Scandinavian Journal of Clinical & Laboratory Investigation最新文献_第8页

Interpreting two test results of one analyte from the same individual using bivariate reference values. 使用双变量参考值解释同一个体的同一分析物的两个测试结果。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-03-08 DOI: 10.1080/00365513.2026.2640361

Arne Åsberg, Gunhild Garmo Hov, Gustav Mikkelsen

{"title":"Interpreting two test results of one analyte from the same individual using bivariate reference values.","authors":"Arne Åsberg, Gunhild Garmo Hov, Gustav Mikkelsen","doi":"10.1080/00365513.2026.2640361","DOIUrl":"10.1080/00365513.2026.2640361","url":null,"abstract":"Often a measurement of an analyte is repeated in the same patient. Then the physician must interpret a pair of test results of the same analyte (x1, x2), measured in specimens collected hours to weeks apart. Physicians compare both test results against the univariate reference limits (RLs) and perhaps the difference x2 - x1 against reference change values (RCVs). We believe that it would be rational to compare a specific pair of (x1, x2) values against percentiles in the bivariate distribution of (x1, x2) from reference individuals. That has never been done, so we simulated (x1, x2) reference values using data on RLs, intraindividual biological variation in healthy individuals, and analytical variation. The bivariate percentiles corresponding to (x1, x2) observations were estimated from the Mahalanobis distances (MDs) in the bivariate distribution of (x1, x2) reference values. With a very few exceptions, the combination of 95% RLs and 95% RCVs did not enclose any (x1, x2) reference value with a bivariate percentile above 95. However, the combination enclosed only 92-93% of the (x1, x2) reference values below the bivariate 95 percentile. In conclusion, bivariate percentiles in the distribution of (x1, x2) reference values from a healthy reference population can be derived from available data, and used for reporting and interpreting the finding of a specific (x1, x2) observation in a patient.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"192-197"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coverage of antenatal haemoglobinopathy screening in the Capital Region of Denmark: a laboratory-based evaluation of screening implementation. 丹麦首都地区产前血红蛋白病筛查的覆盖率：基于实验室的筛查实施评估。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-08-11 DOI: 10.1080/00365513.2026.2713140

Andreas Glenthøj, Jens Helby, Mathilde Charlotte Schmidt, Maymana Hashim Mohamed Mohamed Salih, Jesper Petersen

{"title":"Coverage of antenatal haemoglobinopathy screening in the Capital Region of Denmark: a laboratory-based evaluation of screening implementation.","authors":"Andreas Glenthøj, Jens Helby, Mathilde Charlotte Schmidt, Maymana Hashim Mohamed Mohamed Salih, Jesper Petersen","doi":"10.1080/00365513.2026.2713140","DOIUrl":"10.1080/00365513.2026.2713140","url":null,"abstract":"Haemoglobinopathies are increasingly encountered in low-prevalence countries due to migration, placing greater demands on effective antenatal screening pathways. In Denmark, antenatal haemoglobinopathy screening is offered through general practice to women considered at high risk. We evaluated the implementation of this screening programme in the Capital Region of Denmark during 2022-2023 and estimated the national burden of haemoglobinopathy carriers. Using laboratory data from the Danish Red Blood Cell Centre, we identified women aged 15-40 years who underwent diagnostic haemoglobinopathy testing after referral from general practice. These data were compared with municipality-level numbers of births in the operational at-risk population obtained from Danish nationwide registries to estimate screening coverage. National carrier estimates were derived from country-specific carrier frequencies combined with Danish population data. Based on these estimates, approximately 57,103 individuals in Denmark were expected to be haemoglobinopathy carriers, with six countries of origin representing over half of this population. In the Capital Region, 4389 women were tested compared with 9359 births in the operational at-risk population, corresponding to an estimated coverage of 46.9%. Coverage ranged from 10.8% in Helsingør to 92.7% in Ishøj. Across the Capital Region, 193 of 618 registered general practice clinics did not order a haemoglobinopathy test during 2022-2023, with substantial variation between municipalities. These findings indicate a substantial haemoglobinopathy carrier burden in Denmark and marked geographical variation in the implementation of antenatal screening in the Capital Region. The current screening programme appears to be applied inconsistently across municipalities and general practice clinics.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"544-553"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin K-dependent proteins in patients undergoing head and neck free flap surgery - a prospective observational study. 头颈部游离皮瓣手术患者的维生素k依赖蛋白-一项前瞻性观察研究。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-06-27 DOI: 10.1080/00365513.2026.2694050

