Science of Advanced Materials最新文献

{"title":"Effect and Mechanism of CircPTPN4 Expression in Carboxylated Single-Walled Carbon Nanotubes on Renal Fibrosis","authors":"Yuhan Liu, Yan Teng, Fangkun Jing, Yanning Zhang","doi":"10.1166/sam.2023.4504","DOIUrl":"https://doi.org/10.1166/sam.2023.4504","url":null,"abstract":"This research was aimed to investigate the effect of circPTPN4 overexpression in carboxylated single-walled carbon nanotubes (SWCNT-COOH) on renal fibrosis (RF) in mice. SWCNT was oxidized to SWCNT-COOH by concentrated sulfuric acid and nitric acid (3:1, v/v). After characterization\u0000 and analysis, the effect of SWCNT-COOH on erythrocyte status was detected. The RF mice (RFM) model was induced by SWCNT-COOH, normal mice as normal control (NC), and 1×108 TU/mL lenti-NC was injected into the tail vein as negative control, and 1×108 TU/mL\u0000 lenti-circPTPN4 was injected for circPTPN4 overexpression. The expression of circPTPN4 was tested by qRT-PCR. Serum creatinine (Cr), blood urea nitrogen (BUN), interleukin 1β (IL-1β), IL-6, transforming growth factor β1 (TGF-β1), kidney injury\u0000 molecule 1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) were tested by ELISA. HE, Masson, and immunohistochemistry were used to detect the pathological changes of kidney tissue. The protein expressions of collagen I (COL1), fibronectin (Fn), α-SMA, TGF-β1,\u0000 Smad3, p-Smad3, and Smad7 were tested by Western blot (WB). It presented SWCNT-COOH was successfully prepared by chemical oxidation method, with an average particle size of 98.1 nm and an average Zeta potential of −38.91 mV. SWCNT-COOH had good hydrophilicity, and did not cause aggregation\u0000 and morphology changes of red blood cells. As against NC, the expression of circPTPN4 in RFM and lenti-NC groups was decreased; the kidney coefficient was increased, and the normal structure of the kidney was abnormal, accompanied by inflammatory cell infiltration and collagen microformation;\u0000 serum Cr, BUN, IL-1β, IL-6, and TGF-β1 were increased, and KIM-1 and NGAL in renal cortex were decreased; the protein expressions of COL1, Fn, α-SMA, TGF-β1, and p-Smad3 in the kidney were increased, and the protein expression of Smad7 was decreased\u0000 (P <0.05). As against RFM, the expression of circPTPN4 in lenti-circPTPN4 group was increased; the kidney coefficient decreased and the kidney structure returned to normal; COL1, Fn, α-SMA, TGF-β1, and p-Smad3 in the kidney were decreased, and that of Smad7\u0000 was increased (P <0.05). SWCNT-COOH has good blood compatibility characteristics and can induce RF in mice. The expression of circPTPN4 was down-regulated in the RFM. Overexpression of circPTPN4 can restore the normal renal function of RFM, inhibiting the inflammatory response and\u0000 RF process.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45176448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Morphologically and Dimensionally Controlled MIL-53(Al)","authors":"Lin Chen, Hang Zhang, H. Fouad, M. S. Akhtar, Zhihong Wang","doi":"10.1166/sam.2023.4466","DOIUrl":"https://doi.org/10.1166/sam.2023.4466","url":null,"abstract":"This study presents a straightforward hydrothermal synthesis technique for modifying the crystal size and shape of MIL-53(Al) via the use of a mixed solvent solution consisting of water and DMF. Without the use of coordination inhibitors or surfactants, a sequence of nanosized MIL-53(Al)\u0000 crystals was efficiently synthesized. The lowest crystal size we were able to achieve in this work was 100 nm, but present technologies are not suited to creating nanoscale crystals of this size. Large crystallinity and yield were attained, and the samples’ very large specific surface\u0000 areas expanded the usefulness of this MOF material for gas adsorption and storage. X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, nitrogen gas adsorption/desorption, and infrared spectroscopy were all used to characterize the samples. Finally, the effect of moisture\u0000 concentration on crystal size and shape was investigated.