Schizophrenia Bulletin最新文献

{"title":"Psychosis Risk: Time to Look Empirically at a First-step Economical-pragmatic Way to Examine Anomalous Self-experience. Exploring the SQuEASE-11.","authors":"Paul Møller, Barnaby Nelson, Patrick D McGorry, Cristina Mei, G Paul Amminger, Hok Pan Yuen, Melissa Kerr, Jessica Spark, Nicky Wallis, Andrea Polari, Shelley Baird, Kate Buccilli, Sarah-Jane A Dempsey, Natalie Ferguson, Melanie Formica, Marija Krcmar, Amelia L Quinn, Yohannes Mebrahtu, Arlan Ruslins, Rebekah Street, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A Niendam, Martha Shumway, Cassandra Wannan","doi":"10.1093/schbul/sbae149","DOIUrl":"10.1093/schbul/sbae149","url":null,"abstract":"<p><strong>Background: </strong>Since the late 1990s, there has been a worldwide surge of scientific interest in the pre-psychotic phase, resulting in the introduction of several clinical tools for early detection. The predictive accuracy of these tools has been limited, motivating the need for methodological and perspectival improvements. The EASE manual supports systematic assessment of anomalous self-experience, and proposes an overall model of understanding how most psychotic experiences may be initially generated on the basis of a unifying, fundamental, pre-reflective distortion of subjectivity.</p><p><strong>Study design: </strong>The EASE is time-consuming, so in order to spread the use of this essential perspective of psychosis risk we selected prototypical and frequent phenomena from the EASE, combining them into SQuEASE-11. To investigate this instrument for clinical relevance, basic psychometric properties, factor structure, and relationships with gold standard instruments and the full EASE, it was administered as an interview in the STEP intervention trial (Melbourne, Australia), with 328 clinical high-risk for psychosis (CHR-P) patients.</p><p><strong>Study results: </strong>The SQuEASE-11 had moderate internal consistency and revealed two correlated factors. Significant relationships were observed between the SQuEASE-11 and the widely used and validated instruments CAARMS, BPRS, SANS, MADRS, DACOBS, and SOFAS. The correlation with the full EASE was very strong.</p><p><strong>Conclusions: </strong>These 11 items do not necessarily relate specifically to ipseity disturbance, but the SQuEASE-11 seems to be a clinically relevant and brief supplementary first-line interview in CHR-P subjects. It may give a qualified indication of the need for a complete EASE interview, and it may also, importantly, inform treatment planning.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"1104-1117"},"PeriodicalIF":4.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Vexing Uncertainty to Intellectual Humility.","authors":"Michael Dickson","doi":"10.1093/schbul/sbad173","DOIUrl":"10.1093/schbul/sbad173","url":null,"abstract":"","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"843-844"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia.","authors":"Jinghui Tong, Kebing Yang, Wei Li, Leilei Wang, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Yanli Zhao, Song Chen, Hongzhen Fan, Yimin Cui, Xingguang Luo, Shuping Tan, Zhiren Wang, Wei Feng, Baopeng Tian, Chiang-Shan R Li, L Elliot Hong, Yunlong Tan","doi":"10.1093/schbul/sbae180","DOIUrl":"10.1093/schbul/sbae180","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Sensory gating deficit is considered a pathophysiological feature of schizophrenia, which has been linked to N-methyl-d-aspartate receptor (NMDAR) hypofunction as one of the potential underlying mechanisms. Here, we hypothesize that higher levels of NMDAR antibody (Ab) may contribute to the sensory gating deficits in schizophrenia.</p><p><strong>Study design: </strong>We enrolled 72 non-smoking inpatients with first-episode schizophrenia (FES), most of them with only a relatively short duration of exposure to antipsychotic medications, and 51 non-smoking healthy controls (HC). Sensory gating was measured by P50 evoked potentials ratio and the difference between the two stimuli in an auditory paired-stimuli paradigm and serum NMDAR Ab levels were quantified by enzyme-linked immunosorbent assay.