Seminars in thrombosis and hemostasis最新文献_第8页

New STH 2023 Impact Factor, Most Highly Cited Papers, and Other Journal Metrics. 新 STH 2023 影响因子、高被引论文及其他期刊指标。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-11-01 Epub Date: 2024-07-19 DOI: 10.1055/s-0044-1788566

Emmanuel J Favaloro

引用次数: 0

Laboratory Diagnostics for Thrombosis and Hemostasis Testing-Part III. 血栓与止血检测的实验室诊断--第 3 部分。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-11-01 Epub Date: 2024-07-19 DOI: 10.1055/s-0044-1788567

Kristi J Smock, Karen A Moffat

引用次数: 0

Platelet Pathophysiology: Unexpected New Research Directions. 血小板病理生理学：意想不到的新研究方向

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-11-01 Epub Date: 2024-06-18 DOI: 10.1055/s-0044-1787663

Alan D Michelson, Andrew L Frelinger Iii, Robin L Haynes, Hannah C Kinney, Thomas Gremmel

引用次数: 0

Laboratory Diagnosis of Activated Protein C Resistance and Factor V Leiden. 活性蛋白C抗性和因子V莱顿的实验室诊断。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-11-01 Epub Date: 2023-07-10 DOI: 10.1055/s-0043-1770773

Mehran Bahraini, Alieh Fazeli, Akbar Dorgalaleh

引用次数: 0

Laboratory Testing for ADAMTS13 for Thrombotic Thrombocytopenia Purpura and Beyond. 血栓性血小板减少性紫癜及其他疾病的 ADAMTS13 实验室检测。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-10-28 DOI: 10.1055/s-0044-1792003

Emmanuel J Favaloro, Leonardo Pasalic, Giuseppe Lippi

{"title":"Laboratory Testing for ADAMTS13 for Thrombotic Thrombocytopenia Purpura and Beyond.","authors":"Emmanuel J Favaloro, Leonardo Pasalic, Giuseppe Lippi","doi":"10.1055/s-0044-1792003","DOIUrl":"https://doi.org/10.1055/s-0044-1792003","url":null,"abstract":"ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), also called von Willebrand factor (VWF) cleaving protease, acts as a moderator of VWF activity. ADAMTS13 cleaves VWF multimers, thereby reducing VWF activity in blood. When ADAMTS13 is absent (e.g., in patients with TTP [thrombotic thrombocytopenia purpura]), accumulation of VWF in plasma can occur, particularly as \"ultra-large\" VWF multimers, with this leading to adverse outcomes such as thrombosis. Relative ADAMTS13 deficiencies also occur in several other conditions, including secondary thrombotic microangiopathies (TMA), cancer, and with severe infections such as in COVID-19 (coronavirus disease 2019). These situations might therefore be accompanied with relative loss of ADAMTS13, thereby potentially also leading to pathological VWF accumulation, with this then generating a prothrombotic milieu, thus contributing to enhance the risk of thrombosis. Laboratory testing for ADAMTS13 can aid in the diagnosis of such disorders (i.e., TTP, TMA), and help guide their management, with testing now accomplished using various assays. As most presentations of TTP reflect an acquired condition due to anti-ADAMTS13 antibodies, there may also be a need to test for these, as this will also influence clinical management. We herein provide an overview of TTP, note other conditions in which low levels of ADAMTS13 may be present, and then detail laboratory testing for both ADAMTS13 and associated inhibitors.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

D-dimer-An International Assessment of the Quality of Laboratory Testing: Implications for D-dimer Use in the Real World. D-二聚体--实验室检测质量的国际评估：在现实世界中使用二聚体的意义》。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-10-17 DOI: 10.1055/s-0044-1791700

Carolyne Elbaz, Martine J Hollestelle, Piet Meijer, Zachary Liederman, Rita Selby

{"title":"D-dimer-An International Assessment of the Quality of Laboratory Testing: Implications for D-dimer Use in the Real World.","authors":"Carolyne Elbaz, Martine J Hollestelle, Piet Meijer, Zachary Liederman, Rita Selby","doi":"10.1055/s-0044-1791700","DOIUrl":"https://doi.org/10.1055/s-0044-1791700","url":null,"abstract":"D-dimer assessment has several established roles in venous thromboembolism (VTE) and disseminated intravascular coagulation diagnosis, and recently the risk stratification of coronavirus disease 2019 (COVID-19). D-dimer assays are neither standardized nor harmonized, use varying methodologies, and use different reporting units, all resulting in a lack of interchangeability and generalizability of assays. Using large multiyear datasets from an international laboratory quality assurance program, we assessed (1) common D-dimer assays in use worldwide, (2) differences in analytical performance between different methods, and (3) interlaboratory variability between positive samples. External proficiency testing results from laboratories participating in the External Quality Control for Assays and Tests (ECAT) Foundation were analyzed from 2017 to 2023. Annually, between 578 and 690 laboratories participated in the D-dimer sample surveys with response rates ranging from 88 to 97%. The three most common assays in use in 2023 were the Siemens Innovance D-dimer (42%), the IL HemosIL D-dimer HS 500 (20%), and the Diagnostica Stago (Stago) Liatest D-dimer Plus (10%)-all these are automated, quantitative, latex immunoassays expressed in fibrinogen equivalent units (FEU). The highest interlaboratory variability was observed around the typical VTE exclusion threshold of 0.5 mg/L FEU. Lower interlaboratory variability was observed at values above 0.8 mg/L FEU. Our study provides recent, international performance data on currently used D-dimer assays and describes the significant variability between assays and across D-dimer concentrations. We demonstrate that assays are not interchangeable and that using them interchangeably has the potential to result in clinically important errors. There is an urgent need to educate users about these issues and to work towards harmonizing D-dimer units and reporting.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Welcome to Seminars in Thrombosis and Hemostasis 2025: Toward the Next 50 Years of Publishing and Announcement of New Online Manuscript Submission System. 欢迎访问《血栓与止血研讨会 2025》：迈向下一个 50 年的出版和宣布新的在线投稿系统。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-10-17 DOI: 10.1055/s-0044-1791941

