Saudi Journal of Biological Sciences最新文献

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Deregulation of TWIST1 expression by promoter methylation in gastrointestinal cancers 胃肠道癌症启动子甲基化对 TWIST1 表达的失调
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.sjbs.2023.103842
{"title":"Deregulation of TWIST1 expression by promoter methylation in gastrointestinal cancers","authors":"","doi":"10.1016/j.sjbs.2023.103842","DOIUrl":"10.1016/j.sjbs.2023.103842","url":null,"abstract":"<div><p><em>TWIST1</em>, a basic helix-loop-helix transcription factor with versatile roles in cancer, is frequently deregulated in cancers, through established pathway perturbations. However. the significance of <em>TWIST1</em> methylation in the deregulation of <em>TWIST1</em> in gastrointestinal cancers is not fully clear. This study hypothesized that <em>TWIST1</em> promoter methylation deregulates <em>TWIST1</em> expression independent of established deregulators such as the <em>WNT</em>, <em>TGFB</em>, <em>NOTCH</em> and miRNA pathways. To prove this hypothesis, colon, gastric and rectal cancer genomic data comprising gene expression, DNA methylation, and miRNA data were retrieved from the Cancer Genome Atlas cohorts which are publicly available in cancer genomic databases, the Genome Data Commons and the <span><span>cBioportal.org</span><svg><path></path></svg></span>. About 217 variables comprising expression levels of genes of the <em>WNT</em>, <em>TGFB</em>, <em>NOTCH</em> and miRNA signalling pathways, as well as the beta values of 17 <em>TWIST1</em> methylation loci were subjected to Principal Component Regression Analysis, and then standard Linear Regression Analysis. The results showed that <em>TWIST1</em> methylation is a predictor of <em>TWIST1</em> expression in the gastrointestinal cancers, independent of <em>WNT</em>, <em>TGFB</em>, and <em>NOTCH</em> signalling and miRNA deregulation. The results also showed that different <em>TWIST1</em> methylation loci may deregulate <em>TWIST1</em> expression in different cancer types. The inference that can be drawn from this study is that <em>TWIST1</em> DNA methylation is an important <em>TWIST1</em> deregulation mechanism in colon, rectal and gastric cancers.</p></div>","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X23002875/pdfft?md5=d89e58d838f933e0b0cfa26bac1f0542&pid=1-s2.0-S1319562X23002875-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135850188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IC - Editorial Board IC - 编辑委员会
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-08-01 DOI: 10.1016/S1319-562X(24)00128-1
{"title":"IC - Editorial Board","authors":"","doi":"10.1016/S1319-562X(24)00128-1","DOIUrl":"10.1016/S1319-562X(24)00128-1","url":null,"abstract":"","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X24001281/pdfft?md5=74799c9c443850ff385c7c08e4184f59&pid=1-s2.0-S1319562X24001281-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene-gene and gene-environmental interaction of dopaminergic system genes in Pakistani children with attention deficit hyperactivity disorder 巴基斯坦注意力缺陷多动障碍儿童多巴胺能系统基因的基因-基因和基因-环境相互作用
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-06-21 DOI: 10.1016/j.sjbs.2024.104045
Moin Ahmed Ansari , Habib Ahmed Naqvi , Feriha Fatima Khidri , Aatir Hanif Rajput , Ambar Mahmood , Ali Muhammad Waryah
{"title":"Gene-gene and gene-environmental interaction of dopaminergic system genes in Pakistani children with attention deficit hyperactivity disorder","authors":"Moin Ahmed Ansari ,&nbsp;Habib Ahmed Naqvi ,&nbsp;Feriha Fatima Khidri ,&nbsp;Aatir Hanif Rajput ,&nbsp;Ambar Mahmood ,&nbsp;Ali Muhammad Waryah","doi":"10.1016/j.sjbs.2024.104045","DOIUrl":"10.1016/j.sjbs.2024.104045","url":null,"abstract":"<div><h3>Background</h3><p>Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder influenced by genetic and environmental factors. This study examined the specific gene variants, dopamine transporter 1 (DAT1) rs6350, dopamine receptor D3 (DRD3) rs6280, dopamine receptor D2 (DRD2) rs6277, and catechol-O-methyltransferase (COMT) rs4633, in relation to ADHD among Pakistani children by exploring the potential gene-gene and gene-environment interactions.