Schizophrenia Bulletin最新文献

{"title":"From Protective Factors to Mechanisms: Charting the Neurobiology of Schizophrenia Resilience","authors":"","doi":"10.1093/schbul/sbag146","DOIUrl":"https://doi.org/10.1093/schbul/sbag146","url":null,"abstract":"<span class=\"paragraphSection\"><div class=\"boxTitle\">Background and Hypothesis</div>Elucidating the neurobiological and psychological mechanisms that promote resilience to the adverse effects of schizophrenia’s genetic and environmental risk architecture may reveal new avenues for advancing treatment and prevention. Identification of genetic loci associated with schizophrenia resilience enables links between protective polygenic variation, non-genetic resilience factors, and intermediate phenotypes. This approach may help identify protective traits and delineate potentially evolutionarily shaped resilience mechanisms that attenuate schizophrenia pathophysiology across biological levels.<div class=\"boxTitle\">Study Design</div>This narrative review integrates current concepts in psychiatric resilience research with findings from schizophrenia resilience genetics and evolutionary medicine. Within a decompositional, dimensional framework, we summarize evidence for trait-level resilience factors that may be linked to schizophrenia resilience variants and discuss candidate neurobiological mechanisms.<div class=\"boxTitle\">Study Results</div>Schizophrenia’s substantial fitness costs and evolutionary dynamics may have favored common genetic variants that buffer elevated polygenic liability and promote resilience to the disorder. Existing evidence implicates protective traits across obstetric, immunological, cognitive, and visual-system domains as candidate mediators of resilience to schizophrenia pathophysiology.<div class=\"boxTitle\">Conclusions</div>Current findings suggest that common genetic variants may confer resilience to schizophrenia by enhancing neural plasticity, fluid intelligence, and visual cognition. Immune-related and obstetric pathways remain promising candidates, although direct links to resilience variants have not been established. Such mechanisms may reflect evolutionarily shaped adaptations that attenuate risk-allele penetrance and could also modify clinical expression, course, and somatic comorbidity. Their characterization may provide initial insights into the neurobiology of schizophrenia resilience and identify targets for preventive and disease-modifying interventions.</span>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"12 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dual Prediction Error Populations Model of Schizophrenia Spectrum Disorders: Bridging NMDA Hypofunction and Gain Hyperfunction","authors":"Shunsuke Sato, Tadahumi Kato, Taro Toyoizumi","doi":"10.1093/schbul/sbag095","DOIUrl":"https://doi.org/10.1093/schbul/sbag095","url":null,"abstract":"Background and Hypothesis Schizophrenia spectrum disorders (SSDs) span heterogeneous clinical states, from rapidly fluctuating psychosis to rigid, systematized delusions.1 NMDA receptor hypofunction on inhibitory interneurons,2–4 dopaminergic dysregulation,5 and abnormalities of volatility estimation6–10 or precision weighting11–13 have all been implicated, yet a framework linking these mechanisms to spectrum-level heterogeneity remains incomplete. Study Design We developed a biologically plausible predictive-coding model with separable positive and negative prediction error (PE) populations. For clarity, the main text presents a one-dimensional linear Kalman filter. Study Results NMDA hypofunction selectively weakened negative PE, thereby reducing disconfirmatory updating and biasing inference toward prior-consistent interpretations. Gain hyperfunction amplified precision-weighted updating and produced observation-dominated instability. Their interaction reproduced attenuated mismatch responses, reduced illusion susceptibility, and a bias–volatility plane spanning rigid and unstable delusional dynamics. Conclusions The model suggests that SSD heterogeneity can be understood as an interaction between sign-selective bias and abnormal precision weighting. This offers a circuit-to-symptom framework and motivates stratification by the asymmetry and overall gain of PE responses.","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"5 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal Ideation and Non-suicidal Self-injury Following Childhood Psychotic Experiences in Adolescents at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 15.","authors":"Maja Gregersen, Sinnika Birkehøj Rohd, Jens Richardt Møllegaard Jepsen, Anne Søndergaard, Lotte Veddum, Mette Falkenberg Krantz, Doris Helena Bjarnadóttir Streymá, Marta Schiavon, Andreas Færgemand Laursen, Anette Faurskov Bundgaard, Carsten Hjorthøj, Ole Mors, Aja Neergaard Greve, Nicoline Hemager, Anne Amalie Elgaard Thorup, Merete Nordentoft","doi":"10.1093/schbul/sbag042","DOIUrl":"10.1093/schbul/sbag042","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Suicidal ideation (SI) and non-suicidal self-injury (NSSI) peak in adolescence and are strong predictors of future suicide. Identifying childhood risk markers for SI and NSSI could improve early suicide prevention.