Scandinavian Journal of Urology and Nephrology最新文献

Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations. 植入式神经技术：双向神经接口--应用和 VLSI 电路实现。

IF 3.2

Scandinavian Journal of Urology and Nephrology Pub Date : 2016-01-01 Epub Date: 2016-01-11 DOI: 10.1007/s11517-015-1429-x

Elliot Greenwald, Matthew R Masters, Nitish V Thakor

引用次数: 0

Sexual and relationship functioning before and after renal transplantation: a descriptive study with patients and partners. 肾移植前后的性和关系功能:对患者和伴侣的描述性研究。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-06-25 DOI: 10.3109/00365599.2012.693132

Matthias Claudius Raggi, Stephanie Barbara Siebert, Helmut Friess, Elisabeth Schremmer-Danninger, Stefan Thorban, Andreas Dinkel

{"title":"Sexual and relationship functioning before and after renal transplantation: a descriptive study with patients and partners.","authors":"Matthias Claudius Raggi, Stephanie Barbara Siebert, Helmut Friess, Elisabeth Schremmer-Danninger, Stefan Thorban, Andreas Dinkel","doi":"10.3109/00365599.2012.693132","DOIUrl":"https://doi.org/10.3109/00365599.2012.693132","url":null,"abstract":"Objective: Many patients experience problems with sexual functioning after renal transplantation (RTx). Research on the sexual functioning of the partners of those patients and the consequences for relationship satisfaction and quality of life is lacking. This study sought to explore changes in sexual and relationship functioning from before to after RTx in patients and their partners.Material and methods: Twenty-nine patients (mean ± SD age 53.4 ± 14.2 years) and 13 partners (age 57.1 ± 11.6 years) provided data 12-15 months after RTx. They retrospectively evaluated sexual and relationship functioning as well as general life satisfaction before RTx and, in comparison, in the most recent months.Results: Among the patients, most items on sexual experience indicated deterioration in sexual functioning. Among their partners, the wish for sexual activity with the patient and the actual frequency of sexual activity decreased from before to after RTx. The rate of partners indicating high personal importance for intercourse decreased from 83.3% to 69.2%, as did the rate of partners stating high sexual satisfaction (from 63.6% to 41.7%). Despite these trends, most patients and partners reported high relationship and life satisfaction after RTx.Conclusions: Partners of patients who had received a kidney transplant seem to be affected by negative changes in the patients' sexual functioning. Nonetheless, many couples maintain high relationship and life satisfaction.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"431-6"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.693132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30711808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Current equations estimating glomerular filtration rate in primary care: comparison and determinants. 估计初级保健肾小球滤过率的现行方程式:比较和决定因素。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-06-25 DOI: 10.3109/00365599.2012.695389

Dorothea Dehnen, Thomas Quellmann, Stefan Herget-Rosenthal

{"title":"Current equations estimating glomerular filtration rate in primary care: comparison and determinants.","authors":"Dorothea Dehnen, Thomas Quellmann, Stefan Herget-Rosenthal","doi":"10.3109/00365599.2012.695389","DOIUrl":"https://doi.org/10.3109/00365599.2012.695389","url":null,"abstract":"Objective: The aims of this study were to compare estimated glomerular filtration rate (eGFR) by Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, to assess the classification of chronic kidney disease (CKD) stages by both equations, and to identify factors associated with differences between both equations in patients with or at high risk of CKD managed in primary care.Material and methods: This was an observational study of 803 patients with CKD, long-standing, severe hypertension and diabetes exclusively managed in primary care. Bias and precision between the two equations used to calculate eGFR were quantified as proposed by Bland and Altman.Results: In 1534 eGFR calculations, mean eGFR(MDRD) was 0.8 ± 3.6 ml/min/1.73 m(2) higher than eGFR(CKD-EPI). Precision between the two equations was ±7.1 ml/min/1.73 m(2). Classification of CKD stages by MDRD or CKD-EPI equations agreed in 93.3% of cases. Age above 70 years, eGFR below 60 and above 120 ml/min/1.73 m(2) were associated with higher eGFR(MDRD) values; and age below 50 years and inadequately controlled hypertension with higher eGFR(CKD-EPI) values.Conclusions: Comparison of eGFR calculated by MDRD and CKD-EPI equations demonstrated no clinically relevant difference. In addition, CKD classification by both equations agreed highly. As both equations performed equally well, the simpler and more established MDRD equation should be preferred in patients with or at high risk of CKD managed in primary care. Patients' characteristics seem to account for previously reported differences in the performance of CKD-EPI and MDRD equations.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"448-53"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.695389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30711809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Current routines for transrectal ultrasound-guided prostate biopsy: a web-based survey by the Swedish Urology Network. 经直肠超声引导前列腺活检的当前常规:瑞典泌尿外科网络的一项基于网络的调查。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-05-31 DOI: 10.3109/00365599.2012.691111