</p></div><div><h3>Methods</h3><p>A total of 100 cases of ADHD and 100 healthy children were recruited. The tetra-primer amplification refractory mutation system (ARMS) assays were designed for genotyping the selected variants in both groups, and their association with ADHD was determined in different genetic models. Gene-gene and gene-environmental interactions were determined by the multifactor dimensionality reduction (MDR) method.</p></div><div><h3>Results</h3><p>The DAT1 rs6350 SNV AA genotype showed a significantly increased risk for ADHD in the codominant and recessive models. Conversely, the AG genotype demonstrated a protective factor for ADHD in the codominant and overdominant models. The DRD3 rs6280 T allele exhibited a decreased risk for ADHD, and the TT genotype showed a reduced risk in the recessive and log-additive models. No association between the DRD2 rs6277 and COMT rs4633 SNVs with ADHD was found in our population. The MDR analysis of the best three-fold interaction model showed redundancy between DAT1 rs6350 and DRD3 rs6280; however, the risk was increased with the gender variable, which showed a weak synergistic interaction with these SNVs.</p></div><div><h3>Conclusion</h3><p>Genes associated with dopaminergic neurotransmission may contribute to the occurrence of ADHD. Furthermore, gene-gene and gene-environmental interactions may increase ADHD susceptibility.</p></div>","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X24001232/pdfft?md5=419e27b38c1d64d72c5e443be90934d9&pid=1-s2.0-S1319562X24001232-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141506779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LC-MS metabolomics and molecular docking approaches to identify antihyperglycemic and antioxidant compounds from Melastoma malabathricum L. Leaf 用 LC-MS 代谢组学和分子对接方法鉴定 Melastoma malabathricum L. 叶中的抗高血糖和抗氧化化合物
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-06-14 DOI: 10.1016/j.sjbs.2024.104047
Oke Anandika Lestari , Nurheni Sri Palupi , Agus Setiyono , Feri Kusnandar , Nancy Dewi Yuliana
{"title":"LC-MS metabolomics and molecular docking approaches to identify antihyperglycemic and antioxidant compounds from Melastoma malabathricum L. Leaf","authors":"Oke Anandika Lestari ,&nbsp;Nurheni Sri Palupi ,&nbsp;Agus Setiyono ,&nbsp;Feri Kusnandar ,&nbsp;Nancy Dewi Yuliana","doi":"10.1016/j.sjbs.2024.104047","DOIUrl":"10.1016/j.sjbs.2024.104047","url":null,"abstract":"<div><p>The dried leaves of Melastoma malabathricum L.<em>,</em> locally named Karamunting or Senduduk, is traditionally consumed in many regions in Indonesia as herbal tea to cure different illnesses, including diabetes. To date, information on the compounds responsible for their antidiabetic activity is still very rare. The study aimed to identify bioactive compounds of M. malabathricum L. leaves using LC-MS based metabolomics and molecular docking approaches. The leaves brewed with different methods were subjected to LC−MS measurements and several bioactivity tests (<em>in vivo</em> and <em>in vitro</em> antihyperglycemic, and <em>in vitro</em> antioxidant). LC−MS data were linked to the activity data using multivariate data analysis. Molecular docking using alpha-glucosidase, alpha-amylase, and insulin receptor as protein targets was used to verify the results and study the interaction between the identified compound and protein targets. As results, isoquercetin and myricitrin were identified as compounds strongly associated with alpha-amylase inhibitors, while rutin and epicatechin were identified as alpha-glucosidase inhibitors. Quercitrin, citric acid, quercetin, epicatechin, isoquercitrin, and 7-hydroxycoumarine were strongly correlated with both antihyperglycemic and antioxidant activities. The results of metabolomics were confirmed with molecular docking studies, which showed that some of these compounds acted as competitive inhibitors, while others acted as non-competitive ones. Possible synergism between epicatechin and citric acid in their interaction with IR was detected. Metabolomics combined with molecular docking efficiently identified and confirmed several antihyperglycemic and antioxidant compounds from M. malabathricum L.