Scandinavian Journal of Urology and Nephrology最新文献_第6页

Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosis. 实验性单侧急性和慢性肾积水患者尿液和肾脏细胞因子谱。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2011-12-12 DOI: 10.3109/00365599.2011.637958

Mia Gebauer Madsen, Rikke Nørregaard, Lene Stødkilde, Jane Hvarregaard Christensen, Troels Munch Jørgensen, Jørgen Frøkiær

{"title":"Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosis.","authors":"Mia Gebauer Madsen, Rikke Nørregaard, Lene Stødkilde, Jane Hvarregaard Christensen, Troels Munch Jørgensen, Jørgen Frøkiær","doi":"10.3109/00365599.2011.637958","DOIUrl":"https://doi.org/10.3109/00365599.2011.637958","url":null,"abstract":"Objective: In search of potential urinary biomarkers of obstructive nephropathy, this study examined whether a potential change in the concentration of urinary cytokines [interferon-γ(IFN-γ), interleukin-1β (IL-1β), IL-2, IL-6, IL-10 and tumour necrosis factor-α (TNF-α)] reliably reflects changes in renal parenchymal levels of the same cytokines following the release of acute and chronic unilateral ureteral obstruction, respectively.Material and methods: Acute obstruction was performed in 12 adult rats. After 48 h, six rats were used for selective urine collection and six rats had their kidneys removed and dissected into inner medulla and cortex. Chronic obstruction was performed in newborn rats. After 10 weeks, a similar set-up to that of the acute study was implemented. Sham-operated rats were prepared in parallel. Urine and tissue cytokines were measured with a bead-based multiplex sandwich immunoassay and analysed on a Luminex 100 IS instrument.Results: In the acute study, there were significantly increased concentrations of IL-1β and IL-6 in inner medulla and in urine from the obstructed kidney, significantly increased concentrations of TNF-α in urine from the obstructed kidney and, importantly, significantly increased levels of IL-10 in cortex and in urine from the non-obstructed kidney. In the chronic study, there were similar changes in IL-1β and IL-6 (not significant) but no changes in TNF-α and IL-10.Conclusions: This study showed that inflammatory cytokines can be detected both in renal parenchyma and in urine from rats with experimental unilateral ureteral obstruction. Further studies are needed to confirm the diagnostic accuracy of IL-1β, IL-6, IL-10 and TNF-α in urine.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"91-6"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.637958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30309021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Successful non-surgical treatment of perirenal haematoma after percutaneous renal artery angioplasty in a solitary kidney. 单发肾经皮肾动脉成形术后肾周血肿的成功非手术治疗。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2011-12-12 DOI: 10.3109/00365599.2011.638933

Chrysoula Pipili, Eirini Grapsa, Vassilis Arapoglou, Helen Tzanatos

引用次数: 0

Impact of the apolipoprotein B/apolipoprotein A-I ratio on renal outcome in immunoglobulin A nephropathy. 载脂蛋白B/载脂蛋白A- i比值对免疫球蛋白A肾病肾预后的影响。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2012-01-03 DOI: 10.3109/00365599.2011.644635

S Lundberg, I Gunnarsson, S H Jacobson

{"title":"Impact of the apolipoprotein B/apolipoprotein A-I ratio on renal outcome in immunoglobulin A nephropathy.","authors":"S Lundberg, I Gunnarsson, S H Jacobson","doi":"10.3109/00365599.2011.644635","DOIUrl":"https://doi.org/10.3109/00365599.2011.644635","url":null,"abstract":"Objective: Serum levels of the apolipoprotein B/apolipoprotein A-I ratio (ApoB/ApoA-I) have been shown to identify patients at risk of cardiovascular disease. The aim of this study was to evaluate whether raised ApoB/ApoA-I values are also predictive of renal outcome in patients with chronic kidney disease (CKD), as similar mechanisms seem to be involved in the development of atherosclerosis and glomerulosclerosis. Only patients with immunoglobulin A nephropathy (IgAN) were included, since they represent a homogeneous group of patients with CKD.Material and methods: ApoB and ApoA-I, serum albumin, urine albumin and blood pressure were measured, and a highly sensitive C-reactive protein test was carried out, in 70 patients with IgAN and in 70 age- and gender-matched healthy control subjects. Patients were followed over a period of up to 11 years (median 3.8 years). End-stage renal disease (ESRD) was defined as reaching CKD stage 5 [estimated glomerular filtration rate (eGFR) <15 ml/min/1.73 m²].Results: Baseline ApoB/ApoA-I values greater than 0.9 for men and greater than 0.8 for women were associated with a risk of developing CKD stage 5 (risk ratio 5.7, p = 0.037), independently of baseline GFR and serum albumin.Conclusion: Patients with IgAN and an increased ApoB/ApoA-I ratio have a significantly higher risk of developing ESRD compared with patients with a low ratio. Controlled studies are warranted to demonstrate whether interventions focusing on the ApoB/ApoA-I ratio may have beneficial clinical effects.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"148-55"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.644635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30361753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Estimated glomerular filtration rate decline in 567 patients with acute stroke. 估计567例急性脑卒中患者肾小球滤过率下降。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2011-12-16 DOI: 10.3109/00365599.2011.639032