Stefan Carlsson, Ola Bratt, Pär Stattin, Lars Egevad

{"title":"Current routines for transrectal ultrasound-guided prostate biopsy: a web-based survey by the Swedish Urology Network.","authors":"Stefan Carlsson, Ola Bratt, Pär Stattin, Lars Egevad","doi":"10.3109/00365599.2012.691111","DOIUrl":"https://doi.org/10.3109/00365599.2012.691111","url":null,"abstract":"Objective: This study aimed to survey current Swedish practices for performing and handling transrectal ultrasound-guided prostate biopsies.Material and methods: A Swedish Urology Network (SUNe) was organized for the distribution of information, survey studies and research collaborations. A web-based questionnaire was distributed to the members in 2011.Results: In this first SUNe survey, 137 (91%) of the 151 members replied. All used antibiotic prophylaxis (84% ciprofloxacin, 12% trimethoprim-sulfamethoxazole), most commonly (63%) as a single dose of ciprofloxacin. Local anaesthesia was used by 87%. Half of the respondents only used a \"side-fire\" probe, whereas 17% always used an \"end-fire\" probe. Most (84%) routinely took 10 or more biopsy cores. About three-quarters started with the right base of the prostate and did not routinely take midline biopsies. More than one-third never or rarely sampled the anterior part of the prostate. There was great variability in how biopsy location was reported, but 71% considered a national standardized coordinate system desirable. Fine-needle aspiration was used occasionally by 39%, in more than 10% of cases by 6% and always by 2%. Most urologists mounted the biopsy cores on paper before fixation (78%), put only one core per jar (75%) and used flat-bottomed jars (70%).Conclusions: Most routines for handling of prostate biopsies, antibiotic prophylaxis, local anaesthesia and number of cores were uniform. However, there is still a need for standardization of the performance of ultrasound-guided biopsies. Although the method used to specify biopsy location varied greatly, most urologists would prefer a national standardized system.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"405-10"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.691111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30655554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Low-calcium dialysate as a risk factor for decline in bone mineral density in peritoneal dialysis patients. 低钙透析液是腹膜透析患者骨密度下降的危险因素。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-08-31 DOI: 10.3109/00365599.2012.700643

