Seminars in thrombosis and hemostasis最新文献_第10页

Global Hemostasis Testing in Chronic Kidney Disease-Are They Better Predictors of Bleeding and Thrombosis Risk? 慢性肾脏疾病的全球止血试验是否能更好地预测出血和血栓形成风险？

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-15 DOI: 10.1055/s-0045-1809162

Hui Yin Lim, Eng Soo Yap, Prahlad Ho

引用次数: 0

Pulmonary Embolism-Related Mortality in Femur Fracture Patients: A Recent Retrospective Epidemiological Analysis. 股骨骨折患者肺栓塞相关死亡率：最近的回顾性流行病学分析。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-15 DOI: 10.1055/a-2597-5208

Camilla Mattiuzzi, Giuseppe Lippi

引用次数: 0

Risk Factors of Catheter-Related Thrombosis in Elderly Patients with Lung Cancer Based on Thromboelastography: A Retrospective, Case-Control Study. 基于血栓弹性成像的老年肺癌患者导管相关血栓形成的危险因素：回顾性病例对照研究。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-05-02 DOI: 10.1055/a-2576-4895

Jiaji Hu, Binbin Xu, Nian Yao, Sha Peng, Jiaxin Lv, Haixia Yu, Jianmei Hou, Zhengkun Shi, Jianan Wang, Xin Huang, Guiyuan Ma, Jinghui Zhang

{"title":"Risk Factors of Catheter-Related Thrombosis in Elderly Patients with Lung Cancer Based on Thromboelastography: A Retrospective, Case-Control Study.","authors":"Jiaji Hu, Binbin Xu, Nian Yao, Sha Peng, Jiaxin Lv, Haixia Yu, Jianmei Hou, Zhengkun Shi, Jianan Wang, Xin Huang, Guiyuan Ma, Jinghui Zhang","doi":"10.1055/a-2576-4895","DOIUrl":"https://doi.org/10.1055/a-2576-4895","url":null,"abstract":"Catheter-related thrombosis (CRT) poses serious risks for cancer patients. Identifying risk factors and implementing targeted interventions can prevent CRT. To explore thromboelastogram parameters and clinical risk factors for CRT in elderly lung cancer patients. A total of 663 elderly lung cancer patients were selected from three hospitals in Hunan, Hainan, and Qinghai provinces in China from January 1, 2022, to June 30, 2024. The patients were divided into two groups: a CRT group (221 patients) and a non-CRT group (442 patients), with a ratio of 1:2. A between-group comparison and binary logistic regression were used to analyze risk factors for CRT in elderly lung cancer patients. Binary logistic regression analysis showed that decreased R (odds ratio [OR]: 0.849, 95% confidence interval [CI]: 0.763-0.945, p = 0.003), decreased K (0.571, 95% CI: 0.404-0.807, p = 0.001), advanced age (OR: 1.073, 95% CI: 1.033-1.113, p < 0.001), elevated platelet count (OR: 1.006, 95% CI: 1.004-1.009, p < 0.001), increased hemoglobin level (OR: 1.020, 95% CI: 1.009-1.031, p < 0.001), shortened PT (OR: 0.904, 95% CI: 0.830-0.985, p = 0.022), surgery ≤ 1 month (OR: 2.258, 95% CI: 1.420-3.590, p = 0.001), male sex (OR: 4.534, 95% CI: 2.815-7.304, p < 0.001), diabetes (OR: 2.478, 95% CI: 1.373-4.472, p = 0.003), hypertension (OR: 2.386, 95% CI: 1.505-3.784, p < 0.001), physical activity disorders (OR: 9.038, 95% CI: 4.462-18.309, p < 0.001) were independent risk factors for CRT in elderly lung cancer patients. Independent risk factors for CRT in elderly lung cancer patients include decreased K-values and decreased R-values, shortened PT, advanced age, elevated platelet count, increased hemoglobin level, surgery ≤ 1 month, male sex, diabetes, hypertension, and physical activity disorders.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Hematocrit on Coagulation Measured by Rotational Thromboelastometry in Healthy Subjects and Patients with Polycythemia. 健康人及红细胞增多症患者血液压积对凝血的影响

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-04-25 DOI: 10.1055/a-2570-4455