Diange Liu, Hong Ding, Shaohua Liu, Jingqun Shen

{"title":"Estimated glomerular filtration rate decline in 567 patients with acute stroke.","authors":"Diange Liu, Hong Ding, Shaohua Liu, Jingqun Shen","doi":"10.3109/00365599.2011.639032","DOIUrl":"https://doi.org/10.3109/00365599.2011.639032","url":null,"abstract":"Objective: Chronic kidney disease, characterized by a decline in renal function, is a public health challenge, affecting around 10% of the population worldwide. The aim of this study was to investigate the prevalence of decline in renal function in patients admitted for acute first-ever stroke from a local centre in China, and its impact on mortality and neurological impairment during a short follow-up period.Material and methods: In total, 640 patients hospitalized due to acute stroke were enrolled in this prospective study. Clinical data were obtained and a 3-month follow-up was executed by a team of trained investigators. The data indicated that the prevalence of estimated glomerular filtration rate (eGFR) decline (≤60 ml/min/1.73 m(2)) was 18.5% in this specific population.Results: Hyperuricaemia, elevated homocysteine and smoking history were identified as three major risk factors associated with eGFR decline. An eGFR ≤60 ml/min/1.73 m(2) was detected in 45.1% of haemorrhagic stroke patients, while 14.7% of ischaemic stroke patients had an accompanying eGFR decline. During the follow-up period, the mortality rate was 18.1% in patients with eGFR decline and 1.5% in patients with eGFR >60 ml/min/1.73 m(2).Conclusions: This study clearly shows that the prevalence of renal impairment is high in acute stroke patients in China, and renal impairment may confer a significant risk for worse outcomes such as impaired neurological function and death, at least in the short term.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"142-7"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.639032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30327277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Assessment of late urinary, bowel and sexual function after dose escalation from 70 to 76 Gy using image-guided radiotherapy in curative treatment of prostate cancer. 影像引导放射治疗前列腺癌剂量从70 Gy增加到76 Gy后晚期尿、肠和性功能的评估

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2012-02-22 DOI: 10.3109/00365599.2012.659205

Hege S Haugnes, Bianca Melby, Kari M Larsen, Ingrid Langdal, Mana Rasi, Roy M Bremnes