Karolina Persson, Caroline Ulfsdotter Nilsson, Johanna Sjövall, Louise Walther Sturesson, Leon Schurgers, Thomas Kander

{"title":"Vitamin K-dependent proteins in patients undergoing head and neck free flap surgery - a prospective observational study.","authors":"Karolina Persson, Caroline Ulfsdotter Nilsson, Johanna Sjövall, Louise Walther Sturesson, Leon Schurgers, Thomas Kander","doi":"10.1080/00365513.2026.2694050","DOIUrl":"10.1080/00365513.2026.2694050","url":null,"abstract":"Background/objectives: Vitamin K dependent proteins are involved in numerous biological processes, including coagulation, cancer development and inflammation, but their profile and functions in many patient groups and conditions are still unknown. The aim of this study was to describe vitamin K dependent proteins in patients undergoing head and neck free flap surgery, with the hypothesis that these patients experience postoperative vitamin K deficiency.Methods: A prospective observational study including 39 patients undergoing extensive head and neck resection and reconstruction using free flap(s) was conducted with analyses of the γ-carboxyglutamic acid-containing proteins desphospho-uncarboxylated Matrix Gla Protein (dp-uc-MGP), Growth arrest-specific gene 6 (Gas6) and Protein Induced by Vitamin K Absence/Antagonist for FII (PIVKA-II), as well as soluble Axl receptor (sAxl), on the day of surgery and postoperative (POD) days 1, 2 and 6. Changes from preoperative levels were explored using Kruskal-Wallis test with a Dunn's post hoc multiple comparison's test.Results: Gas6 showed a significant increase from preoperative levels to all postoperative days (POD1 and 2 p < 0.001, POD6 p = 0.002). For PIVKA-II a continuous increase was seen throughout the study period (POD1 ns, POD2 and 6 p < 0.001). No significant changes were seen in dp-uc-MGP or sAxl levels.Conclusions: Patients undergoing head and neck free flap surgery show signs of vitamin K deficiency during the first postoperative week.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"480-488"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clause-based framework for evaluating AI-assisted SOP generation in an ISO-aligned clinical laboratory: a proof-of-concept study. 在符合iso标准的临床实验室中评估人工智能辅助SOP生成的基于条款的框架：概念验证研究

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-06-05 DOI: 10.1080/00365513.2026.2684025

Ahmed Naseer Kaftan

{"title":"A clause-based framework for evaluating AI-assisted SOP generation in an ISO-aligned clinical laboratory: a proof-of-concept study.","authors":"Ahmed Naseer Kaftan","doi":"10.1080/00365513.2026.2684025","DOIUrl":"10.1080/00365513.2026.2684025","url":null,"abstract":"Standard operating procedures (SOPs) are foundational to quality assurance in ISO-accredited clinical laboratories, but manual SOP development is labor-intensive and prone to error. With the emergence of large language models (LLMs), such as ChatGPT-5, there is growing interest in their potential to generate compliant, context-specific laboratory documentation. To test a regulatory-aligned, clause-based evaluation framework for assessing whether ChatGPT-5 can generate context-aware, fit-for-purpose SOP drafts within a real ISO-aligned laboratory environment. In a single-site, paired proof-of-concept study, 10 high-priority SOPs were generated using ChatGPT-5 and compared with matched SOPs written by experienced laboratory professionals. AI prompts were enriched with laboratory-specific inputs (e.g. operator manuals, reagent inserts and LIS codes). SOPs were evaluated using a seven-domain ISO/CLSI-aligned rubric, a laboratory-specificity audit, clause-mapping checklists, content validity indexing and usability testing by junior staff. Inter-rater reliability and paired non-parametric statistics were applied. AI-assisted SOPs demonstrated higher median quality scores, more complete ISO clause referencing, improved traceability and stronger lifecycle conformity compared with manual SOPs. Drafting time was reduced by approximately 91%. Expert reviewers showed excellent agreement (ICC = 0.91), and content validity indices exceeded established thresholds. Junior staff rated AI-assisted SOPs as clearer and more independently usable. Context-anchored prompts improved laboratory-specific relevance. This study demonstrates a replicable, clause-based framework for evaluating AI-assisted SOP generation within a regulated laboratory context. While findings support the feasibility of AI as a documentation co-author under expert oversight, external multi-center validation is required before broader regulatory or clinical adoption.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"415-425"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between snus use and concentrations of CRP, 25(OH)D and testosterone: a population-based study. 鼻烟使用与CRP、25(OH)D和睾酮浓度之间的关系：一项基于人群的研究。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.1080/00365513.2026.2647283

