Science of Advanced Materials最新文献

{"title":"Advanced Foam Decontamination Agent for Enhanced Reactor Pool Purification in Nuclear Power Plants: Development, Evaluation, and Operational Insights","authors":"Yijun Yu, Dingwen Zhang, Feng Liu, Lu Zhang","doi":"10.1166/sam.2024.4736","DOIUrl":"https://doi.org/10.1166/sam.2024.4736","url":null,"abstract":"During the comprehensive maintenance of nuclear power plants, the purification of the reactor pool is a critical task. Integrating foam decontamination with traditional high-pressure water washing can effectively shorten decontamination time and reduce radiation exposure to maintenance personnel. This study developed a novel foam decontamination agent through experimentation, assessing the effects of each component in the decontaminant on the foaming and liquid-carrying capabilities of the foam solution. Immersion corrosion tests confirmed that this foam decontaminant does not corrode the reactor pool material (022Cr23Ni5Mo3N). Additionally, a laboratory evaluation method for the performance of foam decontaminants was established, and by comparing the foaming and decontaminating performance between a commercial foam decontaminant (NETAMIX-F) and the developed foam decontaminant, it revealed that the developed decontaminant can effectively prevent the re-deposition of pollutants. Furthermore, the decontaminant developed in this work has superior liquidcarrying capacity than the commercial product, achieving a 98.6% removal rate of Fe 3 O 4 after the first wash, with a re-deposition removal rate of 99.4%. This work identified a foam decontamination system suitable for nuclear power stations, providing operational guidelines and serving as a reference for future reactor pool decontaminations.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"16 12","pages":"1242-1250"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Alginate-Collagen Hydrogel and Its Related Mechanisms in the Repair of Rat Cartilage Injuries","authors":"Yezhou Li, Chengjian Tang","doi":"10.1166/sam.2024.4726","DOIUrl":"https://doi.org/10.1166/sam.2024.4726","url":null,"abstract":"This research investigated the application of alginate-collagen hydrogel (ACH) in rat cartilage injury (CI) repair and its related mechanisms through in vitro and in vivo experiments. Alginate solution and modified collagen solution were mixed to prepare the ACH. The obtained samples were characterized and their sustained release properties were determined. L929 mouse fibroblasts were assigned into a blank control group (BC group, untreated), a positive control group (PC group, treated with 6.4% phenol), a negative control group (NC group, treated with tissue culture polystyrene), and an ACH group (treated with ACH). Cell viability was assessed using the MTT assay. Meanwhile, the cytotoxicity of the ACH and its impact on cell proliferation and cell attachment capabilities were analyzed. Thirty 4-week-old specific pathogen-free (SPF) Sprague Dawley (SD) rats were randomly grouped into a chondrocyte group (5 rats, chondrocytes collected and cultured), a cPAGE group (5 rats, chondrocytes treated with ACH), a model group (10 rats, CI model), and a mPAGE group (10 rats, CI model treated with CAH). The influence of CAH on chondrocyte proliferation and the type II collagen (COLII) expression were assessed using the cell counting kit 8 (CCK-8) assay and immunofluorescence staining. Furthermore, the impacts of CAH on chondrocyte tissue and COL-II expression were analyzed using Safranin O-Fast Green (SOFG) staining, the International Cartilage Repair Society (ICRS) score, and COL-II tissue staining. Immunoblotting was utilized to detect the TNF- α , NF- κ B, matrix metalloproteinase 13 (MMP-13), and COL-II proteins in cartilage tissue. The results showed that release rate (RR) of the constructed ACH reached over 85% within 72 hours and achieved degradation equilibrium within 5 days with a weight loss (WL) rate of over 60%. L929 fibroblasts culture results showed that the ACH posed no significant cytotoxicity, and cell attachment results were not obviously different from those on tissue culture plates (P >0.05). MTT assay results demonstrated that the ACH exerted no adverse effects on L929 cell proliferation and growth, indicating a good biocompatibility. CCK-8 and COL-II results indicated that chondrocyte proliferation in cPAGE group was much higher in contrast to that in chondrocyte group ( P <0.05). Besides, the animal experiments unveiled that in comparison to the CI group, the mPAGE group had more chondrocytes, upregulated COL-II, and higher ICRS scores ( P <0.05). MMP-13, NF- κ B, and TNF- α were downregulated, and COL-II was upshifted in the mPAGE group, with remarkable differences ( P <0.05). In conclusion, ACH exhibited excellent biocompatibility and low cytotoxicity, promoted cell proliferation and growth, facilitated chondrocyte proliferation in rat CI repair, offering a valuable research foundation for CI treatment.