Humboldt kolleg Ibarra 2019最新文献_第2页

Bacteriophages applications in agriculture 噬菌体在农业中的应用

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.24

A. V. Cordova, J. C. Laglaguano

引用次数: 0

Prevention of cervical cancer development through early detection of HPV using novelty molecular applications 利用新颖的分子技术及早侦测HPV，预防子宫颈癌的发展

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.15

Kerly León-Ordóñez, Sofía Abad-Sojos

{"title":"Prevention of cervical cancer development through early detection of HPV using novelty molecular applications","authors":"Kerly León-Ordóñez, Sofía Abad-Sojos","doi":"10.21931/RB/CS/2019.02.01.15","DOIUrl":"https://doi.org/10.21931/RB/CS/2019.02.01.15","url":null,"abstract":"Human Papillomavirus (HPV) is the predominant cause of cervical cancer worldwide. The infections with HPVs 16 and 18 have a high oncogenic risk for cancer development. Besides, the genes E6 and E7 encode viral oncoproteins associated with infection. New molecular techniques for HPV detection, show important advantages such as high sensitivity, recognition capacity, reliability, among others. These techniques allow the standardization of new protocols associated with the detection in a variety of substances and samples. The stretch relationship between the virus and the disease open a new field to study early detection of the HPV infection. Additionally, less concentration of the sample is needed. Considering the significance of the detection, the present paper explains five novelty molecular applications for the prevention cervical cancer and early detection of HPV such as RNA in situ Hybridization for the detection of HPV E6/E7, genosensors, electrochemical DNA biosensor, PCR-based urine assay and a semen assay for detection of HPV. All the methods related to DNA samples could be used for both genders, there are more acceptable and easy to collect.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123497985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene therapy in liver diseases focus on Adeno-Associate Virus Vector (AAV) and Virus-Like Particles (VLPS) 肝脏疾病的基因治疗:腺相关病毒载体(AAV)和病毒样颗粒(VLPS)

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.20

Mayra V. Quinga, Lizbeth X. Quiroz

引用次数: 0

Therapeutic angiogenesis as a treatment for Coronary Artery Occlusions 治疗性血管生成治疗冠状动脉闭塞

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.18

Sebastian Alcivar, Jonathan Hermenejildo

引用次数: 0

Current prevalence and risk factors related to Chagas disease in Bolivia 玻利维亚恰加斯病的流行现状和相关风险因素

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.7

N. Medrano-Mercado, Tania Alba Medrano, G. Schaub, E. Grisard, M. Steindel

引用次数: 0

Effect of six bis-THTT derivatives in the control of parasitaemia in two rodent malaria species 六种双thtt衍生物对两种啮齿动物疟疾寄生虫病的控制效果

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.11

Katherine S. Loachamin, H. Rodríguez

{"title":"Effect of six bis-THTT derivatives in the control of parasitaemia in two rodent malaria species","authors":"Katherine S. Loachamin, H. Rodríguez","doi":"10.21931/rb/cs/2019.02.01.11","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.11","url":null,"abstract":"Malaria is a life-threatening disease caused by parasites of the genus Plasmodium and is transmitted to humans by the bite of female mosquitoes of the genus Anopheles. WHO has reported 219 million cases of malaria and 435,000 deaths were estimated in 2017. The anti-malarial treatment more frequently used is based on Chloroquine, which has been used for several decades. This prolonged application has caused the parasite to develop resistance to the use of the mentioned drug, so it becomes necessary to search for new treatments. In addition, some tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (THTT) derivatives have been previously studied as possible trypanosomicides, obtaining satisfactory results in the treatment to Trypanosoma cruzi; Trichomonas vaginalis and T. b. rhodesiense, although no studies against malaria have been reported. In the present work, six bis-THTT derivatives were evaluated as potential anti-malarial drugs (JH1, JH2, JH3, JH4, JH5, and JH6) with BALB/c mice, which were inoculated with Plasmodium berghei ANKA strain and Plasmodium yoelii 17XL strain. The percentages of parasitemia were determined for each tested compound, which was assessed daily on smears from tail blood, stained with Giemsa’s reagent and observed under light microscopy as evidence of cure. Our results showed that JH2 and JH4 presented effective parasitemia control similar to chloroquine in P. berghei. Besides, JH5 and JH6 exhibited better results than Chloroquine with P. yoelii infection. In summary, four of the six bis-THTT derivatives tested, could be considerate as potential new drugs to infection malaria rodent control. Immune response essays should be realized in order to confirm our preliminary results.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131880911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sickle Cell Anemia: A review on the most severe form of Sickle Cell Disease 镰状细胞性贫血:镰状细胞病最严重形式的综述

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.19

Maria Belén Paredes, María Eugenia Sulen

引用次数: 0

Determination of Aflatoxin M1 concentration in volunteers from rural and urban areas of Cochabamba-Bolivia 玻利维亚科恰班巴城乡志愿者黄曲霉毒素M1浓度测定

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.6

Andrea Condori Vincenti, Stefania Torrico Torrico, Tania Alba Medrano, Yesica Nina Guaravia, N. Medrano-Mercado, T. P. Huynh

引用次数: 0

Relationship between Charge Transfer Diffusion Coefficients and Doping Level for electro generated thin PEDOT films on ITO ITO上电致PEDOT薄膜的电荷转移扩散系数与掺杂水平的关系

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.8

Alex Palma-Cando, B. Frontana-Uribe, V. Varela-Guerrero

引用次数: 3

A Hemophilia Disorder Review: Gene Therapy for Hemophilia B Treatment using rAAV vectors 血友病综述:利用rAAV载体治疗血友病B的基因疗法

Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.16

Abad Gallardo Claudia Sofía, Merchán Muñoz Brian David

{"title":"A Hemophilia Disorder Review: Gene Therapy for Hemophilia B Treatment using rAAV vectors","authors":"Abad Gallardo Claudia Sofía, Merchán Muñoz Brian David","doi":"10.21931/rb/cs/2019.02.01.16","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.16","url":null,"abstract":"Hemophilia is an X-linked recessive disorder characterized by the deficiency in one protein essential for blood coagulation. There are two main types of variants of this disease; hemophilia A (HA) which is related with blood clotting factor VIII (FVIII) deficiency and hemophilia B (HB) which is related with factor IX (FIX) deficiency. Nowadays, there are several options to treat this disorder, however, the most efficient is gene therapy since it has a long-term effect, and contrasts with traditional methods. This review is focused on hemophilia B treatment because FIX is a smaller protein than FVIII (<1kb), and thereby is easier to study. Within gene therapy, methods which use recombinant adeno-associated virus (rAAV) vectors are the best alternative to treat HB since they are safe and reliable. Moreover, rAAV vectors have the advantage of having a low inflammatory potential, a non-pathogenic status, plus the potential for long-term expression of the transferred gene. However, some patients showed an immune response to the capsids of the vectors before treatment. Hence, possible solutions were needed; one of them being the use of anti-antibodies. Finally, clinical trials results showed that under the use of the optimized codon hFIXco and serotype 8 the levels of expression were persistent, demonstrating the potential of gene therapy for hemophilia B treatment.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127088406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0