Marja Lisa Byhamre, Stefan Blankenberg, Per Dahlqvist, Marie Eriksson, Viktor Oskarsson, Stefan Söderberg, Tanja Zeller, Patrik Wennberg

{"title":"Associations between snus use and concentrations of CRP, 25(OH)D and testosterone: a population-based study.","authors":"Marja Lisa Byhamre, Stefan Blankenberg, Per Dahlqvist, Marie Eriksson, Viktor Oskarsson, Stefan Söderberg, Tanja Zeller, Patrik Wennberg","doi":"10.1080/00365513.2026.2647283","DOIUrl":"10.1080/00365513.2026.2647283","url":null,"abstract":"Previous research suggests that the use of snus, a smokeless tobacco product, is associated with increased all-cause and cardiovascular mortality, but the underlying mechanisms are unknown. We aimed to evaluate the associations of snus use with biomarkers of cardiometabolic importance: high-sensitivity C-reactive protein (hs-CRP), 25-hydroxyvitamin D (25(OH)D) and calculated free testosterone (cfT). We performed cross-sectional analyses within the population-based Northern Sweden MONICA-study. The study sample consisted of 6 158 never-smoking men and women (of whom 21 and 3.3% were current snus users, respectively), examined between 1990 and 2014. Harmonized analyses on biomarkers were conducted 2016 to 2018. We evaluated the relationships between snus use and biomarker concentrations using linear and logistic regression. Snus use, compared to never-use, was associated with lower hs-CRP (exp(βln) 0.88, 95% CI 0.81; 0.96) and 25(OH)D-concentrations (β - 1.01, 95% CI -1.70; -0.33) in mixed-sex analyses. Among men, snus use was also associated with higher cfT-concentrations (exp(βln) 1.04, 95% CI 1.01; 1.07). Former snus users had no significant differences in biomarker concentrations. Snus users have lower concentrations of 25(OH)D and hs-CRP, irrespective of sex, while male users have higher cfT-concentrations. These findings may in part contribute to the previously observed increased mortality among snus users.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"253-262"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting poor prognosis risk after endovascular thrombectomy for acute ischemic stroke: combination of TMAO and white matter lesions. 预测急性缺血性脑卒中血管内取栓术后不良预后风险：TMAO与白质病变的联合

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-04-21 DOI: 10.1080/00365513.2026.2643859

Chu Zhou, Qi-Yang Yuan, Yu-Kun Wang, Chong-Ke Zhong, Yao-Wu Liu, Fen-Fang Gao, Rong-Rong Liu, Wei Li, Ruo-Yu Qin, Shi-Guang Zhu, De-Qin Geng