<em>,</em> leaf. This study provides scientific evidence for the traditional use of M. malabathricum L. as an antidiabetic herbal.</p></div>","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X24001256/pdfft?md5=cf1b4483980852d20c5e01007d4b9272&pid=1-s2.0-S1319562X24001256-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Global Trends of Bacillus, Trichoderma and Entomopathogenic Fungi for Pathogen and Pest Control in Chili Cultivation 探索辣椒种植中病虫害控制微生物制剂的全球趋势
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-06-12 DOI: 10.1016/j.sjbs.2024.104046
Muhamad Firdaus Syahmi Sam-on , Shuhaimi Mustafa , Mohd Termizi Yusof , Amalia Mohd Hashim , Ku Nur Azwa Ku Aizuddin
{"title":"Exploring the Global Trends of Bacillus, Trichoderma and Entomopathogenic Fungi for Pathogen and Pest Control in Chili Cultivation","authors":"Muhamad Firdaus Syahmi Sam-on ,&nbsp;Shuhaimi Mustafa ,&nbsp;Mohd Termizi Yusof ,&nbsp;Amalia Mohd Hashim ,&nbsp;Ku Nur Azwa Ku Aizuddin","doi":"10.1016/j.sjbs.2024.104046","DOIUrl":"10.1016/j.sjbs.2024.104046","url":null,"abstract":"<div><p>Chili, renowned globally and deeply ingrained in various cultures. Regrettably, the onset of diseases instigated by pests and pathogens has inflicted substantial losses on chili crops, with some farms experiencing complete production decimation. Challenges confronting chili cultivation include threats from pathogenic microbes like <em>Xanthomonas, Fusarium, Phytophthora, Verticillium, Rhizoctonia, Colletotrichium</em> and Viruses, alongside pests such as whiteflies, mites, thrips, aphids, and fruit flies. While conventional farming practices often resort to chemical pesticides to combat these challenges, their utilization poses substantial risks to both human health and the environment. In response to this pressing issue, this review aims to evaluate the potential of microbe-based biological control as eco-friendly alternatives to chemical pesticides for chili cultivation. Biocontrol agents such as <em>Bacillus</em> spp., <em>Trichoderma</em> spp., and entomopathogenic fungi present safer and more environmentally sustainable alternatives to chemical pesticides. However, despite the recognised potential of biocontrol agents, research on their efficacy in controlling the array of pests and pathogens affecting chili farming remains limited. This review addresses this gap by evaluating the efficiency of biocontrol agents, drawing insights from existing studies conducted in other crop systems, regarding pest and pathogen management. Notably, an analysis of Scopus publications revealed fewer than 30 publications in 2023 focused on these three microbial agents. Intriguingly, India, as the world’s largest chili producer, leads in the number of publications concerning <em>Bacillus</em> spp., <em>Trichoderma</em> spp., and entomopathogenic fungi in chili cultivation. Further research on microbial agents is imperative to mitigate infections and reduce reliance on chemical pesticides for sustainable chili production.</p></div>","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X24001244/pdfft?md5=e10e3f39bdc1b39f0316b98f75a575d4&pid=1-s2.0-S1319562X24001244-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of 6-gingerol and semi-synthesis of 1,4-benzodiazepines derivatives: An in-situ pharmacokinetics properties, molecular docking and molecular dynamics simulation assessments 6-gingerol 的分离和 1,4-苯并二氮杂卓衍生物的半合成:原位药代动力学特性、分子对接和分子动力学模拟评估
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-06-10 DOI: 10.1016/j.sjbs.2024.104048
Mariyappan Vaithiyalingam , Ramasamy Mohan Kumar , Prerna Khagar , Sarvesh Sabarathinam , Yahia Alghazwani , Kumarappan Chidambaram