Seok Hui Kang, Kyu Hyang Cho, Jong Won Park, Kyung Woo Yoon, Jun Young Do

{"title":"Low-calcium dialysate as a risk factor for decline in bone mineral density in peritoneal dialysis patients.","authors":"Seok Hui Kang, Kyu Hyang Cho, Jong Won Park, Kyung Woo Yoon, Jun Young Do","doi":"10.3109/00365599.2012.700643","DOIUrl":"https://doi.org/10.3109/00365599.2012.700643","url":null,"abstract":"Objective: Few studies have linked changes in bone mineral density (BMD) in peritoneal dialysis (PD) patients to the calcium concentration in peritoneal dialysate.Material and methods: In total, 236 incident patients who underwent an annual BMD determination for 2 years were enrolled. The patients were divided into two groups: the standard calcium dialysate (SCD) group (n = 190; 1.75 mmol/l) and the low-calcium dialysate (LCD) group (n = 46; 1.25 mmol/l).Results: There were no significant differences between the baseline demographics of the two groups, such as age, diabetes, calcium, phosphorus, alkaline phosphatase (ALP), intact parathyroid hormone (i-PTH) levels or variables related to BMD. Univariate and multivariate analyses [adjusted for age, gender and time-averaged 25(OH)-vitamin D] determined that the LCD group had higher time-averaged i-PTH and ALP and a greater decrease in bone mineral content, lumbar spine BMD, subtotal BMD and total BMD compared to the SCD group.Conclusion: LCD is associated with a more rapid decline in BMD, higher i-PTH and higher ALP in PD patients. It is suggested that LCD be avoided for PD patients at risk of osteoporosis and hyperparathyroidism.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"454-60"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.700643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30870694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Risk factors and interventional strategies for BK polyomavirus infection after renal transplantation. 肾移植术后BK多瘤病毒感染的危险因素及干预策略

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-09-28 DOI: 10.3109/00365599.2012.726643

Dominik Steubl, Marcus Baumann, Tibor Schuster, Michael Fischereder, Bernhard K Krämer, Uwe Heemann, Jens Lutz

{"title":"Risk factors and interventional strategies for BK polyomavirus infection after renal transplantation.","authors":"Dominik Steubl, Marcus Baumann, Tibor Schuster, Michael Fischereder, Bernhard K Krämer, Uwe Heemann, Jens Lutz","doi":"10.3109/00365599.2012.726643","DOIUrl":"https://doi.org/10.3109/00365599.2012.726643","url":null,"abstract":"Objective: BK virus (BKV)-induced viraemia after renal transplantation can be associated with severe impairment of graft function. This study evaluated possible risk factors for BKV replication and examined the outcomes following various currently used treatment approaches.Material and methods: Fifty-seven renal transplant recipients with BKV viraemia were retrospectively compared with 71 BKV-negative recipients to identify risk factors for BKV viraemia. Furthermore, outcome and graft function in 14 patients with BKV replication, in whom mycophenolate mofetil (MMF) was discontinued with a dose reduction of the remaining immunosuppressants, were compared with 32 patients in whom both MMF and the additional immunosuppressants were reduced.Results: Patients with BKV viraemia received MMF (p < 0.01) and triple immunosuppression (p < 0.01) significantly more often, and displayed tacrolimus (p = 0.034) at higher blood concentrations (p = 0.002), a lower lymphocyte count (p = 0.006) and a longer warm ischaemic time (p = 0.019), and were more often male (p = 0.026). Patients in whom MMF was stopped had a higher chance of clearance of BKV viraemia (p = 0.022), which was achieved more rapidly (p = 0.048). Graft function improved during treatment and no graft losses occurred, compared with eight graft losses in the MMF-treated group (p = 0.04).Conclusions: MMF and tacrolimus could promote BKV viraemia after renal transplantation. Discontinuation of MMF together with a reduction of calcineurin inhibitors and glucocorticoids could be an option to reduce BKV replication after renal transplantation.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"466-74"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.726643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30938091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis. 脂联素是血液透析患者组织纤溶酶原激活物水平的独立预测因子。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-08-02 DOI: 10.3109/00365599.2012.708943

Maria do Sameiro Faria, Sandra Ribeiro, Henrique Nascimento, Petronila Rocha-Pereira, Vasco Miranda, Denisa Mendonça, Alexandre Quintanilha, Elísio Costa, Luís Belo, Alice Santos-Silva