{"title":"Predicting poor prognosis risk after endovascular thrombectomy for acute ischemic stroke: combination of TMAO and white matter lesions.","authors":"Chu Zhou, Qi-Yang Yuan, Yu-Kun Wang, Chong-Ke Zhong, Yao-Wu Liu, Fen-Fang Gao, Rong-Rong Liu, Wei Li, Ruo-Yu Qin, Shi-Guang Zhu, De-Qin Geng","doi":"10.1080/00365513.2026.2643859","DOIUrl":"10.1080/00365513.2026.2643859","url":null,"abstract":"To investigate the combined predictive value of plasma trimethylamine N-oxide (TMAO) and white matter lesions (WMLs) burden for 90-day prognosis after endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) with large vessel occlusion (AIS-LVO). This retrospective study included 202 AIS-LVO patients from six centers who achieved successful recanalization after EVT between February 2023 and October 2024. Patients were categorized into good (mRS ≤ 3, n = 89) and poor prognosis (mRS > 3, n = 113) groups based on 90-day modified Rankin Scale (mRS). Univariate and multivariable logistic regression analyses were performed to identify independent predictors of poor prognosis. Receiver operating characteristic (ROC) curves evaluated the predictive performance of combined TMAO and WML scores. DeLong's test confirmed that combining TMAO with the Aharon Peretz score improves the predictive value for poor outcomes over traditional risk factors (NIHSS score and age). The poor prognosis group exhibited significantly higher age, TMAO levels, creatinine, Aharon Peretz scores and NIHSS compared to the good prognosis group (p < 0.05). Multivariable analysis identified TMAO (OR = 2.854, 95%CI: 1.693-4.812), and Aharon Peretz score (OR = 1.881, 95%CI: 1.384-2.558) as new independent predictors (p < 0.05). The combination of TMAO and Aharon Peretz scores predicted poor prognosis with an AUC of 0.786 (95%CI: 0.723-0.848). TMAO and Aharon Peretz scores are independent risk factors for poor short-term prognosis after EVT in patients with AIS. The combination of TMAO and Aharon Peretz scores more accurately predicts the occurrence of short-term poor prognosis after EVT in patients with AIS.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"224-236"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutoff-dependent test responses and age, sex and seasonal variations of the alcohol biomarkers phosphatidylethanol (PEth) and carbohydrate-deficient transferrin (CDT). 酒精生物标志物磷脂酰乙醇（PEth）和缺碳水化合物转铁蛋白（CDT）的截止依赖性测试反应和年龄、性别和季节变化。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-06-01 DOI: 10.1080/00365513.2026.2679466

Anders Helander, Fredrik Sparring

{"title":"Cutoff-dependent test responses and age, sex and seasonal variations of the alcohol biomarkers phosphatidylethanol (PEth) and carbohydrate-deficient transferrin (CDT).","authors":"Anders Helander, Fredrik Sparring","doi":"10.1080/00365513.2026.2679466","DOIUrl":"10.1080/00365513.2026.2679466","url":null,"abstract":"Phosphatidylethanol (PEth) in whole blood and carbohydrate-deficient transferrin (CDT) in serum are routinely used alcohol biomarkers of repeated high intake and harmful drinking over the preceding weeks to month. The study compared 27,293 paired measurements of PEth (PEth 16:0/18:1) and CDT (%disialotransferrin) from occupational health care testing in Sweden. PEth concentrations ranged <0.01-9.0 µmol/L (mean 0.09, median 0.36), and CDT values ranged <0.5-19.1% (mean 1.78, median 1.40). The values were significantly correlated (R = 0.64, p < 0.0001) but with substantial individual variability. Clinical classification was concordant in most cases, 66% being negative for both and 16% being positive for both at routine cutoffs (PEth >0.30 µmol/L; CDT ≥2.0%). However, PEth alone was positive in 15% and CDT alone in ∼3%. PEth identified 90% of all positive cases (i.e. by PEth and/or CDT) compared with 57% for CDT, while 47% were positive for both. Increasing the PEth cutoff to >0.50 µmol/L reduced positivity to 66%, whereas lowering the CDT cutoff to ≥1.7% increased positivity to 90%. The prevalence of positive test results increased with age. For CDT, men showed higher positivity across all age groups, while PEth scored higher for men only in those aged <30 years. In routine hospital testing (>64,000 test per biomarker), the monthly average and proportion of positive PEth values correlated with population-level alcohol consumption showing peaks during summer holidays and after Christmas-New Year, whereas no correlation was observed for CDT. In conclusion, differences between PEth and CDT are largely driven by cutoff-dependent classification rather than discordant biomarker behavior.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"384-393"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Likelihood ratios of quantitative diagnostic test results. 定量诊断试验结果的似然比。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-05-14 DOI: 10.1080/00365513.2026.2673545