{"title":"Isolation of 6-gingerol and semi-synthesis of 1,4-benzodiazepines derivatives: An in-situ pharmacokinetics properties, molecular docking and molecular dynamics simulation assessments","authors":"Mariyappan Vaithiyalingam ,&nbsp;Ramasamy Mohan Kumar ,&nbsp;Prerna Khagar ,&nbsp;Sarvesh Sabarathinam ,&nbsp;Yahia Alghazwani ,&nbsp;Kumarappan Chidambaram","doi":"10.1016/j.sjbs.2024.104048","DOIUrl":"https://doi.org/10.1016/j.sjbs.2024.104048","url":null,"abstract":"<div><p>This paper outlines a methodical approach for isolating 6-gingerol (1a) from <em>Zingiber officinale Roscoe</em> rhizomes on a gram-scale, resulting in a product of high purity and significant yield. Further, 6-gingerol (1a) [SSG1] derivatives, including 1-(4-hydroxy-3-methoxyphenyl)decane-3,5-dione (1ab), were synthesized via a semi-synthetic pathway involving DMP-mediated fast oxidation and replication. Subsequently, a new series of 1,4-benzodiazepines (3a-c) was synthesized quantitatively using a basic technique. This synthesis necessitated the interaction of 1ab with various o-phenylenediamine (2a-c) compounds. Spectroscopic methods were employed to characterize the synthesized 1,4-benzodiazepines (3a-c)[SSG2, SSG3 &amp; SSG4]. Despite extensive investments by pharmaceutical companies in traditional drug research and development for diseases like type 2 diabetes (T2D), successful treatments remain elusive. Medication repurposing has gained traction as a strategy to address not only diabetes but also other disorders. Leveraging existing molecular pharmacology data accelerates the development of new medications. This paper underscores the importance of repurposing traditional medicines to combat a range of communicable and non-communicable diseases, offering a promising avenue for therapeutic advancement. Additionally, molecular docking studies suggested that one derivative (SSG2) exhibited stronger binding affinity compared to the reference standards. Overall, the findings of this study highlight the potential of semi-synthetic gingerol derivatives for the development of novel therapeutic agents.</p></div>","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X24001268/pdfft?md5=903aa2dd1a8ddd657d0b5abad206925d&pid=1-s2.0-S1319562X24001268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IC - Editorial Board IC - 编辑委员会
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-06-03 DOI: 10.1016/S1319-562X(24)00115-3
{"title":"IC - Editorial Board","authors":"","doi":"10.1016/S1319-562X(24)00115-3","DOIUrl":"https://doi.org/10.1016/S1319-562X(24)00115-3","url":null,"abstract":"","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X24001153/pdfft?md5=897303caada034ca3ce1a2c262ff9b9e&pid=1-s2.0-S1319562X24001153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach 研究姜黄素阻断与乳腺癌相关的白细胞介素-8 信号通路的机理:一种内模拟方法
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-05-31 DOI: 10.1016/j.sjbs.2024.104035
Bader S. Alotaibi , Mohammed Ageeli Hakami , Ali Hazazi , Ahad Amer Alsaiari , Mohammad Khalid , Anam Beg
{"title":"Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach","authors":"Bader S. Alotaibi ,&nbsp;Mohammed Ageeli Hakami ,&nbsp;Ali Hazazi ,&nbsp;Ahad Amer Alsaiari ,&nbsp;Mohammad Khalid ,&nbsp;Anam Beg","doi":"10.1016/j.sjbs.2024.104035","DOIUrl":"https://doi.org/10.1016/j.sjbs.2024.104035","url":null,"abstract":"<div><p>Interleukin-8 (IL-8) is a chemokine, a type of signaling molecule that has a role in immunological responses and inflammation. In recent years, IL-8 is additionally related to cancer growth and recurrence. Breast cancer growth, progression, and metastatic development<!--> <!