</p><p><strong>Study design: </strong>Adolescents (mean age 15.9, SD 0.4) at familial high risk of schizophrenia (n = 145) or bipolar disorder (n = 94), and population-based controls (n = 154) were assessed for psychotic experiences (PE) in early (until age 7) and middle (age 7-11) childhood, and for SI and NSSI in early childhood, middle childhood, and adolescence (age 11-15).</p><p><strong>Study results: </strong>Middle childhood PE predicted adolescent SI (OR 3.8; 95% CI, 2.0-7.4; P < .001) and NSSI (OR 2.8; 95% CI, 1.4-5.5, P = .004) after accounting for previous SI and NSSI, childhood mental disorders, current symptom severity, and familial risk. Persistent and incident but not remittent childhood PE predicted adolescent SI (OR 5.5; 95% CI, 2.2-13.8; P < .001 and OR 4.3; 95% CI, 1.6-11.3; P = .003) and NSSI (OR 3.3; 95% CI, 1.3-8.6; P = .01 and OR 3.2; 95% CI, 1.2-8.7; P = .02) in the fully adjusted models. Among children without childhood SI and NSSI, those with persistent PE had nearly 6-fold increased odds of incident adolescent SI (OR 5.7; 95% CI, 1.7-19.0; P = .005) relative to those without childhood PE. Psychotic experiences were non-differentially associated with SI and NSSI across familial risk groups.</p><p><strong>Conclusions: </strong>Childhood PE, particularly when persistent, mark risk for adolescent SI and NSSI beyond the effects attributable to known risk factors. Persistent childhood PE are strong risk markers for incident adolescent SI. Childhood PE should be considered in suicide risk assessments in general and familial high-risk populations.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"52 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsupervised Clustering of ACC and Hippocampal Metabolites Identifies Subgroups in Antipsychotic-Naïve First-Episode Psychosis.","authors":"Eric A Nelson, Joshua S Richman, Adil Bashir, Jose O Maximo, Adrienne C Lahti","doi":"10.1093/schbul/sbag100","DOIUrl":"10.1093/schbul/sbag100","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Glutamatergic abnormalities are among the most consistent neurometabolic findings in psychosis spectrum disorders, but individual variability suggests biologically distinct subgroups. Proton magnetic resonance spectroscopy (1H-MRS) enables in vivo quantification of glutamate (Glu) and related metabolites but has rarely been applied to subgroup discovery in early psychosis. We hypothesized that metabolite-based clustering of hippocampal and anterior cingulate cortex (ACC) measures would identify biologically distinct subtypes differing in symptom severity and cognition.</p><p><strong>Study design: </strong>Single-voxel 1H-MRS data were acquired from the left hippocampus and ACC in 90 antipsychotic-naïve first-episode psychosis (FEP) patients. Metabolites included Glu, composite creatine, composite choline, and N-acetylaspartate, quantified in both regions (eight total measures). K-means clustering was applied to these variables. Classification trees identified the most discriminative features, guiding simplified two-dimens-ional (2D) clustering models. Subgroup differences in demographics, symptoms, and cognition were evaluated using ANOVAs.</p><p><strong>Study results: </strong>Clustering of all eight metabolites revealed two stable subgroups differing in baseline positive symptoms but not cognition or treatment response. Across models, classification trees consistently identified hippocampal Glu as the primary split, with secondary variables varying by method. These pairings guided three 2D clustering models, of which the hippocampal Glu + ACC Cr solution yielded four metabolically distinct subgroups. One subgroup, characterized by intermediate hippocampal Glu and low ACC Cr, showed significantly better cognitive performance after adjusting for age and sex.</p><p><strong>Conclusions: </strong>Data-driven clustering of hippocampal and ACC metabolites identified subgroups with distinct cognitive profiles in antipsychotic-naïve FEP, supporting 1H-MRS-based biotyping in early psychosis.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"52 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness, Genetic Susceptibility, Brain Structure, and the Risk of Schizophrenia: A Large Prospective Study.","authors":"Jianing Wang, Zhongpeng Dai","doi":"10.1093/schbul/sbaf179","DOIUrl":"10.1093/schbul/sbaf179","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Loneliness has been linked to adverse mental health outcomes, including psychosis, but its independent role in schizophrenia (SZ) development is unclear. We hypothesize that loneliness independently increases the risk of incident SZ and is associated with structural brain changes, especially in individuals with high genetic predisposition.</p><p><strong>Study design: </strong>This prospective cohort study analyzed data from 491 613 UK Biobank participants aged 38-73 years without baseline SZ. Participants reported loneliness, provided demographic, socioeconomic, lifestyle information, and polygenic risk scores (PRSs) for SZ. Follow-up lasted until 2022, tracking incident SZ cases. Neuroimaging analyses examined gray matter volume associations with loneliness, considering genetic risk.