Emmanuel J Favaloro

引用次数: 0

Tailored Treatment of Immune Thrombotic Thrombocytopenic Purpura. 免疫性血栓性血小板减少性紫癜的定制治疗。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-10-17 DOI: 10.1055/s-0044-1791780

Gennadiy M Galstyan, Elizaveta Klebanova, Svetlana Mamleeva, Zalina Fidarova, Michail Drokov, Dmitriy Bessmertniy

引用次数: 0

Thromboembolic Complications in Takotsubo Cardiomyopathy. Takotsubo 心肌病的血栓栓塞并发症。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-10-08 DOI: 10.1055/s-0044-1791511

Manhal Habib, Doron Aronson

{"title":"Thromboembolic Complications in Takotsubo Cardiomyopathy.","authors":"Manhal Habib, Doron Aronson","doi":"10.1055/s-0044-1791511","DOIUrl":"https://doi.org/10.1055/s-0044-1791511","url":null,"abstract":"Apical ballooning syndrome, commonly known as Takotsubo syndrome, is a distinct cardiomyopathy often resembling acute myocardial infarction in presentation. Takotsubo syndrome patients exhibit varied patterns of left ventricular wall motion abnormalities, most frequently apical dyskinesis with basal hyperkinesis, that are characteristically transient. Although emotional or physical stressors precipitate Takotsubo syndrome in most cases, a significant proportion presents without identifiable triggers, with a pronounced female predominance. Despite recovery of left ventricular function, Takotsubo syndrome may lead to serious complications akin to acute coronary syndromes. The pathophysiology remains incompletely understood, with catecholamine surge implicated in the genesis of myocardial injury, although direct causation remains debated. Diagnosis involves integrating clinical history, imaging modalities like echocardiography, and cardiac MRI. Psychiatric disorders, particularly anxiety and depression, are frequently associated with Takotsubo syndrome, suggesting a role of chronic stress in disease susceptibility. Management includes supportive care, with anticoagulation considered in cases of apical thrombus, alongside close monitoring for complications and recovery of left ventricular function. This article reviews the current understanding, challenges in diagnosis, and management strategies for Takotsubo syndrome.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L. 调节免疫反应：血小板 CD40L 的双刃剑

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2024-10-08 DOI: 10.1055/s-0044-1791512

Gerd Bendas, Martina Gobec, Martin Schlesinger

{"title":"Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L.","authors":"Gerd Bendas, Martina Gobec, Martin Schlesinger","doi":"10.1055/s-0044-1791512","DOIUrl":"https://doi.org/10.1055/s-0044-1791512","url":null,"abstract":"The CD40-CD40L receptor ligand pair plays a fundamental role in the modulation of the innate as well as the adaptive immune response, regulating monocyte, T and B cell activation, and antibody isotype switching. Although the expression and function of the CD40-CD40L dyad is mainly attributed to the classical immune cells, the majority of CD40L is expressed by activated platelets, either in a membrane-bound form or shed as soluble molecules in the circulation. Platelet-derived CD40L is involved in the communication with different immune cell subpopulations and regulates their functions effectively. Thus, platelet CD40L contributes to the containment and clearance of bacterial and viral infections, and additionally guides leukocytes to sites of infection. However, platelet CD40L promotes inflammatory cellular responses also in a pathophysiological context. For example, in HIV infections, platelet CD40L is supportive of neuronal inflammation, damage, and finally HIV-related dementia. In sepsis, platelet CD40L can induce extensive endothelial and epithelial damage resulting in barrier dysfunction of the gut, whereby the translocation of microbiota into the circulation further aggravates the uncontrolled systemic inflammation. Nevertheless, a distinct platelet subpopulation expressing CD40L under septic conditions can attenuate systemic inflammation and reduce mortality in mice. This review focuses on recent findings in the field of platelet CD40L biology and its physiological and pathophysiological implications, and thereby highlights platelets as vital immune cells that are essential for a proper immune surveillance. In this context, platelet CD40L proves to be an interesting target for various inflammatory diseases. However, either an agonism or a blockade of CD40L needs to be well balanced since both the approaches can cause severe adverse events, ranging from hyperinflammation to immune deficiency. Thus, an interference in CD40L activities should be likely done in a context-dependent and timely restricted manner.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0