-->are all linked to IL-8. Breast cancer cells are known to develop faster when IL-8 stimulates their proliferation and survival. It can also cause angiogenesis, or the creation of new blood vessels, which is necessary for tumor nutrition and growth. IL-8 and curcumin have been subjects of interest in drug design, particularly in the context of inflammation-related disorders and cancer. This study aims to give an overview of the role of IL-8. Inhibitor-based treatment approaches were being used to target IL-8 with curcumin. Molecular docking method was employed to find a potential interaction to supress competitive inhibition of IL-8 with curcumin. PASS analysis and ADMET characteristics were also being carried out. In the end, IL-8 complexed with curcumin is chosen for MD simulations. Overall, our results showed that during the simulation, the complex stayed comparatively stable. It is also possible to investigate curcumin further as a possible treatment option. The combined results imply that IL-8 and their genetic alterations can be studied in precision cancer therapeutic treatments, utilizing target-driven therapy and early diagnosis.</p></div>","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X2400113X/pdfft?md5=d61d6a10fa889500361791ba642fc9b4&pid=1-s2.0-S1319562X2400113X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141286323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sprouted rough rice as an alternative to corn for growth, health performance and meat quality of broilers 用发芽糙米替代玉米,提高肉鸡的生长、健康表现和肉质
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-05-29 DOI: 10.1016/j.sjbs.2024.104034
Nguyen Hoang Qui, Nguyen Thuy Linh, Nguyen Thi Anh Thu
{"title":"Sprouted rough rice as an alternative to corn for growth, health performance and meat quality of broilers","authors":"Nguyen Hoang Qui,&nbsp;Nguyen Thuy Linh,&nbsp;Nguyen Thi Anh Thu","doi":"10.1016/j.sjbs.2024.104034","DOIUrl":"https://doi.org/10.1016/j.sjbs.2024.104034","url":null,"abstract":"<div><p>Sprouted rough rice (SR) is not commly used for poultry diets but it could be a potential replacement ingredient to improve nutritional value of feed. This study aimed to evaluate the growth performance, carcass quality, blood lipids, hepatic enzymes, and fatty acid profiles of broiler meat when corn was replaced with sprouted rough rice in the feed. A completely randomized design was used with four groups and six replicate groups with 10 birds per replicate. The 4 treatment groups were 0, 15, 40 and 45 % sprouted-rice-replacement of corn. Growth performance and carcass quality were highest when corn was replaced with 45 % SR (<em>p</em> &lt; 0.05). In particular, live weight and body weight gain increased linearly with increasing SR inclusion, whereas feed conversion ratio and feed intake linearly decreased with increasing SR (<em>p</em> &lt; 0.05). Carcass, thigh, and breast weights showed the same trend of increase (<em>p</em> &lt; 0.05). In addition, the pH of the thigh meat was significantly higher in diet with 45 % SR than in the other treatment groups. With increasing SR content, the weight of immune organs linearly increased, particularly the thymus and spleen (<em>p</em> &lt; 0.05). Additionally, the fatty acids examined including saturated fatty acids, unsaturated fatty acid, transfat were mostly highest when 30 or 45 % of corn was replaced with SR and linearly increased from 0 to 45 % of SR. There were no significant differences of linear relationships with cooking loss, or blood lipid and hepatic enzyme profiles between treatments (<em>p</em> &gt; 0.05). Replacing 45 % of corn in a broiler diet with SR could improve the growth and meat paramenters of broilers.</p></div>","PeriodicalId":21540,"journal":{"name":"Saudi Journal of Biological Sciences","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319562X24001128/pdfft?md5=f8a77e228fd9d93ee2f2d14e13b06ecc&pid=1-s2.0-S1319562X24001128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141244666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and effect of PIK3CA H1047R somatic mutation among Indian head and neck cancer patients 印度头颈癌患者中 PIK3CA H1047R 体细胞突变的发生率及其影响
IF 4.4 2区 生物学
Saudi Journal of Biological Sciences Pub Date : 2024-05-27 DOI: 10.1016/j.sjbs.2024.104029
Arjita Ghosh , Anbalagan Moorthy
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