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"16 11","pages":"1157-1166"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic ZnIn₂S₄ for 2-Mercaptobenzothiazole Degradation: Facile Synthesis, Influencing Factors and Mechanism","authors":"Xiaoxu Zhao, Siyao Wang, Bingbing Wang, Na Chang, Haitao Wang, Yanjun Jia","doi":"10.1166/sam.2024.4724","DOIUrl":"https://doi.org/10.1166/sam.2024.4724","url":null,"abstract":"The development of an efficient, stable and environmentally friendly semiconductor photocatalyst is great research significance in the field of environment and energy. In this paper, ZnIn 2 S 4 semiconductor photocatalysts with flower-like hierarchies were prepared by simple and environmentally friendly method. The influence of ZnIn 2 S 4 dosage, pH and different inorganic salt ions on the photocatalytic degradation of 2-mercaptobenzothiazole (MBT) under visible light was investigated in detail. The results showed that the photocatalyst dosage was 0.05 g, and the photocatalytic degradation efficiency of MBT was the highest in the weakly acidic environment with pH was five. Meanwhile, the addition of some inorganic anions has a significant inhibitory effect on the photocatalytic activity of ZnIn 2 S 4 semiconductor photocatalyst, while cations have less effect. Moreover, the ZnIn 2 S 4 semiconductor photocatalyst had excellent stability and recyclability, and its photodegradation mechanism had been deeply studied. This work provides a theoretical and experimental foundation for exploring the different influencing factors of photocatalytic degradation of organic pollutants in wastewater by other semiconductors.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"16 11","pages":"1101-1108"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Modified Mesenchymal Stem Cells on Endothelial and Stromal Cells in the Enhancement of Endometrial Injuries","authors":"Shiqing Yang, Yunfei Lian, Ge Song, Huiyan Ni, Beidi Jia, Xinyu Qian, Guanxu He, Aftab Ullah, Xueyong Qi","doi":"10.1166/sam.2024.4727","DOIUrl":"https://doi.org/10.1166/sam.2024.4727","url":null,"abstract":"Background: The uterine endometrium plays a important role in the processes of fertilization and embryogenesis, with its impairment or dysfunction leading to pathologies such as intrauterine adhesions, miscarriage, and infertility. In addressing endometrial damage, the application of stem cell has attracted considerable attention. To promote the paracrine capabilities of mesenchymal stem cells (MSCs), this study employed pro-inflammatory cytokines (Tumor Necrosis Factor-α and Interferon-γ, TNF-α and IFN-γ, IT) along with 3D culture techniques on pretreated MSCs (3D-IT-MSCs). We focused on evaluating the therapeutic potential of 3D-IT-MSCs and elucidating the mechanisms involved in endometrial repair. Method: Pretreated MSCs were co-cultured with human umbilical vein endothelial cells (HUVECs) or drug-induced endometrial stromal cells (ESCs) to observe the promoting effect on biological function. Results: The findings demonstrated that 3D-IT-MSCs exhibit markedly elevated paracrine molecule expression and secretion compared to conventional MSCs. Additionally, treatment with 3D-IT-MSCs significantly promoted the proliferation and migration of HUVECs and ESCs, resulting in increased HUVECs angiogenesis and inhibition of mifepristone-induced ESCs apoptosis. Conclusion: Our findings demonstrated that the combined approach of applying pro-inflammatory cytokines and 3D culture techniques on pretreated MSCs holds substantial promise as a therapeutic strategy for repairing endometrial injuries.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"16 11","pages":"1150-1156"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing PDCD4 Mediates Transcription Factor EB Overexpression Promoting Proliferation, Migration, and Invasion of Cervical Cancer Hela Cells","authors":"Xing Gao, Ziying Liang, Yanan Yuan, Wenbo Liu","doi":"10.1166/sam.2024.4636","DOIUrl":"https://doi.org/10.1166/sam.2024.4636","url":null,"abstract":"Cervical cancer is a common gynecologic malignant tumor, the occurrence and development of which are related to multiple genetic and environmental factors. Recent studies have shown that Programmed Cell Death 4 (PDCD4) plays a crucial role in cervical cancer, and that silencing PDCD4 mediates Transcription Factor EB (TFEB) overexpression, promoting cell proliferation, migration, and invasion in this disease. This study utilized the Hela cell line as a cervical cancer model to investigate the changes in TFEB expression levels and the proliferation, migration, invasion, and EMT processes of cervical cancer cells through the silencing of PDCD4. Real-time quantitative PCR and Western blot were employed to assess the expression levels of PDCD4 and TFEB, while CCK-8, scratch assay, Transwell invasion assay, and Western blot were used to evaluate changes in cell proliferation, migration, invasion capabilities, and EMT processes. The experimental results demonstrated that silencing PDCD4 significantly increased the expression level of TFEB. Simultaneously, silencing PDCD4 also significantly accelerated the proliferation rate of Hela cells, enhanced the cells’ migration, invasion capabilities, and promoted the EMT processes. Further experimental results showed that silencing TFEB could partially reverse the promoting effects of PDCD4 silencing on cell proliferation, migration, and invasion. In cervical cancer, silencing PDCD4 can lead to TFEB overexpression, thereby promoting the proliferation, migration, and invasion of Hela cells. These findings provide crucial clues for the in-depth study of molecular mechanisms in cervical cancer and indicate that the PDCD4-TFEB pathway could potentially serve as a target for the treatment and prevention of this disease.