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Antibody response after hepatitis B vaccine boost mapped with peptide-phage display 乙型肝炎疫苗增强后的抗体反应与肽噬菌体显示
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-21 DOI: 10.21931/rb/cs/2019.02.01.2
L. R. Caballero, N. Delaroque, M. Szardenings
{"title":"Antibody response after hepatitis B vaccine boost mapped with peptide-phage display","authors":"L. R. Caballero, N. Delaroque, M. Szardenings","doi":"10.21931/rb/cs/2019.02.01.2","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.2","url":null,"abstract":"Recombinant hepatitis B virus vaccines confer protection by eliciting specific antibodies against the hepatitis B surface antigen (HBsAg), known as anti-HBs. However, the performance of rapid anti-HBs diagnostic tests generates concerns regarding consistency. Novel indicators of protection might be developed by monitoring changes in targeted HBsAg-epitope profile after vaccination. In this work, we test the feasibility of our peptide-phage display platform in identifying B-cell epitopes targeted at different time-points after hepatitis B vaccination. We combined this platform with a unique approach for in silico analysis of enriched sequences. Serum samples collected from one single patient who had two boosting immunizations against hepatitis B virus were used in two-rounds of selection experiments. Five epitope candidates from HBsAg were identified in silico; most of them were previously reported in the literature. Our results suggest that the number of recognized HBsAg epitopes is related to the decrease of anti-HBs over time.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124815046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gangliosides generalities and role in cancer therapies 神经节苷类及其在癌症治疗中的作用
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.28
Daniela S Pasquel-Dávila, Sabrina A. Yanez-Vaca, Nicole D Espinosa-Hidalgo, Evelin G Cuadros Buenaventura
{"title":"Gangliosides generalities and role in cancer therapies","authors":"Daniela S Pasquel-Dávila, Sabrina A. Yanez-Vaca, Nicole D Espinosa-Hidalgo, Evelin G Cuadros Buenaventura","doi":"10.21931/rb/cs/2019.02.01.28","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.28","url":null,"abstract":"Gangliosides are located in the plasma membrane; this confers them the ability to interact with other molecules in order to participate in important cellular processes. Some gangliosides presence or absence in the cell surface is associated with either normal condition or pathologies. Particularly in cancer, gangliosides play a critical role in pathological events like cellular malignancy, tumor formation, and metastasis, defining gangliosides as good candidates to be used as cellular markers. When specific gangliosides are exhibited, immunotherapy could be applied in order to inhibit tumorigenesis or induce an immunogenic response. Novel cancer treatments such as NGcGM3/VSSP vaccines, valproic acid, BMS-345541 inhibitor of GD2 and immunotherapies using 1E10 and 14F7 monoclonal antibodies are described. On this review, there will be studied the gangliosides that allowed developing biological techniques that can give immunogenicity to cancer cells","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"71 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126973001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic antidepressant research: a brief assay on how to justify your alpha 抗抑郁药的基础研究:如何证明你的alpha值的简短分析
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.3
C. Lino de Oliveira
{"title":"Basic antidepressant research: a brief assay on how to justify your alpha","authors":"C. Lino de Oliveira","doi":"10.21931/RB/CS/2019.02.01.3","DOIUrl":"https://doi.org/10.21931/RB/CS/2019.02.01.3","url":null,"abstract":"Antidepressant research seems under risk of bias and poor reproducibility. Recent debates brought the use of the p values in hypothesis testing to the center of a reproducibility crisis. In basic biomedicine, the use of p values has been justified by tradition instead of reasoning. Here, a biomedical researcher commented concerns with the traditional use of the p values in basic antidepressant research and discussed the missing pieces limiting the plausible justifications to their use in the field.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130567190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General Approach to Drug Delivery Systems (DDS) 药物输送系统(DDS)的一般方法
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.14
Danna Belén Castillo, H. M. Rodriguez