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41799528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring the Structural, Optical and Electrical Properties of Mn Doped ZnO Thin Films for Gas Sensing Response","authors":"Santosh Kumar Kundara, M. Verma, Rahul Bidiyasar, Kanhaiya Chawla, N. Lal, C. Lal, B. Tripathi, Narendra Jakhar, Mohamed H. Mahmoud, M. S. Akhtar","doi":"10.1166/sam.2023.4475","DOIUrl":"https://doi.org/10.1166/sam.2023.4475","url":null,"abstract":"This manuscript presents a study on the photoinduced and gas sensing response of Mn-doped ZnO thin films (Zn1−xMnxO, x = 5, 10 mol %) synthesized using the spin coating method. The fabricated thin films were characterized to investigate their structural,\u0000 bonding, optical, surface morphology, electrical, and gas sensing properties. SEM images displayed a homogeneous surface morphology across the fabricated films with typical grain size ranging from 25 to 30 nm. Optical absorption spectra demonstrated a variation in the optical band gap, ranging\u0000 from 3.41 eV to 3.87 eV, indicating the tunability of the optical properties with the Mn doping concentration. Photoluminescence (PL) spectra exhibited Near Band Edge emission, as well as blue and green emission peaks, which can be attributed to the presence of defects and impurities in the\u0000 Mn-doped ZnO thin films. The photoinduced effect was observed through the variation in I–V characteristics due to the excitation of electron-hole pairs, highlighting the influence of Mn doping on the charge transport properties of the thin films. Additionally, the gas sensing\u0000 response of the Mn-doped ZnO thin films to hydrogen gas was investigated. The results indicated an improved gas sensing response with increasing Mn concentration in the doped ZnO thin films, suggesting the active role of Mn in enhancing the sensitivity of ZnO to hydrogen gas. Based on these\u0000 findings, Mn-doped ZnO thin films show promise for application in gas sensors.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48320978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of PRMT7 and KLF4 in Driving the Malignant Progression of Gastric Cancer","authors":"Peng Dong, Meng Liu, Yanfei Feng, Xiaochen Bi","doi":"10.1166/sam.2023.4489","DOIUrl":"https://doi.org/10.1166/sam.2023.4489","url":null,"abstract":"This study investigates the impact of PRMT7 on the malignant behaviors of gastric cancer (GC) and explores its potential as a therapeutic target for GC treatment. Clinical specimens and cytological experiments were analyzed to assess the effects of PRMT7. Quantitative real-time polymerase\u0000 chain reaction (qRT-PCR) was employed to measure relative levels of PRMT7 in 48 pairs of GC and adjacent normal tissues. The influence of PRMT7 on clinical features and prognosis in GC patients was examined. The regulatory effects of PRMT7 on proliferative and migratory potentials in GC cells\u0000 were evaluated using cell counting kit-8 (CCK-8) and transwell assay, respectively. Additionally, the role of PRMT7 and its downstream target in regulating malignant behaviors of GC was elucidated. Results showed that PRMT7 was upregulated in GC tissues, and its high expression in GC patients\u0000 was associated with tumor staging and lymphatic metastasis, indicating a poor prognosis. PRMT7 stimulated proliferative and migratory potentials in GC cells, and KLF4 was identified as the downstream gene of PRMT7 responsible for the PRMT7-mediated malignant phenotypes of GC. In conclusion,\u0000 PRMT7 is upregulated in GC tissues and its elevated levels are closely linked to tumor staging and lymphatic metastasis, predicting an unfavorable prognosis. PRMT7 drives the proliferative and migratory potentials of GC cells through the negative regulation of KLF4. The findings suggest that\u0000 PRMT7 could be a potential therapeutic target for GC.