</p><p><strong>Study results: </strong>The FES group showed higher serum NMDAR Ab levels [(9.23 ± 4.15) ng/mL vs. (7.08 ± 2.83) ng/mL; P = .002], higher P50 ratio (P = .002), and less P50 difference (P = .001) than HC. In partial correlation analysis, serum NMDAR Ab levels were positively correlated with the P50 ratio (r = 0.36, P = .003) and negatively with the P50 difference (r = -0.39, P = .001) in the FES group. The NMDAR Ab levels mediated the diagnosis of schizophrenia and P50 sensory gating deficits (P50 ratio and P50 difference).</p><p><strong>Conclusions: </strong>Autoimmunity targeting NMDAR is a crucial intermediate mechanism in impaired sensory gating in patients with schizophrenia. The findings support early intervention targeting NMDAR for patients with schizophrenia.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"1072-1081"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Exploring the Interactions Between Psychotic Symptoms, Cognition, and Environmental Risk Factors: A Bayesian Analysis of Networks.","authors":"","doi":"10.1093/schbul/sbae203","DOIUrl":"10.1093/schbul/sbae203","url":null,"abstract":"","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"1175"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.","authors":"","doi":"10.1093/schbul/sbaf082","DOIUrl":"10.1093/schbul/sbaf082","url":null,"abstract":"","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"1173"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Use of Visuospatial Context in Psychotic Psychopathology: A Meta-analysis.","authors":"Victor J Pokorny, Samuel D Klein, Collin D Teich, Scott R Sponheim, Cheryl A Olman, Sylia Wilson","doi":"10.1093/schbul/sbae081","DOIUrl":"10.1093/schbul/sbae081","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Visual perception in people with psychotic disorders is thought to be minimally influenced by surrounding visual elements (ie, visuospatial context). Visuospatial context paradigms have the unique potential to clarify the neural bases of psychotic disorders because the neural mechanisms are well studied in both animal and human models. However, the published literature on the subject is conflicting and heterogeneous. A systematic consolidation and evaluation of the published evidence is needed.</p><p><strong>Study design: </strong>We conducted a meta-analysis of 54 articles spanning over 50 years of research. Articles included behavioral, functional magnetic resonance imaging, and electroencephalogram reports of size, contrast, contour, lightness, orientation, and motion perception in schizophrenia (SCZ), bipolar disorder, and subclinical populations.</p><p><strong>Study results: </strong>When pooling across all task types, we found weak evidence of reduced use of visuospatial context in SCZ (Hedges' g = 0.20) and bipolar disorder (g = 0.25). The strongest evidence was observed for altered contrast perception in SCZ (g = 0.73). With respect to subclinical populations, we observed immense heterogeneity in populations of interest and study designs.</p><p><strong>Conclusions: </strong>We observed surprisingly weak evidence that psychotic disorders are associated with generally reduced use of visuospatial context. Instead, we observed the strongest evidence for a specific alteration in contrast perception. We propose altered feedback to the primary visual cortex as a potential neural mechanism underlying this effect. Moderating factors such as stage and phase of illness may explain some of the heterogeneity we observed in effect sizes; further research is needed to clarify how disease state relates to altered use of visuospatial context.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"51 4","pages":"983-996"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schizophrenia Quality of Life Scale and Schizophrenia Quality of Life Scale Revision 4: A Systematic Review of Measurement Properties.","authors":"Milena Zúñiga Le-Bert, Max Wiessner, Sophia Wehr, Lucia Weigel, Stefan Leucht","doi":"10.1093/schbul/sbae119","DOIUrl":"10.1093/schbul/sbae119","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Schizophrenia is a severe mental disorder that has a significant impact on quality of life (QOL). Measuring QOL can offer insights into treatment efficacy and areas of intervention, highlighting the importance of valid tools assessing QOL in people with schizophrenia.</p><p><strong>Study design: </strong>We employed the COSMIN systematic review guideline to assess the psychometric properties of the schizophrenia quality of life scale (SQLS) and its 4th revision, the schizophrenia quality of life scale revision 4 (SQLS-R4), as patient-reported outcome measures (PROMs).