</p><p><strong>Study results: </strong>Over an average follow-up of 13.3 years, 675 individuals developed SZ. Those reporting loneliness (n = 91 017; 18.5%) had a significantly increased SZ risk, with an unadjusted hazard ratio (HR) of 3.84 (95% CI, 3.30-4.46). After adjusting for age, sex, socioeconomic factors, lifestyle, depression and anxiety symptoms, and PRS, the association remained stable (HR = 1.84; 95% CI, 1.36-2.49). Neuroimaging revealed widespread gray matter volume reductions linked to loneliness, notably in regions involved in emotion regulation and social cognition, such as the middle frontal gyrus, insula, hippocampus, and thalamus. These effects were more pronounced in individuals with higher SZ-PRS, with significant regional brain volume reductions among those with elevated genetic risk.</p><p><strong>Conclusions: </strong>Loneliness independently predicts increased SZ risk and is associated with widespread brain volume changes, especially in genetically vulnerable individuals. Addressing loneliness may be a key strategy to mitigate SZ development and brain structural alterations.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Functioning and Work in People With Severe Mental Illness Living in Urban and Rural Areas in India.","authors":"Chitra Khare, Kim T Mueser, Susan R McGurk","doi":"10.1093/schbul/sbaf203","DOIUrl":"10.1093/schbul/sbaf203","url":null,"abstract":"<p><strong>Background and hypotheses: </strong>Evidence on the role of cognition in employment of people with severe mental illness (SMI) living in India and other developing countries is limited. This study examined the relationship between cognitive functioning and work in people with SMI living in urban and rural areas in India.</p><p><strong>Study design: </strong>Cognition (evaluated with the Montreal Cognitive Assessment: MoCA) and vocational functioning were assessed in 340 persons with SMI (59% schizophrenia-schizoaffective) receiving private psychiatric outpatient treatment at two hospitals in western India.</p><p><strong>Study results: </strong>Participants with higher levels of cognitive functioning were more likely to be employed than those with lower levels, including both those living in urban and rural areas. Among employed participants, better cognitive functioning was associated with working at more complex and skilled jobs that paid higher wages. There were no differences in cognitive functioning between participants working for a family-run business (eg, a farm) vs. an independent employer, suggesting that families operating such businesses did not provide more work accommodations for cognitive impairment to their relatives with SMI than independent employers.</p><p><strong>Conclusions: </strong>Impaired cognitive functioning is an important predictor of unemployment in people with SMI in both rural and urban regions in India. Providing interventions for enhancing cognitive functioning may increase the ability of unemployed people with SMI in developing countries to work for both family-operated businesses and independent employers, thereby improving their economic standing and the welfare of their families.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Anticholinergic Agent Use With Co-prescription of CYP2D6-Inhibiting SSRIs and Risperidone, but not Aripiprazole: A Nationwide Cohort Study.","authors":"Wonsuk Shin, Dong Hyeon Lee, Minseok Hong, Min-Kyoung Kim, Hyounggyoon Yoo, Yil-Seob Lee, Sra Jung","doi":"10.1093/schbul/sbaf189","DOIUrl":"10.1093/schbul/sbaf189","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Co-prescription of selective serotonin reuptake inhibitors (SSRIs) and second-generation antipsychotics is common in the management of schizophrenia. However, the real-world clinical impact of cytochrome P450 (CYP)-mediated drug-drug interactions (DDIs) remains unclear. We investigated whether the co-prescription of risperidone or aripiprazole with SSRIs that differ in their CYP2D6 inhibition potential is associated with an increased burden of extrapyramidal symptoms (EPS).</p><p><strong>Study design: </strong>Using the Korean National Health Insurance Service database (2002-2022), we identified 4100 patients with schizophrenia who were treated with one of four medication combinations: risperidone plus escitalopram (Risp+Esc; n = 1611), risperidone plus fluoxetine/paroxetine (Risp+CYP2D6i; n = 1051), aripiprazole plus escitalopram (Arip+Esc; n = 1025), or aripiprazole plus fluoxetine/paroxetine (Arip+CYP2D6i; n = 413). The primary outcome was the mean proportion of days covered (PDC) by anticholinergic agents, used as a proxy for EPS burden. Groups were compared using multivariate analysis of covariance, adjusting for confounders.</p><p><strong>Study results: </strong>The Risp+CYP2D6i group had a significantly higher mean PDC for anticholinergics compared with the Risp+Esc group (56.4% vs. 47.3%; F = 23.98, P < .0001). Conversely, no significant difference was observed between the Arip+CYP2D6i and Arip+Esc groups (26.1% vs. 28.6%; F = 1.47, P = .225). The use of zolpidem and mood stabilizers was also significantly higher in both CYP2D6i groups.</p><p><strong>Conclusions: </strong>Co-prescription of strong CYP2D6-inhibiting SSRIs with risperidone, but not aripiprazole, is associated with a significant increase in anticholinergic use, providing large-scale, real-world evidence of a clinically meaningful DDI. These findings underscore the importance of considering SSRI metabolic profiles to mitigate EPS risk in patients treated with risperidone.