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45937033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Calcination Temperature on Surface Acidity and Photocatalytic Activity of Nano-TiO2/Diatomite Composite Photocatalyst","authors":"Jinjun Zhang, Ruirui Liu, Meng Kuang, Jing Wang, Z. Ji","doi":"10.1166/sam.2023.4454","DOIUrl":"https://doi.org/10.1166/sam.2023.4454","url":null,"abstract":"Nano-TiO2/diatomite composite photocatalysts were prepared by hydrolysis-deposition method in the present study. The effect of calcination temperature on surface acidity and photocatalytic activity of the photocatalysts was characterized by X-ray diffraction, N2\u0000 adsorption/desorption, Fransmission electron microscope, Fourier transform infrared, X-ray photoelectron spectroscopy, pyridine adsorption in situ fourier transform infrared and the adsorption and photodegradation of formaldehyde in air. Results revealed that the high temperature and\u0000 the nucleation of titanium dioxide both can consume the surface Brönsted acid sites, and with the formation of Ti–O–Si bond to form surface Lewis acid. The composite calcined at 600 °C presents the highest decomposition of formaldehyde under UV irradiation at the room\u0000 temperature.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49640708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Key Genes and Molecular Mechanisms Related to Myocardial Hypertrophy Based on Bioinformatics","authors":"P. Dai, Hang Wang, Xin Mu, Zhen Ren, Genli Liu, Longying Gao","doi":"10.1166/sam.2023.4488","DOIUrl":"https://doi.org/10.1166/sam.2023.4488","url":null,"abstract":"This study aimed to identify key genes and molecular mechanisms associated with cardiac hypertrophy using bioinformatics analysis. Datasets from the Gene Expression Omnibus (GEO) database were analyzed using the GEO2R tool to identify differentially expressed genes (DEGs) related to\u0000 cardiac hypertrophy. The top 10 DEGs from two datasets (GSE18801 and GSE47420) were used to generate heatmaps and a volcano plot. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed using the DAVID website. The protein interaction data for DEGs were visualized\u0000 using Cytoscape software. A total of 767 DEGs were identified in GSE18801 and 447 DEGs in GSE47420, with 48 common differential genes named co-DEGs. GO enrichment analysis suggested these co-DEGs were mostly related to extracellular matrix organization, muscle system process, and tissue remodeling.\u0000 KEGG pathway analysis demonstrated co-DEGs were related to malaria, estrogen signaling pathway, ECM-receptor interaction, and apelin signaling pathway. Eight hub genes were identified, including Fn1, Fbn1, Dcn, Ctgf, Timp1, Lox, Tlr4, and Lcn2. These hub genes might serve as therapeutic potential\u0000 biomarkers of cardiac hypertrophy.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44467749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA NCK1-AS1 Facilitates Colorectal Carcinoma Proliferation by Modulating the IGF1/AKT Signaling Pathway: A Detailed Study","authors":"Li Qi, Yue Yin, Mengqi Sun","doi":"10.1166/sam.2023.4491","DOIUrl":"https://doi.org/10.1166/sam.2023.4491","url":null,"abstract":"The study aimed to investigate the regulatory effects of lncRNA NCK1-AS1 on colorectal carcinoma (CRC) proliferation and the involvement of the IGF1/AKT signaling. The study detected the expression levels of NCK1-AS1 in paired CRC and normal tissues using qRT-PCR and analyzed its prognostic\u0000 value in CRC through the Kaplan-Meier method. The study assessed the proliferative ability in HT-29 and HCT-8 cells after transfection of sh-NCK1-AS1 through CCK-8, colony formation, and EdU assay. The study determined the protein levels of IGF1 and AKT in CRC cells with NCK1-AS1 knockdown\u0000 by Western blot and verified the binding relationship between NCK1-AS1 and IGF1 through the dual-luciferase reporter assay. The study also examined the role of IGF1 in CRC process through a series of rescue experiments. The study found that NCK1-AS1 was highly expressed in CRC tissues and\u0000 had a prognostic value. Knockdown of NCK1-AS1 markedly suppressed the proliferative ability of CRC cells. The study also showed that NCK1-AS1 promoted the proliferative ability of CRC cells by activating the IGF1/AKT signaling. Therefore, NCK1-AS1 is a potential indicator for predicting poor\u0000 prognosis of CRC. In conclusion, highly abundant NCK1-AS1 in CRC tissues triggers cancer cell proliferation by activating the IGF1/AKT signaling.