Seminars in thrombosis and hemostasis最新文献_第9页

Alterations in the Blood-Brain Barrier in Mood Disorders and Neurodegenerative Diseases. 情绪障碍和神经退行性疾病的血脑屏障改变。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-01 Epub Date: 2025-03-09 DOI: 10.1055/s-0045-1804893

Ismael Conejero, Mathias Chea, Philippe Courtet, Sylvie Bouvier, Fabricio Pereira

{"title":"Alterations in the Blood-Brain Barrier in Mood Disorders and Neurodegenerative Diseases.","authors":"Ismael Conejero, Mathias Chea, Philippe Courtet, Sylvie Bouvier, Fabricio Pereira","doi":"10.1055/s-0045-1804893","DOIUrl":"10.1055/s-0045-1804893","url":null,"abstract":"Depressive disorders and suicidal behaviors represent major causes of health loss. Modifications of brain microvasculature, and specifically alterations of the blood-brain barrier have been supposed to participate in the vulnerability to those disorders along with cognitive impairment, especially in the older adults. In this article, we addressed evidence linking blood-brain barrier impairments with mood disorders and suicide. Secondly, we investigated their relationship with depression in old age, and with neurodegenerative processes. Particular attention was drawn toward the potential interactions between the coagulation processes and the blood-brain barrier dysfunctions, as innovative treatment strategies may emerge from research in those fields. Overall, the studies reviewed highlight the implication of multiple dysfunctions of the blood-brain barrier in mood disorders and suicide. Impairments of the blood-brain barrier show relationships with altered expression of endothelial cell junction proteins. These modifications also implicate receptors of the extracellular matrix, the vascular endothelial growth factor, changes in perivascular astrocytes, and has links with local and systemic inflammatory processes. Dysfunctions of the blood-brain barrier underly chronic stress and participate in psychiatric diathesis in old age. In addition, we outline that coagulation processes are likely to interact with the blood-brain barrier and further contribute to neurodegenerative disorders. In conclusion, new pathophysiological models offer perspectives toward detecting new biomarkers in mood disorders and suicide. In parallel, these models open avenues for developing innovative therapeutic agents, although further considering their potential risks and eventual benefits is needed.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":"457-464"},"PeriodicalIF":3.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2025 Eberhard F. Mammen Award Announcements: Part I-Most Popular Articles. 2025 Eberhard F. Mammen奖公告：第一部分-最受欢迎的文章。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-01 Epub Date: 2025-03-25 DOI: 10.1055/s-0045-1806855

Emmanuel J Favaloro

引用次数: 0

Stress and Pregnancy Outcomes: A Review of the Literature. 压力与妊娠结果：文献综述。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-01 Epub Date: 2024-11-04 DOI: 10.1055/s-0044-1792002

Shayna Miodownik, Eyal Sheiner

引用次数: 0

Tailored Treatment of Immune Thrombotic Thrombocytopenic Purpura. 免疫性血栓性血小板减少性紫癜的定制治疗。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-01 Epub Date: 2024-10-17 DOI: 10.1055/s-0044-1791780

Gennadiy M Galstyan, Elizaveta Klebanova, Svetlana Mamleeva, Zalina Fidarova, Michail Drokov, Dmitriy Bessmertniy

引用次数: 0

2024 Eberhard F. Mammen Award Announcements: Part II-Young Investigator Awards. 2024年Eberhard F. Mammen奖公告：第二部分-青年研究者奖。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-01 Epub Date: 2025-04-16 DOI: 10.1055/s-0045-1807739

Emmanuel J Favaloro

引用次数: 0

The Erythrocyte-ROS Axis in Thrombosis and Hemostasis. 红细胞- ros轴在血栓和止血中的作用。

IF 4.1 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-30 DOI: 10.1055/a-2615-0136

Serena Borghi, Francesca Nencini, Elvira Giurranna, Claudia Fiorillo, Matteo Becatti

