Scientific African最新文献

{"title":"Heat transfer analysis of mixed convective hybrid nanofluid flow with variable permeability","authors":"Manimegalai C. , Peri K. Kameswaran , P. Sibanda","doi":"10.1016/j.sciaf.2025.e02670","DOIUrl":"10.1016/j.sciaf.2025.e02670","url":null,"abstract":"<div><div>The main focus of this study is to enhance the thermal performance of oil-cooled engines with the help of hybrid nanofluid in the automobile industry. The problem arises from the fact that conventional fluids are inadequate to enable efficient heat absorption and generation issues in industrial sectors. The present work examines how thermal dispersion affects the fluid in a non-Darcy porous medium over a vertical cylinder. In addition, mixed convection, variable permeability, and hybrid nanofluids are utilized to model the present boundary layer problem. A combination of hybrid nanofluids is chosen as carbon nanotubes, due to its temperature resistant property. Engine Oil is used as a base fluid which plays a vital role in lubrication and cooling process. The promising thermophysical properties of nanoparticles and Engine Oil are considered at <span><math><mrow><mn>27</mn><msup><mrow><mspace></mspace></mrow><mrow><mo>∘</mo></mrow></msup><mi>C</mi></mrow></math></span>. Moreover, the effects of Engine Oil at <span><math><mrow><mn>10</mn><msup><mrow><mspace></mspace></mrow><mrow><mo>∘</mo></mrow></msup><mi>C</mi></mrow></math></span>, <span><math><mrow><mn>20</mn><msup><mrow><mspace></mspace></mrow><mrow><mo>∘</mo></mrow></msup><mi>C</mi></mrow></math></span>, <span><math><mrow><mn>30</mn><msup><mrow><mspace></mspace></mrow><mrow><mo>∘</mo></mrow></msup><mi>C</mi></mrow></math></span>, and <span><math><mrow><mn>40</mn><msup><mrow><mspace></mspace></mrow><mrow><mo>∘</mo></mrow></msup><mi>C</mi></mrow></math></span> are analyzed to detect the heat transfer augmentation. The numerical findings of the converted system are solved by the bvp4c solver through MATLAB. The graphical results explore the strengthened temperature distribution, as the nanoparticle’s volume fraction enhances. Also, the numerical outcomes are validated with existing literature. Furthermore, the numerical results are explored for different fluid temperatures of Engine Oil. The thermal dispersion model-based simulations demonstrate an increase in thermal conductivity at maximum velocity. Based on these simulations, the results showed that the fluid’s surface area and heat transmission capacity is increased by the suspended solid nanoparticle volume fraction. The average Nusselt number improves as the solid volume fraction improves. Furthermore, considerable improvement in thermal conductivity is observed for <span><math><mrow><mi>A</mi><mi>g</mi><mo>−</mo><mi>S</mi><mi>W</mi><mi>C</mi><mi>N</mi><mi>T</mi><mo>/</mo><mi>E</mi><mi>O</mi></mrow></math></span>. The <span><math><mrow><mi>A</mi><mi>g</mi><mo>−</mo><mi>S</mi><mi>W</mi><mi>C</mi><mi>N</mi><mi>T</mi><mo>/</mo><mi>E</mi><mi>O</mi></mrow></math></span> achieve more heat transfer than <span><math><mrow><mi>C</mi><mi>u</mi><mi>O</mi><mo>−</mo><mi>M</mi><mi>W</mi><mi>C</mi><mi>N</mi><mi>T</mi><mo>/</mo><mi>E</mi><mi>O</mi></mrow></math></span>. We also examined the effects of the variable permeability variation on the p","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02670"},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of hybrid and individual models for predicting the Moroccan MASI index: Integrating machine learning and deep learning approaches","authors":"Hamza Kadiri ,&nbsp;Hassan Oukhouya ,&nbsp;Khalid Belkhoutout","doi":"10.1016/j.sciaf.2025.e02671","DOIUrl":"10.1016/j.sciaf.2025.e02671","url":null,"abstract":"<div><div>Forecasting financial market fluctuations is inherently challenging due to its complexity, volatility, and non-linear behavior. This research investigates the predictive accuracy of novel machine learning (ML) approaches for forecasting stock prices. Our approach combines individual ML and deep learning (DL) techniques to predict the daily price of the Moroccan all-share index (MASI). This study introduces novel hybrid models, specifically SVR-XGBoost, MLP-XGBoost, and LSTM-XGBoost. Daily closing price data for the