{"title":"General Approach to Drug Delivery Systems (DDS)","authors":"Danna Belén Castillo, H. M. Rodriguez","doi":"10.21931/RB/CS/2019.02.01.14","DOIUrl":"https://doi.org/10.21931/RB/CS/2019.02.01.14","url":null,"abstract":"The field of drug discovery drives to find out efficient, selective, stable and biocompatible new drugs. The purpose of drug delivery systems (DDS) is to reduce the side effects that treatments usually cause to mitigate some diseases, especially cancer. Cancer treatments are usually so strong and invasive that they end up weakening the patient, so the cure became as dangerous as the disease. That is the reason that DDS try to maximize the effectiveness of the drugs administered by wanting them to reach specifically to the area affected by the disease (High specificity). In this regard, the fruitfully use of liposome-, erythrocytes-, nanoparticles- or antibodies-based therapies became a choice for the treatment of a huge range of diseases, due to the biocompatibility that these macromolecular systems present. In the last five years, a broad range of DDS have been developed, and some of them, specifically four ADC´s are approved by the FDA and commercializing. In this work, we summarized the most important approach to DDS obtained through chemical conjugation, highlighting ADC´s like the most promising controlled release systems.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134286612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-angiogenesis therapy for the treatment ovarian cancer 抗血管生成疗法治疗卵巢癌
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.26
Alejandra Cevallos, A. Solórzano
{"title":"Anti-angiogenesis therapy for the treatment ovarian cancer","authors":"Alejandra Cevallos, A. Solórzano","doi":"10.21931/rb/cs/2019.02.01.26","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.26","url":null,"abstract":"The process of angiogenesis is regulated by several growth factors, the most important factor is VEGF which is an important mediator because it facilitates the growth of blood vessels and the remodeling processes. In addition, angiogenesis is significantly involved in tumor progression giving the tumor the necessary supplies for its survival and thus causing metastases in other organs by providing a site of entry to the circulation of vessels blood. The objective of this review is to reflect the fundamental role that angiogenesis has in the development and spread of cancer through vascular endothelial growth factor, its receptors, and its signaling pathways. On the other hand, antiangiogenics strategies (angiogenesis inhibitors) are proposed to fight cancer and clinical trials are presented to verify the survival range of patients who have been treated with anti-angiogenic therapy.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133549399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostate Cancer: Treatments and Diagnosis 前列腺癌:治疗和诊断
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.27
R. Angulo, B. Herrera, K. Ibarra
{"title":"Prostate Cancer: Treatments and Diagnosis","authors":"R. Angulo, B. Herrera, K. Ibarra","doi":"10.21931/rb/cs/2019.02.01.27","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.27","url":null,"abstract":"Prostate cancer is a disease in which malignant (cancer) cells form in the tissues of the prostate. Prostate tumors were responsible for nearly six thousand deaths in Spain in 2016 as the symptoms are very silent and appear like advanced cancer or when this cancer has proliferated to other organs and senses. Therefore, there are 4 characteristic stages of this type of cancer that are classified according to their extension in the body. To make the diagnosis of this type of disease there are methods that in many cases show to be effective and in others not depending on the stage in which you are. Therefore, the number of treatments against prostate cancer has been increasing over the years from medications that help prevent tumor proliferation to strong surgeries. These treatments are not a solution to fight cancer, they simply have the function of maintaining cancer and its proliferation in order to generate a suitable lifestyle for patients for a time. Currently, several investigations have focused on combating prostate cancer through clinical trials that promise to generate favorable and acceptable solutions for patients.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126863361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking Paradigms: Towards a Multi-, Inter- and Transdisciplinary Science” In commemoration of the 250th Anniversary of Alexander von Humboldt 《打破范式:走向多学科、跨学科的科学》，纪念亚历山大·冯·洪堡诞辰250周年
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.1
Vivian Morera Córdova
{"title":"Breaking Paradigms: Towards a Multi-, Inter- and Transdisciplinary Science” In commemoration of the 250th Anniversary of Alexander von Humboldt","authors":"Vivian Morera Córdova","doi":"10.21931/rb/cs/2019.02.01.1","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.1","url":null,"abstract":"To celebrate the 250th anniversary of Alexander von Humboldt, from February 22th to February 24th occurred in the city of Ibarra, Ecuador the Humboldt kolleg “Breaking Paradigms: Towards a Multi-, Inter- and Transdisciplinary Science”. The event was held at the facilities of the Hotel Ajaví. This Humboldt kolleg aimed to create a space for Humboldtians, young doctors in science and young researchers of Latin America for disseminating their results, as well as to create collaborative and cooperative relationships and strengthen the existing one, in order to take steps forward in scientific knowledge within Latin America. The event also had the purpose of creating the space for the dissemination of the programs offered by the Alexander von Humboldt Foundation to young doctors in science for conducting their research in leading laboratories in Germany.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126219422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantification of fumonisins by the ELISA method in maize of different communities of the Cochabamba and Chuquisaca Departments 用ELISA法定量测定科恰班巴省和丘基萨卡省不同群落玉米中伏马菌素含量