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145392572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationship between Cognitive Performance, Performance-Based Functioning, and Everyday Functioning in People with Schizophrenia: a Systematic Literature Review.","authors":"Philip D Harvey, Nina Schooler, Anthony O Ahmed","doi":"10.1093/schbul/sbag121","DOIUrl":"https://doi.org/10.1093/schbul/sbag121","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Cognitive and functional impairments are core features of schizophrenia with considerable disease burden. However, the relationships between cognitive performance, functional capacity, and real-world functioning remain incompletely understood. This systematic review aimed to clarify the magnitude and nature of these interrelationships across primary research studies.</p><p><strong>Study design: </strong>A systematic review (PROSPERO CRD42024532729) was conducted across MEDLINE, Embase, PsycINFO, and Cochrane Database. Eligible articles assessed cognitive performance, functional capacity, and real-world functioning in adults with schizophrenia using standard psychometric instruments, and reported quantitative relationships between ≥1 of these constructs. Due to substantial heterogeneity in study designs, outcome measures, and reported metrics, a narrative synthesis was performed.</p><p><strong>Study results: </strong>Overall, 104 articles with unique datasets were included (88 observational, 16 interventional). The relationship between cognitive performance and functional capacity was the most studied (63/104 articles; 60.5%), with predominantly medium-to-large effect sizes. In contrast, associations between cognitive performance and real-world functioning were less frequently reported (43/104 articles, 41.3%) and largely small-to-medium, with only 2 large effect sizes identified. Associations between functional capacity and real-world functioning were variable (41/104 articles; 39.4%) and predominantly small-to-medium, with only 4 large effect sizes reported. Associations were less consistent when examined at the level of specific cognitive or functional domain.</p><p><strong>Conclusions: </strong>This review highlights the central role of cognition in shaping functional abilities, while reinforcing the complexity of translating these gains into meaningful improvements in everyday functioning. A multimodal, person-centered approach is needed to effectively translate cognitive improvements into meaningful real-world outcomes in people with schizophrenia.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"52 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide and Self-Harm Risk in Young People at Clinical High Risk of Psychosis: Exploring Comorbid Risk Factors and Potential Points for Intervention.","authors":"Samuel McKay, Jo Robinson, Patrick McGorry, Cassandra Wannan, Melissa Kerr, Paul Amminger, Hok Pan Yuen, Jessica Spark, Nicky Wallis, Andrea Polari, Barnaby Nelson","doi":"10.1093/schbul/sbag080","DOIUrl":"10.1093/schbul/sbag080","url":null,"abstract":"<p><strong>Background: </strong>Suicide is a leading cause of death among young people, and those at clinical high risk (CHR) of psychosis face increased suicide risk. Despite recommendations for routine suicide monitoring in CHR individuals, identifying effective intervention points remains challenging. This study investigates clinical correlates of suicidality in CHR youth, with particular focus on depression severity and DSM-5 diagnoses.</p><p><strong>Hypotheses: </strong>We expected suicidality to be positively associated with depressive symptoms, psychiatric symptoms, and common comorbid DSM-5 diagnoses, particularly depression and substance use disorders, and negatively associated with social and occupational functioning.</p><p><strong>Study design: </strong>Cross-sectional data were drawn from the baseline assessment in the Staged Treatment in Early Psychosis (STEP) trial. Participants were 342 CHR young people (age M = 17.7, SD = 3.1, 57.9% female and 42.1% male). Measures included psychosis risk, suicidal ideation, and self-harm, psychiatric symptoms, functioning, depression, and DSM-5 disorders (SCID).</p><p><strong>Study results: </strong>Seventy-seven percent of participants reported lifetime thoughts of suicide or engaging in self-harm. While there were positive relationships between suicidality and severity of attenuated psychiatric symptoms, multivariable analyses showed that only depression, particularly moderate to severe depression, was associated with suicidality when controlling for other clinical factors and diagnoses. This pattern remained consistent across sensitivity analyses.</p><p><strong>Conclusions: </strong>Suicidality is highly prevalent among CHR young people. This study shows that depression severity, particularly severe and ongoing depression, should be a key consideration in monitoring and treating suicide risk within CHR services.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"52 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A First-Person Account: Living with Chronic Epistemic Invalidation.","authors":"Joyce M G Vromen","doi":"10.1093/schbul/sbag029","DOIUrl":"https://doi.org/10.1093/schbul/sbag029","url":null,"abstract":"","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"52 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}