MASI index and sector indices, from 2013 to 2023, is collected. The dataset is used to train and optimize Support Vector Regression (SVR), XGBoost, Multilayer Perceptron (MLP), and Long Short-Term Memory (LSTM) models using the Grid search (GS) algorithm. The performance of these individual models is compared with the hybrid model using standard metrics such as mean absolute error (MAE), mean square error (MSE), mean absolute percentage error (MAPE), and root mean square error (RMSE). In addition, backtesting and bootstrapping interval from the Skforecast library are used. The results demonstrate that the hybrid model achieves the highest accuracy. Moreover, this research holds significant value for investors, financial analysts, and policymakers by refining investment strategies and improving risk management practices.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02671"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and analysis of improved rectangular-shape millimeter-wave microstrip patch antenna for 5 G and future generation wireless communication systems","authors":"J.S. Ojo ,&nbsp;O.O. Omoleye ,&nbsp;O.P. Faromika ,&nbsp;G.A. Owolabi","doi":"10.1016/j.sciaf.2025.e02676","DOIUrl":"10.1016/j.sciaf.2025.e02676","url":null,"abstract":"<div><div>Microstrip patch antennas (MPA) are one of the most efficient when it comes to handheld devices using wireless communication systems because they are low-profile, less expensive, and not difficult to manufacture. The current evolution experienced in the world of communication systems requires that the incorporated antennas be upgraded to meet the high-capacity demands. The aim of this paper is to design and an improved rectangular-shape MPA for 5 G and other future generations wireless communication systems. The proposed improved rectangular-shaped microstrip patch antenna resonates at 31.5 GHz centre frequency using a substrate FR4 with a dielectric constant of 4.4 and a thickness of 1.6 mm. The proposed antenna is simulated using the High Frequency Simulation Software (HFSS). The antenna produces a return loss of -28.39 dB and a gain and directivity of 7.04 dB and 8.25 dB, respectively, while also having a bandwidth of 4.9 GHz. When compared to other MPAs from recent publications, the proposed antenna has significant improvements in terms of return loss, and bandwidth, etc. Thus making it a good choice when compared with other MPAs in 5 G and future-generation wireless systems.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02676"},"PeriodicalIF":2.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cisplatin-based chemotherapy-induced nephrotoxicity and its impact on the survival status of patients with gynecological cancer in Ethiopia: A multicenter retrospective cohort study","authors":"Samuel Agegnew Wondm ,&nbsp;Samuel Berihun Dagnew ,&nbsp;Fisseha Nigussie Dagnew ,&nbsp;Getachew Yitayew Tarekegn ,&nbsp;Tilaye Arega Moges ,&nbsp;Rahel Belete Abebe ,&nbsp;Tirsit Ketsela Zeleke ,&nbsp;Wubetu Yihunie Belay ,&nbsp;Fasil Bayafers Tamene","doi":"10.1016/j.sciaf.2025.e02666","DOIUrl":"10.1016/j.sciaf.2025.e02666","url":null,"abstract":"<div><h3>Background</h3><div>Cisplatin-based chemotherapy regimen associated nephrotoxicity is a significant adverse effect that restricts the standard dose of cisplatin by impairing renal function. There is a lack of data on cisplatin-based chemotherapy-induced nephrotoxicity (CIN) in Ethiopian patients with gynecological cancer. This study evaluated the factors associated with CIN and its impact on the survival status of patients with gynecological cancer at Northwest Ethiopia oncology centers.</div></div><div><h3>Methods</h3><div>This institutional-based retrospective cohort study included patients with gynecological cancer who received cisplatin-based chemotherapy between 2020 and 2021 at Northwest Ethiopia oncology centers. CIN was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) version 4 criteria and Kidney Disease Improving Global Outcomes (KDIGO) Guideline. A logistic regression model was used to identify the factors associated with CIN. The Cox proportional hazards regression model was used to determine the impact of CIN onpatients survival. The cutoff point was a P value of &lt; 0.05 for declaring statistical significance.