</p><p><strong>Study results: </strong>The search yielded 455 papers, 16 were included, 7 for the SQLS and 9 for the SQLS-R4. Both scales demonstrated good results in risk of bias assessment for internal consistency and convergent validity, the SQLS-R4 additionally for known-groups validity. For the SQLS, PROM development, structural validity, and reliability were suboptimal. The SQLS-R4 showed suboptimality regarding structural validity and reliability and inadequacy for cross-cultural validity and responsiveness. The updated criteria for good measurement properties indicated good convergent validity for the SQLS and good internal consistency, reliability, and convergent validity for the SQLS-R4. The SQLS showed suboptimal results for reliability and known-groups validity, while the SQLS-R4 demonstrated suboptimality in structural validity and known-groups validity. The SQLS had indeterminate structural validity and internal consistency; the SQLS-R4 showed indeterminate responsiveness, and insufficient cross-cultural validity. When using the updated GRADE approach of the COSMIN group, both scales received a very low grade.</p><p><strong>Conclusions: </strong>The SQLS and SQLS-R4 hold the potential for recommendation in rating QOL. Identified weaknesses necessitate further validations.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"997-1008"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech-Gesture Matching and Schizotypal Traits: A Network Approach.","authors":"Bertalan Polner, Hamidreza Jamalabadi, Bianca M van Kemenade, Jutta Billino, Tilo Kircher, Benjamin Straube","doi":"10.1093/schbul/sbae134","DOIUrl":"10.1093/schbul/sbae134","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Impaired speech-gesture matching has repeatedly been shown in patients with schizophrenia spectrum disorders. Here, we tested the hypothesis that schizotypal traits in the general population are related to reduced speech-gesture matching performance and reduced self-reports about gesture perception. We further explored the relationships between facets of schizotypy and gesture processing in a network model.</p><p><strong>Study design: </strong>Participants (1094 mainly healthy adults) were presented with concrete or abstract sentences accompanied with videos showing related or unrelated gestures. For each video, participants evaluated the alignment between speech and gesture. They also completed self-rating scales about the perception and production of gestures (Brief Assessment of Gesture scale) and schizotypal traits (Schizotypal Personality Questionnaire-Brief 22-item version). We analyzed bivariate associations and estimated a non-regularized partial Spearman correlation network. We characterized the network by analyzing bridge centrality and controllability metrics of nodes.</p><p><strong>Study results: </strong>We found a negative relationship between both concrete and abstract gesture-speech matching performance and overall schizotypy. In the network, disorganization had the highest average controllability and it was negatively related to abstract speech-gesture matching. Bridge centralities indicated that self-reported production of gestures to enhance communication in social interactions connects self-reported gesture perception, schizotypal traits, and gesture processing task performance.</p><p><strong>Conclusion: </strong>The association between impaired abstract speech-gesture matching and disorganization supports a continuum between schizophrenia and schizotypy. Using gestures to facilitate communication connects subjective and objective aspects of gesture processing and schizotypal traits. Future interventional studies in patients should test the potential causal pathways implied by this network model.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"1009-1018"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Idealist to Realist-Designing and Implementing Shared Decision-Making Interventions in the Choice of Antipsychotic Prescription in People Living with Psychosis (SHAPE): A Realist Review.","authors":"Ita Fitzgerald, Laura J Sahm, Ian Maidment, Emma Wallace, Yaara Zisman-Ilani, Mikkel Højlund, Sarah O'Dwyer, Ciara Ní Dhubhlaing, Erin K Crowley, Jo Howe","doi":"10.1093/schbul/sbaf058","DOIUrl":"10.1093/schbul/sbaf058","url":null,"abstract":"<p><strong>Background: </strong>Shared decision-making (SDM) implementation remains limited in psychosis management, particularly within antipsychotic prescribing. When and why prescribers engage in SDM within these contexts is largely unknown. Part 1 of this two-part realist review aimed to understand the impact of structural and contextual factors on prescriber engagement in SDM within antipsychotic prescribing.