{"title":"Assessment of late urinary, bowel and sexual function after dose escalation from 70 to 76 Gy using image-guided radiotherapy in curative treatment of prostate cancer.","authors":"Hege S Haugnes, Bianca Melby, Kari M Larsen, Ingrid Langdal, Mana Rasi, Roy M Bremnes","doi":"10.3109/00365599.2012.659205","DOIUrl":"https://doi.org/10.3109/00365599.2012.659205","url":null,"abstract":"Objective: The aim of this study was to evaluate the late urinary, bowel and sexual function among men with localized or locally advanced prostate cancer treated with curative radiotherapy after the introduction of image-guided radiotherapy to 76 Gy using the Swedish BeamCath® technique.Material and methods: All patients treated with curative radiotherapy during 2003-2006 were invited to participate in this retrospective study. In total, 87% (158/181) participated in the study. The median observation time was 35 months. Comparisons were made between the standard 70 Gy (n = 73) and the 76 Gy (n = 85) treatment groups. Assessments of late urinary, bowel and sexual function were questionnaire based, and included function items in the Expanded Prostate Cancer Index Composite.Results: Most late urinary and bowel symptoms were reported to occur seldom or never in the majority of men, while late sexual toxicity was reported in a large proportion (66%) of men. Seven men (4%) used diapers. Only 25% (n = 40) reported having an erection firm enough for intercourse. None of the reported urinary or sexual function symptoms differed between the treatment groups. Rectal urgency at least once daily was a more frequent symptom in the 70 Gy group than the 76 Gy group (28% vs 9%, p = 0.006). Painful bowel movements were a more common symptom in the 70 Gy group (11% vs 1%, p = 0.01).Conclusion: Dose escalation up to 76 Gy using the BeamCath technique was not associated with more late toxicities than the standard 70 Gy dose.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"124-32"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.659205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30476148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Effects of short and long-term indapamide treatments on urinary calcium excretion in patients with calcium oxalate dihydrate urinary stone disease: a pilot study. 短期和长期吲达帕胺治疗对草酸钙二水合尿路结石患者尿钙排泄的影响:一项初步研究

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2012-01-18 DOI: 10.3109/00365599.2011.644862

Diego Alonso, Enrique Pieras, Pedro Pizá, Felix Grases, Rafel M Prieto

{"title":"Effects of short and long-term indapamide treatments on urinary calcium excretion in patients with calcium oxalate dihydrate urinary stone disease: a pilot study.","authors":"Diego Alonso, Enrique Pieras, Pedro Pizá, Felix Grases, Rafel M Prieto","doi":"10.3109/00365599.2011.644862","DOIUrl":"https://doi.org/10.3109/00365599.2011.644862","url":null,"abstract":"Objective: The aim of this study was to determine the relative calcium-reducing effects of indapamide at 6 and 18 months using a dose of 1.5 mg/day.Material and methods: Twenty-two patients with idiopathic hypercalciuria and calcium oxalate dihydrate urinary stone disease (minimum one stone episode) were selected. Each patient began a therapy regime of 1.5 mg indapamide sustained release taken once a day in the evening. Under basal conditions and after 6 and 18 months of treatment, subjects submitted urine and blood samples for analysis. The primary aim of this study was to assess the effects on excretion and concentration of calcium in urine.Results: For 2 h urine, there was a mean decrease in urinary calcium concentration of 47%, whereas urinary calcium concentrations decreased by 53% in 24 h urine (p < 0.05) at 6 months of treatment. Blood urate levels rose by 19% (p < 0.05). Treatment for 18 months resulted in significant reduction in urinary calcium levels, by approximately 48% (p < 0.05) in both 2 h and 24 h urine. A 21% increase in urate levels in the blood was observed (p < 0.05). The remaining parameters remained unaltered.Conclusions: Owing to the low effective dosage of indapamide (1.5 mg/day) and the lack of any severe side-effects, this drug would appear to be a good candidate for use in the control of hypercalciuria. As such, it could prove efficacious in the prevention of recurrent kidney stones that are often associated with this condition.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"97-101"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.644862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30390603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Role of hexaminolevulinate-guided fluorescence cystoscopy in bladder cancer: critical analysis of the latest data and European guidance. 六检氨基乙酰丙酸引导的荧光膀胱镜检查在膀胱癌中的作用:最新数据和欧洲指南的关键分析。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2011-11-16 DOI: 10.3109/00365599.2011.633279

Per-Uno Malmström, Magnus Grabe, Erik Skaaheim Haug, Pekka Hellström, Gregers G Hermann, Karin Mogensen, Mika Raitanen, Rolf Wahlqvist