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42749777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interface Between Grey Brick and Lime Mortar: Chemical Reactions and Resulting Microstructure","authors":"Peng Zhao, Yun Zhang, Yang Shen, Xin-Jian Li, Weiwei Zhu, Guo-Jian Liu, Bo Pang","doi":"10.1166/sam.2023.4481","DOIUrl":"https://doi.org/10.1166/sam.2023.4481","url":null,"abstract":"In recent years, the use of lime mortar has garnered a lot of attention due to its sustainability and its ability to renew old architecture. However, there has been a lack of research on the adhesion between lime mortar and grey brick. To clarify the adhesion of lime mortar and grey\u0000 brick, we comprehensively investigated a representative sample, which was constructed between 1366 and 1386 CE, using various techniques. The results of our analysis indicated that the calcium from the lime mortar diffused from the surface of the lime mortar through the grey brick matrix in\u0000 an approximately 1.5 mm-thick layer. This physical process led to a decrease in the porosity of the grey brick’s appearance, providing a historical explanation for the long-term durability of the partial structure of the adhesive as a load-bearing element.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47957961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two New Cobalt(II) Heterotrispin Dimers Bridged by Functional Nitronyl Nitroxides: Structure and Magnetic Properties","authors":"Jin-Ke Ma, J. Chen, You-Juan Zhang, Qing-Lun Wang","doi":"10.1166/sam.2023.4492","DOIUrl":"https://doi.org/10.1166/sam.2023.4492","url":null,"abstract":"Two dimers Co(II)-nitronyl nitroxide (NITR) compounds, [Co(hfac)2(NITmPh3Py)]2 1 and [Co(hfac)2(NIToPh3Py)]2 2 (NITmPh3Py = 2-[3-methoxyphenyl(3-pyridinyl)]-4,4,5,5-tetramethyl imidazoline-1-oxyl-3-oxide;\u0000 NIToPy3Ph = 2-[2-methoxyphenyl(3-pyridinyl)]-4,4,5,5-tetramethyl imidazoline-1-oxyl-3-oxide; hfac = hexaflfluoroacetylacetonate) have been prepared and characterized. Compound 1 crystallizes in orthorhombi space group Pbcn; compound 2 is in monoclinic space group\u0000 P21/c. The magnetic susceptibility studies show antiferromagnetic interactions between Co(II) ion and NITR radical in 1 and 2.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44198085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Activity of Vitex leucoxylon Aqueous Leaf Extract Against A549 and NCIH-460 Lung Cancer Cell Lines","authors":"I. Shaikh, A. Nasreen, M. Mahnashi, J. Hoskeri, Arun K. Shettar, B. A. Mannasaheb, M. Ghoneim, S. M. Asdaq, U. Muddapur, A. Khan, S. Dafalla, Tasneem Mohammed","doi":"10.1166/sam.2023.4455","DOIUrl":"https://doi.org/10.1166/sam.2023.4455","url":null,"abstract":"The primary goal of this research was to determine the cytotoxic potential of an aqueous extract of Vitex leucoxylon aerial parts on the lung cancer A549 and non-small cell lung cancer NCIH-460 cell lines. The Soxhlet apparatus and distilled water were used for the extraction\u0000 of the medicinal plant. The MTT in vitro assay was used to test the compounds for anticancer activity against two different lines of lung cancer. The cytotoxic activity of V. leucoxylon in the present study was very substantial as measured by its ability to suppress the growth\u0000 of both cell lines. The IC50 values for A549 and NCI-H460 were determined to be 315.57 and 560.48 μg/mL, respectively. The current research confirmed that V. leucoxylon’s aqueous leaf extract possessed potent anticancer properties. Both the cancer cell lines\u0000 were significantly inhibited in their ability to differentiate when subjected to the MTT assay. In future, flavonoid compounds in the aqueous extract need to be purified, characterized, and structurally elucidated for in-vivo studies, which could lead to the creation of new drug candidates.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48830123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}