Marie Martin, Elie Nader, Hamdi Rezigue, Yesim Dargaud, Céline Renoux, Philippe Joly, Mael Heiblig, Christophe Nougier, Philippe Connes

{"title":"Impact of Hematocrit on Coagulation Measured by Rotational Thromboelastometry in Healthy Subjects and Patients with Polycythemia.","authors":"Marie Martin, Elie Nader, Hamdi Rezigue, Yesim Dargaud, Céline Renoux, Philippe Joly, Mael Heiblig, Christophe Nougier, Philippe Connes","doi":"10.1055/a-2570-4455","DOIUrl":"10.1055/a-2570-4455","url":null,"abstract":"Thrombotic and cardiovascular events are among the leading causes of death for patients with polycythemia, more specifically for those with primary origin. It has been suggested that the high hematocrit (Hct) would favor hypercoagulability. However, the impact of Hct on coagulation in patients with polycythemia has not been investigated so far. The aim of our study was to compare the coagulation profiles of healthy subjects and patients with polycythemia and to evaluate the in vitro impact of Hct on coagulation. Blood from healthy individuals (n = 100 for blood viscosity; n = 19 for coagulation) and patients with primary/secondary polycythemia (n = 29 for blood viscosity; n = 20 for coagulation) was used to perform measurements at native Hct. The impact of Hct modulation (20% vs. 50%) on coagulation was tested in vitro in 9 healthy subjects and 19 patients with polycythemia. Blood viscosity was measured by viscosimetry and coagulation and fibrinolysis by rotational thromboelastometry. In patients with polycythemia, Hct, and blood viscosity were higher, clotting time was prolonged and clot lysis was faster compared to healthy individuals. Our in vitro results showed that the clotting time was faster and the clot firmness higher at 20% versus 50% Hct for both populations, without any difference between the two populations at a given Hct. Our findings suggest that the interpretation of thromboelastometry results should be approached with caution in patients with high Hct. The in vivo hypercoagulable state of patients with polycythemia is probably the consequence of changes in hemodynamic conditions attributed to blood hyper-viscosity, that may promote venous stasis and platelet margination.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments to the International Council for Standardization in Hematology Guidance for New Lot Verification of Coagulation Reagents, Calibrators, and Controls. 对国际血液学标准化委员会关于凝血试剂、校准器和对照品新批号验证指南的意见。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-04-25 DOI: 10.1055/a-2572-1299

Marc H M Thelen, Marith van Schrojenstein Lantman, Anne Stavelin, Tze Ping Loh

引用次数: 0

Comparison of Platelet Function Tests for Long-Term Cardiovascular Events after Percutaneous Coronary Interventions. 经皮冠状动脉介入术后长期心血管事件的血小板功能检测比较

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-04-25 DOI: 10.1055/a-2570-4538

Mingyao Zhou, Pan Hou, Ying Liang, Wenqi Tao, Zhifu Guo, Bili Zhang, Yang Lu, Guojun Chu, Pan Li

{"title":"Comparison of Platelet Function Tests for Long-Term Cardiovascular Events after Percutaneous Coronary Interventions.","authors":"Mingyao Zhou, Pan Hou, Ying Liang, Wenqi Tao, Zhifu Guo, Bili Zhang, Yang Lu, Guojun Chu, Pan Li","doi":"10.1055/a-2570-4538","DOIUrl":"https://doi.org/10.1055/a-2570-4538","url":null,"abstract":"Patients with high on-treatment platelet reactivity (HTPR) undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) face increased risks of major adverse cardiovascular events (MACEs). Although platelet function tests like thrombelastography (TEG), vasodilator-stimulated phosphoprotein (VASP), PL-11, and VerifyNow have been described, the correlation between them and their prognostic implications remains uncertain. This prospective study aims to evaluate the consistency and effectiveness of four platelet function detection methods in predicting long-term MACEs in patients with ACS. All 98 ACS patients undergoing PCI with clopidogrel were assessed for HTPR using four platelet function detection methods. The endpoint was the occurrence of MACEs, including cardiac death, nonfatal myocardial infarction (MI), and target vessel revascularization (TVR). Among 98 patients enrolled from April 1, 2014 to June 30, 2014, 27 (27.6%) patients with VerifyNow-detected HTPR (P2Y12 reaction units [PRUs] >240). The incidence of HTPR was 58.2% for TEG, 52% for VASP, and 13.3% for PL-11. VerifyNow and TEG showed the highest consistency in detecting HTPR (kappa = 0.201, p = 0.015). During a median follow-up of 6.1 years, 29 MACEs occurred, including 24 TVRs, 3 cardiovascular deaths, and 2 nonfatal MIs. VerifyNow-detected HTPR independently predicted long-term MACEs (hazard ratio: 5.73, 95% confidence interval: 2.04-16.09, p = 0.001), even after adjusting for traditional risk factors (TRFs). Receiver operating characteristic (ROC) analysis indicated that the model incorporating TRFs and VerifyNow-detected HTPR had superior predictive discrimination for MACEs (area under ROC curve = 0.889). VerifyNow-detected HTPR independently emerges as a robust predictor for long-term MACEs, demonstrating superior predictive discrimination compared with other platelet function tests.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Co-Occurrence of Low-Frequency Pathogenic Variants in TBXA2R Exacerbating the Hemorrhagic Symptoms in Siblings with Hemophilia B. TBXA2R基因低频致病变异共同出现加重血友病B兄弟姐妹出血症状