{"title":"Role of hexaminolevulinate-guided fluorescence cystoscopy in bladder cancer: critical analysis of the latest data and European guidance.","authors":"Per-Uno Malmström, Magnus Grabe, Erik Skaaheim Haug, Pekka Hellström, Gregers G Hermann, Karin Mogensen, Mika Raitanen, Rolf Wahlqvist","doi":"10.3109/00365599.2011.633279","DOIUrl":"https://doi.org/10.3109/00365599.2011.633279","url":null,"abstract":"Objective: Hexaminolevulinate (HAL) is an optical imaging agent used with fluorescence cystoscopy (FC) for the detection of non-muscle-invasive bladder cancer (NMIBC). Guidelines from the European Association of Urology (EAU) and a recent, more detailed European expert consensus statement agree that HAL-FC has a role in improving detection of NMIBC and provide recommendations on situations for its use. Since the publication of the EAU guidelines and the European consensus statement, new evidence on the efficacy of HAL-FC in reducing recurrence of NMIBC, compared with white light cystoscopy (WLC), have been published.Material and methods: To consider whether these new trials have an impact on the expert guidelines and on clinical practice (e.g. supporting existing recommendations or providing evidence for a change or expansion of practice), a group of bladder cancer experts from Denmark, Finland, Norway and Sweden met to address the following questions: What is the relevance of the new data on HAL-FC for clinical practice in managing NMIBC? What impact do the new data have on European guidelines? How could HAL-FC be used in clinical practice? and What further information on HAL-FC is required to optimize the management of NMIBC?Results and conclusions: This article reports the outcomes of the discussion at the Nordic expert panel meeting, concluding that, in line with European guidance, HAL-FC has an important role in the initial detection of NMIBC and for follow-up of patients to assess tumour recurrence after WLC. It provides practical advice, with an algorithm on the use of this diagnostic procedure for urologists managing NMIBC.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"108-16"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.633279","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30256509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Preoperative ultrasound monitoring can reduce postoperative bladder distension: a randomized study. 术前超声监测可以减少术后膀胱膨胀:一项随机研究。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2011-12-12 DOI: 10.3109/00365599.2011.637959

Eva Joelsson-Alm, Johanna Ulfvarson, Claes R Nyman, Mona-Britt Divander, Christer Svensén

{"title":"Preoperative ultrasound monitoring can reduce postoperative bladder distension: a randomized study.","authors":"Eva Joelsson-Alm, Johanna Ulfvarson, Claes R Nyman, Mona-Britt Divander, Christer Svensén","doi":"10.3109/00365599.2011.637959","DOIUrl":"https://doi.org/10.3109/00365599.2011.637959","url":null,"abstract":"Objective: The aim of this study was to explore whether close preoperative ultrasound monitoring starting in the emergency room (ER) could prevent postoperative bladder distension among acute orthopaedic patients.Material and methods: A randomized controlled trial was conducted at a 650-bed level-2 centre in Sweden. Inclusion criteria were admittance via ER to an orthopaedic ward for acute surgery. Bladder volumes were measured with a portable ultrasound scanner (Bladderscan BVI 3000). In the intervention group, all patients were scanned in the ER and then regularly at the ward at predefined times until surgery. In the control group, no regular scanning was performed before surgery. During surgery, the same procedure was performed for both groups: bladder scanning immediately after arrival to the recovery room and continuous postoperative scanning until voiding. The primary outcome was postoperative bladder distension, defined as a bladder volume ≥500 ml. Secondary outcomes were postoperative urinary tract infection and hospital length of stay.Results: A total of 281 patients completed the study, 141 in the intervention group and 140 in the control group. Postoperative bladder distension was significantly higher in the control group (27.1% vs 17.0%; p = 0.045, 95% confidence interval 4.9-19.8) in the intention-to-treat, per-protocol and as-treated analyses. No statistical difference was found between the intervention group and the control group regarding the secondary outcomes.Conclusions: Frequent bladder monitoring starting in the ER can reduce postoperative bladder distension among acute orthopaedic patients. A preoperative bladder monitoring protocol should be implemented early in the ER for all patients admitted for acute orthopaedic procedures.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.637959","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30309778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Single-centre evaluation of the extraperitoneal and transperitoneal approach in robotic-assisted radical prostatectomy. 单中心评价机器人辅助根治性前列腺切除术的腹膜外和经腹膜入路。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2011-12-16 DOI: 10.3109/00365599.2011.637957

Marcus Horstmann, Christian Vollmer, Christoph Schwab, Michael Kurz, Christian Padevit, Kevin Horton, Hubert John