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"16 8","pages":"916-922"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Pot Synthesis of Phosphomolybdenate Based Hybrids for Efficient Oxidative Desulfurization","authors":"Yizhen Su, Jiangfeng Sheng, Aiqing Tang, Linhua Zhu","doi":"10.1166/sam.2024.4693","DOIUrl":"https://doi.org/10.1166/sam.2024.4693","url":null,"abstract":"With increasing stringent standard of sulfur content in fuels, there is a growing need for high-efficiency deep desulfurization to meet ecological and environmental demands. Herein, a series of heteropolyacid catalysts with phosphomolybdic acid base melamine (MHPMo-n) were synthesized by one-pot method and applied to oxidative desulfurization. Further, the optimum conditions for desulfurizations could be explored, which the desulfurization rate of the catalyst could reach 100% within 60 min under the conditions of m(catalyst)= 0.01 g, T = 40 °C, O/S = 3. Furthermore, the catalyst demonstrated excellent catalytic efficiency during the five cycles. One-pot method of phosphomolybdic acid base melamine provides a new idea for the synthesis of catalysts with outstanding catalytic properties for oxidative desulfurization (ODS).","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"16 8","pages":"871-878"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Influence of miR-597-5p on the Tumor Stem Cell Characteristics of Gastric Cancer Cells Through the STAT3/NF-<i>κ</i>B Signaling Pathway","authors":"Yuchao Zhang, Guangyu Zhong, Kaihu Fan, Jialun He, Ying Sun, Linping Li","doi":"10.1166/sam.2023.4592","DOIUrl":"https://doi.org/10.1166/sam.2023.4592","url":null,"abstract":"In this study, we investigated the impact of miR-597-5p on the tumor stem cell characteristics of gastric cancer cells and the underlying mechanisms. Gastric cancer cell lines were transfected with miR-597-5p mimics to elevate miR-597-5p expression, confirmed by qRT-PCR. Overexpression of miR-597-5p led to reduced cell viability, proliferation, migration, invasion, and sphere-forming ability, while increasing apoptosis. Additionally, the expression of stem cell markers OCT4 and SOX2, as well as the phosphorylation of STAT3 and NF- κ B, decreased with miR-597-5p overexpression. Co-treatment with a STAT3 activator reversed these effects, promoting cell proliferation, invasion, migration, sphere formation, and increasing p-STAT3, p-NF- κ B, SOX2, and OCT4 expression. Importantly, miR-597-5p inhibited the STAT3/NF- κ B signaling pathway, preventing gastric cancer cells from exhibiting stem-like characteristics. These findings suggest that miR-597-5p may have therapeutic potential in suppressing the stem cell properties of gastric cancer cells through STAT3/NF- κ B pathway regulation.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"15 12","pages":"1662-1672"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147920663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Chitosan Nanoparticles Loaded with Vascular Endothelial Growth Factor and Its Application in the Treatment of Skin Injury","authors":"Hongmei Tang, Zhe Deng, Tianlan Zhao","doi":"10.1166/sam.2023.4574","DOIUrl":"https://doi.org/10.1166/sam.2023.4574","url":null,"abstract":"This research was aimed to explore the application of chitosan (CS) nanoparticles (NPs) loaded with vascular endothelial growth factor (VEGF) in rat skin injury. Method: the VEGF-loaded CS NPs (VEGF/CS-NPs) were prepared, and a skin injury model on the back skin of rats was established. The VEGF/CS-NPs were applied to the injury model to observe the skin changes in the wound area of each group, compare the healing rate, the number of micro-vessels, and VEGF expression in each group of rats, so as to explore the intervention effect of VEGF/CS-NPs in skin injury. Results: the prepared VEGF/CS-NPs were spherical or quasi-spherical in morphology, uniformly dispersed, with smooth surfaces and relatively uniform size. The average particle size (PS) of the blank CS-NPs was 267.5 nm± 25.3 nm, while that of the drug-loaded CS-NPs was 298.6 nm ±44.7 nm, and the PS distribution was also very concentrated. The genipin cross-linked NPs could effectively prevent the degradation of the spherical wall and achieve the slow release of VEGF. After VEGF was applied to rats in the form of NPs, its healing rate and micro-vessel count were markedly superior to those of VEGF injection alone and blank group ( P &lt; 0.05), and VEGF expression in skin injury tissues was also greatly increased ( P &lt; 0.05). Conclusion: VEGF/CS-NPs could improve the bioavailability of VEGF and promote the healing of rat skin injuries.