</div></div><div><h3>Results</h3><div>A total of 394 patients with gynecological cancer were included in the final analysis. The incidence of CIN was 27.9 % (95 % CI 23.4,32.7). Old age (≥60 years) [adjusted odds ratio (AOR)=1.7,95 % confidence interval (CI) (1.1–2.9); P=0.039],low serum albumin (&lt;3.5mg/dl)[AOR =2.2,95 %CI (1.3–3.9), P= 0.004], and high dose of cisplatin (&gt;50 mg/m²) [AOR=2.6,95 % CI (1.4–4.7), P=0.002]were significantly associated with CIN.CIN[(adjusted hazard ratio (AHR)=3.2,95 % CI (2.7–9.5), P=0.004]and cisplatin dose reduction [AHR=2.7,95 % CI (1.7–4.3) P=0.021] were significant factors of death among patients with gynecological cancer.</div></div><div><h3>Conclusion</h3><div>More than a quarter of patients receiving cisplatin-based chemotherapy developed CIN, which negatively affected their survival. This study recommends that prescribers pay special attention to patients with older age, lower serum albumin levels, and high-dose cisplatin to improve renal function and survival. Cisplatin-based chemotherapy-induced nephrotoxicity significantly affects the survival of gynecological cancer patients.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02666"},"PeriodicalIF":2.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A seasonal assessment of urban thermal behavior and its links to land use patterns in Harare, Zimbabwe","authors":"DMSLB Dissanayake ,&nbsp;Takehiro Morimoto ,&nbsp;Manjula Ranagalage ,&nbsp;Yuji Murayama","doi":"10.1016/j.sciaf.2025.e02677","DOIUrl":"10.1016/j.sciaf.2025.e02677","url":null,"abstract":"<div><div>This study explores the seasonal changes of land use and land cover (LULC) changes and their influence on the land surface thermal environment (LSTE) in Harare, Zimbabwe, using Landsat Level 2 data for 2005 and 2019. The analysis focuses on two distinct seasons; hot (mid-September to mid-November) and cool (mid-May to mid-September). Land Surface Temperature (LST) was derived through radiometric and atmospheric corrections, while LULC classification employed the Random Forest method. Results revealed a rise in mean LST across all seasons, from 23.15 °C in the 2005 cool season to 32.28 °C in the 2019 hot season. Residential areas expanded significantly (43.2 % in 2005 to 58.4 % in 2019), primarily at the expense of green spaces and bare lands. Seasonal variations showed that bare lands exhibited the highest LST intensity, increasing from 5.8 °C in 2005 to 7.5 °C in 2019, while green spaces demonstrated cooling effects, albeit with reduced coverage. The research highlights the critical impact of urban expansion on LST and underscores the need for sustainable urban planning strategies, such as green infrastructure and compact development, to mitigate thermal stress. The findings provide actionable insights for urban planners to address the growing challenges posed by urban heat and environmental degradation in tropical cities like Harare.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02677"},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Chitosan/ Zeolite drug delivery composite and curcumin release kinetics in a simulated pH environment","authors":"Gloria Pokuaa Manu ,&nbsp;Daniel Narh ,&nbsp;Bernard Asimeng ,&nbsp;Nadesh Kwakye ,&nbsp;Barbara Ansaah Abusuapa ,&nbsp;Daniel Appuing ,&nbsp;Emmanuel Nyankson ,&nbsp;Johnson K. Efavi","doi":"10.1016/j.sciaf.2025.e02668","DOIUrl":"10.1016/j.sciaf.2025.e02668","url":null,"abstract":"<div><div>Cancer remains a formidable global health challenge, necessitating innovative strategies for effective drug delivery to tumor sites. This study is focused on modeling the release profile of a chitosan/zeolite nanocomposite beads delivery system encapsulating curcumin. The nanocomposites were synthesized by functionalizing zeolite with chitosan and subsequently loading curcumin. The chitosan/zeolite nanocomposite was characterized for its physicochemical properties, including surface morphology, functional groups, elemental profile, crystal structure, and drug loading capacity using SEM, FTIR, EDS, XRD, and UV–vis spectrophotometer respectively. In vitro experiments investigated the release