{"title":"Single-centre evaluation of the extraperitoneal and transperitoneal approach in robotic-assisted radical prostatectomy.","authors":"Marcus Horstmann, Christian Vollmer, Christoph Schwab, Michael Kurz, Christian Padevit, Kevin Horton, Hubert John","doi":"10.3109/00365599.2011.637957","DOIUrl":"https://doi.org/10.3109/00365599.2011.637957","url":null,"abstract":"Objective: Robotic-assisted radical prostatectomy (RARP) is feasible using either an extraperitoneal (EP) or a transperitoneal (TP) approach. This study reports on the experience of a single hospital using both techniques.Material and methods: From July 2009 to March 2011, 170 patients underwent RARP. EP was chosen in 103 patients and TP in 67. TP was preferred in cases previous mesh hernia repair or if extended lymph-node dissection (LND) was considered necessary. Otherwise, EP was performed; it was preferred in cases of obesity (body mass index (BMI) > 30 kg/m(2)) or previous intra-abdominal surgery.Results: There were no significant differences in preoperative mean age (64.4 vs 65.6 years), BMI (26.5 vs 26.3 kg/m(2)) or prostate size (51.8 vs 55.8 cm(3)) between EP and TP patients. Owing to preoperative selection criteria, prostate-specific antigen levels and the average Gleason score were significantly lower in EP than in TP patients (p < 0.001). Whereas access time and time for anastomosis did not differ significantly (21 vs 19 min, p = 0.11, and 26 vs 24 min, p = 0.36, respectively), overall surgical time was significantly longer in TP (225 vs 191 min, p < 0.001). Blood loss was equal in both groups (EP 276 vs TP 281 ml, p = 0.88). Complication rates were lower in EP (n = 7, 6.8% vs n = 8, 12%, p = 0.024). Time until first defecation and last analgesic treatment were significantly shorter in EP (p < 0.05).Conclusions: The results of the current evaluation underline the clinical advantages of an extraperitoneal approach for RARP. However, a transperitoneal approach is still considered necessary for extended LND or special clinical conditions. Robotic teams should be trained using both approaches.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"117-23"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.637957","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30327418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Three cases of granulocyte colony-stimulating factor-producing urinary upper tract carcinomas. 粒细胞集落刺激因子致尿上路癌3例。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-04-01 Epub Date: 2012-01-18 DOI: 10.3109/00365599.2011.644863

Hiroshi Shirakawa, Eiji Kikuchi, Shuji Mikami, Shigeru Fukamachi, Yasumasa Miyazaki, Nobuyuki Tanaka, Akira Miyajima, Mototsugu Oya

{"title":"Three cases of granulocyte colony-stimulating factor-producing urinary upper tract carcinomas.","authors":"Hiroshi Shirakawa, Eiji Kikuchi, Shuji Mikami, Shigeru Fukamachi, Yasumasa Miyazaki, Nobuyuki Tanaka, Akira Miyajima, Mototsugu Oya","doi":"10.3109/00365599.2011.644863","DOIUrl":"https://doi.org/10.3109/00365599.2011.644863","url":null,"abstract":"This report presents three cases of urinary upper tract carcinomas producing granulocyte colony-stimulating factor (G-CSF), with high blood leukocyte counts and poor prognoses. Case 1 was a 73-year-old man who underwent nephroureterectomy for left renal pelvic carcinoma. Pathologically, urothelial carcinoma (UC), high-grade, was observed, and immunohistochemical analysis showed positive staining for G-CSF. Progressive disease (PD) was observed despite administration of systemic chemotherapy for disease relapse, and the patient died 4.5 months after the operation. Case 2 was a 74-year-old man who had left renal pelvic carcinoma with para-aortic lymph-node metastases. The serum G-CSF was elevated (169 pg/ml). The patient refused any aggressive treatment, and died 2.3 months after his first visit to the hospital. Case 3 was a 75-year-old woman who had left renal pelvic carcinoma with adrenal metastasis. Biopsy confirmed the diagnosis as UC with squamous differentiation, and the serum G-CSF was elevated (138 pg/ml). Systemic chemotherapy was administered. However, the patient showed PD, and died 6.9 months after her first visit to the hospital. Effective treatment strategies are warranted for carcinomas producing G-CSF. Elucidation of the actions of G-CSF on both the carcinoma cells and the tumor microenvironment may contribute to the development of useful strategies.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 2","pages":"136-41"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2011.644863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30391002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3