{"title":"The Erythrocyte-ROS Axis in Thrombosis and Hemostasis.","authors":"Serena Borghi, Francesca Nencini, Elvira Giurranna, Claudia Fiorillo, Matteo Becatti","doi":"10.1055/a-2615-0136","DOIUrl":"10.1055/a-2615-0136","url":null,"abstract":"Thrombosis and hemostasis are critical processes that maintain vascular integrity, yet imbalances can lead to life-threatening cardiovascular events. Traditionally, erythrocytes were considered passive bystanders in coagulation, but emerging evidence highlights their active role in thrombogenesis, particularly through redox biology. Erythrocytes generate reactive oxygen and nitrogen species (RONS) via Hb autoxidation, NADPH oxidase activation, and external uptake from other blood components. This oxidative environment induces structural and functional modifications, including increased rigidity, phosphatidylserine exposure, microvesicle release, and enhanced adhesion to endothelial cells and platelets, all contributing to a prothrombotic phenotype. Hemorheological alterations such as increased aggregation and decreased deformability further exacerbate blood stasis and thrombus formation. Oxidative stress also accelerates hemolysis, releasing free Hb and heme, which trigger inflammatory responses and endothelial dysfunction, further amplifying thrombogenic potential. Additionally, erythrocyte-derived microvesicles act as carriers of procoagulant factors, enhancing thrombin generation and fibrin network formation. These mechanisms underscore the erythrocyte-ROS axis as a crucial determinant of thrombosis. Despite these insights, the full scope of erythrocyte-mediated redox signaling in thrombotic processes remains incompletely understood. This review discusses the multifaceted impact of erythrocyte oxidative stress on thrombosis and hemostasis, exploring its implications in cardiovascular diseases, metabolic disorders, and hematological conditions. Understanding these pathways may lead to novel therapeutic approaches targeting erythrocyte redox homeostasis to mitigate thrombotic risk and improve patient outcomes.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Viral Infections on the Hemostatic System. 病毒感染对止血系统的影响。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-27 DOI: 10.1055/a-2601-9302

Marco Marietta, Valeria Coluccio, Stefano Cordella, Mario Luppi

{"title":"Impact of Viral Infections on the Hemostatic System.","authors":"Marco Marietta, Valeria Coluccio, Stefano Cordella, Mario Luppi","doi":"10.1055/a-2601-9302","DOIUrl":"10.1055/a-2601-9302","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) pandemic has brought renewed attention to the significant but often overlooked impact of viral infections on the hemostatic system. This review explores the pathophysiological mechanisms underlying the interaction between viruses and hemostasis, directly through viral components or immune-mediated processes. Viruses are recognized as pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) on innate immune cells such as neutrophils, monocytes, and platelets. This recognition triggers immune responses, including the production of type I interferons (IFN-α and IFN-β) and proinflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), which recruit immune cells and induce pyroptotic cell death. Inflammatory cytokines contribute to endothelial dysfunction and coagulation activation, interacting with platelets, neutrophils, neutrophil extracellular traps (NETs), and the kallikrein-kinin system. Hyperactivation of the cytokine system, known as the \"cytokine storm,\" correlates with disease severity. Common features of viral infections include platelet activation and endotheliitis, leading to thrombocytopenia and microvascular thrombosis. Interestingly, similar pathogenic mechanisms in COVID-19 and viral hemorrhagic fevers (VHFs) result in contrasting clinical manifestations. While COVID-19 predominantly induces a thrombotic response characterized by endothelial damage, platelet hyperactivity, and complement activation, VHFs typically lead to hemorrhagic complications due to thrombocytopenia, consumptive coagulopathy, and vascular injury. These differences are influenced by the timing and location of coagulation activation, as well as the dynamics of immune responses. In COVID-19, coagulation initially occurs in the lungs, followed by systemic thrombotic phases, whereas VHFs rapidly progress to consumptive coagulopathy with hemorrhage, compounded by immune suppression.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viscoelastic Hemostatic Assays in Sepsis: From Pathophysiology to Potential Clinical Implications. 脓毒症的粘弹性止血试验：从病理生理学到潜在的临床意义。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-24 DOI: 10.1055/s-0045-1809373

Claudia Bonetti, Ivan Silvestri, Alessio Caccioppola, Andrea Meli, Giacomo Grasselli, Mauro Panigada