kinetics of curcumin from the composite in simulated pH environments, providing insights into the drug release behavior. The chitosan/zeolite nanocomposite demonstrated a controlled, and sustained release of curcumin, exhibiting significant potential for optimizing therapeutic outcomes. The maximum entrapment efficiency of the chitosan/zeolite drug delivery vehicle was recorded at 84 %, indicating high efficiency in encapsulating drug molecules. Drug release kinetics were analysed using the Higuchi, Korsmeyer Peppas, Zero-Order, First-Order, and Hixson-Crowell models. The Higuchi kinetic model, which explains the release rate of drugs from an insoluble matrix based on Fickian diffusion, best explained the release of curcumin, with a correlation coefficient of R² = 0.9351. These results indicate that the zeolite functionalized chitosan nanocomposite beads hold promise as a viable platform for enhanced drug delivery, enabling prolonged drug circulation and improved therapeutic outcome.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02668"},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of manure and mineral fertilizer management on rice growth and methane emissions in nutrient-deficient lowlands of Madagascar's highlands","authors":"Lalaina Andrianarijaona ,&nbsp;Andry Andriamananjara ,&nbsp;Tantely Razafimbelo ,&nbsp;Manoa Arifetra Raminoarison ,&nbsp;Michel Rabenarivo ,&nbsp;Yasuhiro Tsujimoto ,&nbsp;Aung Zaw Oo","doi":"10.1016/j.sciaf.2025.e02675","DOIUrl":"10.1016/j.sciaf.2025.e02675","url":null,"abstract":"<div><div>In Madagascar, rice serves as a primary dietary staple, making the nation the second largest producer of rice on the African continent. However, rice production remains limited in fulfilling the needs of the entire population due to low soil nutrient availability. Conventional organic amendments and mineral fertilizers can enhance soil nutrients and rice growth but can also affect methane (CH₄) emissions from paddy rice soils. Potential CH₄ emissions from fertilizer management in tropical contexts are not well known. This study conducted two experiments to assess the impact of fertilizer management on CH₄ emissions and rice production: a pot experiment involving farmyard manure (FYM; 10 t ha⁻¹), NPK fertilizer (60 kg N: 60 kg P₂O₅: 60 kg K₂O kg ha⁻¹), and a control (no fertilizer); and a field experiment involving FYM (10 t ha⁻¹) and NPK fertilizer (60 kg N, 66 kg P₂O₅, and 48 kg K₂O ha⁻¹). In the pot experiment, the application of both FYM and NPK fertilizers resulted in significant increases in grain yield of 105.1 % and 187.1 %, alongside increases CH₄ emissions of 84.8 % and 71.0 %, respectively, compared to those in the control. The field experiment results partially aligned with those of the pot experiment, showing similar CH₄ emissions from NPK and FYM fertilizers. However, the yield increase for NPK fertilizer was lower in the field (5.7 %) than that for FYM fertilizer. These findings underscore the need for balanced nutrient management strategies to enhance rice productivity while mitigating greenhouse gas emissions, which are crucial for sustainable rice cultivation in Madagascar.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02675"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of physicochemical properties, functional diversity and enzymatic activities in three Opuntia ficus-indica soils across diverse climatic regions in Morocco","authors":"Ilham Zouitane ,&nbsp;Mohamed Ferioun ,&nbsp;Khawla Bouamri ,&nbsp;Khalid Derraz ,&nbsp;Saad Ibnsouda Koraichi ,&nbsp;Mohamed Idbella ,&nbsp;Guido Lingua ,&nbsp;Naïma El Ghachtouli","doi":"10.1016/j.sciaf.2025.e02663","DOIUrl":"10.1016/j.sciaf.2025.e02663","url":null,"abstract":"<div><div>In Morocco, <em>Opuntia ficus-indica</em> is grown in various climatic zones, each of which can greatly impact the soil quality and functioning. This study assesses the soil characteristics, bacterial load, functional microbial diversity, and enzymatic activities in <em>O. ficus-indica</em> soils from three distinct regions: Tafrant (subhumid), Fez (semi-arid), and Chichaoua (arid). Soil samples from these regions exhibited varying physicochemical properties, with neutral to alkaline pH, high