{"title":"Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis.","authors":"Maria do Sameiro Faria, Sandra Ribeiro, Henrique Nascimento, Petronila Rocha-Pereira, Vasco Miranda, Denisa Mendonça, Alexandre Quintanilha, Elísio Costa, Luís Belo, Alice Santos-Silva","doi":"10.3109/00365599.2012.708943","DOIUrl":"https://doi.org/10.3109/00365599.2012.708943","url":null,"abstract":"Objective: The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction.Material and methods: In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured.Results: Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer.Conclusion: Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"461-5"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.708943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30804264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does physiotherapist-guided pelvic floor muscle training increase the quality of life in patients after radical prostatectomy? A randomized clinical study. 物理治疗师指导下的盆底肌肉训练是否能提高根治性前列腺切除术后患者的生活质量?一项随机临床研究。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-07-02 DOI: 10.3109/00365599.2012.694117

Steffan Robstad Nilssen, Siv Mørkved, Mari Overgård, Stian Lydersen, Anders Angelsen

{"title":"Does physiotherapist-guided pelvic floor muscle training increase the quality of life in patients after radical prostatectomy? A randomized clinical study.","authors":"Steffan Robstad Nilssen, Siv Mørkved, Mari Overgård, Stian Lydersen, Anders Angelsen","doi":"10.3109/00365599.2012.694117","DOIUrl":"https://doi.org/10.3109/00365599.2012.694117","url":null,"abstract":"Objective: The aim of this study was to study the effect of postoperative physiotherapist-guided pelvic floor muscle training (PFMT) on health-related quality of life (HRQoL) parameters in patients treated with radical prostatectomy (RP).Material and methods: A prospective randomized controlled trial was conducted at St. Olavs Hospital, Trondheim University Hospital, Norway. Eighty-five men were randomized into two intervention groups (A and B). patients in group A (n = 42) were offered physiotherapist-guided PFMT (in groups or by DVD) once weekly throughout the first 12 months after RP, while those in group B (n = 43) trained on their own. HRQoL data were assessed using the University of California, Los Angeles Prostate Cancer Index (UCLA-PCI) and the Short Form-12 (SF-12) health survey. The physical component summary (PCS) and mental component summary (MCS) scores of the SF-12 plus the urinary, sexual and bowel function and bother of the UCLA-PCI make up the eight quality of life outcomes used in this study. Data were obtained preoperatively (baseline), 6 weeks, and 3, 6 and 12 months postoperatively.Results: Eighty patients completed at least one follow-up assessment, 38 in group A and 42 in group B, giving a dropout rate of 5.9%. The overall response rates were 96% at baseline, 83% at 6 weeks, 90% at 3 months, 88% at 6 months and 68% at 12 months. No statistically significant difference in HRQoL was found between groups A and B.Conclusions: Even though physiotherapist-guided training of the pelvic floor muscles after RP improved postoperative urinary incontinence significantly compared to those patients receiving standard care/training, this was not reflected in better outcome in HRQoL parameters.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"397-404"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.694117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30726892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Prevalence and bother of postmicturition dribble in Finnish men aged 30-80 years: Tampere Ageing Male Urologic Study (TAMUS). 芬兰30-80岁男性排尿后滴漏的患病率和困扰:坦佩雷老年男性泌尿学研究(TAMUS)。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-07-27 DOI: 10.3109/00365599.2012.702786

Antti Pöyhönen, Anssi Auvinen, Juha Koskimäki, Matti Hakama, Teuvo L J Tammela, Jukka T Häkkinen