Arne Åsberg, Gustav Mikkelsen, Ann Elisabeth Åsberg, Øyvind Skadberg

引用次数: 0

Hemoglobin fraction quantitation with Capillarys 2 FP HbA1c mode in patients with known sickle cell disease. 已知镰状细胞病患者血红蛋白含量定量的毛细管2fp HbA1c模式

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-05-13 DOI: 10.1080/00365513.2026.2671961

Olav Klingenberg, Bente Fjeld, Ingunn B O Lundbye

{"title":"Hemoglobin fraction quantitation with Capillarys 2 FP HbA1c mode in patients with known sickle cell disease.","authors":"Olav Klingenberg, Bente Fjeld, Ingunn B O Lundbye","doi":"10.1080/00365513.2026.2671961","DOIUrl":"10.1080/00365513.2026.2671961","url":null,"abstract":"Objective: To evaluate the feasibility of using Sebia Capillarys HbA1c mode for quantifying hemoglobin fractions in patients with known sickle cell disease to reduce turnaround time.Methods: Hemoglobin fractions were analyzed in 58 samples from patients with previously diagnosed sickle cell disease using the Sebia Capillarys 2 FP HbA1c mode (A1c mode) and Sebia Capillarys 2 FP, HEMOGLOBIN(E) mode (Hb mode). Method comparison was performed using Bland-Altman and linear regression analyses. Precision was determined by repeated analysis of internal control material and patient samples, while linearity was studied by serial dilution of a sample containing HbS with a sample without HbS.Results: The A1c mode showed good agreement with the Hb mode for quantification of HbA, HbS, and HbF fractions, with small biases of 1.44%, -1.66%, and 0.-02% respectively. Good linearity was demonstrated for HbS and HbA quantification (R2=0.9995).Conclusion: The A1c mode is appropriate for quick measurement of hemoglobin fractions in patients with known sickle cell disease, allowing for improved turnaround times in clinical settings. Due to occasional peak shifts and peak mislabeling by the software, a flow chart is included to guide proper A1c mode electropherogram interpretation.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"361-368"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal whole blood mercury, cadmium and lead concentrations during pregnancy and lactation and infant heavy metal status at six months. 妊娠和哺乳期孕妇全血汞、镉和铅浓度及6个月婴儿重金属状况。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-06-26 DOI: 10.1080/00365513.2026.2684338

Luca Barsalini, Kristin Holstad, Bjørn Bolann, Alexander Blø, Anne-Lise Bjørke-Monsen

{"title":"Maternal whole blood mercury, cadmium and lead concentrations during pregnancy and lactation and infant heavy metal status at six months.","authors":"Luca Barsalini, Kristin Holstad, Bjørn Bolann, Alexander Blø, Anne-Lise Bjørke-Monsen","doi":"10.1080/00365513.2026.2684338","DOIUrl":"10.1080/00365513.2026.2684338","url":null,"abstract":"Exposure to mercury (Hg), cadmium (Cd) and lead (Pb) in early life is associated with negative health effects. Pregnancy and lactation are particularly sensitive periods as stored maternal body burdens may be mobilized and transported to the child over placenta and in breast milk. The objective of the study was to evaluate relations between maternal and infant whole blood concentrations of Hg, Cd and Pb in a longitudinal study from pregnancy week 18 to 6 months postpartum. Whole blood Hg, Cd and Pb were measured in pregnancy week 18, 28 and 36, as well as 6 weeks, 4 and 6 months postpartum in 114 Norwegian pregnant and lactating women and their infants at age 6 months. Data on maternal nutrition and lifestyle factors, and months of exclusive breastfeeding were collected. Maternal whole blood Hg and Pb during pregnancy and postpartum were significant positive predictors for whole blood Hg and Pb in infants at six months, while no associations were observed for whole blood Cd. The majority of the infants were breastfed with a mean duration of exclusive breastfeeding of 3.8 (SD 1.5) months. Despite a substantial increase in maternal whole blood Hg, Cd and Pb concentrations postpartum, no associations were seen between infant heavy metal status and months of exclusive breastfeeding, indicating that placental transfer may be the major source of early life exposure to Hg and Pb. Public health interventions should focus on reducing the exposure of heavy metals to females from a very young age.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"441-451"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0