</p><p><strong>Study design: </strong>CINAHL Plus, Cochrane Library, Embase, PsycINFO, PubMed, Scopus, Sociological Abstracts, Web of Science, and Google Scholar were searched for evidence to develop realist program theories outlining the relationship between macro-level contexts and their impact on prescriber behaviors.</p><p><strong>Study results: </strong>From 106 included documents, five program theories explaining relationships between (i) leadership and governance, (ii) workforce development, and (iii) service delivery contexts and their impact on reducing prescriber engagement with behaviors required of SDM application were developed. No facilitative macro-level contexts were identified. Key mechanisms reducing prescriber engagement in desired behaviors include fear of individual blame for adverse outcomes and exposure to liability, pressure from service environments to prioritize decreasing risk of harm, devaluing of experiential knowledge, and beliefs that SDM conflicts with duties of beneficence and non-maleficence.</p><p><strong>Conclusion: </strong>Even empirically efficacious interventions will be difficult to implement at scale within real-world settings due to misalignment with complex cultural, legal, and professional realities prominent therein. Mechanisms responsible for reducing prescriber engagement in SDM should be the target of structural interventions necessary to support contextual integration into psychosis management. Part 2 outlines features of service delivery contexts, workforce development, and technology that can increase prescriber engagement in SDM.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"916-932"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Adversity Is Associated With Attenuated Positive Symptoms and Complex Cognition in a Long-term Follow-up of the Philadelphia Neurodevelopmental Cohort.","authors":"Arielle Ered, Tyler E Dietterich, Sarah S Shahriar, Ting Yat Wong, Tyler M Moore, Kosha Ruparel, Ran Barzilay, Jerome H Taylor, Monica E Calkins, Ruben C Gur, Raquel E Gur","doi":"10.1093/schbul/sbaf061","DOIUrl":"10.1093/schbul/sbaf061","url":null,"abstract":"<p><strong>Background: </strong>Environmental adversity has been robustly associated with poor mental health outcomes, including psychosis spectrum (PS) symptoms and cognitive deficits. Environment may differentially impact males and females who differ in stress reactivity. We hypothesized that environmental adversity would predict later PS symptoms and neurocognitive deficits, and this relationship would be more pronounced in females.</p><p><strong>Study design: </strong>A sample of individuals (n = 343) from the racially diverse Philadelphia Neurodevelopmental Cohort, over-sampled for high and low adversity and psychosis risk at baseline (2009-2011), were assessed on average 11 years later. A baseline environment risk score (ERS) was calculated using established methods. The Structured Interview for Prodromal Syndromes assessed PS symptoms at follow-up, and the Penn Computerized Neurocognitive Battery assessed cognitive performance. Mixed-effects regressions were conducted for the full sample and stratified by sex assigned at birth.</p><p><strong>Study results: </strong>Higher baseline ERS was associated with greater PS symptoms (P = .006) at follow-up in the full sample. While there was no significant interaction of adversity × sex, after stratifying, ERS was predictive of total PS symptoms in females (P = .01). ERS impacted cognition in the full sample (P = .001) and in females (p = .003). Mixed-effects models did not reach significance for males. ANOVA results indicated that ERS impacted complex cognition specifically in the full sample (P = .001) and in females (P = .008) and trended toward significance in males (P = .049).</p><p><strong>Conclusions: </strong>Following early adversity, individuals are at risk for PS symptoms and cognitive deficits related to complex cognition.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":"871-882"},"PeriodicalIF":5.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}