{"title":"Prevalence and bother of postmicturition dribble in Finnish men aged 30-80 years: Tampere Ageing Male Urologic Study (TAMUS).","authors":"Antti Pöyhönen, Anssi Auvinen, Juha Koskimäki, Matti Hakama, Teuvo L J Tammela, Jukka T Häkkinen","doi":"10.3109/00365599.2012.702786","DOIUrl":"https://doi.org/10.3109/00365599.2012.702786","url":null,"abstract":"Objective: The aim of this study was to determine the prevalence and bother of postmicturition dribble in relation to age in the male population.Material and methods: Information for a population-based study was collected by means of a mailed self-administered questionnaire, which was returned by 4384 men out of 7470 (58.7%). The participants were men aged 30-80 years from the Pirkanmaa Region in Finland. The Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire was used to evaluate their urinary symptoms. SPSS was used in the data analysis. Two-sided chi-squared test and Kendall tau-b test were used for analysis.Results: The overall prevalence of postmicturition dribble was 58.1% (95% confidence interval 56.6-59.6). Prevalence of postmicturition dribble increased with age (p < 0.001). In men aged 60-80 years, two-thirds reported postmicturition dribble and approximately one out of four had dribbling into their trousers after voiding. In the 30-year-old group, over 40% reported postmicturition dribble and almost one out of five had also dribbling into their trousers. One out of five men in the 30-year-old group reported minor bother; the proportion of men reporting bother increased with age to one-third of the men in the oldest cohort (p < 0.001).Conclusions: The prevalence of the postmicturition dribble was found to be high in this survey. Half of the 30-year-old men and two-thirds of the men aged 60-80 years had postmicturition dribble. Dribbling into trousers increased with age but as a severe symptom, it was rare (0.5%). Minor problems from postmicturition dribble were common, but major bother occurred seldom (1.1%).","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"418-23"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.702786","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30791653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Long-term results of maintenance treatment of mitomycin C or alternating mitomycin C and bacillus Calmette-Guérin instillation therapy of patients with carcinoma in situ of the bladder: a subgroup analysis of the prospective FinnBladder 2 study with a 17-year follow-up. 丝裂霉素C维持治疗或丝裂霉素C与卡介苗-谷氨酰胺交替滴注治疗膀胱原位癌患者的长期结果:前瞻性finn膀胱2研究的亚组分析，随访17年。

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-12-01 Epub Date: 2012-07-02 DOI: 10.3109/00365599.2012.694906

Riikka Järvinen, Eero Kaasinen, Erkki Rintala, The Finnbladder Group

{"title":"Long-term results of maintenance treatment of mitomycin C or alternating mitomycin C and bacillus Calmette-Guérin instillation therapy of patients with carcinoma in situ of the bladder: a subgroup analysis of the prospective FinnBladder 2 study with a 17-year follow-up.","authors":"Riikka Järvinen, Eero Kaasinen, Erkki Rintala, The Finnbladder Group","doi":"10.3109/00365599.2012.694906","DOIUrl":"https://doi.org/10.3109/00365599.2012.694906","url":null,"abstract":"Objective: Only a few studies with a long-term follow-up exist on patients with carcinoma in situ (CIS) treated with instillation therapy. The objective was to study the long-term outcome of patients with CIS after mitomycin C (MMC) monotherapy or alternating therapy with MMC and bacillus Calmette-Guérin (BCG).Material and methods: The study population comprised 68 patients with CIS belonging to a larger material of 256 patients with non-muscle-invasive bladder carcinoma who were randomized between 1987 and 1992 in a prospective multicentre study. Patients received the same induction period with MMC and continued with maintenance treatment comprising either monthly instillations of MMC alone or alternating MMC and BCG instillations for up to 2 years. Primary endpoints were cancer-specific and overall mortality. Secondary endpoints were time to first recurrence and time to progression. The principal statistical methods were the Kaplan-Meier method and cumulative incidence analysis.Results: The overall median follow-up time of the patients with CIS was 7.2 years and the median follow-up time of the patients still alive was 17.1 years. The non-stratified probability of dying from bladder carcinoma at 5, 10 and 15 years was 13%, 25% and 28%, respectively. No significant difference was found between the study groups with respect to time to first recurrence, progression, or disease-specific or overall mortality.Conclusions: The long-term bladder cancer-specific mortality was unexpectedly low despite the relatively ineffective instillation therapy and the poor outcome of the patients after progression.","PeriodicalId":21543,"journal":{"name":"Scandinavian Journal of Urology and Nephrology","volume":"46 6","pages":"411-7"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365599.2012.694906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30729845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16