concentrations of K, Na, and Ca, and biological activities, including microbial metabolic preferences and enzymatic activities. The data analysis and principal component analysis (PCA) revealed significant correlations in <em>O ficus-indica</em> soils across three regions of Morocco. In the subhumid region of Tafrant, there was a notable correlation between Shannon evenness index, amino acid metabolism by the microbial community, and β-galactosidase activity, with high levels of Fe, NH₄⁺, and Cu. Conversely, in the semi-arid region of Fez, strong associations were observed between organic matter content, Mg, P, NO₃-N, and increased microbial load, average well color development (AWCD), carbohydrate and polymer metabolism, and elevated phosphatase activity. The arid region of Chichaoua exhibited a distinct correlation between K and Zn levels, urease activity, and the metabolism of amines and amides substrates. Our results highlight distinct variations in the physicochemical properties, microbial community function, and enzymatic activities of <em>O. ficus-indica</em> soils across the three Morocco's regions. These findings highlight ecosystem uniqueness and offer key insights for biodiversity conservation and soil fertility management.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02663"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical determination of ascorbic acid at Ag2S - CuO - ZnO ternary nanocomposite modified glassy carbon electrode","authors":"Abdulwahid Abamecha,&nbsp;Ahmed Awol Yimer,&nbsp;Guta Gonfa Muleta,&nbsp;Shimeles Addisu Kitte","doi":"10.1016/j.sciaf.2025.e02669","DOIUrl":"10.1016/j.sciaf.2025.e02669","url":null,"abstract":"<div><div>In this work, a novel ternary nanocomposite electrochemical sensor based on Ag₂S-CuO-ZnO was developed and put to use for ascorbic acid (AA) electrochemical detection. By combining CuO-ZnO and AgNO₃ precursors, an easy-to-use and inexpensive homogeneous precipitation procedure was used to produce the Ag₂S-CuO-ZnO nanocomposite. X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and ultraviolet-visible (UV–VIS) spectroscopy were used to analyze the produced ternary nanocomposite. AA displayed an irreversible oxidation peak on the cyclic voltammograms (CVs) at Ag₂S-CuO-ZnO nanocomposite modified glassy carbon electrode (Ag₂S-CuO-ZnO/GCE). The enhanced sensitivity of AA detection at Ag₂S-CuO-ZnO/GCE was attributed to the ternary nanocomposite's synergistic effects and improved electron transfer efficiency. Using linear sweep voltammetry (LSV), the proposed electrochemical sensor demonstrated a linear range of 1 - 150 μM with a limit of detection (LOD) of 0.73 μM. The demonstrated sensor's practical applicability was successfully used to determine the amount of AA in an orange sample.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02669"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QSPR analysis of vitiligo treatment of some drugs using reverse degree-based topological indices","authors":"S. Gayathri ,&nbsp;K. Dhanalakshmi ,&nbsp;Ebenezer Bonyah","doi":"10.1016/j.sciaf.2025.e02636","DOIUrl":"10.1016/j.sciaf.2025.e02636","url":null,"abstract":"<div><div>This article explores the use of various medications, including azathioprine, clobetasone, desonide, and hydrocortisone valerate for the treatment of vitiligo. This study does not just use experiments; it also uses reverse degree-based topological indices (<span><math><mi>ℜ</mi></math></span>TI’s) to look at the drugs’ structural properties. These indices capture essential structural features that influence drug behavior. Quantitative Structure–Property Relationships (QSPR) are used in the study to look at how these indicators relate to how well vitiligo treatments work. This can assist chemists and pharmaceutical manufacturers in designing and optimizing drugs efficiently. This study shows an alternative way to look at vitiligo treatment without using expensive and time-consuming experiments. It does this by using mathematical modeling and graph-based topological indices.</div></div>","PeriodicalId":21690,"journal":{"name":"Scientific African","volume":"28 ","pages":"Article e02636"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}