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"15 12","pages":"1621-1628"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Biodegradable Biomaterials Combined with Bone Marrow Mesenchymal Stem Cells Transplantation on Neurological Function in Rats with Ischemic Cerebral Infarction","authors":"Qun Liu, Hong Tan, Qingfang Liu, Penghui Liu","doi":"10.1166/sam.2023.4610","DOIUrl":"https://doi.org/10.1166/sam.2023.4610","url":null,"abstract":"The aim of this research was to explore the effects of degradable biomaterial self-polypeptide nanofiber scaffolds plus bone marrow mesenchymal stem cells (BMSCs) on the behavior and neurological function of rats with focal ischemic cerebral infarction (ICI). BMSCs were isolated and cultured. The self-assembling peptides and BMSCs were mixed to prepare self-assembling peptides/BMSCs (SAP/BMSCs) material. BMSCs and SAP/BMSCs were injected into the carotid artery of rats in Model group. The rats without ligation were used as Sham group. Longa 5 and modified neurological severity scores (mNSS) of each group were evaluated. The adhesive removal test and forelimb asymmetry test were used to examine the behavior of the rats. The brain tissues were collected, and the infarct size, neuronal apoptosis, and the protein expression of Nogo-A and lipoprotein a (LPA) in the hippocampus were detected by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining, TdT-mediated dUTP nick end labeling (TUNEL) staining, enzyme-linked immunosorbent assay (ELISA), and Western blot. The results indicated that the fiber diameter of the self-polymerizing peptide material was about 12 nm, and the length was about 100-250 nm. The cells grew well after composite BMSCs. Compared with Sham group, Longa 5, mNSS score, adhesive removal time, forelimb asymmetry test score, cerebral infarction volume, and neuronal apoptosis rate were increased, interleukin 6 (IL-6) and Tumor Necrosis Factor alpha (TNF- α ) were raised, IL-10 was decreased, and Nogo-A and LPA protein was increased in Model group ( P &lt; 0.05). As against Model group, Longa 5, mNSS score, adhesive removal time, forelimb asymmetry test score, cerebral infarction volume, neuronal apoptosis rate, IL-6 and TNF- α were clearly decreased, and IL-10 was raised, and Nogo-A and LPA protein was clearly decreased in BMSCs and SAP/BMSCs groups ( P &lt; 0.05). As against BMSCs group, Longa 5, mNSS score, adhesive removal time, forelimb asymmetry test score, cerebral infarction volume, and neuronal apoptosis rate were clearly decreased, and IL-6 and TNF- α were decreased, and IL-10 was raised, and Nogo-A and LPA protein was decreased in SAP/BMSCs group ( P &lt; 0.05). Early transplantation of BMSCs can improve the neurobehavioral symptoms of ICI rats and inhibit neuronal apoptosis and inflammatory response. The effect of self-polymerizing peptide nanofiber scaffold plus BMSCs transplantation in ICI is superior to the transplantation of BMSCs alone.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"15 12","pages":"1645-1652"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gefitinib Induces Apoptosis of Gastric Cancer Cells by Promoting Glutaminolysis Through the MEK/ERK Signaling Pathway","authors":"Zhiyang Peng, Yahui Liu, Yongbing Zheng, Rui Zhou","doi":"10.1166/sam.2023.4594","DOIUrl":"https://doi.org/10.1166/sam.2023.4594","url":null,"abstract":"We aimed to investigate the effect of gefitinib on the proliferation and apoptosis of gastric cancer (GC) cells through the MEK/ERK signaling pathway. The GC cell line NCI-N87 was cultured in vitro and divided into a control group and a gefitinib group. Cell viability for NCI-N87 was determined using the MTT test. The amount of apoptosis in NCI-N87 cells was measured using flow cytometry. Real-time quantitative PCR was used to measure GDH1 mRNA expression in NCI-N87 cells. P-MEK1/2, MEK1/2, P-ERK1/2, and ERK1/2 protein expression levels in NCI-N87 cells were determined using Western blotting. An assay kit for measuring glutamine was used to determine the intracellular glutamine concentration of NCI-N87 cells. The proliferative activity of NCI-N87 cells was significantly inhibited in the gefitinib group compared to the control group, along with the transcription level of GDH1, intracellular glutamine content, intracellular glutamine content reduction, and p-MEK1/2 and p-ERK1/2 protein expression levels. Gefitinib inhibits proliferation and promotes apoptosis in the GC cell line NCI-N87 by downregulating the EGFR/MEK/ERK signaling pathway. Mechanistically, it is achieved by promoting the expression of GDH1 to promote glutaminolysis in NCI-N87 cells.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":"15 11","pages":"1554-1559"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}