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-04-17 DOI: 10.1055/a-2563-9899

Maiko Shimomura, Yoko Mizoguchi, Kyoko Kajihara, Fumiaki Sakura, Kosuke Noma, Teruhisa Fujii, Masao Kobayashi, Satoshi Okada

引用次数: 0

The ABO Blood System and Associated Implications for Hemostasis and Thrombosis. ABO血液系统及其对止血和血栓形成的影响。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-04-16 DOI: 10.1055/a-2565-3382

Eleni Petrou, Anna Maria Donta, Sophia Mellou, Stavros Tsalas, Andreas G Tsantes, Dimitrios Andreas Bethanis, Anastasios Kriebardis, Elias Kyriakou, Rozeta Sokou, Argirios E Tsantes

{"title":"The ABO Blood System and Associated Implications for Hemostasis and Thrombosis.","authors":"Eleni Petrou, Anna Maria Donta, Sophia Mellou, Stavros Tsalas, Andreas G Tsantes, Dimitrios Andreas Bethanis, Anastasios Kriebardis, Elias Kyriakou, Rozeta Sokou, Argirios E Tsantes","doi":"10.1055/a-2565-3382","DOIUrl":"https://doi.org/10.1055/a-2565-3382","url":null,"abstract":"The relationship between non-O blood groups and thromboembolic events has been suggested by several studies, although the exact underlying mechanisms are not fully elucidated. However, the correlation between ABO blood groups with the opposite pole of hemostasis, hemorrhage, has been investigated less thoroughly. Non-O blood groups confer an overall increased risk of single, recurrent, and provoked thromboembolic episodes. On the other hand, blood group O has been associated with more severe bleeding events and less favorable manifestations in individuals with hemorrhagic disorders. Therefore, ABO blood group screening may have a role in both thrombotic and hemorrhagic risk assessment and could potentially be added to available clinical prediction systems. This strong belief is supported by the ongoing research. Nevertheless, up to date, the majority of studies represent important heterogeneity, and given the frequency of non-O blood groups, a natural reluctance to incorporate blood groups in risk assessment models arises. Therefore, a more targeted approach should be considered to provide safe outcomes. The in vitro estimation of the thrombotic and hemorrhagic profile of each blood group separately, the quantitative estimation of VWF, FVIII, and platelet function in several disease settings and in well-organized studies, could be useful to establish a clear relationship of ABO blood types with hemostatic and thrombotic disorders. This may ensure a safe approach to categorizing a patient's risk, managing treatment, and influencing prognosis.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2024 Eberhard F. Mammen Award Announcements: Part II-Young Investigator Awards. 2024年Eberhard F. Mammen奖公告：第二部分-青年研究者奖。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-04-16 DOI: 10.1055/s-0045-1807739

Emmanuel J Favaloro

引用次数: 0

Thrombin Generation Assays: What are the Current Clinical Applications? 凝血酶生成测定：目前的临床应用是什么？

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-04-07 DOI: 10.1055/s-0045-1807261

Armando Tripodi, Marigrazia Clerici, Erica Scalambrino, Flora Peyvandi

引用次数: 0