdg/l), and TSH (mIU/L) were 109.8 ± 50.6, 8.36 ± 3.7, and 2.5 ± 1.8, respectively. Mean total protein and albumin were 5.5 ± 1.4 g/dl and 2.97 ± 0.9 g/dl. Overall, 18 (36%) children had low total protein and 17 (34%) have low serum albumin. Low serum TT3, and TT4 levels were found in 11 (22%) and 14 (28%), respectively, and elevated TSH in 4 (8%) children. Low T3 was significantly associated with low albumin (P < 0.01).\u0000\u0000\u0000\u0000The impaired thyroid function and low serum T3 levels seen in SAM children were probably an adaptive change to malnutrition.\u0000","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133374311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An unusual deep seated haemangioma successfully treated with propranolol 用心得安成功治疗了一个不寻常的深部血管瘤
Karnataka Pediatric Journal Pub Date : 2021-12-30 DOI: 10.25259/kpj_28_2021
Kumarswamy Dudala, Sujatha Ramabhatta, S. Lakshmipathy, B. Raghunandan, K. Rashmi, P. Mol
{"title":"An unusual deep seated haemangioma successfully treated with propranolol","authors":"Kumarswamy Dudala, Sujatha Ramabhatta, S. Lakshmipathy, B. Raghunandan, K. Rashmi, P. Mol","doi":"10.25259/kpj_28_2021","DOIUrl":"https://doi.org/10.25259/kpj_28_2021","url":null,"abstract":"Infantile hemangiomas (IH) are most common vascular tumors. It usually resolves on its own, treatment becomes necessary if there is disease progression. Oral propranolol is a medical therapeutic option for complicated IH with impressive efficacy and generally good tolerance. We report a case of deep seated IH of the cheek in a 4 month old successfully treated with propranolol.","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124726223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What’s new in paediatric sleep medicine? 儿科睡眠医学有什么新进展?
Karnataka Pediatric Journal Pub Date : 2021-12-30 DOI: 10.25259/kpj_38_2021
Vikram Kumar
{"title":"What’s new in paediatric sleep medicine?","authors":"Vikram Kumar","doi":"10.25259/kpj_38_2021","DOIUrl":"https://doi.org/10.25259/kpj_38_2021","url":null,"abstract":"","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133289797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profile of paediatric sleep patients and polysomnography findings: Experience from an exclusive paediatric sleep clinic in India 儿科睡眠患者的概况和多导睡眠检查结果:来自印度一家独家儿科睡眠诊所的经验
Karnataka Pediatric Journal Pub Date : 2021-12-30 DOI: 10.25259/kpj_27_2021
K. B. K. Reddy
{"title":"Profile of paediatric sleep patients and polysomnography findings: Experience from an exclusive paediatric sleep clinic in India","authors":"K. B. K. Reddy","doi":"10.25259/kpj_27_2021","DOIUrl":"https://doi.org/10.25259/kpj_27_2021","url":null,"abstract":"\u0000\u0000The objectives of the study were to describe the profile of patients attending an exclusive paediatric sleep clinic in India.\u0000\u0000\u0000\u0000Children aged 1 month–18 years, attending an exclusive paediatric sleep clinic, were assessed using standardized questionnaires. Children underwent sleep coaching, were treated medically, or underwent polysomnography based on the decision of the paediatric pulmonologist. Level 1 polysomnography was conducted by trained personnel.\u0000\u0000\u0000\u0000Of 186 children, 36.5% were for infant sleep issues, 24.7% suspected obstructive sleep apnea (OSA), 18.2% neuromuscular diseases with sleep problems, 15.6% genetic disorders with sleep problems, 4.3% parasomnias, and 0.5% abnormal movements during sleep. Of the 85 paediatric polysomnographies conducted, 9.4% were normal studies, 87% had OSA, 1.1% restless leg syndrome, and 2.3% were inadequate studies.\u0000\u0000\u0000\u0000Sleep disorders in children are not uncommon and paediatricians need to be aware and identify them early. More number of exclusive paediatric sleep clinics need to be established in India.\u0000","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116174672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronavirus disease 2019: The quintessential wave of change and challenge for the norms 2019冠状病毒病:规范的变革和挑战的典型浪潮
Karnataka Pediatric Journal Pub Date : 2021-12-30 DOI: 10.25259/kpj_5_2021
P. Agarwal, Neeraj Gupta
{"title":"Coronavirus disease 2019: The quintessential wave of change and challenge for the norms","authors":"P. Agarwal, Neeraj Gupta","doi":"10.25259/kpj_5_2021","DOIUrl":"https://doi.org/10.25259/kpj_5_2021","url":null,"abstract":"","PeriodicalId":217083,"journal":{"name":"Karnataka Pediatric Journal","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128724336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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