{"title":"Viscoelastic Hemostatic Assays in Sepsis: From Pathophysiology to Potential Clinical Implications.","authors":"Claudia Bonetti, Ivan Silvestri, Alessio Caccioppola, Andrea Meli, Giacomo Grasselli, Mauro Panigada","doi":"10.1055/s-0045-1809373","DOIUrl":"https://doi.org/10.1055/s-0045-1809373","url":null,"abstract":"Sepsis is a complex syndrome characterized by physiological, pathological, and biochemical abnormalities induced by infection, with up to 70% of patients experiencing coagulation alterations, ranging from subclinical coagulopathy to disseminated intravascular coagulation (DIC). The multifactorial nature of sepsis-related coagulopathy and the limitations of standard diagnostic parameters, such as platelet count and traditional coagulation tests, complicate its definition and management. Assessing coagulopathy related to sepsis presents significant challenges due to current definitions primarily focusing on diagnosing advanced stages of coagulation dysfunction, thereby overlooking the dynamic and evolving nature of the condition. Viscoelastic hemostatic assays (VHAs) have emerged as valuable tools in this context, offering real-time insights into clot formation, stabilization, and lysis by integrating both plasma and cellular contributions to coagulation. Data from clinical studies suggest that early stages of sepsis coagulopathy are characterized by hypercoagulability, while advanced stages may lead to hypocoagulability and DIC. Moreover, specific point-of-care assays can evaluate platelet performance in the clotting mechanism and potentially help the diagnosis of platelet dysfunction in sepsis. Additionally, the phenomenon of fibrinolysis inhibition contributes to the persistence of fibrin clots, promoting tissue ischemia and multiorgan dysfunction. Modified VHAs appear promising for detecting fibrinolysis impairment, which is associated with poorer outcomes, but the standardization of results is still a work in progress. Incorporating VHAs data into treatment strategies could lead to more targeted therapies, potentially improving outcomes in septic patients by addressing both hypercoagulable and hypocoagulable states, as well as fibrinolysis abnormalities.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombotic Complications in Hemophilia: An Intricate Conundrum. 血友病的血栓并发症：一个复杂的难题。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-23 DOI: 10.1055/a-2603-0344

Massimo Franchini, Daniele Focosi, Pier Mannuccio Mannucci

引用次数: 0

Rethinking Platelet and Plasma Transfusion Strategies for Neonates: Evidence, Guidelines, and Unanswered Questions. 重新思考新生儿血小板和血浆输注策略：证据、指南和未解决的问题。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-23 DOI: 10.1055/a-2601-9364

Rozeta Sokou, Eleni A Gounari, Alexandra Lianou, Andreas G Tsantes, Daniele Piovani, Stefanos Bonovas, Nicoletta Iacovidou, Argirios E Tsantes

{"title":"Rethinking Platelet and Plasma Transfusion Strategies for Neonates: Evidence, Guidelines, and Unanswered Questions.","authors":"Rozeta Sokou, Eleni A Gounari, Alexandra Lianou, Andreas G Tsantes, Daniele Piovani, Stefanos Bonovas, Nicoletta Iacovidou, Argirios E Tsantes","doi":"10.1055/a-2601-9364","DOIUrl":"10.1055/a-2601-9364","url":null,"abstract":"The transfusion of platelets and fresh frozen plasma (FFP) to critically ill neonates in neonatal intensive care units (NICUs) is a common intervention, yet it is still widely performed without adhering to international guidelines. The guidance itself on the therapeutic management of neonatal coagulation disorders is generally limited due to the absence of strong indications for treatment and is mainly aimed at the prevention of major hemorrhagic events such as intraventricular hemorrhage (IVH) in premature neonates. Historically, the underrepresentation of neonates in clinical studies related to transfusion medicine had led to significant gaps in our knowledge regarding the best transfusion practices in this vulnerable group and to a wide variability in policies among different neonatal units, often based on local experience or guidance designed for older children or adults, and possibly increasing the risk of inappropriate or ineffective interventions. Platelet transfusion and, particularly, FFP administration have been linked to potentially fatal complications in neonates and thus any decision needs to be carefully balanced and requires a thorough consideration of multiple factors in the neonatal population. Despite recent advances toward more restrictive practices, platelet and FFP transfusions are still subject to wide variability in practices.This review examines the existing literature on platelet and FFP transfusions and on the management of massive hemorrhage in neonates, provides a summary of evidence-based guidelines on these topics, and highlights current developments and areas for ongoing and future research with the aim of improving clinical practices.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0