Situation of Human Papilloma Virus: Generalities and current treatments

Abstract

Human papillomavirus represents the commonest STD, and it is the principal causative agent of different genital lesions, including genital warts and cervical cancer. Two high-risk HPV genotypes are responsible for the 70% of cervical cancer, and the prevalence of these types reaches alarming levels in many developing countries (e.g., 43.58% in Ecuador). However, the information about HPV in developing countries is limited, becoming an obstacle for breakthrough treatments or prevention strategies. Current strategies include the development of new vaccines, combined chemo- and radiotherapy, and the use of CRISPR/Cas9. Moreover, HPV can be used to treat other non-related cancers, such as ovarian cancer. The present review aims to describe the different prevention strategies and treatments for HPV available worldwide, cover the usage of HPV for the treatment of other diseases, as well as comment on their possible application in Ecuador.