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/RB/CS/2019.02.01.5
Stefania Torrico Torrico, Andrea Condori Vincenti, Miguel Angel Florido, Nora Medrano Mercado
{"title":"Quantification of fumonisins by the ELISA method in maize of different communities of the Cochabamba and Chuquisaca Departments","authors":"Stefania Torrico Torrico, Andrea Condori Vincenti, Miguel Angel Florido, Nora Medrano Mercado","doi":"10.21931/RB/CS/2019.02.01.5","DOIUrl":"https://doi.org/10.21931/RB/CS/2019.02.01.5","url":null,"abstract":"Maize constitutes more than 75% of the food base of the Inter-Andean Valleys and is one of the foods most at risk of fumonisin and yet there is no information about the incidence level of fumonisins in this region. In this project we collected 174 samples from organic maize producers communities of the inter-Andean valleys that work with the Valles Foundation, the number of fumonisins was determined by the Elisa Method, with 0.05 ng/ml being the lowest value obtained in the community of Alcalá and 12.05 ng/ml,Highest value obtained in the community of Mizque.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128975765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microalgae species as potential inhibitors of the bioactivity of Vibrio parahaemolyticus in shrimps 微藻种对对虾副溶血性弧菌生物活性的潜在抑制作用
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.13
Freddy Figueroa, B. Aldaz
{"title":"Microalgae species as potential inhibitors of the bioactivity of Vibrio parahaemolyticus in shrimps","authors":"Freddy Figueroa, B. Aldaz","doi":"10.21931/rb/cs/2019.02.01.13","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.13","url":null,"abstract":"Vibrio parahaemolyticus is a Gram-negative motile bacteria belonging to Vibrionaceae family causing cytotoxicity in cultured cells and enterotoxicity in animal models. Similarly, this bacterium is a major foodborne pathogen that causes life-threatening diseases in human, including gastroenteritis and septicemia, via consumption of contaminated seafood. Based on the increasing interest in developing novel environmental friendly solutions for the inhibition of the bioactivity of V. parahaemolyticus, microalgae species have emerged as potential candidates due to the microbiota associated with microalgae cultures, oxygen radicals produced during the photosynthetic process and the production of secondary metabolites, useful for antibacterial properties. In the present review, conventional treatments concerning V. parahaemolyticus bioactivity have been presented. However, in terms of effectiveness, numerous studies explaining the use of microalgae species for antibacterial activity against V. parahaemolyticus have been detailed suggesting that microalgae-based treatment are considerably better. Finally, we presented a proposed microalgae-based solution that can act as an inhibitor of V. parahaemolyticus bioactivity and therefore can be applied in the aquaculture industrial field to improve productivity and reduce costs.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133580063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Situation of Human Papilloma Virus: Generalities and current treatments 人乳头状瘤病毒的情况:概况和目前的治疗方法
Humboldt kolleg Ibarra 2019 Pub Date : 2019-02-19 DOI: 10.21931/rb/cs/2019.02.01.25
Cristhian Preciado, Paolo Vallejo Janeta
{"title":"Situation of Human Papilloma Virus: Generalities and current treatments","authors":"Cristhian Preciado, Paolo Vallejo Janeta","doi":"10.21931/rb/cs/2019.02.01.25","DOIUrl":"https://doi.org/10.21931/rb/cs/2019.02.01.25","url":null,"abstract":"Human papillomavirus represents the commonest STD, and it is the principal causative agent of different genital lesions, including genital warts and cervical cancer. Two high-risk HPV genotypes are responsible for the 70% of cervical cancer, and the prevalence of these types reaches alarming levels in many developing countries (e.g., 43.58% in Ecuador). However, the information about HPV in developing countries is limited, becoming an obstacle for breakthrough treatments or prevention strategies. Current strategies include the development of new vaccines, combined chemo- and radiotherapy, and the use of CRISPR/Cas9. Moreover, HPV can be used to treat other non-related cancers, such as ovarian cancer. The present review aims to describe the different prevention strategies and treatments for HPV available worldwide, cover the usage of HPV for the treatment of other diseases, as well as comment on their possible application in Ecuador.","PeriodicalId":214615,"journal":{"name":"Humboldt kolleg Ibarra 2019","volume":"468 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131795723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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